A two-dimensional non-selfsimilar initial value problem for adhesion particle dynamics with two pieces of constant states separated by a circular ring is considered. By using the generalized characteristic method and ...A two-dimensional non-selfsimilar initial value problem for adhesion particle dynamics with two pieces of constant states separated by a circular ring is considered. By using the generalized characteristic method and the generalized Rankine-Hugoniot relation, which is a system of ordinary equations, the global solution which includes delta-shock waves and vacuum is constructed.展开更多
Anti-icing is crucial for numerous instruments and devices in low temperature circum- stance. One of the approaches in anti-icing is to reduce ice adhesion strength, seeking spontaneous de-icing processes by natural f...Anti-icing is crucial for numerous instruments and devices in low temperature circum- stance. One of the approaches in anti-icing is to reduce ice adhesion strength, seeking spontaneous de-icing processes by natural forces of gravity or by winds. In order to enable tai- lored surface icephobicity design, research requires a good theoretical understanding of the atomistic interacting mechanisms between water/ice molecules and their adhering substrates. Herein, this work focuses on using atomistic modeling and molecular dynamics simulation to build a nanosized ice-cube adhering onto silicon surface, with different contact modes of solid-solid and solid-liquid-solid patterns. This study provides atomistic models for probing nanoscale ice adhesion mechanics and theoretical platforms for explaining experimental results.展开更多
Postoperative abdominal adhesion represents a frequent clinical challenge.Despite the numerous direct and indirect approaches developed to address this issue,standalone physical or chemical strategies exhibit inherent...Postoperative abdominal adhesion represents a frequent clinical challenge.Despite the numerous direct and indirect approaches developed to address this issue,standalone physical or chemical strategies exhibit inherent limitations and often fail to achieve optimal antiadhesion outcomes.In this study,an injectable,biodegradable hydrogel incorporating micelles formed through Schiff base cross-linking between lauric acid-modified carboxymethyl chitosan(CMCS-LA)and oxidized hyaluronic acid(OHA)is presented as an efficient physical-chemical combined antiadhesion solution.The hydrogel demonstrates rapid gelation,tunable stiffness,biodegradability,injectability,and outstanding self-healing properties.Serving as an adherent physical barrier on abdominal tissues prevents abnormal tissue attachment.The release of the hydrophobic drug honokiol,which is physically encapsulated in CMCS-LA micelles,is sustained to activate peritoneal mesothelial cells,thereby reducing postoperative adhesion formation after surgery.In a rat model of lateral wall defects and caecal abrasion,the hydrogel effectively suppressed abnormal fibrous tissue hyperplasia and inflammatory responses while preventing adhesion.This dualfunction system successfully integrates physical barrier properties with chemical activity,offering a promising approach for future antiadhesion therapies.展开更多
Sensitivity analysis （SA） is a critical part of modeling any biological system due to the inherent uncertainty in model output, as introduced by parameter values that have not been experimentally determined. SA ther...Sensitivity analysis （SA） is a critical part of modeling any biological system due to the inherent uncertainty in model output, as introduced by parameter values that have not been experimentally determined. SA therefore provides deeper understanding of the system by painting a picture of the extent to which certain model outputs vary in rela- tionship to changes in model parameters. Here we explore two types of global SA for recently developed models of nascent focal adhesion formation, a key step in cellular movement. While many SA methods have been used for deterministic methods, we uti- lize methods for both stochastic and deterministic models, providing a more complete description of the parameters to which the focal adhesion model is most sensitive. Spe- cific recommendations for further experimentation in the process of cellular motility are proposed in response to the SA.展开更多
Wedge-shaped microstructures have the ability to reproduce the excellent adhesive properties of geckos’feet because of their unique anisotropic structure.In particular,the controllability of the wedge-shaped microstr...Wedge-shaped microstructures have the ability to reproduce the excellent adhesive properties of geckos’feet because of their unique anisotropic structure.In particular,the controllability of the wedge-shaped microstructures on adhesion is beneficial to the undisturbed grasp or the capture of space targets.However,the problem currently remains of how to process it efficiently and with high quality.Here a strategy called ultraprecision multistep and layered scribing is proposed for the manufacture of the biomimetic controllable adhesive surface.The results show that the metal master mold prepared based on the manufacturing strategy has not only good surface topography but also high reliability and durability.Furthermore,the controllable adhesive surface of 1.96 cm2,fabricated by the proposed manufacturing strategy,has a normal adhesion of 1.012 N,and the corresponding shear friction and adhesion coefficient are 3.105 N and 4.82,respectively.Additionally,the controllable adhesive surface has been shown to be approximately superhydrophobic and also to possess the properties of controllable adhesion and dynamic adhesion.Also,after 250 adhesion-detachment cycles,the normal adhesion and shear friction only decrease by 5%and 3%,respectively.The research realizes an environmentally friendly and efficient method by which to manufacture a durable metal mold for fabricating a biomimetic controllable adhesive surface,laying a foundation for its effective application in the adherence of space-floating targets.展开更多
基金the National Natural Science Foundation of China(No.10671120)
文摘A two-dimensional non-selfsimilar initial value problem for adhesion particle dynamics with two pieces of constant states separated by a circular ring is considered. By using the generalized characteristic method and the generalized Rankine-Hugoniot relation, which is a system of ordinary equations, the global solution which includes delta-shock waves and vacuum is constructed.
