The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor...The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products.展开更多
Based on non-Darcian flow law described by exponent and threshold gradient within a double-layered soil, the classic theory of one-dimensional consolidation of double-layered soil was modified to consider the change o...Based on non-Darcian flow law described by exponent and threshold gradient within a double-layered soil, the classic theory of one-dimensional consolidation of double-layered soil was modified to consider the change of vertical total stress with depth and time together. Because of the complexity of governing equations, the numerical solutions were obtained in detail by finite difference method. Then, the numerical solutions were compared with the analytical solutions in condition that non-Darcian flow law was degenerated to Dary's law, and the comparison results show that numerical solutions are reliable. Finally, consolidation behavior of double-layered soil with different parameters was analyzed, and the results show that the consolidation rate of double-layered soil decreases with increasing the value of exponent and threshold of non-Darcian flow, and the exponent and threshold gradient of the first soil layer greatly influence the consolidation rate of double-layered soil. The larger the ratio of the equivalent water head of external load to the total thickness of double-layered soil, the larger the rate of the consolidation, and the similitude relationship in classical consolidation theory of double-layered soil is not satisfied. The other consolidation behavior of double-layered soil with non-Darcian flow is the same as that with Darcy's law.展开更多
To further investigate the one-dimensional(1D)rheological consolidation mechanism of double-layered soil,the fractional derivative Merchant model(FDMM)and the non-Darcian flow model with the non-Newtonian index are re...To further investigate the one-dimensional(1D)rheological consolidation mechanism of double-layered soil,the fractional derivative Merchant model(FDMM)and the non-Darcian flow model with the non-Newtonian index are respectively introduced to describe the deformation of viscoelastic soil and the flow of pore water in the process of consolidation.Accordingly,an 1D rheological consolidation equation of double-layered soil is obtained,and its numerical analysis is performed by the implicit finite difference method.In order to verify its validity,the numerical solutions by the present method for some simplified cases are compared with the results in the related literature.Then,the influence of the revelent parameters on the rheological consolidation of double-layered soil are investigated.Numerical results indicate that the parameters of non-Darcian flow and FDMM of the first soil layer greatly influence the consolidation rate of double-layered soil.As the decrease of relative compressibility or the increase of relative permeability between the lower soil and the upper soil,the dissipation rate of excess pore water pressure and the settlement rate of the ground will be accelerated.Increasing the relative thickness of soil layer with high permeability or low compressibility will also accelerate the consolidation rate of double-layered soil.展开更多
The velocity structures of flow through vertically double-layered vegetation(VDLV)as well as single-layered rigid vegetation(SLV)were investigated computationally with a three-dimensional(3D)Reynolds stress turbulence...The velocity structures of flow through vertically double-layered vegetation(VDLV)as well as single-layered rigid vegetation(SLV)were investigated computationally with a three-dimensional(3D)Reynolds stress turbulence model,using the computational fluid dynamics(CFD)code FLUENT.The detailed velocity distribution was explored with a varying initial Froude number(Fr),with consideration of the steady subcritical flow conditions of an inland tsunami.In VDLV flows,the numerical model successfully captured the inflection point in the profiles of mean streamwise velocities in the mixing-layer region around the top of short submerged vegetation.An upward and downward movement of flow occurred at the positions located just behind the tall and short vegetation,respectively.Overall,higher streamwise velocities were observed in the upper vegetation layer due to high porosity,with Pr=98%(sparse vegetation,where Pr is the porosity),as compared to those in the lower vegetation layer,which had comparatively low porosity,with Pr=91%(dense vegetation).A rising trend of velocities was found as the flow passed through the vegetation region,followed by a clear sawtooth distribution,as compared to the regions just upstream and downstream of vegetation where the flow was almost uniform.In VDLV flows,a rising trend in the flow resistance was observed with the increase in the initial Froude number,i.e.,Fr?0.67,0.70,and 0.73.However,the flow resistance in the case of SLV was relatively very low.The numerical results also show the flow structures within the vicinity of short and tall vegetation,which are difficult to attain through experimental measurements.展开更多
AIM To investigate the efficacy of double-layered covered stent in the treatment of malignant oesophageal obstructions.METHODS A systematic review and meta-analysis was performed following the PRISMA process. Pub Med(...AIM To investigate the efficacy of double-layered covered stent in the treatment of malignant oesophageal obstructions.METHODS A systematic review and meta-analysis was performed following the PRISMA process. Pub Med(Medline),EMBASE(Excerpta Medical Database),AMED(Allied and Complementary medicine Database),Scopus and online content,were searched for studies reporting on the Ni Ti-S polyurethane-covered double oesophageal stent for the treatment of malignant dysphagia. Weighted pooled outcomes were synthesized with a random effects model to account for clinical heterogeneity. All studies reporting the outcome of palliative management of dysphagia due to histologically confirmed malignant oesophageal obstruction using double-layered covered nitinol stent were included. The level of statistical