This paper develops a moderated mediation model in which the interactive effects of food traceability and environmental dynamism on firm performance are mediated by the core capabilities(operating capabilities and mar...This paper develops a moderated mediation model in which the interactive effects of food traceability and environmental dynamism on firm performance are mediated by the core capabilities(operating capabilities and marketing capabilities)in food supply chain context, by invoking the indirect view of organizational learning theory. Our hypotheses were tested using hierarchical regression and bootstrapping methods with a sample of 216 food manufacturing firms in China, and a survey-based, two-informant design was used to collect data. The results revealed that operating and marketing capabilities fully mediate the food traceability-performance link. In addition, environmental dynamism positively moderates the food traceability-core capabilities link. Moreover, it is found that operating and marketing capabilities transform the interactive impacts of environmental dynamism and food traceability into firm performance. Our study offers a fine-grained picture of the essential food traceability-performance link by revealing for the first time that there is an interactive impacts of food traceability and environmental dynamism on firm performance via core capabilities.展开更多
Communicative dynamism is of great importance in the field of linguistics, which would help a lot to extract the useful experience for the numerous fields as the educational field. In order to make full advantage of t...Communicative dynamism is of great importance in the field of linguistics, which would help a lot to extract the useful experience for the numerous fields as the educational field. In order to make full advantage of the communicative dynamism,it is imperative to find out the details. Therefore, a summary should be made so as to get a better understanding of the discourse analysis. In the summary, the distribution of communicative dynamism and prosodic prominence would be discussed together with the related details.展开更多
In the Southern African context,businesses,governments,and community-based organizations have become reliant on teamwork to streamline processes,augment participation and improve performance.In this regard,the histori...In the Southern African context,businesses,governments,and community-based organizations have become reliant on teamwork to streamline processes,augment participation and improve performance.In this regard,the historically formalized,centralized,and departmentalized mechanistic structures are being replaced by team-based structures.Research from the North,on team building,suggests that teams have a potential to give diversity in knowledge,attitudes,skills,and experience,whose integration would make it possible to offer rapid,flexible and innovative responses to problems and challenges,promoting performance and improving the satisfaction of those making the team.In South Africa,a state-owned entity launched a team-building initiative to improve team effectiveness and functioning within the water sector.This initiative was implemented contemporaneously with climate and culture change management initiatives envisioned to usher in a new culture,to improve employee morale,and,ultimately,to ensure a high-performing organization.These initiatives sought to help articulate and cultivate leadership accord,create a common vision,as well as develop a consensus on a set of collective values that would become the bedrock of the organization.In the light of this background,this paper examines the effectiveness of the“growing-our-teams”initiative,with the goal of lending insights into the strengths and weaknesses of strategies and processes deployed to implement and manage the initiative.In assessing the strengths and weaknesses of the program,the underpinning research was conducted by reviewing and analyzing related articles and papers,as well as interrogating employee experiences relating to the program.How do state-owned entities learn and implement lessons distilled from their programs or initiatives to build capacity and improve efficiencies?展开更多
Taken discourse production as the research objective,it holds that discourse production is dynamic in human communication.It attempts to analyze the dynamics on the basis of Relevance-adaption model from the perspecti...Taken discourse production as the research objective,it holds that discourse production is dynamic in human communication.It attempts to analyze the dynamics on the basis of Relevance-adaption model from the perspective of cognitive pragmatics and explain the role of the context dynamics that plays in the discourse production.展开更多
