Psychological stress is an important factor for the development of irritable bowel syndrome(IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brai...Psychological stress is an important factor for the development of irritable bowel syndrome(IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with mucosal immune activation, alterations in central nervous system, peripheral neurons and gastrointestinal microbiota. Stress-induced alterations in neuro-endocrine-immune pathways acts on the gut-brain axis and microbiota-gut-brain axis, and cause symptom flare-ups or exaggeration in IBS. IBS is a stresssensitive disorder, therefore, the treatment of IBS should focus on managing stress and stress-induced responses. Now, non-pharmacological approaches and pharmacological strategies that target on stress-related alterations, such as antidepressants, antipsychotics, miscellaneous agents, 5-HT synthesis inhibitors, selective 5-HT reuptake inhibitors, and specific 5-HT receptor antagonists or agonists have shown a critical role in IBS management. A integrative approach for IBS management is a necessary.展开更多
OBJECTIVE: To observe the efficacy and safety of different dosages of modified Zhibaidihuang decoction(MZBDD) on polycystic ovary syndrome(PCOS) hyperandrogenism(HA) patients.METHODS: Ninety PCOS HA patients and 30 in...OBJECTIVE: To observe the efficacy and safety of different dosages of modified Zhibaidihuang decoction(MZBDD) on polycystic ovary syndrome(PCOS) hyperandrogenism(HA) patients.METHODS: Ninety PCOS HA patients and 30 infertile patients due to tubal factor were selected. Ninety PCOS HA patients were randomly divided into three groups: low dosage group(LDG), medium dosage group(MDG) and high dosage group(HDG) and infertile patients were selected as normal control group(NCG). PCOS HA patients were treated with different dosage of MZBDD for 4 weeks. For HA patients, serum total testosterone(T), estrodial(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH), prolatin(PRL), alanine aminotransferase(AST), aspartate amino transferase(AST) were determined before and after treatment, while acne scores(Rosenfield) were signed. Basal body temperatures(BBT) were asked to be measured every day. And for the else, T, E2,FSH, LH, PRL, AST, and AST were determined before treatment.RESULTS: Totally 111 patients completed the clinical research. There were no differences among the four groups on serum T before treatment(P =0.221). Serum T concentration of both MDG and HDG after treatment significantly were lower than that of before treatment(P = 0.039, P = 0.000),while there was no obvious difference in LDG(P =0.829). Serum T concentration of both MDG and HDG were significantly lower than that of LDG after treatment(P = 0.048, P = 0.006). To compared with before treatment, there were no differences in Serum FSH, LH, E2, P and PRL among the three groups(LDG, MDG, HDG)(as for FSH, P = 0.136, P = 0.503,P = 0.062; as for LH, P = 0.473, P = 0.513, P = 0.096;as for E2, P = 0.206, P = 0.927, P = 0.076; as for PRL,P = 0.120, P = 0.903, P = 0.407, as for P, P = 0.308, P =0.866, P = 0480). Acne scores of all the three groups were obviously lower than that of before treatment(P = 0.031; P = 0.033; P = 0.002). 39.5% of the patients had biphasic BBT, but there were no differences among the three groups(P = 0.510). There were no differences with ALT and AST between after and before treatment among the three groups(LDG, MDG, HDG)(as for ALT, P = 0.742, P = 0.383,P = 0.053; as for AST, P = 0.732, P = 0.519, P = 0.120).CONCLUSION: Different dosage of MZBDD has dose-effect relationship in treating PCOS HA.展开更多
OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with co...OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality.展开更多
Irritable bowel syndrome(IBS)is considered a biopsychosocial disorder,whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances,abnormalities of gastroin...Irritable bowel syndrome(IBS)is considered a biopsychosocial disorder,whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances,abnormalities of gastrointestinal sensation,gut inflammation and infection,altered processing of afferent sensory information,psychological distress,and affective disturbances.Several models have been proposed in order to describe and explain IBS,each of them focusing on specific aspects or mechanisms of the disorder.This review attempts to present and discuss different determinants of IBS and its symptoms,from a cognitive behavioral therapy framework,distinguishing between the developmental predispositions and precipitants of the disorder,and its perpetuating cognitive,behavioral,affective and physiological factors.The main focus in understanding IBS will be placed on the numerouspsychosocial factors,such as personality traits,early experiences,affective disturbances,altered attention and cognitions,avoidance behavior,stress,coping and social support.In conclusion,a symptom perpetuation model is proposed.展开更多
