The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors...The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors such as bacterial infections,hyperglycemia,and oxidative stress disrupt cellular functions and impair angiogenesis,substantially delaying wound repair.Nanozymes,which are engineered nanoscale materials with enzyme-like activities,offer distinct advantages over conventional enzymes and traditional nanomaterials,making them promising candidates for chronic wound treatment.To enhance their clinical potential,nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility,anti-oxidant activity,antibacterial efficacy,and tissue repair capabilities,ensuring their safety and clinical applicability.When integrated into multifunctional wound dressings,nanozymes modulate reactive oxygen species levels,promote tissue regeneration,and simultaneously combat infections and oxidative damage,extending beyond conventional enzyme-like catalysis in chronic wound treatment.The customizable architectures of nanozymes enable precise therapeutic applications,enhancing their effectiveness in managing complex wound conditions.This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings,detailing fabrication methods and emphasizing their transformative potential in chronic wound management.By identifying and addressing key limitations,we introduce strategic advancements to drive the development of nanozyme-driven dressings,paving the way for next-generation chronic wound treatments.展开更多
Simulating U(1) quantum gauge theories with spatial dimensions greater than one is of great physical significance. Here we propose a simple realization of U(1) gauge theory with Rydberg and Rydberg-dressed atom arrays...Simulating U(1) quantum gauge theories with spatial dimensions greater than one is of great physical significance. Here we propose a simple realization of U(1) gauge theory with Rydberg and Rydberg-dressed atom arrays. Within the experimentally accessible range, we find that the various aspects of the U(1) gauge theory can be well simulated, such as the emergence of topological sectors, incommensurability, and the Rokhsar–Kivelson point that hosts deconfined charge excitations and degenerate topological sectors. Our proposal is promising to implement experimentally and exhibits pronounced quantum dynamics.展开更多
The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measu...The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.展开更多
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ...High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).展开更多
Mechanoluminescent(ML)materials that emit light under mechanical stress are attracting growing attention for their potential in next-generation sensing,display,and energy-harvesting technologies[1].Among these,Mn/Cu-d...Mechanoluminescent(ML)materials that emit light under mechanical stress are attracting growing attention for their potential in next-generation sensing,display,and energy-harvesting technologies[1].Among these,Mn/Cu-doped zinc sulfide(ZnS)has emerged as a leading candidate due to its bright emission,low activation threshold,and remarkable self-recovery over thousands of cycles[2-5].展开更多
High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potenti...High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potential of He atom was used for getting the accurate energy levels of singlet states. The satellite-peak structures of the below-threshold harmonic generation(BTHG) of He are observed. We analyze the emission properties of the BTHG by employing a synchrosqueezing transform technique. We find that the satellite-peak structures have two types related to two kinds of transitions. One is the transition of the dressed states of the excited states, the other is the transition between the excited states and the ground state in the field-free case. Furthermore, our results show that the maximum Stark shift of the 2 p state is about 0.9 Up(penderomotive energy), and that of the 4 p state is about 1.0 Up. It indicates that the energy difference between some satellite-and main-peaks of the BTHG can be used to measure the maximum Stark shift of the excited states of He atom in the laser field.展开更多
