This study investigated the operation features of a dropshaft-tunnel system under varying downstream water levels through a large-scale physical model.In the experiments,the air pressure distribution in the system was...This study investigated the operation features of a dropshaft-tunnel system under varying downstream water levels through a large-scale physical model.In the experiments,the air pressure distribution in the system was measured,and the flow pattern was recorded by cameras.The results revealed that the air pressure in the drop-shaft increased with increasing water flow rate under free outflow conditions but changed little when the outflow was submerged,even when the flow rate further increased.Additionally,there was a wavy flow in the tunnel un-der free outflow conditions,whereas plug flow with air pockets occurred under submerged outflow conditions.The downstream water level was found to affect the system through changing the linkage between the drop-shaft and tunnel and the resistance to air release downstream.The findings of this study contribute to a more comprehensive understanding of the operation of deep tunnel systems.展开更多
Phosphoinositide 3-kinase(PI3K)catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate(PIP_(2))to phosphatidylinositol 3,4,5-trisphosphate(PIP_(3)),a key second messenger that orchestrates downstream signali...Phosphoinositide 3-kinase(PI3K)catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate(PIP_(2))to phosphatidylinositol 3,4,5-trisphosphate(PIP_(3)),a key second messenger that orchestrates downstream signaling by recruiting and activating effector proteins,such as protein kinase B(AKT).PI3Ks are categorized into four classes(IA,IB,II,and III)based on structural characteristics and substrate preferences1.Class IA PI3K enzymes are heterodimeric complexes composed of a catalytic subunit(p110α,p110β,or p110δ)and a regulatory subunit(p85α,p55α,p50α,p85β,or p55γ)2.Although the catalytic isoforms p110αand p110β,are ubiquitously expressed across tissues,p110δis predominantly found in leukocytes3.Notably,p85αfunctions as the primary regulatory subunit.展开更多
Hydrogen peroxide(H_(2)O_(2))production via electrochemical two-electron oxygen reduction reaction(ORR)holds a great promise for sustainable energy storage.However,the issues such as high energy consumption and diffic...Hydrogen peroxide(H_(2)O_(2))production via electrochemical two-electron oxygen reduction reaction(ORR)holds a great promise for sustainable energy storage.However,the issues such as high energy consumption and difficult extraction of thermodynamically unstable H_(2)O_(2) still need to be resolved.Herein,we reported a unified system for energy-out production and downstream conversion of H_(2)O_(2).By replacing the sluggish oxygen evolution reaction with a hydrazine oxidation reaction(HzOR),the cell of twoelectron ORR coupled with HzOR achieves the co-generation of electricity energy and valuable H_(2)O_(2).By employing Ru single atoms anchored on cobalt hydroxide(for HzOR)and NiSe_(2)(for ORR)as electrocatalysts,both exhibiting onset potentials near the theoretical values for their respective reactions,the ORR‖HzOR cell exhibits an energy output of 3.58 mW cm^(-2) and generates 0.66 kWh of electricity per kg of H_(2)O_(2).with a production rate of 583 mmol h^(-1) H_(2)O_(2).The produced H_(2)O_(2) was subsequently in-situ upgraded via three downstream conversion pathways to yield value-added products of sodium percarbonate,sodium peroxyborate,and ethylene glycol.A techno-economic analysis confirmed the economic viability of this ORR‖HzOR coupled with downstream conversion system.展开更多
Past investigations of the hydrodynamic forces on vertical columns have generally been based on rigid structure assumptions.The effects of structural flexibility and geometry characteristics on the hydrodynamic force ...Past investigations of the hydrodynamic forces on vertical columns have generally been based on rigid structure assumptions.The effects of structural flexibility and geometry characteristics on the hydrodynamic force distribution are not well understood.In this study,fluid-structure interaction models are developed for numerical analyses.This modeling technique is verified with an experimental test in the literature using both circular and rectangular cross-sections.A series of material elasticities that present structural properties ranging from rigid to flexible is then used to conduct analyses.This finding indicates that an increase in structural flexibility can decrease the impact force to some extent,but this effect is limited.A concrete bridge pier with fluid flow impact can be considered rigid when it is fixed at the bottom.After that,the effects of the initial downstream water height and the width of water tank on the hydrodynamic force are thoroughly investigated.The results demonstrate that the increase in the downstream water height with a constant upstream water height corresponds to a decreased force.Moreover,the vertical column results in a blockage effect on the fluid flow.The greater the blockage effect,the higher the hydrodynamic force.The blockage effect from the vertical column can be neglected when the tank width is greater than eight times the structural cross-section diameter.展开更多
