Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In f...Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In fact,many agents showing excellent neuroprotection but no blood flow-improving activity in animals have not achieved ideal clinical efficacy,while thrombolytic drugs only improving blood flow without neuroprotection have limited their wider application.To address these challenges and meet the huge unmet clinical need,we have designed and identified a novel compound AAPB with dual effects of neuroprotection and cerebral blood flow improvement.AAPB significantly reduced cerebral infarction and neural function deficit in tMCAO rats,pMCAO rats,and IS rhesus monkeys,as well as displayed exceptional safety profiles and excellent pharmacokinetic properties in rats and dogs.AAPB has now entered phase I of clinical trials fighting IS in China.展开更多
Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfa...Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.展开更多
Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the ...Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.展开更多
Gel polymer electrolytes(GPEs)with high flame‐retardant concentration can remarkably reduce the thermal runaway risk of lithium metal batteries(LMBs).However,higher flame‐retardant content in GPEs always leads to in...Gel polymer electrolytes(GPEs)with high flame‐retardant concentration can remarkably reduce the thermal runaway risk of lithium metal batteries(LMBs).However,higher flame‐retardant content in GPEs always leads to increased leakage of active component and severe lithium corrosion,which greatly hinders the service life of LMBs.Herein,GPEs with high‐loading triphenyl phosphate(TPP)are originally fabricated by coaxial electrospinning and stabilized by dual confinement effects,including chemisorption of polyvinylidene fluoride‐hexafluoropropylene(PVDF‐HFP),and physical encapsulation of polyacrylonitrile(PAN)/PVDF‐HFP.These effects arise from the strong polar interactions between the−CF3 group in PVDF‐HFP and P=O group in TPP,as well as the superior anti‐swelling property of PAN.To mitigate TPP‐induced corrosion during cycling,the optimized Li anode is armored with LiF‐rich solid electrolyte interphase(SEI)layer through immersing it in fluoroethylene carbonate‐containing electrolyte.As expected,the corresponding Li||Li symmetric cells deliver long‐term stable cycling behavior over 2400 h at 0.5 mA cm−2,and the LiFePO4||Li batteries hold a high‐capacity retention ratio of 81.7%after 6000 cycles at 10 C with excellent flame retardancy.These findings offer new insight into designing the SEI layer for lithium metal in flame‐retardant electrolytes,thus promoting the development and application of high‐security LMBs.展开更多
The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resista...The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative pathogens.Antibiotic adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene transmission.We found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(E.coli)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated genes.These dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.展开更多
Hierarchically three-dimensional(3D)materials present a pivotal challenge and opportunity in achieving effective microwave absorption with synergistic effects.In this work,α-Fe_(2)O_(3)@ZrO_(2)with core-shell structu...Hierarchically three-dimensional(3D)materials present a pivotal challenge and opportunity in achieving effective microwave absorption with synergistic effects.In this work,α-Fe_(2)O_(3)@ZrO_(2)with core-shell structure were fabricated in-situ on aramid nanofibers by a solvothermal method.Following calcination,3D ZrO_(2)/Fe_(3)O_(4)/C nanocomposites with Janus structure have been successfully synthesized.By controlling the lattice match and mismatch in both processes,a core-shell structure ofα-Fe_(2)O_(3)@ZrO_(2)and Janus structure of ZrO_(2)/Fe_(3)O_(4)have been well-define performed.The composite material ZrO_(2)/Fe_(3)O_(4)/C-700 has a minimum reflection loss(RLmin)of−67.4 dB at a thickness of 2.0 mm.The effective absorption bandwidth(EAB)at a thickness of 2.4 mm is 6.0 GHz(11.0-17.0 GHz).This study provides a novel strategy for fabricating high-efficiency electromagnetic wave absorption materials with dual synergistic effects in nanosized scale.展开更多
To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction m...To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.展开更多
Investigating the attributes of the dual oasis effect and oasis–desert interactions is crucial for understanding the climatic and ecological effects of oases.In this study,oasis effect intensity(OEI)was used as an in...Investigating the attributes of the dual oasis effect and oasis–desert interactions is crucial for understanding the climatic and ecological effects of oases.In this study,oasis effect intensity(OEI)was used as an indicator to investigate the factors that contribute to the dual oasis effect.The oasis effect has two attributes:the surface oasis heating effect(OHE)occurred in winter,while the oasis cooling effect(OCE)occurred in the other three seasons,especially in summer.During the day,the OEI of the whole oasis was−12.8℃,−5.2℃,and−4.5℃ in summer,spring,and autumn,respectively,which indicated a strong OCE;and OEI was 0.5℃ in winter,which indicated a weaker OHE.In arid regions,the OCE dominated most of the time,but the OHE occurred in winter and cannot be ignored.In addition,through statistical analysis and energy balance analysis,high evapotranspiration of the oasis was the main factor leading to the occurrence of OCE in the summer,while low albedo to the occurrence of OHE in winter.展开更多
