Alzheimer s disease is a devastating neurodegenerative disorder affecting millions worldwide,with current treatments offering only limited benefits.Central to emerging research is the role of autophagy and endolysosom...Alzheimer s disease is a devastating neurodegenerative disorder affecting millions worldwide,with current treatments offering only limited benefits.Central to emerging research is the role of autophagy and endolysosomal pathways,which are essential for clearing misfolded proteins and damaged organelles.Bridging integrator 1(BIN1),traditionally recognized for its role in membrane remodeling and endocytosis,has recently emerged as a top genetic risk factor for Alzheimer's disease,linking cellular clearance mechanisms to the development of toxic amyloid-beta plaques and tau tangles.In this review,we provide an accessible overview of how disruptions in autophagy and endolysosomal trafficking contribute to the neurodegeneration process in Alzheimer's disease,positioning BIN1 as a central mediator within this complex network.Recent advances have shown that alte rations in BIN1 expression and isoform distribution are associated with increased tau pathology and changes in amyloid-beta processing.Moreover,BIN1 appears to also influence synaptic transmission,neuroinflammation,and overall cellular homeostasis.The integration of recent findings not only deepens our understanding of Alzheimer s disease pathology but also opens new avenues for the development of targeted treatments.This timely perspective underscores the potential of modulating BIN1 activity to enhance cellular clearance mechanisms and offers hope for more effective inte rventions for Alzheimer's disease.展开更多
The vehicle-road coupling dynamics problem is a prominent issue in transportation,drawing significant attention in recent years.These dynamic equations are characterized by high-dimensionality,coupling,and time-varyin...The vehicle-road coupling dynamics problem is a prominent issue in transportation,drawing significant attention in recent years.These dynamic equations are characterized by high-dimensionality,coupling,and time-varying dynamics,making the exact solutions challenging to obtain.As a result,numerical integration methods are typically employed.However,conventional methods often suffer from low computational efficiency.To address this,this paper explores the application of the parameter freezing precise exponential integrator to vehicle-road coupling models.The model accounts for road roughness irregularities,incorporating all terms unrelated to the linear part into the algorithm's inhomogeneous vector.The general construction process of the algorithm is detailed.The validity of numerical results is verified through approximate analytical solutions(AASs),and the advantages of this method over traditional numerical integration methods are demonstrated.Multiple parameter freezing precise exponential integrator schemes are constructed based on the Runge-Kutta framework,with the fourth-order four-stage scheme identified as the optimal one.The study indicates that this method can quickly and accurately capture the dynamic system's vibration response,offering a new,efficient approach for numerical studies of high-dimensional vehicle-road coupling systems.展开更多
Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sen...Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.展开更多
The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′...The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.展开更多
This study develops a high-order computational scheme for analyzing unsteady tangent hyperbolic fluid flow with variable thermal conductivity,thermal radiation,and coupled heat andmass transfer effects.Amodified twost...This study develops a high-order computational scheme for analyzing unsteady tangent hyperbolic fluid flow with variable thermal conductivity,thermal radiation,and coupled heat andmass transfer effects.Amodified twostage Exponential Time Integrator is introduced for temporal discretization,providing second-order accuracy in time.A compact finite difference method is employed for spatial discretization,yielding sixth-order accuracy at most grid points.The proposed framework ensures numerical stability and convergence when solving stiff,nonlinear parabolic systems arising in fluid flow and heat transfer problems.The novelty of the work lies in combining exponential integrator schemes with compact high-order spatial discretization,enabling accurate and efficient simulations of tangent hyperbolic fluids under complex boundary conditions,such as oscillatory plates and varying thermal conductivity.This approach addresses limitations of classical Euler,Runge–Kutta,and spectral methods by significantly reducing numerical errors(up to 45%)and computational cost.Comprehensive parametric studies demonstrate how viscous dissipation,chemical reactions,the Weissenberg number,and the Hartmann number influence flow behaviour,heat transfer,and mass transfer.Notably,heat transfer rates increase by 18.6%with stronger viscous dissipation,while mass transfer rates rise by 21.3%with more intense chemical reactions.The real-world relevance of the study is underscored by its direct applications in polymer processing,heat exchanger design,radiative thermal management in aerospace,and biofluid transport in biomedical systems.The proposed scheme thus provides a robust numerical framework that not only advances the mathematical modelling of non-Newtonian fluid flows but also offers practical insights for engineering systems involving tangent hyperbolic fluids.展开更多
Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、...Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。展开更多
This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requireme...This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requirements,and integration capabilities.By implementing a sub-wavelength grating structure,we achieve a Po⁃larization Extinction Ratio(PER)exceeding 29 dB.Furthermore,our electrode design facilitates a voltage-length product(V_(π)L)below 2 V·cm,while a double-tapered coupling structure significantly reduces insertion loss.This advancement provides a pivotal direction for the miniaturization and integration of optical gyroscopes,marking a substantial contribution to the field.展开更多
In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)a...In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.展开更多
This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industr...This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industry,the course content has been updated to incorporate AI techniques such as large language models and deep learning.The reform enriches educational resources and introduces innovative instructional approaches.In addition,high-quality practical teaching cases have been developed,and immersive,hands-on learning experiences have been designed based on industrial platforms and real-world applications.These initiatives aim to enhance the practical skills and innovative thinking of professional degree graduate students,fostering high-caliber talent that aligns with industry demands.A survey of 90 graduate students revealed high levels of satisfaction regarding course content,teaching methodology,and skill development.The reform has proven effective in cultivating interdisciplinary professionals with solid foundations in software engineering and AI-driven innovation.展开更多
Ningxia is an ethnic gathering area boasting abundant tourism and cultural resources.Developing the cause of tourism and culture is an important way to encourage all ethnic groups to respect differences,embrace divers...Ningxia is an ethnic gathering area boasting abundant tourism and cultural resources.Developing the cause of tourism and culture is an important way to encourage all ethnic groups to respect differences,embrace diversity,and demonstrate their interactions,exchanges,and integration in tourism activities.As an important preserve of the distinctive cultures of the Chinese nation and a prominent world tourist destination,Ningxia should strive to foster and consolidate the sense of a community with a shared future for the Chinese nation in developing its tourism and culture under the new historical conditions.It is imperative to advance the prosperity and development of tourism and culture in boosting ethnic interactions,exchanges,and integration through the formulation of tourism and cultural policies and plans,as well as the development and design of tourism and cultural projects.展开更多
An efficient scheme is applied to generate a nonisospectral Botie-Pempinelli-Tu(BPT)integrable hierarchy under the case whereλ_(t)=n∑j=0 k_(j)(t)λ^(-j).Based on an expanding higherdimensional Lie algebra,we obtain ...An efficient scheme is applied to generate a nonisospectral Botie-Pempinelli-Tu(BPT)integrable hierarchy under the case whereλ_(t)=n∑j=0 k_(j)(t)λ^(-j).Based on an expanding higherdimensional Lie algebra,we obtain a nonisospectral BPT integrable coupling hieararchy.It follws that some new nonisospectral nonlinear systems are obtained by reducing these two nonisospectral BPT hierarchies.Actually,these nonisospectral integrable models that we obtained can enrich the existing integrable models and possibly describe new nonlinear phenomena.展开更多
This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential g...This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs.展开更多
This paper undertakes a systematic combing of the development of research on integrating Chinese culture into foreign language education in China from the 1980s to 2025,dividing it into three stages:cultural attachmen...This paper undertakes a systematic combing of the development of research on integrating Chinese culture into foreign language education in China from the 1980s to 2025,dividing it into three stages:cultural attachment,cultural compensation,and cultural symbiosis,and reveals the logical shift of the research from the dominance of target language culture to the construction of the subjectivity of Chinese culture.Through quantitative and qualitative analysis of 435 CSSCI papers,three core themes are extracted:what to integrate,why to integrate,and how to integrate.This paper critically analyzes three pairs of contradictions:the imbalance between instrumentality and humanism,the separation of national narrative and individual expression,and the disconnection between traditional inheritance and modern transformation.It is proposed that future research should reconstruct the educational logic based on the Chinese context,integrate the national and individual dimensions,and build a dialogue mechanism between tradition and modernity,so as to provide theoretical and practical reference for the construction of a foreign language education system with Chinese characteristics.展开更多