233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4...233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4)acupoint medicinal injection plus field effect,and 5)electroacupuncture(EA)plus cupping for observation of the therapeutic effect.The total effective ratewas 89.2％.No significant differences were found among the five groups in the total effective rate.But,the markedly effective rate was highest in the acupoint medicinal injection plus field effect group.And the therapeutic effect in patients with pain arthralgia and migratory arthralgia and shorter courseof disease was best.展开更多
In- 2012 Middle-East respiratory syn-drome coron-avirus(MERS-CoV) was evolved in- the Arabian- Pen-in-sula. Tre-men-dous an-d successful efforts have been- con-ducted to discover the gen-ome structure, epidemiology, c...In- 2012 Middle-East respiratory syn-drome coron-avirus(MERS-CoV) was evolved in- the Arabian- Pen-in-sula. Tre-men-dous an-d successful efforts have been- con-ducted to discover the gen-ome structure, epidemiology, clin-ical sign-s, pathogen-esis, diagn-osis an-d an-tiviral therapy. Taphozous perforatus bats are the in-crimin-ated reservoir host and camels are the currently confirmed an-imal lin-ker. The virus resulted in- less than- 1000 in-fected cases an-d 355 deaths. The case fatality rate of the MERS-Co V is high, however, man-y survivors of MERS-CoV in-fection- showed in-apparen-t in-fection-s an-d, in- several cases, multiple co-in-fectin-g agen-ts did exist. Although MERS-CoV appears to be a dan-gerous disease, it is argued here that a full assessmen-t of curren-t kn-owledge about the disease does n-ot suggest that it is a truly scary killer.展开更多
Purpose: To report a case of bilateral regression of anterior segment neovascularisation after carotid endarterectomy in a patient with bilateral ocular ischaemic syndrome (OIS). Patient and Methods: Case report. A 61...Purpose: To report a case of bilateral regression of anterior segment neovascularisation after carotid endarterectomy in a patient with bilateral ocular ischaemic syndrome (OIS). Patient and Methods: Case report. A 61 year-old man suffering from bilateral ocular ischaemic syndrome causing iris neovascularisation (NVI) and neovascular glaucoma (NVG), was planned for bilateral panretinal photocoagulation (PRP) and endarterectomy. PRP was technically only possible in his right eye, while endarterectomy was performed in both carotids. Results: Bilateral complete NVI regression was observed a month after surgery. Conclusion: In some OIS uveal ischaemia could be the major responsible for NVI. Carotid endarterectomy benefits patients who have more than 70% stenosis and improves ocular blood flow, so it should be considered in patients suffering OIS with NVI unre- spective of other cerebral ischaemic symptoms.展开更多
目的探究通里化瘀醒脑汤联合下肢穴位针刺提升脑卒中患者生存质量效果。方法研究纳入113例脑卒中患者,均由医院2021年1月—2022年12月收治,并以随机数字表法分为观察组与对照组,对照组患者(56例)常规临床治疗,观察组患者(57例)在对照组...目的探究通里化瘀醒脑汤联合下肢穴位针刺提升脑卒中患者生存质量效果。方法研究纳入113例脑卒中患者,均由医院2021年1月—2022年12月收治,并以随机数字表法分为观察组与对照组,对照组患者(56例)常规临床治疗,观察组患者(57例)在对照组治疗基础上联合通里化瘀醒脑汤及下肢穴位针刺治疗,比较两组患者疗效、并发症、治疗前及治疗后患者中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)变化及神经功能缺损评分(National Institute of Health stroke scale,NIHSS)变化、Brunel平衡量表(Brunel Balance Assessment,BBA)评分变化、运动功能评分(Fugl-Meyer motor function assessment,FMA)变化、生活质量评分(Barthel index,Barthel)、患者治疗满意度。结果较对照组(71.43%),观察组患者有效率(87.72%)更高,P<0.05;观察组与对照组患者并发症率比较(1.75%vs 12.50%),P<0.05;观察组与对照组治疗前中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分相当,P>0.05,治疗后各组患者中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分均改善,观察组患者治疗后中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分均优于对照组,P<0.05;观察组患者治疗满意率(96.49%)高于对照组(82.14%),P<0.05。结论通里化瘀醒脑汤联合下肢穴位针刺可显著提升脑卒中患者临床疗效及生活质量、运动功能,患者并发症率降低,恢复好,满意率高。展开更多
文摘Psychological stress is an important factor for the development of irritable bowel syndrome(IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with mucosal immune activation, alterations in central nervous system, peripheral neurons and gastrointestinal microbiota. Stress-induced alterations in neuro-endocrine-immune pathways acts on the gut-brain axis and microbiota-gut-brain axis, and cause symptom flare-ups or exaggeration in IBS. IBS is a stresssensitive disorder, therefore, the treatment of IBS should focus on managing stress and stress-induced responses. Now, non-pharmacological approaches and pharmacological strategies that target on stress-related alterations, such as antidepressants, antipsychotics, miscellaneous agents, 5-HT synthesis inhibitors, selective 5-HT reuptake inhibitors, and specific 5-HT receptor antagonists or agonists have shown a critical role in IBS management. A integrative approach for IBS management is a necessary.