The development of the Internet has provided firms with the ideal opportunity to make up for the knowledge gap for achieving internal knowledge generation(IKG)and external knowledge acquisition(EKA).It is worth explor...The development of the Internet has provided firms with the ideal opportunity to make up for the knowledge gap for achieving internal knowledge generation(IKG)and external knowledge acquisition(EKA).It is worth exploring how Internet resources can be used to satisfy organizational knowledge needs efficiently to adapt to dynamic environments.Thus,according to the resource-based view,knowledge-based view,and contingency theory,we study the impact of different types of Internet resources on the two modes of knowledge creation(IKG and EKA),as well as the moderating effect of environmental dynamism(ED)on this relationship.The hypothesized relationships were tested using the hierarchical regression analysis method with survey data collected from 399 Chinese firms.We found that Internet relationship resource and Internet human resource can simultaneously facilitate IKG and EKA,while Internet infrastructure resource positively affects IKG but has no significant impact on EKA.Furthermore,ED positively moderates the relationship between Internet relationship resource and IKG and EKA,but negatively moderates the relationship between Internet human resource and EKA.展开更多
Understanding the temperature dependent deformation behavior of Mg alloys is crucial for their expanding use in the aerospace sector.This study investigates the deformation mechanisms of hot-rolled AZ61 Mg alloy under...Understanding the temperature dependent deformation behavior of Mg alloys is crucial for their expanding use in the aerospace sector.This study investigates the deformation mechanisms of hot-rolled AZ61 Mg alloy under uniaxial tension along rolling direction(RD)and transverse direction(TD)at-50,25,50,and 150℃.Results reveal a transition from high strength with limited elongation at-50℃ to significant softening and maximum ductility at 150℃.TD samples consistently showed 2%-6%higher strength than RD;however,this yield anisotropy diminished at 150℃ due to the shift from twinning to thermally activated slip and recovery.Fractography indicated a change from semi-brittle to fully ductile fracture with increasing temperature.Electron backscattered diffraction(EBSD)analysis confirmed twinning-driven grain refinement at low temperatures,while deformation at high temperatures involved grain elongation along shear zones,enabling greater strain accommodation before material failure.展开更多
Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve thro...Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.展开更多
The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing ...The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing hull.The original hull was modified by introducing a step to allow air ventilation.Following an assessment of the hull performance,a simulation campaign in calm water was conducted to characterize the hull at various forward speeds and air insufflation rates for a defined single step geometry.Geometric analysis of the air layer thickness beneath the hull for each simulated condition was performed using a novel method for visualizing local air thickness.Additionally,two new parameters were introduced to understand the influence of spray rails on the air volume beneath the hull and to indicate the primary direction of ventilated air escape.A validation campaign and an assessment of uncertainty of the simulation has been conducted.The features offered by the CFD methodology include the evaluation of the air layer thickness as a function of hull velocity and injection flow rate and the air volume distribution beneath the hull.The air injection velocity can be adjusted across various operating conditions,thereby preventing performance or efficiency loss during navigation.Based on these findings,the study highlights the benefits of air insufflation in reducing hull resistance for high-speed planing vessels.This work lays a robust foundation for future research and new promising topics,as the exploration of air insufflation continues to be a topic of contemporary interest within naval architecture and hydrodynamics.展开更多
