结核病是现代社会严重危害人群健康的公共卫生问题之一。现代结核病控制策略(Directly ObservedTherapy Short course,DOTS)是WHO向全世界推荐的目前成本效果最好的结核病控制策略。文章针对目前我国结核病防治特点,分析了DOTS策略在结...结核病是现代社会严重危害人群健康的公共卫生问题之一。现代结核病控制策略(Directly ObservedTherapy Short course,DOTS)是WHO向全世界推荐的目前成本效果最好的结核病控制策略。文章针对目前我国结核病防治特点,分析了DOTS策略在结核病控制工作中的应用,并提出了思考与建议。展开更多
We studied the quantum dot-liposome complex (QLC), which is the giant unilamellar vesicle with quantum dots (QDs) incorporated in its lipid bilayer. A spin coating method in conjunction with the electroformation techn...We studied the quantum dot-liposome complex (QLC), which is the giant unilamellar vesicle with quantum dots (QDs) incorporated in its lipid bilayer. A spin coating method in conjunction with the electroformation technique yielded vesicles with highly homogeneous unilamellar structure. We observed QD size dependence of the QLC formation: QLCs form with blue, green and yellow-emission QD (core radius ~1.05 nm, 1.25 nm and 1.65 nm) but not with red-emission QD (core radius ~2.5 nm). In order to explain this size dependence, we made a simple model explaining the QD size effect on QLC formation in terms of the molecular packing parameter and the lipid conformational change. This model predicts that QDs below a certain critical size (radius ≈ 1.8 nm) can stably reside in a lipid bilayer of 4 - 5 nm in thickness for Egg-PC lipids. This is consistent with our previous experimental results. In the case of red-emission QD, QD-aggregations are only observed on the fluorescent microscopy instead of QLC. We expected that the reduction of packing parameter (P) would lead to the change of specific QD radius. This prediction could be verified by our experimental observation of the shift of the specific QD size by mixing DOPG.展开更多
文摘结核病是现代社会严重危害人群健康的公共卫生问题之一。现代结核病控制策略(Directly ObservedTherapy Short course,DOTS)是WHO向全世界推荐的目前成本效果最好的结核病控制策略。文章针对目前我国结核病防治特点,分析了DOTS策略在结核病控制工作中的应用,并提出了思考与建议。
文摘We studied the quantum dot-liposome complex (QLC), which is the giant unilamellar vesicle with quantum dots (QDs) incorporated in its lipid bilayer. A spin coating method in conjunction with the electroformation technique yielded vesicles with highly homogeneous unilamellar structure. We observed QD size dependence of the QLC formation: QLCs form with blue, green and yellow-emission QD (core radius ~1.05 nm, 1.25 nm and 1.65 nm) but not with red-emission QD (core radius ~2.5 nm). In order to explain this size dependence, we made a simple model explaining the QD size effect on QLC formation in terms of the molecular packing parameter and the lipid conformational change. This model predicts that QDs below a certain critical size (radius ≈ 1.8 nm) can stably reside in a lipid bilayer of 4 - 5 nm in thickness for Egg-PC lipids. This is consistent with our previous experimental results. In the case of red-emission QD, QD-aggregations are only observed on the fluorescent microscopy instead of QLC. We expected that the reduction of packing parameter (P) would lead to the change of specific QD radius. This prediction could be verified by our experimental observation of the shift of the specific QD size by mixing DOPG.