With the acceleration of industrialization,the pollution problem of sulfur dioxide(SO_(2))emitted from coal-fired power plants has become increasingly severe.Although wet flue gas desulfurization(FGD)technology can re...With the acceleration of industrialization,the pollution problem of sulfur dioxide(SO_(2))emitted from coal-fired power plants has become increasingly severe.Although wet flue gas desulfurization(FGD)technology can remove about 95%of SO_(2),its high energy consumption and the corrosion risk of downstream equipment caused by residual SO_(2)(500–3000 ppm)still need to be addressed[1].Previous porous materials(such as MOFs)achieve selective adsorption of SO_(2) through open metal sites,M–OH sites or functional organic groups,but the problem of CO_(2) co-adsorption limits their practical application[2].In recent years,hydrogen-bonded organic frameworks(HOFs)have emerged as a research hotspot due to their reversible hydrogen-bonding networks and flexible structures[3],but their stability under extreme conditions and efficient separation performance still need to be improved[4].展开更多
The research selected three typical areas for plant investigation, including upper reaches of Gangnan Reservoir, the area between Gangnan and downstream of Huangbizhuang Reservoir, and Huangbizhuang Reservoir. The res...The research selected three typical areas for plant investigation, including upper reaches of Gangnan Reservoir, the area between Gangnan and downstream of Huangbizhuang Reservoir, and Huangbizhuang Reservoir. The results showed that affected by water, plant species, species diversity and species richness were all decreasing in varying degrees as the distance with watercourse upper reaches was increasing, but the ratio of Anthropochory plants was growing. The research finally proposed countermeasures, including increasing wetland area, constructing forests and artificial water landscape of Hutuo River and reinforcing watercourse compre- hensive management.展开更多
A small spring fed stream precipitates calcite by outgassing of CO<sub>2</sub> due to chemically controlled inorganic processes. The chemical composition of the water was measured along 9 stations downstre...A small spring fed stream precipitates calcite by outgassing of CO<sub>2</sub> due to chemically controlled inorganic processes. The chemical composition of the water was measured along 9 stations downstream with respect to Ca<sup>2+</sup>, Mg<sup>2+</sup>, Na<sup>+</sup>,K<sup>+</sup>, Cl<sup>-</sup>, carbonate alkalinlty, and SO<sub>4</sub><sup>2-</sup>. Temperature and pH were measured in situ. Small rectangular shaped tablets of limestone from the area were immersed into the stream for short periods and water analyses were carried out at the same time. From weight increase of the tablets, precipitation rates展开更多
We use the Wind Farm Parameterization(WFP) scheme coupled with the Weather Research and Forecasting model under multiple resolution regimes to simulate turbulent wake dynamics generated by a real onshore wind farm and...We use the Wind Farm Parameterization(WFP) scheme coupled with the Weather Research and Forecasting model under multiple resolution regimes to simulate turbulent wake dynamics generated by a real onshore wind farm and their influence at the local meteorological scale. The model outputs are compared with earlier modeling and observation studies. It is found that higher vertical and horizontal resolutions have great impacts on the simulated wake flow dynamics. The corresponding wind speed deficit and turbulent kinetic energy results match well with previous studies. In addition, the effect of horizontal resolution on near-surface meteorology is significantly higher than that of vertical resolution. The wake flow field extends from the start of the wind farm to downstream within 10 km, where the wind speed deficit may exceed 4%. For a height of 150 m or at a distance of about 25 km downstream, the wind speed deficit is around 2%. This indicates that, at a distance of more than 25 km downstream, the impact of the wind turbines can be ignored. Analysis of near-surface meteorology indicates a night and early morning warming near the surface, and increase in near-surface water vapor mixing ratio with decreasing surface sensible and latent heat fluxes. During daytime, a slight cooling near the surface and decrease in the near-surface water vapor mixing ratio with increasing surface sensible and latent heat fluxes is noticed over the wind farm area.展开更多
Using gauge precipitation data and NCEP-NCAR reanalysis data, the interdecadal changes in summer precipitation during the period 1956-2007 in North China and the link with atmospheric circulation change over Eurasia a...Using gauge precipitation data and NCEP-NCAR reanalysis data, the interdecadal changes in summer precipitation during the period 1956-2007 in North China and the link with atmospheric circulation change over Eurasia are studied. Results show that precipitation amounts decreased by 16.2 mm per decade, which was attributable to a significant reduction in precipitation frequency. Contrary wave trains were found in the subtropical westerly jet （wave guide） over Eurasia for the wet and dry years of North China. When the wave trains had a ridge （trough） around the Korean Peninsula, conditions favored （disfavored） the westward and northward extension of the West Pacific subtropical high. The westward and northward extension of the West Pacific subtropical high is, and was, beneficial to rainfall in North China. The downstream propagation of Rossby waves was found to favor the maintenance of these wave trains. Sensible heating in the south of Lake Baikal and latent heating from the Korean Peninsula to the south of Japan increased during the period 1980-2007, as compared to that during 1957-1979. the wet period. These changes had positive influences on the maintenance of Anticyclonic-Cyclonic anomaly centers in the wave trains. Furthermore, northerly winds were prevalent in the lower troposphere during the dry period （1980-2007）. which prohibited the transportation of water vapor to North China from the seas and thereby led to a decrease in rainfall in North China. The weakening of the Indian Monsoon during the dry period might be one of reasons for the reduction in water vapor transportation.展开更多