significance was set at α = 0.05.RESULTS Six clinical studies comprising 250 patients in total were identified. Pooled technical success of stent insertion was 97.2%(95%CI: 94.8%-98.9%; I2 = 5.8%). Pooled complication rate was 27.6%(95%CI: 20.7%-35.2%; I2 = 41.9%). Weighted improvement of dysphagia on a scale of 0-5 scoring system was-2.00 [95%CI:-2.29%-(-1.72%); I2 = 87%]. Distal stent migration was documented in 10 out of the 250 cases examined.Pooled stent migration rate was 4.7%(95%CI: 2.5%-7.7%; I2 = 0%). Finally,tumour overgrowth was reported in 34 out of the 250 cases with pooled rate of tumour overgrowth of 11.2%(95%CI: 3.7%-22.1%; I2 = 82.2%). No funnel plot asymmetry to suggest publication bias(bias = 0.39,P = 0.78). In the sensitivity analysis all results were largely similar between the fixed and random effects models.CONCLUSION The double-layered nitinol stent provides immediate relief of malignant dysphagia with low rates of stent migration and tumour展开更多
In this study, CrN/Cr2O3 double-layered coatings with various thickness ratios of CrN vs Cr2O3 layer were prepared by arc ion plating technology. The influences of the thickness ratio of CrN vs Cr2O3 layer on the micr...In this study, CrN/Cr2O3 double-layered coatings with various thickness ratios of CrN vs Cr2O3 layer were prepared by arc ion plating technology. The influences of the thickness ratio of CrN vs Cr2O3 layer on the microstructural characteristics as well as the mechanical and tribological properties of the CrN/Cr2O3 doublelayered coatings were investigated. The corresponding mechanisms were also discussed. The results indicated that the insertion of CrN layer between the Cr2O3 layer and substrate can effectively decrease the internal stress level of the coating. With increasing the thickness ratio of CrN vs Cr2O3 layer, the surface roughness of double-layered coatings decreased gradually, which had a certain influence on the friction coefficient. In addition, the microhardness also declined gradually, the adhesive strength almost increased linearly, whereas the wear rate declined firstly and then increased slightly. As the thickness ratio was 2：1, the double-layered coating exhibited the best wear resistance.展开更多
The Songliao Basin(SLB)covers an area of approximately 260,000 km2in northeastern Asia and preserves a continuous and complete Cretaceous terrestrial record(Wang et al.,2021).The region is the most important petrolife...The Songliao Basin(SLB)covers an area of approximately 260,000 km2in northeastern Asia and preserves a continuous and complete Cretaceous terrestrial record(Wang et al.,2021).The region is the most important petroliferous sedimentary basin in China because of its continual annual oil and gas equivalent production of tens of millions of tons(ca.220–440 million barrels per year)since 1959.The SLB was previously thought to have developed on Hercynian basement and accumulated continuous sedimentary deposits during the Late Jurassic and Cretaceous(Wan et al.,2013;Wang et al.,2016).展开更多
Double-layered pellet （DLP） roasting is a novel pretreatment method for sulfur and arsenic-bearing gold concentrates. In this process, preparation of DLPs is a fundamental step which is required to produce DLPs with...Double-layered pellet （DLP） roasting is a novel pretreatment method for sulfur and arsenic-bearing gold concentrates. In this process, preparation of DLPs is a fundamental step which is required to produce DLPs with favorable mechanical strength and thermal stability. Studies were carried out to investigate the affecting factors and conditions on the preparation and properties of DLPs. The results show that moisture content has significant influence on DLPs preparation. With the increase of moisture content in the range of no more than 9.8%, drop resistance and compressive strength of green DLPs are raised and the pelletizing dynamics is improved accordingly. The optimum conditions are determined as moisture content of 9.8%, coating time of 14-16 min, drying temperature 〈80 ℃and drying gas velocity 〈1.2 m/s. When DLPs prepared under these conditions are roasted at 600 ℃ for 1 h, favorable removal and solidifying rates can be obtained, in which the removal rates of arsenic and sulfur are 94.38% and 82.55%, and the solidifying rates of arsenic and sulfur reach 99.62% and 99.79%, respectively. These results promise industrial application of DLP roasting.展开更多
The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimenta...The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of LMBs.Introducing three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'time.Nevertheless,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal foam.Herein,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling strategy.Due to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional variation.Synergistically,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.展开更多
Double-layered graphene sheets （DLGSs） can be applied to the development of a new generation of nanomechanical sensors due to their unique physical properties. A rectangular DLGS with a nanoparticle randomly located...Double-layered graphene sheets （DLGSs） can be applied to the development of a new generation of nanomechanical sensors due to their unique physical properties. A rectangular DLGS with a nanoparticle randomly located in the upper sheet is modeled as two nonlocal Kirchhoff plates connected by van der Waals forces. The Galerkin strip transfer function method which is a semi-analytical method is developed to compute the natural frequencies of the mass- plate vibrating system. It can give exact closed-form solutions along the longitudinal direction of the strip. The results obtained from the semi-analytical method are compared with the previous ones, and the differences between the single-layered graphene sheet （SLGS） and the DLGS mass sensors are also investigated. The results demonstrate the similarity of the in-phase mode between the SLGS and DLGS mass sensors. The sensitivity of the DLGS mass sensor can be increased by decreasing the nonlocal parameter, moving the attached nanoparticle closer to the DLGS center and making the DLGS smaller. These conclusions are helpful for the design and application of graphene-sheet-based resonators as nano-mass sensors.展开更多