The rapid expansion of the low-altitude economy is driving strong demand for highly accurate and reliable positioning technologies to support diverse aerial operations.This review examines core positioning methodologi...The rapid expansion of the low-altitude economy is driving strong demand for highly accurate and reliable positioning technologies to support diverse aerial operations.This review examines core positioning methodologies within the low-altitude intelligent network(LAIN)framework,beginning with an analysis of positioning requirements and performance metrics for low-altitude flight scenarios.It systematically assesses the principles,strengths,and limitations of mainstream positioning systems,including Global Navigation Satellite Systems(GNSS),terrestrial wireless positioning,and autonomous navigation,and it surveys prevalent integrated and cooperative positioning schemes.Our analysis demonstrates that standalone positioning technologies are inadequate in complex low-altitude settings,underscoring the pivotal role of multi-source fusion and unmanned aerial vehicle(UAV)swarm cooperative positioning as future trends.To address infrastructure gaps and high deployment costs in current LAIN systems,we propose a“space−air−ground”integrated and cooperative positioning architecture centered on GNSS and the 5th generation mobile communication technology(5G).The ground layer integrates 5G and GNSS for wide-area enhanced positioning.The aerial layer uses 5G aircraft-to-everything(A2X)and sidelink(SL)communications to build self-organizing networks for cooperative UAV localization.The space layer leverages low Earth orbit(LEO)satellites to overcome coverage limitations in communication and positioning.This hierarchical architecture reduces deployment costs through infrastructure reuse and enables deep integration of communication and navigation capabilities.By supporting collaborative enhancement across all three domains,the framework improves positioning robustness and delivers cost-effective,ubiquitous,and highly reliable positioning services.Finally,we outline promising research directions.This review aims to provide a systematic reference and a novel architectural perspective for the ongoing development of LAIN.展开更多
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
Objective:This integrative review aims to synthesize observational evidence on the prevalence,predictors,and psychosocial correlates of death anxiety in patients with hear t failure(HF).Methods:A comprehensive literat...Objective:This integrative review aims to synthesize observational evidence on the prevalence,predictors,and psychosocial correlates of death anxiety in patients with hear t failure(HF).Methods:A comprehensive literature search was conducted using 5 major databases:Scopus,Pub Med,Science Direct,Embase,and Pro Quest.Inclusion criteria were primary research studies published in English between January 2014 and March 2025 that quantitatively assessed death anxiety among patients with HF and explored its associations with demographic,clinical,or psychosocial variables.Results:A total of 12 eligible studies were identified and systematically reviewed,revealing that death anxiety is moderate to high among most samples.Key predictors of this anxiety included older age,feelings of loneliness,low socioeconomic status,and longer duration of HF.Additionally,several studies highlighted protective factors such as spiritual orientation,religious coping,and resilience.Interventions,including cognitive-behavioral therapy(CBT)and illness perception training,showed significant reductions in death anxiety.Conclusions:Death anxiety is a prevalent and impactful concern among Patients with HF,influenced by both individual and contextual factors.Routine assessment and integration of psychosocial and spiritual care—alongside evidence-based psychological interventions—are essential to address this critical aspect of HF management.展开更多
Objective:To analyze the clinical effect of sensory integration training combined with cognitive training in the rehabilitation treatment of children with mental retardation.Methods:A total of 120 children with mental...Objective:To analyze the clinical effect of sensory integration training combined with cognitive training in the rehabilitation treatment of children with mental retardation.Methods:A total of 120 children with mental retardation who received rehabilitation intervention in our hospital from January 2022 to December 2025 were selected and divided into a control group and an experimental group,with 60 children in each group.The control group adopted a conventional rehabilitation training program;the experimental group adopted a combined sensory integration training and cognitive training program.The sensory integration ability,cognitive function,and daily living skills of children in the two groups were compared.Results:The sensory integration ability score of the experimental group(85.3±6.2)was significantly higher than that of the control group(72.1±7.5)(p<0.05);the cognitive function score(88.7±5.8)was significantly improved compared with that of the control group(76.4±6.9)(p<0.05);the daily living skills score(90.2±4.7)was significantly higher than that of the control group(80.5±5.3)(p<0.05).The social interaction ability of the experimental group reached 92.5%,which was significantly higher than that of the control group(81.3%)(p<0.05).Conclusion:Sensory integration training combined with cognitive training demonstrates favorable outcomes in the rehabilitation treatment of children with mental retardation,exhibiting a notable neurofunctional remodeling effect.It can optimize the multidimensional rehabilitation process,effectively enhance the comprehensive developmental potential of children,and hold significant clinical application value.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