基金the financial support from Statoil ASA (Norway) through the project of nanotechnology for anti-icing application, NTNU stjerneprogramthe Research Council of Norway through the FRINATEK project Towards Design of Super-Low Ice Adhesion Surfaces ( SLICE,250990 )
文摘Anti-icing is crucial for numerous instruments and devices in low temperature circum- stance. One of the approaches in anti-icing is to reduce ice adhesion strength, seeking spontaneous de-icing processes by natural forces of gravity or by winds. In order to enable tai- lored surface icephobicity design, research requires a good theoretical understanding of the atomistic interacting mechanisms between water/ice molecules and their adhering substrates. Herein, this work focuses on using atomistic modeling and molecular dynamics simulation to build a nanosized ice-cube adhering onto silicon surface, with different contact modes of solid-solid and solid-liquid-solid patterns. This study provides atomistic models for probing nanoscale ice adhesion mechanics and theoretical platforms for explaining experimental results.
基金supported by the National Natural Science Foundation of China(Grant Nos.82200563,52273149,82272155)the Shaanxi Provincial Natural Science Foundation(Grant Nos.2022JQ-763,2023-YBSF-420,2024SF-YBXM-205)+2 种基金the Key Science and Technology Innovation Team of Shaanxi Province(Grant No.2024RSCXTD66)the World-Class Universities(Disciplines)and Characteristic Development Guidance Funds for the Central UniversitiesFundamental Research Funds for the Central Universities。
文摘Postoperative abdominal adhesion represents a frequent clinical challenge.Despite the numerous direct and indirect approaches developed to address this issue,standalone physical or chemical strategies exhibit inherent limitations and often fail to achieve optimal antiadhesion outcomes.In this study,an injectable,biodegradable hydrogel incorporating micelles formed through Schiff base cross-linking between lauric acid-modified carboxymethyl chitosan(CMCS-LA)and oxidized hyaluronic acid(OHA)is presented as an efficient physical-chemical combined antiadhesion solution.The hydrogel demonstrates rapid gelation,tunable stiffness,biodegradability,injectability,and outstanding self-healing properties.Serving as an adherent physical barrier on abdominal tissues prevents abnormal tissue attachment.The release of the hydrophobic drug honokiol,which is physically encapsulated in CMCS-LA micelles,is sustained to activate peritoneal mesothelial cells,thereby reducing postoperative adhesion formation after surgery.In a rat model of lateral wall defects and caecal abrasion,the hydrogel effectively suppressed abnormal fibrous tissue hyperplasia and inflammatory responses while preventing adhesion.This dualfunction system successfully integrates physical barrier properties with chemical activity,offering a promising approach for future antiadhesion therapies.
文摘Sensitivity analysis （SA） is a critical part of modeling any biological system due to the inherent uncertainty in model output, as introduced by parameter values that have not been experimentally determined. SA therefore provides deeper understanding of the system by painting a picture of the extent to which certain model outputs vary in rela- tionship to changes in model parameters. Here we explore two types of global SA for recently developed models of nascent focal adhesion formation, a key step in cellular movement. While many SA methods have been used for deterministic methods, we uti- lize methods for both stochastic and deterministic models, providing a more complete description of the parameters to which the focal adhesion model is most sensitive. Spe- cific recommendations for further experimentation in the process of cellular motility are proposed in response to the SA.
基金supported by the Major Research Plan of the National Natural Science Foundation of China(Grant No.91848202)。
文摘Wedge-shaped microstructures have the ability to reproduce the excellent adhesive properties of geckos’feet because of their unique anisotropic structure.In particular,the controllability of the wedge-shaped microstructures on adhesion is beneficial to the undisturbed grasp or the capture of space targets.However,the problem currently remains of how to process it efficiently and with high quality.Here a strategy called ultraprecision multistep and layered scribing is proposed for the manufacture of the biomimetic controllable adhesive surface.The results show that the metal master mold prepared based on the manufacturing strategy has not only good surface topography but also high reliability and durability.Furthermore,the controllable adhesive surface of 1.96 cm2,fabricated by the proposed manufacturing strategy,has a normal adhesion of 1.012 N,and the corresponding shear friction and adhesion coefficient are 3.105 N and 4.82,respectively.Additionally,the controllable adhesive surface has been shown to be approximately superhydrophobic and also to possess the properties of controllable adhesion and dynamic adhesion.Also,after 250 adhesion-detachment cycles,the normal adhesion and shear friction only decrease by 5%and 3%,respectively.The research realizes an environmentally friendly and efficient method by which to manufacture a durable metal mold for fabricating a biomimetic controllable adhesive surface,laying a foundation for its effective application in the adherence of space-floating targets.