In this paper, an analytical solution for the dynamic response of a double-layered subgrade with rock substratum to a moving point load is derived. The subgrade profile is divided into two layers. The upper layer is m...In this paper, an analytical solution for the dynamic response of a double-layered subgrade with rock substratum to a moving point load is derived. The subgrade profile is divided into two layers. The upper layer is modeled by an elastic medium and the lower layer by a fully saturated poroelastic medium governed by Biot’s theory. In the meanwhile, the subgrade is resting on the rock substratum. The analytical solutions for stress, displacement and pore pressure are derived by using the Fourier transform. Numerical results obtained by using the inverse fast Fourier transform (IFFT) are used to analyze the influence of the moving load velocity, the thickness of an elastic medium layer and a fully saturated poroelastic medium layer on the dynamic response.展开更多
Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material co...Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material combining the solvent evaporation method and spray drying method.The protection by the outer capsule wall was used to prolong the service life of the corrosion inhibitor.The dispersion,encapsulation,thermal stability of microcapsules,and the degradation rate of capsule wall in concrete pore solution were analyzed by ultra-deep field microscopy,scanning electron microscopy,thermal analyzer,and sodium ion release rate analysis.The microcapsules were incorporated into mortar samples containing steel reinforcement,and the effects of double-layered microcapsule corrosion inhibitors on the performance of the cement matrix and the actual corrosion-inhibiting effect were analyzed.The experimental results show that the double-layered microcapsules have a moderate particle size and uniform distribution,and the capsules were completely wrapped.The microcapsules as a whole have good thermal stability below 230 ℃.The monolayer membrane structure microcapsules completely broke within 1 day in the simulated concrete pore solution,and the double-layer membrane structure prolonged the service life of the microcapsules to 80 days in the simulated concrete pore solution before the core material was completely released.The mortar samples containing steel reinforcement incorporated with the double-layered microcapsule corrosion inhibitors still maintained a higher corrosion potential than the monolayer microcapsule corrosion inhibitors control group at 60 days.The incorporation of double-layered microcapsules into the cement matrix has no significant adverse effect on the setting time and early strength.展开更多
Surgical repair with artificial chordae replacement has emerged asa standard treatment for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) sutures are commonly employed asartificial chordae;however, the...Surgical repair with artificial chordae replacement has emerged asa standard treatment for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) sutures are commonly employed asartificial chordae;however, they have certain limitations, such aspotential long-term rupture and undesired material/tissueresponse. This study introduces a novel approach to artificialchordae design, termed the New Artificial Chordae (NAC), whichincorporates a double-layered structure. The NAC comprises amulti-strand braided core composed of ultra-high molecularweight polyethylene (UHMWPE) fibers as the inner core, and anouter tube made of hydrophobic porous ePTFE. Compared totraditional ePTFE sutures, NAC exhibits increased flexibility,enhanced tensile strength, longer elongation and improved fatigue resistance. Moreover, NAC exhibits a more hydrophobic surface,which contributes to enhanced hemocompatibility. The study also includes in vivo investigations conducted on animal models to evaluate the biocompatibility and functional efficacy of the artificial chordae. These experiments demonstrate the enhanced durability andbiocompatibility of the NAC, characterized by improved mechanical strength, minimal tissue response and reduced thrombus formation.These findings suggest the potential application of NAC as a prosthetic chordae replacement, offering promising prospects to address thelimitations associated with current artificial chordae materials and providing novel ideas and approaches for the development of sustainable and biocompatible regenerative biomaterials.展开更多
Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly e...Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly encapsulated in the interlayer space of DLHCs with a high loading of 75% （weight percentage） and serves as the active component for lithium storage. The presence of Se in the composite and the carbon framework not only alleviate the shuttling of polysulfide, but also improve the conductivity of electrodes. Migration of active materials from the interlayer void to the hollow cavity of DLHCs after cycling, which further mitigates the loss of active materials and the shuttle effect, is observed. As a result, the SeS2/DLHC composite delivers a high specific capacity （930 mA.h.g-1 at 0.2 C） and outstanding rate capability （400 mA.h.g-1 at 6 C）, which is much better than those of SeS2/single-layered hollow carbon sphere, Se/DLHC, and S/DLHC composites. Notably, the SeS2/DLHC composite shows an ultralong cycle life with 89% capacity retention over 900 cycles at 1 C, or only 0.012% capacity decay per cycle. Our study reveals that both SeS2 and the double-layered structures are responsible for the excellent electrochemical performance.展开更多