基金National Institutes of Health,No.R01AG083943Alzheimer's Association Strategic Fund No.ABA-22-965518(to YWAH)。
文摘Alzheimer s disease is a devastating neurodegenerative disorder affecting millions worldwide,with current treatments offering only limited benefits.Central to emerging research is the role of autophagy and endolysosomal pathways,which are essential for clearing misfolded proteins and damaged organelles.Bridging integrator 1(BIN1),traditionally recognized for its role in membrane remodeling and endocytosis,has recently emerged as a top genetic risk factor for Alzheimer's disease,linking cellular clearance mechanisms to the development of toxic amyloid-beta plaques and tau tangles.In this review,we provide an accessible overview of how disruptions in autophagy and endolysosomal trafficking contribute to the neurodegeneration process in Alzheimer's disease,positioning BIN1 as a central mediator within this complex network.Recent advances have shown that alte rations in BIN1 expression and isoform distribution are associated with increased tau pathology and changes in amyloid-beta processing.Moreover,BIN1 appears to also influence synaptic transmission,neuroinflammation,and overall cellular homeostasis.The integration of recent findings not only deepens our understanding of Alzheimer s disease pathology but also opens new avenues for the development of targeted treatments.This timely perspective underscores the potential of modulating BIN1 activity to enhance cellular clearance mechanisms and offers hope for more effective inte rventions for Alzheimer's disease.
基金Supported by the National Natural Science Foundation of China(No.U22A20246)the Key Project of Natural Science Foundation of Hebei Province of China(Basic Research Base Project)(No.A2023210064)the Science and Technology Program of Hebei Province of China(Nos.246Z1904G and 225676162GH)。
文摘The vehicle-road coupling dynamics problem is a prominent issue in transportation,drawing significant attention in recent years.These dynamic equations are characterized by high-dimensionality,coupling,and time-varying dynamics,making the exact solutions challenging to obtain.As a result,numerical integration methods are typically employed.However,conventional methods often suffer from low computational efficiency.To address this,this paper explores the application of the parameter freezing precise exponential integrator to vehicle-road coupling models.The model accounts for road roughness irregularities,incorporating all terms unrelated to the linear part into the algorithm's inhomogeneous vector.The general construction process of the algorithm is detailed.The validity of numerical results is verified through approximate analytical solutions(AASs),and the advantages of this method over traditional numerical integration methods are demonstrated.Multiple parameter freezing precise exponential integrator schemes are constructed based on the Runge-Kutta framework,with the fourth-order four-stage scheme identified as the optimal one.The study indicates that this method can quickly and accurately capture the dynamic system's vibration response,offering a new,efficient approach for numerical studies of high-dimensional vehicle-road coupling systems.
基金supported by the National Natural Science Foundation of China(52272177,12204010)the Foundation for the Introduction of High-Level Talents of Anhui University(S020118002/097)+1 种基金the University Synergy Innovation Program of Anhui Province(GXXT-2023-066)the Scientific Research Project of Anhui Provincial Higher Education Institution(2023AH040008)。
文摘Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.
基金Supported by Natural Science Foundation of China(12461021)。
文摘The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-DDRSP2503).
文摘This study develops a high-order computational scheme for analyzing unsteady tangent hyperbolic fluid flow with variable thermal conductivity,thermal radiation,and coupled heat andmass transfer effects.Amodified twostage Exponential Time Integrator is introduced for temporal discretization,providing second-order accuracy in time.A compact finite difference method is employed for spatial discretization,yielding sixth-order accuracy at most grid points.The proposed framework ensures numerical stability and convergence when solving stiff,nonlinear parabolic systems arising in fluid flow and heat transfer problems.The novelty of the work lies in combining exponential integrator schemes with compact high-order spatial discretization,enabling accurate and efficient simulations of tangent hyperbolic fluids under complex boundary conditions,such as oscillatory plates and varying thermal conductivity.This approach addresses limitations of classical Euler,Runge–Kutta,and spectral methods by significantly reducing numerical errors(up to 45%)and computational cost.Comprehensive parametric studies demonstrate how viscous dissipation,chemical reactions,the Weissenberg number,and the Hartmann number influence flow behaviour,heat transfer,and mass transfer.Notably,heat transfer rates increase by 18.6%with stronger viscous dissipation,while mass transfer rates rise by 21.3%with more intense chemical reactions.The real-world relevance of the study is underscored by its direct applications in polymer processing,heat exchanger design,radiative thermal management in aerospace,and biofluid transport in biomedical systems.The proposed scheme thus provides a robust numerical framework that not only advances the mathematical modelling of non-Newtonian fluid flows but also offers practical insights for engineering systems involving tangent hyperbolic fluids.