This study of renaturation by dilution and size exclusion chromatogra phy (SEC) addition of urea to improve yield as well as the initial and final pro tein concentrations showed that although urea decreased the rate o...This study of renaturation by dilution and size exclusion chromatogra phy (SEC) addition of urea to improve yield as well as the initial and final pro tein concentrations showed that although urea decreased the rate of lysozyme ref o lding, it could suppress protein aggregation to sustain the pathway of correct r efolding at high protein concentration; and that there existed an optimum urea c oncentration in renaturation buffer. Under the above conditions, lysozyme was su ccessfully refolded from initial concentration of up to 40 mg/mL by dilution and 100 mg/mL by SEC, with the yield of the former being more than 40% and that of the latter being 34.8%. Especially, under the condition of 30 min interval time, i.e. τ>2(t_R2 -t_R1 ), the efficiency was increased by 25% and the renaturation buffe r could be recycled for SEC refolding in continuous operation of downstream proc ess.展开更多
Gezhouba hydroproject was impounded and put into operation in 1981. In order to analyse the impact on the downstream river course, Jingjiang Hydrologic and Water Resources Survey Bureau of Changjiang Water Resources C...Gezhouba hydroproject was impounded and put into operation in 1981. In order to analyse the impact on the downstream river course, Jingjiang Hydrologic and Water Resources Survey Bureau of Changjiang Water Resources Commission has conducted prototype observation on the Yichang-Chenglingji river stretch. On basis of the observed data, the change in river regime and scour-sedimentation evolution and water surface profile below the dam are analysed systematically. The results show that the scouring of downstream river course mainly stretches from Yichang to Ouchikou, mainly occurring in 1980～1987; the scourring mainly takes place in the river channel and the water surface profile drops significantly in dry season,but not quite in high flood season.展开更多
In this study,the nonplanar post-buckling behavior of a simply supported fluid-conveying pipe with an axially sliding downstream end is investigated within the framework of a three-dimensional(3 D)theoretical model.Th...In this study,the nonplanar post-buckling behavior of a simply supported fluid-conveying pipe with an axially sliding downstream end is investigated within the framework of a three-dimensional(3 D)theoretical model.The complete nonlinear governing equations are discretized via Galerkin’s method and then numerically solved by the use of a fourth-order Runge-Kutta integration algorithm.Different initial conditions are chosen for calculations to show the nonplanar buckling characteristics of the pipe in two perpendicular lateral directions.A detailed parametric analysis is performed in order to study the influence of several key system parameters such as the mass ratio,the flow velocity,and the gravity parameter on the post-buckling behavior of the pipe.Typical results are presented in the form of bifurcation diagrams when the flow velocity is selected as the variable parameter.It is found that the pipe will stay at its original straight equilibrium position until the critical flow velocity is reached.Just beyond the critical flow velocity,the pipe would lose stability by static divergence via a pitchfork bifurcation,and two possible nonzero equilibrium positions are generated.It is shown that the buckling and post-buckling behaviors of the pipe cannot be influenced by the mass ratio parameter.Unlike a pipe with two immovable ends,however,the pinned-pinned pipe with an axially sliding downstream end shows some different features regarding post-buckling behaviors.The most important feature is that the buckling amplitude of the pipe with an axially sliding downstream end would increase first and then decrease with the increase in the flow velocity.In addition,the buckled shapes of the pipe varying with the flow velocity are displayed in order to further show the new post-buckling features of the pipe with an axially sliding downstream end.展开更多
Elucidating the influence of dams on fluvial processes can inform river protection and basin management. However, relatively few studies have focused on how multiple factors interact to affect the morphological evolut...Elucidating the influence of dams on fluvial processes can inform river protection and basin management. However, relatively few studies have focused on how multiple factors interact to affect the morphological evolution of meandering reaches. Using hydrological and topographical data, we analyzed the factors that influence and regulate the meandering reaches downstream the Three Gorges Dam （TGD）. Our conclusions are as follows. （1） The meandering reaches can be classified into two types based on their evolution during the pre-dam period： G1 reaches, characterized by convex point bar erosion and concave channel deposition （CECD）, and G2 reaches, characterized by convex point bar deposition and concave channel erosion （CDCE）. Both reach types exhibited CECD features during the post-dam period, （2） Flow processes and sediment transport are the factors that caused serious erosion of the low beaches located in the convex point bars. However, changes in the river regime, river boundaries and jacking of Dongting Lake do not act as primary controls on the morphological evolution of the meandering reaches. （3） Flood discharges ranging from 20,000 to 25,000 m^3/s result in greater erosion of convex point bars. The point bars become scoured if the durations of these flows, which are close to bankfull discharge, exceed 20 days. In addition, the reduction in bedload causes the decreasing of point bar siltation in the water-falling period. （4） During the post-dam period, flood abatement, the increased duration of discharges ranging from 20,000 to 25,000 m^3/s, and a significant reduction in sediment transport are the main factors that caused meandering reaches to show CECD features. Our results are relevant to other meandering reaches, where they can inform estimates of riverbed change, river management strategies and river protection.展开更多