The cooling performance of air-cooled condenser(ACC)is susceptible to adverse impacts of ambient winds.In this work,three kinds of lateral double-layered deflectors installed under the ACC platform are proposed to wea...The cooling performance of air-cooled condenser(ACC)is susceptible to adverse impacts of ambient winds.In this work,three kinds of lateral double-layered deflectors installed under the ACC platform are proposed to weaken the unfavorable effects of cross winds.Through CFD simulation methods,the main parameters of thermo-flow performances of a 2×660 MW direct dry cooling system are obtained,by which it can be concluded that the deflectors can effectively reduce the inlet air temperatures while enhance the mass flow rates of upwind fans due to the guiding effect,especially at high wind speeds,while the improvement of cooling capacity of ACCs in the 0°wind direction is weak.The inclined-vertical deflectors are superior to others in performance improvement of ACCs for all cases,which can reduce the turbine back pressure by 12.15%when the wind speed is 12 m/s,so they can be applied to the performance enhancement of ACCs under windy conditions in practical engineering.展开更多
Double-layered thermal barrier coatings(DL-TBCs)have been developed to meet multiple service requirements,such as low thermal conductivity,high thermal stability,and high fracture toughness.Conventional DL-TBCs are of...Double-layered thermal barrier coatings(DL-TBCs)have been developed to meet multiple service requirements,such as low thermal conductivity,high thermal stability,and high fracture toughness.Conventional DL-TBCs are often designed on the basis of equal total thickness to have long lifespans,which may weaken the thermal insulation.The reason is that the single-scale designed structure often has opposite effects on the thermal and mechanical properties.To enhance both the thermal insulation and lifespan,this work designed durable DL-TBCs at multiple scales under equivalent thermal insulation.The macroscopic thickness ratio of the top layer to the bottom layer was tailored to optimize the total and single thicknesses,and the microscopic pore size in the top layer was tailored to resist sintering.Six groups of samples with different thickness ratios were prepared.The thermal cycling test revealed that the lifespan of DL-TBCs first increases but then decreases with increasing thickness ratio.The optimized thickness ratio is 2:3 for DL-TBCs,which have the largest lifespan among the six groups.The cross-sectional morphologies revealed that the failure mode changed from the spallation of the top layer to the delamination of the total double layers.The long lifespan of the optimized DL-TBCs stems from the cotailored thickness ratio and porous structure in the top layer to lower the total cracking driving force.展开更多
The strategy of incorporating polymers into MXene-based functional materials has been widely used to improve their mechanical properties,however with inevitable sacrifice of their electrical conductivity and electroma...The strategy of incorporating polymers into MXene-based functional materials has been widely used to improve their mechanical properties,however with inevitable sacrifice of their electrical conductivity and electromagnetic interference(EMI)shielding performance.This study demonstrates a facile yet efficient layering structure design to prepare the highly robust and conductive double-layer Janus films comprised of independent aramid nanofiber(ANF)and Ti3C2Tx MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)layers.The ANF layer serves to provide good mechanical stability,whilst the MXene/PEDOT:PSS layer ensures excellent electrical conductivity.Doping PEDOT:PSS into the MXene layer enhances the interfacial bonding strength between the MXene and ANF layers and improves the hydrophobicity and water/oxidation resistance of MXene layer.The resultant ANF/MXene-PEDOT:PSS Janus film with a conductive layer thickness of 4.4μm was shown to display low sheet resistance(2.18Ω/sq),good EMI shielding effectiveness(EMI SE of 48.1 dB),high mechanical strength(155.9 MPa),and overall toughness(19.4 MJ/m^(3)).Moreover,the excellent electrical conductivity and light absorption capacity of the MXene-PEDOT:PSS conductive layer mean that these Janus films display multi-source driven heating functions,producing excellent Joule heating(382℃ at 4 V)and photothermal conversion(59.6℃ at 100 mW/m^(2))properties.展开更多
Two-dimensional double-layer honeycomb(DLHC)materials are known for their diverse physical properties,but superconductivity has been a notably absent characteristic in this structure.We address this gap by investigati...Two-dimensional double-layer honeycomb(DLHC)materials are known for their diverse physical properties,but superconductivity has been a notably absent characteristic in this structure.We address this gap by investigating M_(2)N_(2)(M=Nb,Ta)with DLHC structure using first-principles calculations.Our results show that M_(2)N_(2)are stable and metallic,exhibiting superconducting behavior.Specifically,Nb_(2)N_(2)and Ta_(2)N_(2)display superconducting transition temperatures of 6.8 K and 8.8 K,respectively.Their electron-phonon coupling is predominantly driven by the coupling between metal d-orbitals and low-frequency metal-dominated vibration modes.Interestingly,two compounds also exhibit non-trivial band topology.Thus,M_(2)N_(2)are promising platforms for studying the interplay between topology and superconductivity and fill the gap in superconductivity research for DLHC materials.展开更多
In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is p...In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.展开更多
In order to increase the fatigue life (FL) of road wheels (RW), a kind of double layer rubber flange (DLRF) is put forward. It consists of two layers of rubber, where metal wires are laid in the inner layer and the ou...In order to increase the fatigue life (FL) of road wheels (RW), a kind of double layer rubber flange (DLRF) is put forward. It consists of two layers of rubber, where metal wires are laid in the inner layer and the outer layer has no inlaid metal wires. Stress, strain and temperature field of DLRF were calculated with ANSYS finite element analysis (FEA) software, FL of DLRF RW was also computed with fracture mechanics fatigue theory. The results of computation indicate that the heat generated in RW's rubber flange (RF) can be reduced by the use of DLRF, and the FL of RW can be increased without affecting the mechanical intensity of RW.展开更多
文摘The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products.
