Drug synergistic effects refer to combinations that have a greater impact than individual drugs,which are often but sometimes harmful.Predicting synergism via computational methods like intelligence(AI)is popular,yet ...Drug synergistic effects refer to combinations that have a greater impact than individual drugs,which are often but sometimes harmful.Predicting synergism via computational methods like intelligence(AI)is popular,yet experimental validation remains challenging.DNA-programmed labeling(DPAL)is a method for target based on drug-target binding,minimizing interference from photoreactive groups and tags,which has the advantages of high sensitivity and low impact on drug activities[1–3].In the present study,we utilized the DPAL method to reveal the synergistic targets of the three main components(bufalin,cinobufagin,and resibufogenin(BCR))of cinobufacini injection with anti-hepatocarcinoma activities.展开更多
For fifteen years from the end of last century, thousands of items of ancient Tibetan literature, which were on the verge of being lost in Tibet, were collected, sorted and listed at considerable efforts by Dpal Brtse...For fifteen years from the end of last century, thousands of items of ancient Tibetan literature, which were on the verge of being lost in Tibet, were collected, sorted and listed at considerable efforts by Dpal Brtsegs Tibetan Aneient Literature Institute in Tibet.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.:82003711)Open Research Fund of Basic Medicine College(Grant No.:JCKFKT-MS-001)+2 种基金Shanghai Natural Science Foundation(Grant No.:23ZR1477600)Young Elite Scientists Sponsorship Program by CAST(Program No.:2022QNRC001)Shanghai Sailing Program(Program No.:24YF2758300).
文摘Drug synergistic effects refer to combinations that have a greater impact than individual drugs,which are often but sometimes harmful.Predicting synergism via computational methods like intelligence(AI)is popular,yet experimental validation remains challenging.DNA-programmed labeling(DPAL)is a method for target based on drug-target binding,minimizing interference from photoreactive groups and tags,which has the advantages of high sensitivity and low impact on drug activities[1–3].In the present study,we utilized the DPAL method to reveal the synergistic targets of the three main components(bufalin,cinobufagin,and resibufogenin(BCR))of cinobufacini injection with anti-hepatocarcinoma activities.
文摘For fifteen years from the end of last century, thousands of items of ancient Tibetan literature, which were on the verge of being lost in Tibet, were collected, sorted and listed at considerable efforts by Dpal Brtsegs Tibetan Aneient Literature Institute in Tibet.