The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climat...The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climate changes, and landform evolution since the Middle Pleistocene. Based on geomorphological, sedimentological, and chronological investigations, 6-8 terraces are identified in the lower reaches of Yalong catchment and its tributary--the Anning River. The electron spin resonance （ESR） or optically stimulated luminescence （OSL） data on the alluvial sediments in the upper portion of terraces indicate that they formed in 1.10, 0.90, 0.72, 0.06-0.04, 0.03-0.02, and 0.01 Ma. Tectonic uplift and the climatic cycle controlled the formation of the Yalong River terraces. The former dominated the dissection depths and incision rates, whereas the latter controlled the transformation between accumulation, which developed during the glacial period, and incision, which developed during the glacial-interglacial transition. The Yalong downstream incised rapidly from 1.10 to 0.72 Ma and rapidly from 0.06 Ma until the present; the terraces developed during these two periods. The incision rates in space during the two periods indicate the uplifting extent of the Jinpingshan area, which decreases toward the east and the south. The results reveal two rapidly uplifting stages in the SE Tibetan Plateau, including an accelerated uplifting since 0.06 Ma. Since the Middle Pleistocene, the tectonic uplift of the SE and NE parts of the Tibetan Plateau is synchronous, according to the same development stages of the river terraces of the Yalong downstream and the Yellow River in the Lanzhou area of the NE Tibetan Plateau. The difference in the horizontal displacement between the Xianshuihe Fault and the Anninghe Fault bend resulted in the rapid uplift of the Jinpingshan area. The incision rate for the spatial distribution of the Yalong downstream is the geomorphologicai response of crustal shortening and uplift differences in the SE margin block of the Tibetan Plateau. The southeastward diffusion process of the Tibetan Plateau was recorded.展开更多
To date,the Three Gorges Project is the largest hydro junction in the world.It is the key project for the integrated water resource management and development of the Changjiang River.The technology of the project,with...To date,the Three Gorges Project is the largest hydro junction in the world.It is the key project for the integrated water resource management and development of the Changjiang River.The technology of the project,with its huge scale and comprehensive benefits,is extremely complicated,and the design difficulty is greater than that of any other hydro project in the world.A series of new design theories and methods have been proposed and applied in the design and research process.Many key technological problems regarding hydraulic structures have been overcome,such as a gravity dam with multi-layer large discharge orifices,a hydropower station of giant generating units,and a giant continual multi-step ship lock with a high water head.展开更多
AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extracti...AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up period.RESULTS:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast cancer.CONCLUSION:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer.展开更多
This study uses eddy kinetic energy analysis and a targeting method to investigate how an extratropical transition（ET）event induced downstream development（the modification of the midlatitude flow downstream of the ...This study uses eddy kinetic energy analysis and a targeting method to investigate how an extratropical transition（ET）event induced downstream development（the modification of the midlatitude flow downstream of the ET system） in the midlatitude jet environment. The downstream development showed distinct characteristics of ＂coupling development＂ and being ＂boundary-trapped＂. Eddies（potential disturbances） first developed at the upper levels, and these triggered lower-level eddy development, with all eddies decaying away from the tropopause and the surface. Thereafter, a lower-level eddy caught up with the upper-level eddy ahead of it, and they coupled to form a cyclone extending through the whole troposphere. Vertical ageostrophic geopotential flux may be a crucial dynamic factor throughout the eddy＇s lower-level growth, boundary-trapping,and coupling development.Together with barotropic conversion, the ageostrophic geopotential fluxes that were transported from Hurricane Fabian（2003） to the midlatitudes by the outflow led to downstream ridge development in the upper-level jet. The strong downstream advection of eddy kinetic energy in the exit region of the jet streak triggered downstream trough development. The well-known ridge–trough couplet thus formed. The vertical ageostrophic fluxes that were transported downward from the developed upper-level systems converged near the surface and resulted in lower-level eddy growth. Baroclinic conversion was negligible near the boundaries, while it was the main source of eddy kinetic energy at mid-levels. In the upper-level jet, potential energy was converted to the mean kinetic energy of the jet, which in turn was converted to eddy kinetic energy through barotropic conversion.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52300122).