基金Projects(50878191,51109092)supported by the National Natural Science Foundation of China
文摘Based on non-Darcian flow law described by exponent and threshold gradient within a double-layered soil, the classic theory of one-dimensional consolidation of double-layered soil was modified to consider the change of vertical total stress with depth and time together. Because of the complexity of governing equations, the numerical solutions were obtained in detail by finite difference method. Then, the numerical solutions were compared with the analytical solutions in condition that non-Darcian flow law was degenerated to Dary's law, and the comparison results show that numerical solutions are reliable. Finally, consolidation behavior of double-layered soil with different parameters was analyzed, and the results show that the consolidation rate of double-layered soil decreases with increasing the value of exponent and threshold of non-Darcian flow, and the exponent and threshold gradient of the first soil layer greatly influence the consolidation rate of double-layered soil. The larger the ratio of the equivalent water head of external load to the total thickness of double-layered soil, the larger the rate of the consolidation, and the similitude relationship in classical consolidation theory of double-layered soil is not satisfied. The other consolidation behavior of double-layered soil with non-Darcian flow is the same as that with Darcy's law.
基金Project(51578511)supported by the National Natural Science Foundation of China。
文摘To further investigate the one-dimensional(1D)rheological consolidation mechanism of double-layered soil,the fractional derivative Merchant model(FDMM)and the non-Darcian flow model with the non-Newtonian index are respectively introduced to describe the deformation of viscoelastic soil and the flow of pore water in the process of consolidation.Accordingly,an 1D rheological consolidation equation of double-layered soil is obtained,and its numerical analysis is performed by the implicit finite difference method.In order to verify its validity,the numerical solutions by the present method for some simplified cases are compared with the results in the related literature.Then,the influence of the revelent parameters on the rheological consolidation of double-layered soil are investigated.Numerical results indicate that the parameters of non-Darcian flow and FDMM of the first soil layer greatly influence the consolidation rate of double-layered soil.As the decrease of relative compressibility or the increase of relative permeability between the lower soil and the upper soil,the dissipation rate of excess pore water pressure and the settlement rate of the ground will be accelerated.Increasing the relative thickness of soil layer with high permeability or low compressibility will also accelerate the consolidation rate of double-layered soil.
文摘The velocity structures of flow through vertically double-layered vegetation(VDLV)as well as single-layered rigid vegetation(SLV)were investigated computationally with a three-dimensional(3D)Reynolds stress turbulence model,using the computational fluid dynamics(CFD)code FLUENT.The detailed velocity distribution was explored with a varying initial Froude number(Fr),with consideration of the steady subcritical flow conditions of an inland tsunami.In VDLV flows,the numerical model successfully captured the inflection point in the profiles of mean streamwise velocities in the mixing-layer region around the top of short submerged vegetation.An upward and downward movement of flow occurred at the positions located just behind the tall and short vegetation,respectively.Overall,higher streamwise velocities were observed in the upper vegetation layer due to high porosity,with Pr=98%(sparse vegetation,where Pr is the porosity),as compared to those in the lower vegetation layer,which had comparatively low porosity,with Pr=91%(dense vegetation).A rising trend of velocities was found as the flow passed through the vegetation region,followed by a clear sawtooth distribution,as compared to the regions just upstream and downstream of vegetation where the flow was almost uniform.In VDLV flows,a rising trend in the flow resistance was observed with the increase in the initial Froude number,i.e.,Fr?0.67,0.70,and 0.73.However,the flow resistance in the case of SLV was relatively very low.The numerical results also show the flow structures within the vicinity of short and tall vegetation,which are difficult to attain through experimental measurements.
文摘AIM To investigate the efficacy of double-layered covered stent in the treatment of malignant oesophageal obstructions.METHODS A systematic review and meta-analysis was performed following the PRISMA process. Pub Med(Medline),EMBASE(Excerpta Medical Database),AMED(Allied and Complementary medicine Database),Scopus and online content,were searched for studies reporting on the Ni Ti-S polyurethane-covered double oesophageal stent for the treatment of malignant dysphagia. Weighted pooled outcomes were synthesized with a random effects model to account for clinical heterogeneity. All studies reporting the outcome of palliative management of dysphagia due to histologically confirmed malignant oesophageal obstruction using double-layered covered nitinol stent were included. The level of statistical significance was set at α = 0.05.RESULTS Six clinical studies comprising 250 patients in total were identified. Pooled technical success of stent insertion was 97.2%(95%CI: 94.8%-98.9%; I2 = 5.8%). Pooled complication rate was 27.6%(95%CI: 20.7%-35.2%; I2 = 41.9%). Weighted improvement of dysphagia on a scale of 0-5 scoring system was-2.00 [95%CI:-2.29%-(-1.72%); I2 = 87%]. Distal stent migration was documented in 10 out of the 250 cases examined.Pooled stent migration rate was 4.7%(95%CI: 2.5%-7.7%; I2 = 0%). Finally,tumour overgrowth was reported in 34 out of the 250 cases with pooled rate of tumour overgrowth of 11.2%(95%CI: 3.7%-22.1%; I2 = 82.2%). No funnel plot asymmetry to suggest publication bias(bias = 0.39,P = 0.78). In the sensitivity analysis all results were largely similar between the fixed and random effects models.CONCLUSION The double-layered nitinol stent provides immediate relief of malignant dysphagia with low rates of stent migration and tumour
基金the National Key Basic Research Program of China("973 Program",No.2012CB625100)the National Natural Science Foundation of China(No.51001106&No.51301181)the Doctoral Starting up Foundation of Liaoning Province Science and Technology Agency,China(No.20131118)
文摘In this study, CrN/Cr2O3 double-layered coatings with various thickness ratios of CrN vs Cr2O3 layer were prepared by arc ion plating technology. The influences of the thickness ratio of CrN vs Cr2O3 layer on the microstructural characteristics as well as the mechanical and tribological properties of the CrN/Cr2O3 doublelayered coatings were investigated. The corresponding mechanisms were also discussed. The results indicated that the insertion of CrN layer between the Cr2O3 layer and substrate can effectively decrease the internal stress level of the coating. With increasing the thickness ratio of CrN vs Cr2O3 layer, the surface roughness of double-layered coatings decreased gradually, which had a certain influence on the friction coefficient. In addition, the microhardness also declined gradually, the adhesive strength almost increased linearly, whereas the wear rate declined firstly and then increased slightly. As the thickness ratio was 2：1, the double-layered coating exhibited the best wear resistance.