The computational cost required by the Ensemble Kalman Filter （EnKF） is much larger than that of some simpler assimilation schemes, such as Optimal Interpolation （OI） or three-dimension variational as- similation ...The computational cost required by the Ensemble Kalman Filter （EnKF） is much larger than that of some simpler assimilation schemes, such as Optimal Interpolation （OI） or three-dimension variational as- similation （3DVAR）. Ensemble optimal interpolation （EnOI）, a crudely simplified implementation of EnKF, is sometimes used as a substitute in some oceanic applications and requires much less computational time than EnKF. In this paper, to compromise between computational cost and dynamic covariance, we use the idea of ＂dressing＂ a small size dynamical ensemble with a larger number of static ensembles in order to form an approximate dynamic covariance. The term ＂dressing＂ means that a dynamical ensemble seed from model runs is perturbed by adding the anomalies of some static ensembles. This dressing EnKF （DrEnKF for short） scheme is tested in assimilation of real altimetry data in the Pacific using the HYbrid Coordinate Ocean Model （HYCOM） over a four-year period. Ten dynamical ensemble seeds are each dressed by 10 static ensemble members selected from a 100-member static ensemble. Results are compared to two EnKF assimilation runs that use 10 and 100 dynamical ensemble members. Both temperature and salinity fields from the DrEnKF and the EnKF are compared to observations from Argo floats and an OI SST dataset. The results show that the DrEnKF and the 100-member EnKF yield similar root mean square errors （RMSE） at every model level. Error covariance matrices from the DrEnKF and the 100-member EnKF are also compared and show good agreement.展开更多
We propose schemes to realize quantum state transfer and prepare quantum entanglement in coupled cavity and cavity-fiber-cavity systems,respectively,by using the dressed state method.We first give the expression of pu...We propose schemes to realize quantum state transfer and prepare quantum entanglement in coupled cavity and cavity-fiber-cavity systems,respectively,by using the dressed state method.We first give the expression of pulses shape by using dressed states and then find a group of Gaussian pulses that are easy to realize in experiment to replace the ideal pulses by curve fitting.We also study the influence of some parameters fluctuation,atomic spontaneous emission,and photon leakage on fidelity.The results show that our schemes have good robustness.Because the atoms are trapped in different cavities,it is easy to perform different operations on different atoms.The proposed schemes have the potential applications in dressed states for distributed quantum information processing tasks.展开更多
Four-wave-mixing(FWM) process is examined by using density matrix formalism in a periodically-driven atomic medium. Numerical result shows that FWM signals can be controlled by selecting different dynamic parameters o...Four-wave-mixing(FWM) process is examined by using density matrix formalism in a periodically-driven atomic medium. Numerical result shows that FWM signals can be controlled by selecting different dynamic parameters of the probe field and strengths of the inner-dressing fields. It is also shown that the controllable FWM process is dominantly influenced by the evolution of atomic population difference and two-photon coherence. This dynamic and inner-dressing control of FWM is probably used for optimizing the optical nonlinear process and information processing.展开更多
The model of the Coulomb dressed potential is applied to solving the problem of electron scattering for simplifying the calculation in the electrostatic field and the excimer laser field. The introduction and the appl...The model of the Coulomb dressed potential is applied to solving the problem of electron scattering for simplifying the calculation in the electrostatic field and the excimer laser field. The introduction and the application of the model are based on the electric dipole approximation, so the contribution of the electric multipole is neglected. In this paper, rigorous analysis and deduction are carried out for the introduction of the dressed Coulomb potential into the laser field. It is found that the introduction of the dressed potential in the fractional form is feasible only when the laser field （not including far ultraviolet field and x-ray） is a weak field, i.e. the quiver radius of the free electron is smaller than the atomic scale. In addition, the necessary analysis is also conducted of the limitation of the application of the Coulomb dressed potential.展开更多
Introducing a dressed-state description,we show that a trapped ion in a standing wave field can be described by a nonlinear Jaynes-Cummings model different from the counterpart of Vogel and Matos Filho[Phys.Rev.A 52(1...Introducing a dressed-state description,we show that a trapped ion in a standing wave field can be described by a nonlinear Jaynes-Cummings model different from the counterpart of Vogel and Matos Filho[Phys.Rev.A 52(1995)4214]in several aspects,which may carry important implications for the preparation and reconstruction of the nonclassical states of a trapped ion.展开更多
基金supported by the Key Project of the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China(U23A20686)the National Natural Science Foundation of China(81901979)+2 种基金the Peking University People’s Hospital Scientific Research Development Funds(RDJP2022-07)the Joint Funds for the Innovation of Science and Technology,Fujian Province(2023Y9226)the Introduced High-Level Talent Team Project of Quanzhou City(2023CT008).