基金Supported by National Natural Science Foundation of China(Molecular Mechanism Research on Intervention Polycystic Ovary Syndrome of Infertility with Chinses Medicine Based on Androgen-Androgen Receptor Pathway,No.81072839)
文摘OBJECTIVE: To observe the efficacy and safety of different dosages of modified Zhibaidihuang decoction(MZBDD) on polycystic ovary syndrome(PCOS) hyperandrogenism(HA) patients.METHODS: Ninety PCOS HA patients and 30 infertile patients due to tubal factor were selected. Ninety PCOS HA patients were randomly divided into three groups: low dosage group(LDG), medium dosage group(MDG) and high dosage group(HDG) and infertile patients were selected as normal control group(NCG). PCOS HA patients were treated with different dosage of MZBDD for 4 weeks. For HA patients, serum total testosterone(T), estrodial(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH), prolatin(PRL), alanine aminotransferase(AST), aspartate amino transferase(AST) were determined before and after treatment, while acne scores(Rosenfield) were signed. Basal body temperatures(BBT) were asked to be measured every day. And for the else, T, E2,FSH, LH, PRL, AST, and AST were determined before treatment.RESULTS: Totally 111 patients completed the clinical research. There were no differences among the four groups on serum T before treatment(P =0.221). Serum T concentration of both MDG and HDG after treatment significantly were lower than that of before treatment(P = 0.039, P = 0.000),while there was no obvious difference in LDG(P =0.829). Serum T concentration of both MDG and HDG were significantly lower than that of LDG after treatment(P = 0.048, P = 0.006). To compared with before treatment, there were no differences in Serum FSH, LH, E2, P and PRL among the three groups(LDG, MDG, HDG)(as for FSH, P = 0.136, P = 0.503,P = 0.062; as for LH, P = 0.473, P = 0.513, P = 0.096;as for E2, P = 0.206, P = 0.927, P = 0.076; as for PRL,P = 0.120, P = 0.903, P = 0.407, as for P, P = 0.308, P =0.866, P = 0480). Acne scores of all the three groups were obviously lower than that of before treatment(P = 0.031; P = 0.033; P = 0.002). 39.5% of the patients had biphasic BBT, but there were no differences among the three groups(P = 0.510). There were no differences with ALT and AST between after and before treatment among the three groups(LDG, MDG, HDG)(as for ALT, P = 0.742, P = 0.383,P = 0.053; as for AST, P = 0.732, P = 0.519, P = 0.120).CONCLUSION: Different dosage of MZBDD has dose-effect relationship in treating PCOS HA.
基金Supported by Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases:Evaluation of the clinical effect of Acquired Immune Deficiency Syndrome Acquired Immunodeficiency Syndrome(AIDS)patients treated with Traditional Chinese Medicine in Henan province between 2004 and 2012(No.JDZX2012035)National Special Science and Technology Program on Major Infectious Diseases(No.2013ZX10005010-001)Special of Scientific Research of Traditional Chinese Medicine of Henan Province in China(No.2015ZY02097)
文摘OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality.