Colorectal cancer(CRC)with lung oligometastases,particularly in the presence of extrapulmonary disease,poses considerable therapeutic challenges in clinical practice.We have carefully studied the multicenter study by ...Colorectal cancer(CRC)with lung oligometastases,particularly in the presence of extrapulmonary disease,poses considerable therapeutic challenges in clinical practice.We have carefully studied the multicenter study by Hu et al,which evaluated the survival outcomes of patients with metastatic CRC who received image-guided thermal ablation(IGTA).These findings provide valuable clinical evidence supporting IGTA as a feasible,minimally invasive approach and underscore the prognostic significance of metastatic distribution.However,the study by Hu et al has several limitations,including that not all pulmonary lesions were pathologically confirmed,postoperative follow-up mainly relied on dynamic contrast-enhanced computed tomography,no comparative analysis was performed with other local treatments,and the impact of other imaging features on efficacy and prognosis was not evaluated.Future studies should include complete pathological confirmation,integrate functional imaging and radiomics,and use prospective multicenter collaboration to optimize patient selection standards for IGTA treatment,strengthen its clinical evidence base,and ultimately promote individualized decision-making for patients with metastatic CRC.展开更多
Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving...Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving the overall performance of CPEs due to their difficulty in achieving robust electrochemical and mechanical interfaces simultaneously.Here,by regulating the surface charge characteristics of halloysite nanotube(HNT),we propose a concept of lithium-ion dynamic interface(Li^(+)-DI)engineering in nano-charged CPE(NCCPE).Results show that the surface charge characteristics of HNTs fundamentally change the Li^(+)-DI,and thereof the mechanical and ion-conduction behaviors of the NCCPEs.Particularly,the HNTs with positively charged surface(HNTs+)lead to a higher Li^(+)transference number(0.86)than that of HNTs-(0.73),but a lower toughness(102.13 MJ m^(-3)for HNTs+and 159.69 MJ m^(-3)for HNTs-).Meanwhile,a strong interface compatibilization effect by Li^(+)is observed for especially the HNTs+-involved Li^(+)-DI,which improves the toughness by 2000%compared with the control.Moreover,HNTs+are more effective to weaken the Li^(+)-solvation strength and facilitate the formation of Li F-rich solid-electrolyte interphase of Li metal compared to HNTs-.The resultant Li|NCCPE|LiFePO4cell delivers a capacity of 144.9 m Ah g^(-1)after 400 cycles at 0.5 C and a capacity retention of 78.6%.This study provides deep insights into understanding the roles of surface charges of nanofillers in regulating the mechanical and electrochemical interfaces in ASSLMBs.展开更多
Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Alt...Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental pathological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to elucidate the relationship between mitochondrial dynamics dysfunction and neurodevelopmental disorders. Mitochondria are highly dynamic organelles that undergo continuous fusion and fission to meet the substantial energy demands of neural cells. Dysregulation of these processes, as observed in certain neurodevelopmental disorders, causes accumulation of damaged mitochondria, exacerbating oxidative damage and impairing neuronal function. The phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin-protein ligase pathway is crucial for mitophagy, the process of selectively removing malfunctioning mitochondria. Mutations in genes encoding mitochondrial fusion proteins have been identified in autism spectrum disorders, linking disruptions in the fusion-fission equilibrium to neurodevelopmental impairments. Additionally, animal models of Rett syndrome have shown pronounced defects in mitophagy, reinforcing the notion that mitochondrial quality control is indispensable for neuronal health. Clinical studies have highlighted the importance of mitochondrial disturbances in neurodevelopmental disorders. In autism spectrum disorders, elevated oxidative stress markers and mitochondrial DNA deletions indicate compromised mitochondrial function. Attention-deficit/hyperactivity disorder has also been associated with cognitive deficits linked to mitochondrial dysfunction and oxidative stress. Moreover, induced pluripotent stem cell models derived from patients with Rett syndrome have shown impaired mitochondrial dynamics and heightened vulnerability to oxidative injury, suggesting the role of defective mitochondrial homeostasis in these disorders. From a translational standpoint, multiple therapeutic approaches targeting mitochondrial pathways show promise. Interventions aimed at preserving normal fusion-fission cycles or enhancing mitophagy can reduce oxidative damage by limiting the accumulation of defective mitochondria. Pharmacological modulation of mitochondrial permeability and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, an essential regulator of mitochondrial biogenesis, may also ameliorate cellular energy deficits. Identifying early biomarkers of mitochondrial impairment is crucial for precision medicine, since it can help clinicians tailor interventions to individual patient profiles and improve prognoses. Furthermore, integrating mitochondria-focused strategies with established therapies, such as antioxidants or behavioral interventions, may enhance treatment efficacy and yield better clinical outcomes. Leveraging these pathways could open avenues for regenerative strategies, given the influence of mitochondria on neuronal repair and plasticity. In conclusion, this review indicates mitochondrial homeostasis as a unifying therapeutic axis within neurodevelopmental pathophysiology. Disruptions in mitochondrial dynamics and autophagic clearance converge on oxidative stress, and researchers should prioritize validating these interventions in clinical settings to advance precision medicine and enhance outcomes for individuals affected by neurodevelopmental disorders.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