文摘The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors such as bacterial infections,hyperglycemia,and oxidative stress disrupt cellular functions and impair angiogenesis,substantially delaying wound repair.Nanozymes,which are engineered nanoscale materials with enzyme-like activities,offer distinct advantages over conventional enzymes and traditional nanomaterials,making them promising candidates for chronic wound treatment.To enhance their clinical potential,nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility,anti-oxidant activity,antibacterial efficacy,and tissue repair capabilities,ensuring their safety and clinical applicability.When integrated into multifunctional wound dressings,nanozymes modulate reactive oxygen species levels,promote tissue regeneration,and simultaneously combat infections and oxidative damage,extending beyond conventional enzyme-like catalysis in chronic wound treatment.The customizable architectures of nanozymes enable precise therapeutic applications,enhancing their effectiveness in managing complex wound conditions.This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings,detailing fabrication methods and emphasizing their transformative potential in chronic wound management.By identifying and addressing key limitations,we introduce strategic advancements to drive the development of nanozyme-driven dressings,paving the way for next-generation chronic wound treatments.
基金supported by the National Key Research and Development Program of China (Grant Nos. 2022YFA1404204 and 2022YFA1403700)the National Natural Science Foundation of China (Grant Nos. 12274086, 11534001 and 11925402)+5 种基金funding from the National Science Foundation of China (Grant Nos. 12274046, 11874094, 12147102, and 12347101)Chongqing Natural Science Foundation (Grant No. CSTB2022NSCQ-JQX0018)the Fundamental Research Funds for the Central Universities (Grant No. 2021CDJZYJH-003)Xiaomi Foundation/Xiaomi Young Talents Programthe supports of the start-up funding of Westlake Universitysupport from the Natural Sciences and Engineering Research Council of Canada (NSERC) through Discovery Grants。
文摘Simulating U(1) quantum gauge theories with spatial dimensions greater than one is of great physical significance. Here we propose a simple realization of U(1) gauge theory with Rydberg and Rydberg-dressed atom arrays. Within the experimentally accessible range, we find that the various aspects of the U(1) gauge theory can be well simulated, such as the emergence of topological sectors, incommensurability, and the Rokhsar–Kivelson point that hosts deconfined charge excitations and degenerate topological sectors. Our proposal is promising to implement experimentally and exhibits pronounced quantum dynamics.
文摘The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.
文摘High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).
文摘Mechanoluminescent(ML)materials that emit light under mechanical stress are attracting growing attention for their potential in next-generation sensing,display,and energy-harvesting technologies[1].Among these,Mn/Cu-doped zinc sulfide(ZnS)has emerged as a leading candidate due to its bright emission,low activation threshold,and remarkable self-recovery over thousands of cycles[2-5].
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674268,11764038,and 11765018)the Scientific Research Foundation of Physics of CPEE–NWNU and NWNU-LKQN-17-1,China
文摘High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potential of He atom was used for getting the accurate energy levels of singlet states. The satellite-peak structures of the below-threshold harmonic generation(BTHG) of He are observed. We analyze the emission properties of the BTHG by employing a synchrosqueezing transform technique. We find that the satellite-peak structures have two types related to two kinds of transitions. One is the transition of the dressed states of the excited states, the other is the transition between the excited states and the ground state in the field-free case. Furthermore, our results show that the maximum Stark shift of the 2 p state is about 0.9 Up(penderomotive energy), and that of the 4 p state is about 1.0 Up. It indicates that the energy difference between some satellite-and main-peaks of the BTHG can be used to measure the maximum Stark shift of the excited states of He atom in the laser field.