基金supports from the International Continental Scientific Drilling Programfunded by the National Natural Science Foundation of China(Grant Nos.41790453,41472304,42102129,42102135 and 41972313)+2 种基金Natural Science Foundation of Jilin Province(Grant No.20170101001JC)the National Key Research&Development Program of China(Grant No.2019YFC0605402)China Geological Survey(Grant No.DD20189702)。
文摘The Songliao Basin(SLB)covers an area of approximately 260,000 km2in northeastern Asia and preserves a continuous and complete Cretaceous terrestrial record(Wang et al.,2021).The region is the most important petroliferous sedimentary basin in China because of its continual annual oil and gas equivalent production of tens of millions of tons(ca.220–440 million barrels per year)since 1959.The SLB was previously thought to have developed on Hercynian basement and accumulated continuous sedimentary deposits during the Late Jurassic and Cretaceous(Wan et al.,2013;Wang et al.,2016).
基金Project(51074182)supported by the National Natural Science Foundation of ChinaProject(201012200032)supported by the Fundamental Research Funds for the Central Universities,China
文摘Double-layered pellet （DLP） roasting is a novel pretreatment method for sulfur and arsenic-bearing gold concentrates. In this process, preparation of DLPs is a fundamental step which is required to produce DLPs with favorable mechanical strength and thermal stability. Studies were carried out to investigate the affecting factors and conditions on the preparation and properties of DLPs. The results show that moisture content has significant influence on DLPs preparation. With the increase of moisture content in the range of no more than 9.8%, drop resistance and compressive strength of green DLPs are raised and the pelletizing dynamics is improved accordingly. The optimum conditions are determined as moisture content of 9.8%, coating time of 14-16 min, drying temperature 〈80 ℃and drying gas velocity 〈1.2 m/s. When DLPs prepared under these conditions are roasted at 600 ℃ for 1 h, favorable removal and solidifying rates can be obtained, in which the removal rates of arsenic and sulfur are 94.38% and 82.55%, and the solidifying rates of arsenic and sulfur reach 99.62% and 99.79%, respectively. These results promise industrial application of DLP roasting.
基金supported by Huzhou Natural Science Foundation Project(Nos.2022YZ04 and 2022YZ21)S&T Special Program of Huzhou(No.2023GZ03)National Natural Science Foundation of China(No.52172184)。
文摘The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of LMBs.Introducing three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'time.Nevertheless,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal foam.Herein,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling strategy.Due to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional variation.Synergistically,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.
基金supported by the National Natural Science Foundation of China(Grant No.11302254)
文摘Double-layered graphene sheets （DLGSs） can be applied to the development of a new generation of nanomechanical sensors due to their unique physical properties. A rectangular DLGS with a nanoparticle randomly located in the upper sheet is modeled as two nonlocal Kirchhoff plates connected by van der Waals forces. The Galerkin strip transfer function method which is a semi-analytical method is developed to compute the natural frequencies of the mass- plate vibrating system. It can give exact closed-form solutions along the longitudinal direction of the strip. The results obtained from the semi-analytical method are compared with the previous ones, and the differences between the single-layered graphene sheet （SLGS） and the DLGS mass sensors are also investigated. The results demonstrate the similarity of the in-phase mode between the SLGS and DLGS mass sensors. The sensitivity of the DLGS mass sensor can be increased by decreasing the nonlocal parameter, moving the attached nanoparticle closer to the DLGS center and making the DLGS smaller. These conclusions are helpful for the design and application of graphene-sheet-based resonators as nano-mass sensors.
文摘In this paper, an analytical solution for the dynamic response of a double-layered subgrade with rock substratum to a moving point load is derived. The subgrade profile is divided into two layers. The upper layer is modeled by an elastic medium and the lower layer by a fully saturated poroelastic medium governed by Biot’s theory. In the meanwhile, the subgrade is resting on the rock substratum. The analytical solutions for stress, displacement and pore pressure are derived by using the Fourier transform. Numerical results obtained by using the inverse fast Fourier transform (IFFT) are used to analyze the influence of the moving load velocity, the thickness of an elastic medium layer and a fully saturated poroelastic medium layer on the dynamic response.
