Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In f...Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In fact,many agents showing excellent neuroprotection but no blood flow-improving activity in animals have not achieved ideal clinical efficacy,while thrombolytic drugs only improving blood flow without neuroprotection have limited their wider application.To address these challenges and meet the huge unmet clinical need,we have designed and identified a novel compound AAPB with dual effects of neuroprotection and cerebral blood flow improvement.AAPB significantly reduced cerebral infarction and neural function deficit in tMCAO rats,pMCAO rats,and IS rhesus monkeys,as well as displayed exceptional safety profiles and excellent pharmacokinetic properties in rats and dogs.AAPB has now entered phase I of clinical trials fighting IS in China.展开更多
Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfa...Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.展开更多
Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the ...Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.展开更多
Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravi...Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravitropic response of Arabidopsis inflorescence and discovered that although the intact Arabidopsis inflorescence bent upward at the rate of 43° ±3°/h in the first 1.5 h under the given control growth conditions, it bent upward at a rate of 20°±3° and 64°±14°/h in the presence of exogenous ethylene if the plants were pretreated for 0.5 and 12 h, respectively, before the initiation of gravistimulation. The increase in gravicur-vature rate is proportional to the length of ethylene pre-treatment. The minimum ethylene pretreatment time required for achieving the maximum curvature rate is 10 -11 h with removal of exogenous ethylene. The stimulatory effect of ethylene on the inflorescence gravicurvature requires a latent period of time (1h) to become measurable. In contrast, the inhibitory展开更多
In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this pap...In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this paper.In contrast to the traditional technique using only one kind of variables,the symplectic dual variables include displacement components as well as stress components.Therefore,the compatibility conditions of displacement and stress at interfaces can be formulated simultaneously.After being introduced into the symplectic dual system,the uniform schemes,such as the separation of variables and symplectic eigenfunction expansion method,can be implemented conveniently to analyze composite laminate problems.An analytical solution for the free edge effect of composite laminates is obtained,showing the effectiveness of the symplectic dual method in analyzing composite laminates.展开更多
To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction m...To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82273780,82173681 and 82104004)the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D38,China)+2 种基金the open projects of State Key Laboratory of Natural Medicines(No.SKLNMZZ202213,China)the State Key Laboratory of Pathogenesis,Prevention,and Treatment of High Incidence Diseases in Central Asia Fund(SKL-HIDCA-2021-1,China)the Fundamental Research Funds for the Central Universities of China Pharmaceutical University(No.2632023TD04).
文摘Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In fact,many agents showing excellent neuroprotection but no blood flow-improving activity in animals have not achieved ideal clinical efficacy,while thrombolytic drugs only improving blood flow without neuroprotection have limited their wider application.To address these challenges and meet the huge unmet clinical need,we have designed and identified a novel compound AAPB with dual effects of neuroprotection and cerebral blood flow improvement.AAPB significantly reduced cerebral infarction and neural function deficit in tMCAO rats,pMCAO rats,and IS rhesus monkeys,as well as displayed exceptional safety profiles and excellent pharmacokinetic properties in rats and dogs.AAPB has now entered phase I of clinical trials fighting IS in China.
基金financially supported by the National Natural Science Foundation of China(Nos.22175202,22005351,22365016)the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010180)+3 种基金Program of Guangzhou Science and Technology(No.202201011591)the Science and Technology Innovation Program of Hunan Province(No.2023RC3179)Scientific Research Start-up Fund of Jishou University(No.1122003)support of National Supercomputer Center in Sun Yat-sen University,Guangzhou。
文摘Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.
基金supported by the National Key Research and Development Program of China (No.2019YFA0708800)the Fundamental Research Funds for the Central Universities (No.DUT20ZD101)。
文摘Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.
文摘Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravitropic response of Arabidopsis inflorescence and discovered that although the intact Arabidopsis inflorescence bent upward at the rate of 43° ±3°/h in the first 1.5 h under the given control growth conditions, it bent upward at a rate of 20°±3° and 64°±14°/h in the presence of exogenous ethylene if the plants were pretreated for 0.5 and 12 h, respectively, before the initiation of gravistimulation. The increase in gravicur-vature rate is proportional to the length of ethylene pre-treatment. The minimum ethylene pretreatment time required for achieving the maximum curvature rate is 10 -11 h with removal of exogenous ethylene. The stimulatory effect of ethylene on the inflorescence gravicurvature requires a latent period of time (1h) to become measurable. In contrast, the inhibitory
基金supported by the National Basic Research Program of China (No. 2010CB832704)the National Natural Science Foundation of China (No. 10772039)
文摘In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this paper.In contrast to the traditional technique using only one kind of variables,the symplectic dual variables include displacement components as well as stress components.Therefore,the compatibility conditions of displacement and stress at interfaces can be formulated simultaneously.After being introduced into the symplectic dual system,the uniform schemes,such as the separation of variables and symplectic eigenfunction expansion method,can be implemented conveniently to analyze composite laminate problems.An analytical solution for the free edge effect of composite laminates is obtained,showing the effectiveness of the symplectic dual method in analyzing composite laminates.
基金funded by the National Natural Science Foundation of China(51866012).
文摘To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.