基金Supported by Ministry of Science,Education and Sport,Republic of Croatia,No.009-0092660-2655
文摘Irritable bowel syndrome(IBS)is considered a biopsychosocial disorder,whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances,abnormalities of gastrointestinal sensation,gut inflammation and infection,altered processing of afferent sensory information,psychological distress,and affective disturbances.Several models have been proposed in order to describe and explain IBS,each of them focusing on specific aspects or mechanisms of the disorder.This review attempts to present and discuss different determinants of IBS and its symptoms,from a cognitive behavioral therapy framework,distinguishing between the developmental predispositions and precipitants of the disorder,and its perpetuating cognitive,behavioral,affective and physiological factors.The main focus in understanding IBS will be placed on the numerouspsychosocial factors,such as personality traits,early experiences,affective disturbances,altered attention and cognitions,avoidance behavior,stress,coping and social support.In conclusion,a symptom perpetuation model is proposed.
文摘233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4)acupoint medicinal injection plus field effect,and 5)electroacupuncture(EA)plus cupping for observation of the therapeutic effect.The total effective ratewas 89.2％.No significant differences were found among the five groups in the total effective rate.But,the markedly effective rate was highest in the acupoint medicinal injection plus field effect group.And the therapeutic effect in patients with pain arthralgia and migratory arthralgia and shorter courseof disease was best.
文摘In- 2012 Middle-East respiratory syn-drome coron-avirus(MERS-CoV) was evolved in- the Arabian- Pen-in-sula. Tre-men-dous an-d successful efforts have been- con-ducted to discover the gen-ome structure, epidemiology, clin-ical sign-s, pathogen-esis, diagn-osis an-d an-tiviral therapy. Taphozous perforatus bats are the in-crimin-ated reservoir host and camels are the currently confirmed an-imal lin-ker. The virus resulted in- less than- 1000 in-fected cases an-d 355 deaths. The case fatality rate of the MERS-Co V is high, however, man-y survivors of MERS-CoV in-fection- showed in-apparen-t in-fection-s an-d, in- several cases, multiple co-in-fectin-g agen-ts did exist. Although MERS-CoV appears to be a dan-gerous disease, it is argued here that a full assessmen-t of curren-t kn-owledge about the disease does n-ot suggest that it is a truly scary killer.
文摘Purpose: To report a case of bilateral regression of anterior segment neovascularisation after carotid endarterectomy in a patient with bilateral ocular ischaemic syndrome (OIS). Patient and Methods: Case report. A 61 year-old man suffering from bilateral ocular ischaemic syndrome causing iris neovascularisation (NVI) and neovascular glaucoma (NVG), was planned for bilateral panretinal photocoagulation (PRP) and endarterectomy. PRP was technically only possible in his right eye, while endarterectomy was performed in both carotids. Results: Bilateral complete NVI regression was observed a month after surgery. Conclusion: In some OIS uveal ischaemia could be the major responsible for NVI. Carotid endarterectomy benefits patients who have more than 70% stenosis and improves ocular blood flow, so it should be considered in patients suffering OIS with NVI unre- spective of other cerebral ischaemic symptoms.
文摘目的探究通里化瘀醒脑汤联合下肢穴位针刺提升脑卒中患者生存质量效果。方法研究纳入113例脑卒中患者,均由医院2021年1月—2022年12月收治,并以随机数字表法分为观察组与对照组,对照组患者(56例)常规临床治疗,观察组患者(57例)在对照组治疗基础上联合通里化瘀醒脑汤及下肢穴位针刺治疗,比较两组患者疗效、并发症、治疗前及治疗后患者中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)变化及神经功能缺损评分(National Institute of Health stroke scale,NIHSS)变化、Brunel平衡量表(Brunel Balance Assessment,BBA)评分变化、运动功能评分(Fugl-Meyer motor function assessment,FMA)变化、生活质量评分(Barthel index,Barthel)、患者治疗满意度。结果较对照组(71.43%),观察组患者有效率(87.72%)更高,P<0.05;观察组与对照组患者并发症率比较(1.75%vs 12.50%),P<0.05;观察组与对照组治疗前中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分相当,P>0.05,治疗后各组患者中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分均改善,观察组患者治疗后中医证候积分(神昏谵语、口舌歪斜、半身不遂、心悸气短、面色无华等)及NIHSS评分、BBA评分、FMA评分及Barthel指数评分均优于对照组,P<0.05;观察组患者治疗满意率(96.49%)高于对照组(82.14%),P<0.05。结论通里化瘀醒脑汤联合下肢穴位针刺可显著提升脑卒中患者临床疗效及生活质量、运动功能,患者并发症率降低,恢复好,满意率高。