基金supported by the Knowledge Innovation Program of Chinese Academy of Sciences (Grant No. KZCX1-YW-12-03)National Basic Research Program of China (2006CB403600)+3 种基金Project of Young Scientists Fund by National Natural Sciences Foundation of China (Grant No. 40606008)National Science and Technology Infrastructure Program(2006BAC03B04)supported by National Natural Sciences Foundation of China (Grant No.40531006)supported by a private donation from Trond Mohn c/o Frank Mohn AS, Bergenand the MERSEA project from the European Commission (Grant No. SIP3-CT-2003-502885)
文摘The computational cost required by the Ensemble Kalman Filter （EnKF） is much larger than that of some simpler assimilation schemes, such as Optimal Interpolation （OI） or three-dimension variational as- similation （3DVAR）. Ensemble optimal interpolation （EnOI）, a crudely simplified implementation of EnKF, is sometimes used as a substitute in some oceanic applications and requires much less computational time than EnKF. In this paper, to compromise between computational cost and dynamic covariance, we use the idea of ＂dressing＂ a small size dynamical ensemble with a larger number of static ensembles in order to form an approximate dynamic covariance. The term ＂dressing＂ means that a dynamical ensemble seed from model runs is perturbed by adding the anomalies of some static ensembles. This dressing EnKF （DrEnKF for short） scheme is tested in assimilation of real altimetry data in the Pacific using the HYbrid Coordinate Ocean Model （HYCOM） over a four-year period. Ten dynamical ensemble seeds are each dressed by 10 static ensemble members selected from a 100-member static ensemble. Results are compared to two EnKF assimilation runs that use 10 and 100 dynamical ensemble members. Both temperature and salinity fields from the DrEnKF and the EnKF are compared to observations from Argo floats and an OI SST dataset. The results show that the DrEnKF and the 100-member EnKF yield similar root mean square errors （RMSE） at every model level. Error covariance matrices from the DrEnKF and the 100-member EnKF are also compared and show good agreement.
基金Project supported by the National Natural Science Foundation of China(Grant No.11804308).
文摘We propose schemes to realize quantum state transfer and prepare quantum entanglement in coupled cavity and cavity-fiber-cavity systems,respectively,by using the dressed state method.We first give the expression of pulses shape by using dressed states and then find a group of Gaussian pulses that are easy to realize in experiment to replace the ideal pulses by curve fitting.We also study the influence of some parameters fluctuation,atomic spontaneous emission,and photon leakage on fidelity.The results show that our schemes have good robustness.Because the atoms are trapped in different cavities,it is easy to perform different operations on different atoms.The proposed schemes have the potential applications in dressed states for distributed quantum information processing tasks.
基金Project supported by Xi’an Science and Technology Project,China(Grant Nos.2019KJWL05 and 2017CGWl07)
文摘Four-wave-mixing(FWM) process is examined by using density matrix formalism in a periodically-driven atomic medium. Numerical result shows that FWM signals can be controlled by selecting different dynamic parameters of the probe field and strengths of the inner-dressing fields. It is also shown that the controllable FWM process is dominantly influenced by the evolution of atomic population difference and two-photon coherence. This dynamic and inner-dressing control of FWM is probably used for optimizing the optical nonlinear process and information processing.
基金Project supported by the National Natural Science Foundation of China （Grant No 10575140） and the Natural Science Foundation of Chongqing Science and Technology Committee （Grant No 2005BB8267） and The Basic Research Foundation of Chongqing Education Committee （Grant No KJ060813）.
文摘The model of the Coulomb dressed potential is applied to solving the problem of electron scattering for simplifying the calculation in the electrostatic field and the excimer laser field. The introduction and the application of the model are based on the electric dipole approximation, so the contribution of the electric multipole is neglected. In this paper, rigorous analysis and deduction are carried out for the introduction of the dressed Coulomb potential into the laser field. It is found that the introduction of the dressed potential in the fractional form is feasible only when the laser field （not including far ultraviolet field and x-ray） is a weak field, i.e. the quiver radius of the free electron is smaller than the atomic scale. In addition, the necessary analysis is also conducted of the limitation of the application of the Coulomb dressed potential.
基金Supported in part by the National Natural Science Foundation of China under Grant No.69688004,69788002the Trans-Century Training Programme Foundation for the Talents by the Chinese State Education Commissionthe National Laboratory of MRAMP at Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences.
文摘Introducing a dressed-state description,we show that a trapped ion in a standing wave field can be described by a nonlinear Jaynes-Cummings model different from the counterpart of Vogel and Matos Filho[Phys.Rev.A 52(1995)4214]in several aspects,which may carry important implications for the preparation and reconstruction of the nonclassical states of a trapped ion.