现有的烟火检测方法主要依赖员工现场巡视,效率低且实时性差,因此,提出一种基于YOLOv5s的复杂场景下的高效烟火检测算法YOLOv5s-MRD(YOLOv5s-MPDIoU-RevCol-Dyhead)。首先,采用MPDIoU(Maximized Position-Dependent Intersection over U...现有的烟火检测方法主要依赖员工现场巡视,效率低且实时性差,因此,提出一种基于YOLOv5s的复杂场景下的高效烟火检测算法YOLOv5s-MRD(YOLOv5s-MPDIoU-RevCol-Dyhead)。首先,采用MPDIoU(Maximized Position-Dependent Intersection over Union)方法改进边框损失函数,以适应重叠或非重叠的边界框回归(BBR),从而提高BBR的准确性和效率;其次,利用可逆柱状结构RevCol(Reversible Column)网络模型思想重构YOLOv5s模型的主干网络,使它具有多柱状网络架构,并在模型的不同层之间加入可逆链接,从而最大限度地保持特征信息以提高网络的特征提取能力;最后,引入Dynamic head检测头,以统一尺度感知、空间感知和任务感知,从而在不额外增加计算开销的条件下显著提高目标检测头的准确性和有效性。实验结果表明:在DFS(Data of Fire and Smoke)数据集上,与原始YOLOv5s算法相比,所提算法的平均精度均值(mAP@0.5)提升了9.3%,预测准确率提升了6.6%,召回率提升了13.8%。可见,所提算法能满足当前烟火检测应用场景的要求。展开更多
An improved method is proposed for the extraction of the symmetry energy coefficient relative to the temperature,a_(sym)/T,in the heavy-ion reactions near the Fermi energy region,based on the modified Fisher Model.Thi...An improved method is proposed for the extraction of the symmetry energy coefficient relative to the temperature,a_(sym)/T,in the heavy-ion reactions near the Fermi energy region,based on the modified Fisher Model.This method is applied to the primary fragments of antisymmetrized molecular dynamics(AMD)simulations for ^(46)Fe+^(46)Fe,^(40)Ca+^(40)Ca and ^(48)Ca+^(48)Ca at 35 MeV/nucleon,in order to make direct comparison to the results from the K(N,Z)method of Ono et al.In our improved method,the extracted values of a_(sym)/T increase as the size of isotopes increases whereas,in the K(N,Z)method,the results show rather constant behavior.This increase in our result is attributed to the surface contribution of the symmetry energy in finite nuclei.In order to evaluate the surface contribution,the relation a_(sym)/T=[a_(sym)^((V))(1-k_(S/V) A^(-1/3))]/T is applied and k_(S/V)=1.20~1.25 was extracted.This value is smaller than those extracted from the mass table,reflecting the weakened surface contribution at higher temperature regime.Δμ/T,the difference of the neutron-proton chemical potentials relative to the temperature,is also extracted in this method at the same time.The average values of the extractedΔμ/T,Δμ/T show a linear dependence on the proton-neutron a_(sym)metry parameter of the system,δ_(sys),andΔμ/T=(15.1±0.2)δ_(sys)-(0.5±0.1)is obtained.展开更多
基金supported by the research grant from the National Natural Science Foundation of China (71803183)the Financial Funds of Ministry of Agriculture (051821301112421010)
文摘This paper develops a moderated mediation model in which the interactive effects of food traceability and environmental dynamism on firm performance are mediated by the core capabilities(operating capabilities and marketing capabilities)in food supply chain context, by invoking the indirect view of organizational learning theory. Our hypotheses were tested using hierarchical regression and bootstrapping methods with a sample of 216 food manufacturing firms in China, and a survey-based, two-informant design was used to collect data. The results revealed that operating and marketing capabilities fully mediate the food traceability-performance link. In addition, environmental dynamism positively moderates the food traceability-core capabilities link. Moreover, it is found that operating and marketing capabilities transform the interactive impacts of environmental dynamism and food traceability into firm performance. Our study offers a fine-grained picture of the essential food traceability-performance link by revealing for the first time that there is an interactive impacts of food traceability and environmental dynamism on firm performance via core capabilities.
文摘Communicative dynamism is of great importance in the field of linguistics, which would help a lot to extract the useful experience for the numerous fields as the educational field. In order to make full advantage of the communicative dynamism,it is imperative to find out the details. Therefore, a summary should be made so as to get a better understanding of the discourse analysis. In the summary, the distribution of communicative dynamism and prosodic prominence would be discussed together with the related details.