文摘Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。
基金Supported by the Beijing Municipal Natural Science Foundation(424206)the Youth Innovation Promotion Association,CAS(2021108).
文摘This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requirements,and integration capabilities.By implementing a sub-wavelength grating structure,we achieve a Po⁃larization Extinction Ratio(PER)exceeding 29 dB.Furthermore,our electrode design facilitates a voltage-length product(V_(π)L)below 2 V·cm,while a double-tapered coupling structure significantly reduces insertion loss.This advancement provides a pivotal direction for the miniaturization and integration of optical gyroscopes,marking a substantial contribution to the field.
文摘In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.
基金supported by Project of Higher Education Teaching Reform Research in Heilongjiang Province(Graduate Education)(Grant No.SJGYY2024030).
文摘This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industry,the course content has been updated to incorporate AI techniques such as large language models and deep learning.The reform enriches educational resources and introduces innovative instructional approaches.In addition,high-quality practical teaching cases have been developed,and immersive,hands-on learning experiences have been designed based on industrial platforms and real-world applications.These initiatives aim to enhance the practical skills and innovative thinking of professional degree graduate students,fostering high-caliber talent that aligns with industry demands.A survey of 90 graduate students revealed high levels of satisfaction regarding course content,teaching methodology,and skill development.The reform has proven effective in cultivating interdisciplinary professionals with solid foundations in software engineering and AI-driven innovation.
文摘Ningxia is an ethnic gathering area boasting abundant tourism and cultural resources.Developing the cause of tourism and culture is an important way to encourage all ethnic groups to respect differences,embrace diversity,and demonstrate their interactions,exchanges,and integration in tourism activities.As an important preserve of the distinctive cultures of the Chinese nation and a prominent world tourist destination,Ningxia should strive to foster and consolidate the sense of a community with a shared future for the Chinese nation in developing its tourism and culture under the new historical conditions.It is imperative to advance the prosperity and development of tourism and culture in boosting ethnic interactions,exchanges,and integration through the formulation of tourism and cultural policies and plans,as well as the development and design of tourism and cultural projects.
基金Supported by the National Natural Science Foundation of China(11971475)。
文摘An efficient scheme is applied to generate a nonisospectral Botie-Pempinelli-Tu(BPT)integrable hierarchy under the case whereλ_(t)=n∑j=0 k_(j)(t)λ^(-j).Based on an expanding higherdimensional Lie algebra,we obtain a nonisospectral BPT integrable coupling hieararchy.It follws that some new nonisospectral nonlinear systems are obtained by reducing these two nonisospectral BPT hierarchies.Actually,these nonisospectral integrable models that we obtained can enrich the existing integrable models and possibly describe new nonlinear phenomena.
文摘This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs.
基金“A Study on the Value and Path of Integrating Excellent Traditional Chinese Culture Into Intercultural Communication Courses”(ZD2024)a project by the Beijing Higher Education Association,as well as“A Study on the Path of Empowering the Integration of Excellent Traditional Chinese Culture Into Intercultural Communication Courses With Generative AI”(2024),an institutional project of Beijing International Studies University.
文摘This paper undertakes a systematic combing of the development of research on integrating Chinese culture into foreign language education in China from the 1980s to 2025,dividing it into three stages:cultural attachment,cultural compensation,and cultural symbiosis,and reveals the logical shift of the research from the dominance of target language culture to the construction of the subjectivity of Chinese culture.Through quantitative and qualitative analysis of 435 CSSCI papers,three core themes are extracted:what to integrate,why to integrate,and how to integrate.This paper critically analyzes three pairs of contradictions:the imbalance between instrumentality and humanism,the separation of national narrative and individual expression,and the disconnection between traditional inheritance and modern transformation.It is proposed that future research should reconstruct the educational logic based on the Chinese context,integrate the national and individual dimensions,and build a dialogue mechanism between tradition and modernity,so as to provide theoretical and practical reference for the construction of a foreign language education system with Chinese characteristics.
