Chronic skin wounds affect more than 40 million patients globally and represent a severe growing burden for the healthcare systems,with annual costs expected to exceed$15 billions by 2022.To satisfy the huge demand fo...Chronic skin wounds affect more than 40 million patients globally and represent a severe growing burden for the healthcare systems,with annual costs expected to exceed$15 billions by 2022.To satisfy the huge demand for effective wound care products,different types of wound dressings have been introduced on the market dur-ing the last decades.Based on“the moist wound healing theory”postulated by Prof Winter in 1962,bandages were initially designed to recreate the optimal wound environment to favor the healing process.Then,thanks to the advancements achieved in biomaterial design and processing,biotechnology,imaging and electronic fields,great effort has been devoted to the development of formulations able to actively participate to tissue healing.Indeed,both the literature and the market report the design of medicated wound dressings,i.e.,wound care products releasing anti-microbial agents,anti-inflammatory drugs,or bioactive molecules.In this scenario,this review aims at critically describing the currently available wound care products,highlighting their proved effec-tiveness in wound management.Moreover,an overview of the main strategies exploited to design personalized wound dressings has been reported.Lastly,concerns on regulatory affairs and practical issues limiting the clinical translation of advanced research platforms have also been discussed.展开更多
In two-level as well as V-type three-level atomic systems, we study probe transmission, four-wave mixing （FWM） and fluorescence signals with dressing effect experimentally and theoretically. We find both the hyperfi...In two-level as well as V-type three-level atomic systems, we study probe transmission, four-wave mixing （FWM） and fluorescence signals with dressing effect experimentally and theoretically. We find both the hyperfine structure （at the same energy level） and the transition dipole moment （at different energy levels） can affect the dressing effect. We also experimentally investigate that angle- control dynamics in the nonlinear propagation of the images of the probe and generated FWM in two-level atomic systems, and find that the focusing and defocusing of probe beam and FWM signals can be greatly affected by the angles between dressing fields.展开更多
文摘Chronic skin wounds affect more than 40 million patients globally and represent a severe growing burden for the healthcare systems,with annual costs expected to exceed$15 billions by 2022.To satisfy the huge demand for effective wound care products,different types of wound dressings have been introduced on the market dur-ing the last decades.Based on“the moist wound healing theory”postulated by Prof Winter in 1962,bandages were initially designed to recreate the optimal wound environment to favor the healing process.Then,thanks to the advancements achieved in biomaterial design and processing,biotechnology,imaging and electronic fields,great effort has been devoted to the development of formulations able to actively participate to tissue healing.Indeed,both the literature and the market report the design of medicated wound dressings,i.e.,wound care products releasing anti-microbial agents,anti-inflammatory drugs,or bioactive molecules.In this scenario,this review aims at critically describing the currently available wound care products,highlighting their proved effec-tiveness in wound management.Moreover,an overview of the main strategies exploited to design personalized wound dressings has been reported.Lastly,concerns on regulatory affairs and practical issues limiting the clinical translation of advanced research platforms have also been discussed.
基金This work was supported by the Na- tional Basic Research Program of China （973 Program） （Grant No. 2012CB921804） and the National Natural Science Foundation of China （Grant Nos. 10974151, 61078002, 61078020, 11104214, 61108017, 11104216, and 61205112）.
文摘In two-level as well as V-type three-level atomic systems, we study probe transmission, four-wave mixing （FWM） and fluorescence signals with dressing effect experimentally and theoretically. We find both the hyperfine structure （at the same energy level） and the transition dipole moment （at different energy levels） can affect the dressing effect. We also experimentally investigate that angle- control dynamics in the nonlinear propagation of the images of the probe and generated FWM in two-level atomic systems, and find that the focusing and defocusing of probe beam and FWM signals can be greatly affected by the angles between dressing fields.