文摘In the Southern African context,businesses,governments,and community-based organizations have become reliant on teamwork to streamline processes,augment participation and improve performance.In this regard,the historically formalized,centralized,and departmentalized mechanistic structures are being replaced by team-based structures.Research from the North,on team building,suggests that teams have a potential to give diversity in knowledge,attitudes,skills,and experience,whose integration would make it possible to offer rapid,flexible and innovative responses to problems and challenges,promoting performance and improving the satisfaction of those making the team.In South Africa,a state-owned entity launched a team-building initiative to improve team effectiveness and functioning within the water sector.This initiative was implemented contemporaneously with climate and culture change management initiatives envisioned to usher in a new culture,to improve employee morale,and,ultimately,to ensure a high-performing organization.These initiatives sought to help articulate and cultivate leadership accord,create a common vision,as well as develop a consensus on a set of collective values that would become the bedrock of the organization.In the light of this background,this paper examines the effectiveness of the“growing-our-teams”initiative,with the goal of lending insights into the strengths and weaknesses of strategies and processes deployed to implement and manage the initiative.In assessing the strengths and weaknesses of the program,the underpinning research was conducted by reviewing and analyzing related articles and papers,as well as interrogating employee experiences relating to the program.How do state-owned entities learn and implement lessons distilled from their programs or initiatives to build capacity and improve efficiencies?
文摘Taken discourse production as the research objective,it holds that discourse production is dynamic in human communication.It attempts to analyze the dynamics on the basis of Relevance-adaption model from the perspective of cognitive pragmatics and explain the role of the context dynamics that plays in the discourse production.
基金This work was supported by the National Social Science Foundation of China(No.15FGL005)the National Natural Science Foundation of China(Nos.71403052 and 71403055)the Social Science Planning Project of Fujian Province of China(No.FJ2016C030).
文摘The development of the Internet has provided firms with the ideal opportunity to make up for the knowledge gap for achieving internal knowledge generation(IKG)and external knowledge acquisition(EKA).It is worth exploring how Internet resources can be used to satisfy organizational knowledge needs efficiently to adapt to dynamic environments.Thus,according to the resource-based view,knowledge-based view,and contingency theory,we study the impact of different types of Internet resources on the two modes of knowledge creation(IKG and EKA),as well as the moderating effect of environmental dynamism(ED)on this relationship.The hypothesized relationships were tested using the hierarchical regression analysis method with survey data collected from 399 Chinese firms.We found that Internet relationship resource and Internet human resource can simultaneously facilitate IKG and EKA,while Internet infrastructure resource positively affects IKG but has no significant impact on EKA.Furthermore,ED positively moderates the relationship between Internet relationship resource and IKG and EKA,but negatively moderates the relationship between Internet human resource and EKA.
基金supported by the Korea Institute of Energy Technology Evaluation and Planning(KETEP)the Ministry of Trade,Industry&Energy(MOTIE)of the Republic of Korea Program(No.RS-2025-02603127,Innovation Research Center for Zero-carbon Fuel Gas Turbine Design,Manufacture,and Safety)。
文摘Understanding the temperature dependent deformation behavior of Mg alloys is crucial for their expanding use in the aerospace sector.This study investigates the deformation mechanisms of hot-rolled AZ61 Mg alloy under uniaxial tension along rolling direction(RD)and transverse direction(TD)at-50,25,50,and 150℃.Results reveal a transition from high strength with limited elongation at-50℃ to significant softening and maximum ductility at 150℃.TD samples consistently showed 2%-6%higher strength than RD;however,this yield anisotropy diminished at 150℃ due to the shift from twinning to thermally activated slip and recovery.Fractography indicated a change from semi-brittle to fully ductile fracture with increasing temperature.Electron backscattered diffraction(EBSD)analysis confirmed twinning-driven grain refinement at low temperatures,while deformation at high temperatures involved grain elongation along shear zones,enabling greater strain accommodation before material failure.
基金Supported by Chongqing Health Commission and Chongqing Science and Technology Bureau,No.2023MSXM182。
文摘Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.
基金supported by European Union funding(PON“Ricerca e Innovazione”2014‒2020).
文摘The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing hull.The original hull was modified by introducing a step to allow air ventilation.Following an assessment of the hull performance,a simulation campaign in calm water was conducted to characterize the hull at various forward speeds and air insufflation rates for a defined single step geometry.Geometric analysis of the air layer thickness beneath the hull for each simulated condition was performed using a novel method for visualizing local air thickness.Additionally,two new parameters were introduced to understand the influence of spray rails on the air volume beneath the hull and to indicate the primary direction of ventilated air escape.A validation campaign and an assessment of uncertainty of the simulation has been conducted.The features offered by the CFD methodology include the evaluation of the air layer thickness as a function of hull velocity and injection flow rate and the air volume distribution beneath the hull.The air injection velocity can be adjusted across various operating conditions,thereby preventing performance or efficiency loss during navigation.Based on these findings,the study highlights the benefits of air insufflation in reducing hull resistance for high-speed planing vessels.This work lays a robust foundation for future research and new promising topics,as the exploration of air insufflation continues to be a topic of contemporary interest within naval architecture and hydrodynamics.