文摘This study investigated the operation features of a dropshaft-tunnel system under varying downstream water levels through a large-scale physical model.In the experiments,the air pressure distribution in the system was measured,and the flow pattern was recorded by cameras.The results revealed that the air pressure in the drop-shaft increased with increasing water flow rate under free outflow conditions but changed little when the outflow was submerged,even when the flow rate further increased.Additionally,there was a wavy flow in the tunnel un-der free outflow conditions,whereas plug flow with air pockets occurred under submerged outflow conditions.The downstream water level was found to affect the system through changing the linkage between the drop-shaft and tunnel and the resistance to air release downstream.The findings of this study contribute to a more comprehensive understanding of the operation of deep tunnel systems.
基金supported by grants from the Ministry of Science and Technology of China(Grant No.2020YFA0803301)the Natural Science Foundation of Shandong Province(Grant No.ZR2024QH181)The Postdoctoral Fellowship Program(Grade C)of the China Postdoctoral Science Foundation(Grant No.GZC20240770).
文摘Phosphoinositide 3-kinase(PI3K)catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate(PIP_(2))to phosphatidylinositol 3,4,5-trisphosphate(PIP_(3)),a key second messenger that orchestrates downstream signaling by recruiting and activating effector proteins,such as protein kinase B(AKT).PI3Ks are categorized into four classes(IA,IB,II,and III)based on structural characteristics and substrate preferences1.Class IA PI3K enzymes are heterodimeric complexes composed of a catalytic subunit(p110α,p110β,or p110δ)and a regulatory subunit(p85α,p55α,p50α,p85β,or p55γ)2.Although the catalytic isoforms p110αand p110β,are ubiquitously expressed across tissues,p110δis predominantly found in leukocytes3.Notably,p85αfunctions as the primary regulatory subunit.
基金the National Natural Science Foundation of China(U21A20286 to Y.H.,22206054 to Y.H.,and 22478310 to J.Z.)the Fundamental Research Funds for the Central China Normal University(CCNU)。
文摘Hydrogen peroxide(H_(2)O_(2))production via electrochemical two-electron oxygen reduction reaction(ORR)holds a great promise for sustainable energy storage.However,the issues such as high energy consumption and difficult extraction of thermodynamically unstable H_(2)O_(2) still need to be resolved.Herein,we reported a unified system for energy-out production and downstream conversion of H_(2)O_(2).By replacing the sluggish oxygen evolution reaction with a hydrazine oxidation reaction(HzOR),the cell of twoelectron ORR coupled with HzOR achieves the co-generation of electricity energy and valuable H_(2)O_(2).By employing Ru single atoms anchored on cobalt hydroxide(for HzOR)and NiSe_(2)(for ORR)as electrocatalysts,both exhibiting onset potentials near the theoretical values for their respective reactions,the ORR‖HzOR cell exhibits an energy output of 3.58 mW cm^(-2) and generates 0.66 kWh of electricity per kg of H_(2)O_(2).with a production rate of 583 mmol h^(-1) H_(2)O_(2).The produced H_(2)O_(2) was subsequently in-situ upgraded via three downstream conversion pathways to yield value-added products of sodium percarbonate,sodium peroxyborate,and ethylene glycol.A techno-economic analysis confirmed the economic viability of this ORR‖HzOR coupled with downstream conversion system.
基金The National Natural Science Foundation of China(No.52222804,U21A20154).
文摘Past investigations of the hydrodynamic forces on vertical columns have generally been based on rigid structure assumptions.The effects of structural flexibility and geometry characteristics on the hydrodynamic force distribution are not well understood.In this study,fluid-structure interaction models are developed for numerical analyses.This modeling technique is verified with an experimental test in the literature using both circular and rectangular cross-sections.A series of material elasticities that present structural properties ranging from rigid to flexible is then used to conduct analyses.This finding indicates that an increase in structural flexibility can decrease the impact force to some extent,but this effect is limited.A concrete bridge pier with fluid flow impact can be considered rigid when it is fixed at the bottom.After that,the effects of the initial downstream water height and the width of water tank on the hydrodynamic force are thoroughly investigated.The results demonstrate that the increase in the downstream water height with a constant upstream water height corresponds to a decreased force.Moreover,the vertical column results in a blockage effect on the fluid flow.The greater the blockage effect,the higher the hydrodynamic force.The blockage effect from the vertical column can be neglected when the tank width is greater than eight times the structural cross-section diameter.