基金Fund by the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No.2018YFD1101002-03)。
文摘Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material combining the solvent evaporation method and spray drying method.The protection by the outer capsule wall was used to prolong the service life of the corrosion inhibitor.The dispersion,encapsulation,thermal stability of microcapsules,and the degradation rate of capsule wall in concrete pore solution were analyzed by ultra-deep field microscopy,scanning electron microscopy,thermal analyzer,and sodium ion release rate analysis.The microcapsules were incorporated into mortar samples containing steel reinforcement,and the effects of double-layered microcapsule corrosion inhibitors on the performance of the cement matrix and the actual corrosion-inhibiting effect were analyzed.The experimental results show that the double-layered microcapsules have a moderate particle size and uniform distribution,and the capsules were completely wrapped.The microcapsules as a whole have good thermal stability below 230 ℃.The monolayer membrane structure microcapsules completely broke within 1 day in the simulated concrete pore solution,and the double-layer membrane structure prolonged the service life of the microcapsules to 80 days in the simulated concrete pore solution before the core material was completely released.The mortar samples containing steel reinforcement incorporated with the double-layered microcapsule corrosion inhibitors still maintained a higher corrosion potential than the monolayer microcapsule corrosion inhibitors control group at 60 days.The incorporation of double-layered microcapsules into the cement matrix has no significant adverse effect on the setting time and early strength.
基金supported by National Key Research and Development Program 2022YFC2409100Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences[CIFMS,(no.2021-I2M-5-013)]111 Project[The Program of Introducing Talents of Discipline to Universities(no.B16033)].
文摘Surgical repair with artificial chordae replacement has emerged asa standard treatment for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) sutures are commonly employed asartificial chordae;however, they have certain limitations, such aspotential long-term rupture and undesired material/tissueresponse. This study introduces a novel approach to artificialchordae design, termed the New Artificial Chordae (NAC), whichincorporates a double-layered structure. The NAC comprises amulti-strand braided core composed of ultra-high molecularweight polyethylene (UHMWPE) fibers as the inner core, and anouter tube made of hydrophobic porous ePTFE. Compared totraditional ePTFE sutures, NAC exhibits increased flexibility,enhanced tensile strength, longer elongation and improved fatigue resistance. Moreover, NAC exhibits a more hydrophobic surface,which contributes to enhanced hemocompatibility. The study also includes in vivo investigations conducted on animal models to evaluate the biocompatibility and functional efficacy of the artificial chordae. These experiments demonstrate the enhanced durability andbiocompatibility of the NAC, characterized by improved mechanical strength, minimal tissue response and reduced thrombus formation.These findings suggest the potential application of NAC as a prosthetic chordae replacement, offering promising prospects to address thelimitations associated with current artificial chordae materials and providing novel ideas and approaches for the development of sustainable and biocompatible regenerative biomaterials.
基金The authors acknowledge the financial support from the Australian Research Council, the Queensland Government, the CAS/SAFEA International Partnership Program for Creative Research Teams, the Australian National Fabrication Facility and the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland. L. Z. acknowledges the financial support from the National Natural Science Foundation of China （No. 51502226）.
文摘Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly encapsulated in the interlayer space of DLHCs with a high loading of 75% （weight percentage） and serves as the active component for lithium storage. The presence of Se in the composite and the carbon framework not only alleviate the shuttling of polysulfide, but also improve the conductivity of electrodes. Migration of active materials from the interlayer void to the hollow cavity of DLHCs after cycling, which further mitigates the loss of active materials and the shuttle effect, is observed. As a result, the SeS2/DLHC composite delivers a high specific capacity （930 mA.h.g-1 at 0.2 C） and outstanding rate capability （400 mA.h.g-1 at 6 C）, which is much better than those of SeS2/single-layered hollow carbon sphere, Se/DLHC, and S/DLHC composites. Notably, the SeS2/DLHC composite shows an ultralong cycle life with 89% capacity retention over 900 cycles at 1 C, or only 0.012% capacity decay per cycle. Our study reveals that both SeS2 and the double-layered structures are responsible for the excellent electrochemical performance.
基金The National Natural Science Foundation of China(Grant No.51476055,51821004)the National Basic Research Program of China(Grant No.2015CB251503)the Fundamental Research Funds for the Central Universities(Grant No.2018QN036)are gratefully acknowledged for supporting this research.
文摘The cooling performance of air-cooled condenser(ACC)is susceptible to adverse impacts of ambient winds.In this work,three kinds of lateral double-layered deflectors installed under the ACC platform are proposed to weaken the unfavorable effects of cross winds.Through CFD simulation methods,the main parameters of thermo-flow performances of a 2×660 MW direct dry cooling system are obtained,by which it can be concluded that the deflectors can effectively reduce the inlet air temperatures while enhance the mass flow rates of upwind fans due to the guiding effect,especially at high wind speeds,while the improvement of cooling capacity of ACCs in the 0°wind direction is weak.The inclined-vertical deflectors are superior to others in performance improvement of ACCs for all cases,which can reduce the turbine back pressure by 12.15%when the wind speed is 12 m/s,so they can be applied to the performance enhancement of ACCs under windy conditions in practical engineering.