文摘Colorectal cancer(CRC)with lung oligometastases,particularly in the presence of extrapulmonary disease,poses considerable therapeutic challenges in clinical practice.We have carefully studied the multicenter study by Hu et al,which evaluated the survival outcomes of patients with metastatic CRC who received image-guided thermal ablation(IGTA).These findings provide valuable clinical evidence supporting IGTA as a feasible,minimally invasive approach and underscore the prognostic significance of metastatic distribution.However,the study by Hu et al has several limitations,including that not all pulmonary lesions were pathologically confirmed,postoperative follow-up mainly relied on dynamic contrast-enhanced computed tomography,no comparative analysis was performed with other local treatments,and the impact of other imaging features on efficacy and prognosis was not evaluated.Future studies should include complete pathological confirmation,integrate functional imaging and radiomics,and use prospective multicenter collaboration to optimize patient selection standards for IGTA treatment,strengthen its clinical evidence base,and ultimately promote individualized decision-making for patients with metastatic CRC.
基金the financial support from the National Natural Science Foundation of China(52203123 and 52473248)State Key Laboratory of Polymer Materials Engineering(sklpme2024-2-04)+1 种基金the Fundamental Research Funds for the Central Universitiessponsored by the Double First-Class Construction Funds of Sichuan University。
文摘Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving the overall performance of CPEs due to their difficulty in achieving robust electrochemical and mechanical interfaces simultaneously.Here,by regulating the surface charge characteristics of halloysite nanotube(HNT),we propose a concept of lithium-ion dynamic interface(Li^(+)-DI)engineering in nano-charged CPE(NCCPE).Results show that the surface charge characteristics of HNTs fundamentally change the Li^(+)-DI,and thereof the mechanical and ion-conduction behaviors of the NCCPEs.Particularly,the HNTs with positively charged surface(HNTs+)lead to a higher Li^(+)transference number(0.86)than that of HNTs-(0.73),but a lower toughness(102.13 MJ m^(-3)for HNTs+and 159.69 MJ m^(-3)for HNTs-).Meanwhile,a strong interface compatibilization effect by Li^(+)is observed for especially the HNTs+-involved Li^(+)-DI,which improves the toughness by 2000%compared with the control.Moreover,HNTs+are more effective to weaken the Li^(+)-solvation strength and facilitate the formation of Li F-rich solid-electrolyte interphase of Li metal compared to HNTs-.The resultant Li|NCCPE|LiFePO4cell delivers a capacity of 144.9 m Ah g^(-1)after 400 cycles at 0.5 C and a capacity retention of 78.6%.This study provides deep insights into understanding the roles of surface charges of nanofillers in regulating the mechanical and electrochemical interfaces in ASSLMBs.