基金the support of the National Natural Science Foundation of China(Nos.22205207 and 22378369).
文摘With the acceleration of industrialization,the pollution problem of sulfur dioxide(SO_(2))emitted from coal-fired power plants has become increasingly severe.Although wet flue gas desulfurization(FGD)technology can remove about 95%of SO_(2),its high energy consumption and the corrosion risk of downstream equipment caused by residual SO_(2)(500–3000 ppm)still need to be addressed[1].Previous porous materials(such as MOFs)achieve selective adsorption of SO_(2) through open metal sites,M–OH sites or functional organic groups,but the problem of CO_(2) co-adsorption limits their practical application[2].In recent years,hydrogen-bonded organic frameworks(HOFs)have emerged as a research hotspot due to their reversible hydrogen-bonding networks and flexible structures[3],but their stability under extreme conditions and efficient separation performance still need to be improved[4].
基金Supported by Hebei Provincial Natural Science Foundation(D2012302007)Science and Technology Project of Hebei Academy of Sciences(14111)~~
文摘The research selected three typical areas for plant investigation, including upper reaches of Gangnan Reservoir, the area between Gangnan and downstream of Huangbizhuang Reservoir, and Huangbizhuang Reservoir. The results showed that affected by water, plant species, species diversity and species richness were all decreasing in varying degrees as the distance with watercourse upper reaches was increasing, but the ratio of Anthropochory plants was growing. The research finally proposed countermeasures, including increasing wetland area, constructing forests and artificial water landscape of Hutuo River and reinforcing watercourse compre- hensive management.
文摘A small spring fed stream precipitates calcite by outgassing of CO<sub>2</sub> due to chemically controlled inorganic processes. The chemical composition of the water was measured along 9 stations downstream with respect to Ca<sup>2+</sup>, Mg<sup>2+</sup>, Na<sup>+</sup>,K<sup>+</sup>, Cl<sup>-</sup>, carbonate alkalinlty, and SO<sub>4</sub><sup>2-</sup>. Temperature and pH were measured in situ. Small rectangular shaped tablets of limestone from the area were immersed into the stream for short periods and water analyses were carried out at the same time. From weight increase of the tablets, precipitation rates
基金the National Key Research and Development Program of China (Grant No.2017YFA0604501)the National Natural Science Foundation of China (Grant No.41475013) for the funding support
文摘We use the Wind Farm Parameterization(WFP) scheme coupled with the Weather Research and Forecasting model under multiple resolution regimes to simulate turbulent wake dynamics generated by a real onshore wind farm and their influence at the local meteorological scale. The model outputs are compared with earlier modeling and observation studies. It is found that higher vertical and horizontal resolutions have great impacts on the simulated wake flow dynamics. The corresponding wind speed deficit and turbulent kinetic energy results match well with previous studies. In addition, the effect of horizontal resolution on near-surface meteorology is significantly higher than that of vertical resolution. The wake flow field extends from the start of the wind farm to downstream within 10 km, where the wind speed deficit may exceed 4%. For a height of 150 m or at a distance of about 25 km downstream, the wind speed deficit is around 2%. This indicates that, at a distance of more than 25 km downstream, the impact of the wind turbines can be ignored. Analysis of near-surface meteorology indicates a night and early morning warming near the surface, and increase in near-surface water vapor mixing ratio with decreasing surface sensible and latent heat fluxes. During daytime, a slight cooling near the surface and decrease in the near-surface water vapor mixing ratio with increasing surface sensible and latent heat fluxes is noticed over the wind farm area.
基金sponsored by the National Basic Research Program of China (973 Program) (2009CB421401)the Knowledge Innovation Project of the Chinese Academy of Sciences (Grant No. KZCX2-YW-Q03-3)
文摘Using gauge precipitation data and NCEP-NCAR reanalysis data, the interdecadal changes in summer precipitation during the period 1956-2007 in North China and the link with atmospheric circulation change over Eurasia are studied. Results show that precipitation amounts decreased by 16.2 mm per decade, which was attributable to a significant reduction in precipitation frequency. Contrary wave trains were found in the subtropical westerly jet （wave guide） over Eurasia for the wet and dry years of North China. When the wave trains had a ridge （trough） around the Korean Peninsula, conditions favored （disfavored） the westward and northward extension of the West Pacific subtropical high. The westward and northward extension of the West Pacific subtropical high is, and was, beneficial to rainfall in North China. The downstream propagation of Rossby waves was found to favor the maintenance of these wave trains. Sensible heating in the south of Lake Baikal and latent heating from the Korean Peninsula to the south of Japan increased during the period 1980-2007, as compared to that during 1957-1979. the wet period. These changes had positive influences on the maintenance of Anticyclonic-Cyclonic anomaly centers in the wave trains. Furthermore, northerly winds were prevalent in the lower troposphere during the dry period （1980-2007）. which prohibited the transportation of water vapor to North China from the seas and thereby led to a decrease in rainfall in North China. The weakening of the Indian Monsoon during the dry period might be one of reasons for the reduction in water vapor transportation.