The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional therapies.Autophagy,a highly conserved self-degradation process,has received cons...The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional therapies.Autophagy,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for cancer.With the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery performance.Hence,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based nanotherapeutics.Based on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is demonstrated.Further,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated autophagy.In addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also described.Finally,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82273780,82173681 and 82104004)the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D38,China)+2 种基金the open projects of State Key Laboratory of Natural Medicines(No.SKLNMZZ202213,China)the State Key Laboratory of Pathogenesis,Prevention,and Treatment of High Incidence Diseases in Central Asia Fund(SKL-HIDCA-2021-1,China)the Fundamental Research Funds for the Central Universities of China Pharmaceutical University(No.2632023TD04).
文摘Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In fact,many agents showing excellent neuroprotection but no blood flow-improving activity in animals have not achieved ideal clinical efficacy,while thrombolytic drugs only improving blood flow without neuroprotection have limited their wider application.To address these challenges and meet the huge unmet clinical need,we have designed and identified a novel compound AAPB with dual effects of neuroprotection and cerebral blood flow improvement.AAPB significantly reduced cerebral infarction and neural function deficit in tMCAO rats,pMCAO rats,and IS rhesus monkeys,as well as displayed exceptional safety profiles and excellent pharmacokinetic properties in rats and dogs.AAPB has now entered phase I of clinical trials fighting IS in China.
基金financially supported by the National Natural Science Foundation of China(Nos.22175202,22005351,22365016)the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010180)+3 种基金Program of Guangzhou Science and Technology(No.202201011591)the Science and Technology Innovation Program of Hunan Province(No.2023RC3179)Scientific Research Start-up Fund of Jishou University(No.1122003)support of National Supercomputer Center in Sun Yat-sen University,Guangzhou。
文摘Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.
基金supported by the National Key Research and Development Program of China (No.2019YFA0708800)the Fundamental Research Funds for the Central Universities (No.DUT20ZD101)。
文摘Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.
基金supported by the National Natural Science Foundation of China (52404316, 52474325)the S&T program of Hebei Province(225A4404D)+3 种基金the Natural Science Foundation of Hainan Province (524RC475)the Collaborative Innovation Center of Marine Science and Technology of Hainan University (XTCX2022HYC14)the Xingtai City Natural Science Foundation (2023ZZ027)The Pico Electron Microscopy Center of Hainan University partially supported this study
文摘Gel polymer electrolytes(GPEs)with high flame‐retardant concentration can remarkably reduce the thermal runaway risk of lithium metal batteries(LMBs).However,higher flame‐retardant content in GPEs always leads to increased leakage of active component and severe lithium corrosion,which greatly hinders the service life of LMBs.Herein,GPEs with high‐loading triphenyl phosphate(TPP)are originally fabricated by coaxial electrospinning and stabilized by dual confinement effects,including chemisorption of polyvinylidene fluoride‐hexafluoropropylene(PVDF‐HFP),and physical encapsulation of polyacrylonitrile(PAN)/PVDF‐HFP.These effects arise from the strong polar interactions between the−CF3 group in PVDF‐HFP and P=O group in TPP,as well as the superior anti‐swelling property of PAN.To mitigate TPP‐induced corrosion during cycling,the optimized Li anode is armored with LiF‐rich solid electrolyte interphase(SEI)layer through immersing it in fluoroethylene carbonate‐containing electrolyte.As expected,the corresponding Li||Li symmetric cells deliver long‐term stable cycling behavior over 2400 h at 0.5 mA cm−2,and the LiFePO4||Li batteries hold a high‐capacity retention ratio of 81.7%after 6000 cycles at 10 C with excellent flame retardancy.These findings offer new insight into designing the SEI layer for lithium metal in flame‐retardant electrolytes,thus promoting the development and application of high‐security LMBs.