文摘Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental pathological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to elucidate the relationship between mitochondrial dynamics dysfunction and neurodevelopmental disorders. Mitochondria are highly dynamic organelles that undergo continuous fusion and fission to meet the substantial energy demands of neural cells. Dysregulation of these processes, as observed in certain neurodevelopmental disorders, causes accumulation of damaged mitochondria, exacerbating oxidative damage and impairing neuronal function. The phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin-protein ligase pathway is crucial for mitophagy, the process of selectively removing malfunctioning mitochondria. Mutations in genes encoding mitochondrial fusion proteins have been identified in autism spectrum disorders, linking disruptions in the fusion-fission equilibrium to neurodevelopmental impairments. Additionally, animal models of Rett syndrome have shown pronounced defects in mitophagy, reinforcing the notion that mitochondrial quality control is indispensable for neuronal health. Clinical studies have highlighted the importance of mitochondrial disturbances in neurodevelopmental disorders. In autism spectrum disorders, elevated oxidative stress markers and mitochondrial DNA deletions indicate compromised mitochondrial function. Attention-deficit/hyperactivity disorder has also been associated with cognitive deficits linked to mitochondrial dysfunction and oxidative stress. Moreover, induced pluripotent stem cell models derived from patients with Rett syndrome have shown impaired mitochondrial dynamics and heightened vulnerability to oxidative injury, suggesting the role of defective mitochondrial homeostasis in these disorders. From a translational standpoint, multiple therapeutic approaches targeting mitochondrial pathways show promise. Interventions aimed at preserving normal fusion-fission cycles or enhancing mitophagy can reduce oxidative damage by limiting the accumulation of defective mitochondria. Pharmacological modulation of mitochondrial permeability and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, an essential regulator of mitochondrial biogenesis, may also ameliorate cellular energy deficits. Identifying early biomarkers of mitochondrial impairment is crucial for precision medicine, since it can help clinicians tailor interventions to individual patient profiles and improve prognoses. Furthermore, integrating mitochondria-focused strategies with established therapies, such as antioxidants or behavioral interventions, may enhance treatment efficacy and yield better clinical outcomes. Leveraging these pathways could open avenues for regenerative strategies, given the influence of mitochondria on neuronal repair and plasticity. In conclusion, this review indicates mitochondrial homeostasis as a unifying therapeutic axis within neurodevelopmental pathophysiology. Disruptions in mitochondrial dynamics and autophagic clearance converge on oxidative stress, and researchers should prioritize validating these interventions in clinical settings to advance precision medicine and enhance outcomes for individuals affected by neurodevelopmental disorders.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
文摘现有的烟火检测方法主要依赖员工现场巡视,效率低且实时性差,因此,提出一种基于YOLOv5s的复杂场景下的高效烟火检测算法YOLOv5s-MRD(YOLOv5s-MPDIoU-RevCol-Dyhead)。首先,采用MPDIoU(Maximized Position-Dependent Intersection over Union)方法改进边框损失函数,以适应重叠或非重叠的边界框回归(BBR),从而提高BBR的准确性和效率;其次,利用可逆柱状结构RevCol(Reversible Column)网络模型思想重构YOLOv5s模型的主干网络,使它具有多柱状网络架构,并在模型的不同层之间加入可逆链接,从而最大限度地保持特征信息以提高网络的特征提取能力;最后,引入Dynamic head检测头,以统一尺度感知、空间感知和任务感知,从而在不额外增加计算开销的条件下显著提高目标检测头的准确性和有效性。实验结果表明:在DFS(Data of Fire and Smoke)数据集上,与原始YOLOv5s算法相比,所提算法的平均精度均值(mAP@0.5)提升了9.3%,预测准确率提升了6.6%,召回率提升了13.8%。可见,所提算法能满足当前烟火检测应用场景的要求。
文摘An improved method is proposed for the extraction of the symmetry energy coefficient relative to the temperature,a_(sym)/T,in the heavy-ion reactions near the Fermi energy region,based on the modified Fisher Model.This method is applied to the primary fragments of antisymmetrized molecular dynamics(AMD)simulations for ^(46)Fe+^(46)Fe,^(40)Ca+^(40)Ca and ^(48)Ca+^(48)Ca at 35 MeV/nucleon,in order to make direct comparison to the results from the K(N,Z)method of Ono et al.In our improved method,the extracted values of a_(sym)/T increase as the size of isotopes increases whereas,in the K(N,Z)method,the results show rather constant behavior.This increase in our result is attributed to the surface contribution of the symmetry energy in finite nuclei.In order to evaluate the surface contribution,the relation a_(sym)/T=[a_(sym)^((V))(1-k_(S/V) A^(-1/3))]/T is applied and k_(S/V)=1.20~1.25 was extracted.This value is smaller than those extracted from the mass table,reflecting the weakened surface contribution at higher temperature regime.Δμ/T,the difference of the neutron-proton chemical potentials relative to the temperature,is also extracted in this method at the same time.The average values of the extractedΔμ/T,Δμ/T show a linear dependence on the proton-neutron a_(sym)metry parameter of the system,δ_(sys),andΔμ/T=(15.1±0.2)δ_(sys)-(0.5±0.1)is obtained.
