Extracellular vesicles(EVs)are crucial for facilitating intercellular communication,promoting cell migration,and orchestrating the immune response.Recently,EVs can diagnose and treat tumors.EVs can be measured as biom...Extracellular vesicles(EVs)are crucial for facilitating intercellular communication,promoting cell migration,and orchestrating the immune response.Recently,EVs can diagnose and treat tumors.EVs can be measured as biomarkers to provide information about the type of disease and therapeutic efficacy.Furthermore,EVs with lower immunogenicity and better biocompatibility are natural carriers of chemicals and gene drugs.Herein,we review the molecular composition,biogenesis,and separation methods of EVs.We also highlight the important role of EVs from different origins as biomarkers and drug delivery systems in tumor therapy.Finally,we provide deep insights into how EVs play a role in reversing the immunosuppressive microenvironment.展开更多
基金supported by the National Natural Science Foundation of China(No.82274104,82074024,82374042,82104688,China)National Ten Thousand Talents Program for Young Top-notch Talents,the Natural Science Foundation of Jiangsu Province(No.BK20240144,China)+2 种基金Jiangsu 333 High level Talent Training Project,the Innovation Projects of State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture(No.NZYSKL240103,China)Nanjing University of Chinese Medicine’s Project(No.RC202407,China)supported by the College Students’Innovative Entrepreneurial Training(No.202210315056Y,202310315055Z,China).
文摘Extracellular vesicles(EVs)are crucial for facilitating intercellular communication,promoting cell migration,and orchestrating the immune response.Recently,EVs can diagnose and treat tumors.EVs can be measured as biomarkers to provide information about the type of disease and therapeutic efficacy.Furthermore,EVs with lower immunogenicity and better biocompatibility are natural carriers of chemicals and gene drugs.Herein,we review the molecular composition,biogenesis,and separation methods of EVs.We also highlight the important role of EVs from different origins as biomarkers and drug delivery systems in tumor therapy.Finally,we provide deep insights into how EVs play a role in reversing the immunosuppressive microenvironment.