基金grants from the Laboratory of Lingnan Modern Agriculture Project(NT2021006 to Yang Wang and Jianzhong Shen)the National Natural Science Foundation of China(81861138051 and 81991535 to Yang Wang and Congming Wu).
文摘The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative pathogens.Antibiotic adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene transmission.We found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(E.coli)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated genes.These dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.
基金supported by the National Natural Science Foundation of China(No.51873004)。
文摘Hierarchically three-dimensional(3D)materials present a pivotal challenge and opportunity in achieving effective microwave absorption with synergistic effects.In this work,α-Fe_(2)O_(3)@ZrO_(2)with core-shell structure were fabricated in-situ on aramid nanofibers by a solvothermal method.Following calcination,3D ZrO_(2)/Fe_(3)O_(4)/C nanocomposites with Janus structure have been successfully synthesized.By controlling the lattice match and mismatch in both processes,a core-shell structure ofα-Fe_(2)O_(3)@ZrO_(2)and Janus structure of ZrO_(2)/Fe_(3)O_(4)have been well-define performed.The composite material ZrO_(2)/Fe_(3)O_(4)/C-700 has a minimum reflection loss(RLmin)of−67.4 dB at a thickness of 2.0 mm.The effective absorption bandwidth(EAB)at a thickness of 2.4 mm is 6.0 GHz(11.0-17.0 GHz).This study provides a novel strategy for fabricating high-efficiency electromagnetic wave absorption materials with dual synergistic effects in nanosized scale.
基金funded by the National Natural Science Foundation of China(51866012).
文摘To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.
基金This work was supported by the National Key R&D Program of China[2018YFA0606404]the National Natural Science Foundation of China[41601064]+1 种基金Strategic Priority Research Program of Chinese Academy of Sciences[XDA2009000001]Technology Basic Resource Investigation Program of China[2017FY101003].
文摘Investigating the attributes of the dual oasis effect and oasis–desert interactions is crucial for understanding the climatic and ecological effects of oases.In this study,oasis effect intensity(OEI)was used as an indicator to investigate the factors that contribute to the dual oasis effect.The oasis effect has two attributes:the surface oasis heating effect(OHE)occurred in winter,while the oasis cooling effect(OCE)occurred in the other three seasons,especially in summer.During the day,the OEI of the whole oasis was−12.8℃,−5.2℃,and−4.5℃ in summer,spring,and autumn,respectively,which indicated a strong OCE;and OEI was 0.5℃ in winter,which indicated a weaker OHE.In arid regions,the OCE dominated most of the time,but the OHE occurred in winter and cannot be ignored.In addition,through statistical analysis and energy balance analysis,high evapotranspiration of the oasis was the main factor leading to the occurrence of OCE in the summer,while low albedo to the occurrence of OHE in winter.
基金the National Natural Science Foundation of China(No.81971729)for financial support.
文摘The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional therapies.Autophagy,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for cancer.With the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery performance.Hence,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based nanotherapeutics.Based on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is demonstrated.Further,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated autophagy.In addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also described.Finally,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.