文摘This study of renaturation by dilution and size exclusion chromatogra phy (SEC) addition of urea to improve yield as well as the initial and final pro tein concentrations showed that although urea decreased the rate of lysozyme ref o lding, it could suppress protein aggregation to sustain the pathway of correct r efolding at high protein concentration; and that there existed an optimum urea c oncentration in renaturation buffer. Under the above conditions, lysozyme was su ccessfully refolded from initial concentration of up to 40 mg/mL by dilution and 100 mg/mL by SEC, with the yield of the former being more than 40% and that of the latter being 34.8%. Especially, under the condition of 30 min interval time, i.e. τ>2(t_R2 -t_R1 ), the efficiency was increased by 25% and the renaturation buffe r could be recycled for SEC refolding in continuous operation of downstream proc ess.
文摘Gezhouba hydroproject was impounded and put into operation in 1981. In order to analyse the impact on the downstream river course, Jingjiang Hydrologic and Water Resources Survey Bureau of Changjiang Water Resources Commission has conducted prototype observation on the Yichang-Chenglingji river stretch. On basis of the observed data, the change in river regime and scour-sedimentation evolution and water surface profile below the dam are analysed systematically. The results show that the scouring of downstream river course mainly stretches from Yichang to Ouchikou, mainly occurring in 1980～1987; the scourring mainly takes place in the river channel and the water surface profile drops significantly in dry season,but not quite in high flood season.
基金Project supported by the National Natural Science Foundation of China(Nos.11622216,11602090,and 11672115)the Natural Science Foundation of Hubei Province(No.2017CFB429)the fundamental Research Funds for the Central Universities of China(No.2017KFYXJJ135)
文摘In this study,the nonplanar post-buckling behavior of a simply supported fluid-conveying pipe with an axially sliding downstream end is investigated within the framework of a three-dimensional(3 D)theoretical model.The complete nonlinear governing equations are discretized via Galerkin’s method and then numerically solved by the use of a fourth-order Runge-Kutta integration algorithm.Different initial conditions are chosen for calculations to show the nonplanar buckling characteristics of the pipe in two perpendicular lateral directions.A detailed parametric analysis is performed in order to study the influence of several key system parameters such as the mass ratio,the flow velocity,and the gravity parameter on the post-buckling behavior of the pipe.Typical results are presented in the form of bifurcation diagrams when the flow velocity is selected as the variable parameter.It is found that the pipe will stay at its original straight equilibrium position until the critical flow velocity is reached.Just beyond the critical flow velocity,the pipe would lose stability by static divergence via a pitchfork bifurcation,and two possible nonzero equilibrium positions are generated.It is shown that the buckling and post-buckling behaviors of the pipe cannot be influenced by the mass ratio parameter.Unlike a pipe with two immovable ends,however,the pinned-pinned pipe with an axially sliding downstream end shows some different features regarding post-buckling behaviors.The most important feature is that the buckling amplitude of the pipe with an axially sliding downstream end would increase first and then decrease with the increase in the flow velocity.In addition,the buckled shapes of the pipe varying with the flow velocity are displayed in order to further show the new post-buckling features of the pipe with an axially sliding downstream end.
基金National Natural Science Foundation of China, No.51479146 Doctoral Foundation of Northwest A＆F University No.2452015337 National Key Research and Development Plan, No.2016YFC0402303, No.2016YFC0402101
文摘Elucidating the influence of dams on fluvial processes can inform river protection and basin management. However, relatively few studies have focused on how multiple factors interact to affect the morphological evolution of meandering reaches. Using hydrological and topographical data, we analyzed the factors that influence and regulate the meandering reaches downstream the Three Gorges Dam （TGD）. Our conclusions are as follows. （1） The meandering reaches can be classified into two types based on their evolution during the pre-dam period： G1 reaches, characterized by convex point bar erosion and concave channel deposition （CECD）, and G2 reaches, characterized by convex point bar deposition and concave channel erosion （CDCE）. Both reach types exhibited CECD features during the post-dam period, （2） Flow processes and sediment transport are the factors that caused serious erosion of the low beaches located in the convex point bars. However, changes in the river regime, river boundaries and jacking of Dongting Lake do not act as primary controls on the morphological evolution of the meandering reaches. （3） Flood discharges ranging from 20,000 to 25,000 m^3/s result in greater erosion of convex point bars. The point bars become scoured if the durations of these flows, which are close to bankfull discharge, exceed 20 days. In addition, the reduction in bedload causes the decreasing of point bar siltation in the water-falling period. （4） During the post-dam period, flood abatement, the increased duration of discharges ranging from 20,000 to 25,000 m^3/s, and a significant reduction in sediment transport are the main factors that caused meandering reaches to show CECD features. Our results are relevant to other meandering reaches, where they can inform estimates of riverbed change, river management strategies and river protection.