基金supported by the National Key Research&Development Program of China(No.2024YFB3910102).
文摘The rapid expansion of the low-altitude economy is driving strong demand for highly accurate and reliable positioning technologies to support diverse aerial operations.This review examines core positioning methodologies within the low-altitude intelligent network(LAIN)framework,beginning with an analysis of positioning requirements and performance metrics for low-altitude flight scenarios.It systematically assesses the principles,strengths,and limitations of mainstream positioning systems,including Global Navigation Satellite Systems(GNSS),terrestrial wireless positioning,and autonomous navigation,and it surveys prevalent integrated and cooperative positioning schemes.Our analysis demonstrates that standalone positioning technologies are inadequate in complex low-altitude settings,underscoring the pivotal role of multi-source fusion and unmanned aerial vehicle(UAV)swarm cooperative positioning as future trends.To address infrastructure gaps and high deployment costs in current LAIN systems,we propose a“space−air−ground”integrated and cooperative positioning architecture centered on GNSS and the 5th generation mobile communication technology(5G).The ground layer integrates 5G and GNSS for wide-area enhanced positioning.The aerial layer uses 5G aircraft-to-everything(A2X)and sidelink(SL)communications to build self-organizing networks for cooperative UAV localization.The space layer leverages low Earth orbit(LEO)satellites to overcome coverage limitations in communication and positioning.This hierarchical architecture reduces deployment costs through infrastructure reuse and enables deep integration of communication and navigation capabilities.By supporting collaborative enhancement across all three domains,the framework improves positioning robustness and delivers cost-effective,ubiquitous,and highly reliable positioning services.Finally,we outline promising research directions.This review aims to provide a systematic reference and a novel architectural perspective for the ongoing development of LAIN.
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
文摘Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
文摘Objective:This integrative review aims to synthesize observational evidence on the prevalence,predictors,and psychosocial correlates of death anxiety in patients with hear t failure(HF).Methods:A comprehensive literature search was conducted using 5 major databases:Scopus,Pub Med,Science Direct,Embase,and Pro Quest.Inclusion criteria were primary research studies published in English between January 2014 and March 2025 that quantitatively assessed death anxiety among patients with HF and explored its associations with demographic,clinical,or psychosocial variables.Results:A total of 12 eligible studies were identified and systematically reviewed,revealing that death anxiety is moderate to high among most samples.Key predictors of this anxiety included older age,feelings of loneliness,low socioeconomic status,and longer duration of HF.Additionally,several studies highlighted protective factors such as spiritual orientation,religious coping,and resilience.Interventions,including cognitive-behavioral therapy(CBT)and illness perception training,showed significant reductions in death anxiety.Conclusions:Death anxiety is a prevalent and impactful concern among Patients with HF,influenced by both individual and contextual factors.Routine assessment and integration of psychosocial and spiritual care—alongside evidence-based psychological interventions—are essential to address this critical aspect of HF management.
基金Baoding Science and Technology Plan Project(Project No.:2541ZF307)。
文摘Objective:To analyze the clinical effect of sensory integration training combined with cognitive training in the rehabilitation treatment of children with mental retardation.Methods:A total of 120 children with mental retardation who received rehabilitation intervention in our hospital from January 2022 to December 2025 were selected and divided into a control group and an experimental group,with 60 children in each group.The control group adopted a conventional rehabilitation training program;the experimental group adopted a combined sensory integration training and cognitive training program.The sensory integration ability,cognitive function,and daily living skills of children in the two groups were compared.Results:The sensory integration ability score of the experimental group(85.3±6.2)was significantly higher than that of the control group(72.1±7.5)(p<0.05);the cognitive function score(88.7±5.8)was significantly improved compared with that of the control group(76.4±6.9)(p<0.05);the daily living skills score(90.2±4.7)was significantly higher than that of the control group(80.5±5.3)(p<0.05).The social interaction ability of the experimental group reached 92.5%,which was significantly higher than that of the control group(81.3%)(p<0.05).Conclusion:Sensory integration training combined with cognitive training demonstrates favorable outcomes in the rehabilitation treatment of children with mental retardation,exhibiting a notable neurofunctional remodeling effect.It can optimize the multidimensional rehabilitation process,effectively enhance the comprehensive developmental potential of children,and hold significant clinical application value.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