基金supported by the National Natural Science Foundation of China(No.52371075)the National Training Program of Innovation and Entrepreneurship for Undergraduates,the Young Elite Scientists Sponsorship Program by CAST(No.YESS20200083)+1 种基金the Young Talent Fund of the University Association for Science and Technology in Shaanxi,China(No.20190403)the Fundamental Research Funds for the Central Universities(No.xzy012022057).
文摘Double-layered thermal barrier coatings(DL-TBCs)have been developed to meet multiple service requirements,such as low thermal conductivity,high thermal stability,and high fracture toughness.Conventional DL-TBCs are often designed on the basis of equal total thickness to have long lifespans,which may weaken the thermal insulation.The reason is that the single-scale designed structure often has opposite effects on the thermal and mechanical properties.To enhance both the thermal insulation and lifespan,this work designed durable DL-TBCs at multiple scales under equivalent thermal insulation.The macroscopic thickness ratio of the top layer to the bottom layer was tailored to optimize the total and single thicknesses,and the microscopic pore size in the top layer was tailored to resist sintering.Six groups of samples with different thickness ratios were prepared.The thermal cycling test revealed that the lifespan of DL-TBCs first increases but then decreases with increasing thickness ratio.The optimized thickness ratio is 2:3 for DL-TBCs,which have the largest lifespan among the six groups.The cross-sectional morphologies revealed that the failure mode changed from the spallation of the top layer to the delamination of the total double layers.The long lifespan of the optimized DL-TBCs stems from the cotailored thickness ratio and porous structure in the top layer to lower the total cracking driving force.
基金support for this work by the National Key Research and Development Program of China(No.2019YFA0706802)the National Natural Science Foundation of China(Nos.51903223 and 12072325)the National Natural Science Foundation of China of Henan Province(No.222300420541).
文摘The strategy of incorporating polymers into MXene-based functional materials has been widely used to improve their mechanical properties,however with inevitable sacrifice of their electrical conductivity and electromagnetic interference(EMI)shielding performance.This study demonstrates a facile yet efficient layering structure design to prepare the highly robust and conductive double-layer Janus films comprised of independent aramid nanofiber(ANF)and Ti3C2Tx MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)layers.The ANF layer serves to provide good mechanical stability,whilst the MXene/PEDOT:PSS layer ensures excellent electrical conductivity.Doping PEDOT:PSS into the MXene layer enhances the interfacial bonding strength between the MXene and ANF layers and improves the hydrophobicity and water/oxidation resistance of MXene layer.The resultant ANF/MXene-PEDOT:PSS Janus film with a conductive layer thickness of 4.4μm was shown to display low sheet resistance(2.18Ω/sq),good EMI shielding effectiveness(EMI SE of 48.1 dB),high mechanical strength(155.9 MPa),and overall toughness(19.4 MJ/m^(3)).Moreover,the excellent electrical conductivity and light absorption capacity of the MXene-PEDOT:PSS conductive layer mean that these Janus films display multi-source driven heating functions,producing excellent Joule heating(382℃ at 4 V)and photothermal conversion(59.6℃ at 100 mW/m^(2))properties.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12074213 and 11574108)the National Key R&D Program of China(Grant No.2022YFA1403103)+2 种基金the Major Basic Program of Natural Science Foundation of Shandong Province(Grant No.ZR2021ZD01)the Natural Science Foundation of Shandong Province(Grant No.ZR2023MA082)the Project of Introduction and Cultivation for Young Innovative Talents in Colleges and Universities of Shandong Province。
文摘Two-dimensional double-layer honeycomb(DLHC)materials are known for their diverse physical properties,but superconductivity has been a notably absent characteristic in this structure.We address this gap by investigating M_(2)N_(2)(M=Nb,Ta)with DLHC structure using first-principles calculations.Our results show that M_(2)N_(2)are stable and metallic,exhibiting superconducting behavior.Specifically,Nb_(2)N_(2)and Ta_(2)N_(2)display superconducting transition temperatures of 6.8 K and 8.8 K,respectively.Their electron-phonon coupling is predominantly driven by the coupling between metal d-orbitals and low-frequency metal-dominated vibration modes.Interestingly,two compounds also exhibit non-trivial band topology.Thus,M_(2)N_(2)are promising platforms for studying the interplay between topology and superconductivity and fill the gap in superconductivity research for DLHC materials.
基金The Special Project of the Ministry of Construction ofChina (No.20060909).
文摘In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.
文摘In order to increase the fatigue life (FL) of road wheels (RW), a kind of double layer rubber flange (DLRF) is put forward. It consists of two layers of rubber, where metal wires are laid in the inner layer and the outer layer has no inlaid metal wires. Stress, strain and temperature field of DLRF were calculated with ANSYS finite element analysis (FEA) software, FL of DLRF RW was also computed with fracture mechanics fatigue theory. The results of computation indicate that the heat generated in RW's rubber flange (RF) can be reduced by the use of DLRF, and the FL of RW can be increased without affecting the mechanical intensity of RW.