基金supported by the Project of China Geological Survey (grant nos.1212011120071,201211077-3 and 1212011120182)
文摘The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climate changes, and landform evolution since the Middle Pleistocene. Based on geomorphological, sedimentological, and chronological investigations, 6-8 terraces are identified in the lower reaches of Yalong catchment and its tributary--the Anning River. The electron spin resonance （ESR） or optically stimulated luminescence （OSL） data on the alluvial sediments in the upper portion of terraces indicate that they formed in 1.10, 0.90, 0.72, 0.06-0.04, 0.03-0.02, and 0.01 Ma. Tectonic uplift and the climatic cycle controlled the formation of the Yalong River terraces. The former dominated the dissection depths and incision rates, whereas the latter controlled the transformation between accumulation, which developed during the glacial period, and incision, which developed during the glacial-interglacial transition. The Yalong downstream incised rapidly from 1.10 to 0.72 Ma and rapidly from 0.06 Ma until the present; the terraces developed during these two periods. The incision rates in space during the two periods indicate the uplifting extent of the Jinpingshan area, which decreases toward the east and the south. The results reveal two rapidly uplifting stages in the SE Tibetan Plateau, including an accelerated uplifting since 0.06 Ma. Since the Middle Pleistocene, the tectonic uplift of the SE and NE parts of the Tibetan Plateau is synchronous, according to the same development stages of the river terraces of the Yalong downstream and the Yellow River in the Lanzhou area of the NE Tibetan Plateau. The difference in the horizontal displacement between the Xianshuihe Fault and the Anninghe Fault bend resulted in the rapid uplift of the Jinpingshan area. The incision rate for the spatial distribution of the Yalong downstream is the geomorphologicai response of crustal shortening and uplift differences in the SE margin block of the Tibetan Plateau. The southeastward diffusion process of the Tibetan Plateau was recorded.
文摘To date,the Three Gorges Project is the largest hydro junction in the world.It is the key project for the integrated water resource management and development of the Changjiang River.The technology of the project,with its huge scale and comprehensive benefits,is extremely complicated,and the design difficulty is greater than that of any other hydro project in the world.A series of new design theories and methods have been proposed and applied in the design and research process.Many key technological problems regarding hydraulic structures have been overcome,such as a gravity dam with multi-layer large discharge orifices,a hydropower station of giant generating units,and a giant continual multi-step ship lock with a high water head.
文摘AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up period.RESULTS:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast cancer.CONCLUSION:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer.
基金jointly supported by the International Cooperating Program of Science and Technology (Grant No. 2010DFA24650)the National Natural Science Foundation of China (Grant No. 41175061)
文摘This study uses eddy kinetic energy analysis and a targeting method to investigate how an extratropical transition（ET）event induced downstream development（the modification of the midlatitude flow downstream of the ET system） in the midlatitude jet environment. The downstream development showed distinct characteristics of ＂coupling development＂ and being ＂boundary-trapped＂. Eddies（potential disturbances） first developed at the upper levels, and these triggered lower-level eddy development, with all eddies decaying away from the tropopause and the surface. Thereafter, a lower-level eddy caught up with the upper-level eddy ahead of it, and they coupled to form a cyclone extending through the whole troposphere. Vertical ageostrophic geopotential flux may be a crucial dynamic factor throughout the eddy＇s lower-level growth, boundary-trapping,and coupling development.Together with barotropic conversion, the ageostrophic geopotential fluxes that were transported from Hurricane Fabian（2003） to the midlatitudes by the outflow led to downstream ridge development in the upper-level jet. The strong downstream advection of eddy kinetic energy in the exit region of the jet streak triggered downstream trough development. The well-known ridge–trough couplet thus formed. The vertical ageostrophic fluxes that were transported downward from the developed upper-level systems converged near the surface and resulted in lower-level eddy growth. Baroclinic conversion was negligible near the boundaries, while it was the main source of eddy kinetic energy at mid-levels. In the upper-level jet, potential energy was converted to the mean kinetic energy of the jet, which in turn was converted to eddy kinetic energy through barotropic conversion.
