Selective Catalyst Reduction（SCR）Urea Dosing System（UDS）directly affects the system accuracy and the dynamic response performance of a vehicle.However,the UDS dynamic response is hard to keep up with the changes o...Selective Catalyst Reduction（SCR）Urea Dosing System（UDS）directly affects the system accuracy and the dynamic response performance of a vehicle.However,the UDS dynamic response is hard to keep up with the changes of the engine＇s operating conditions.That will lead to low NO_χconversion efficiency or NH_3 slip.In order to optimize the injection accuracy and the response speed of the UDS in dynamic conditions,an advanced control strategy based on an air-assisted volumetric UDS is presented.It covers the methods of flow compensation and switching working conditions.The strategy is authenticated on an UDS and tested in different dynamic conditions.The result shows that the control strategy discussed results in higher dynamic accuracy and faster dynamic response speed of UDS.The inject deviation range is improved from being between-8%and 10%to-4%and 2%and became more stable than before,and the dynamic response time was shortened from 200 ms to 150 ms.The ETC cycle result shows that after using the new strategy the NH_3 emission is reduced by 60%,and the NO_χemission remains almost unchanged.The trade-off between NO_χconversion efficiency and NH_3 slip is mitigated.The studied flow compensation and switching working conditions can improve the dynamic performance of the UDS significantly and make the UDS dynamic response keep up with the changes of the engine＇s operating conditions quickly.展开更多
Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In thi...Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In this study, comparative experiments were conducted to investigate the toxicological impacts of polyvinylpyrrolidone-coated silver nanoparticles(PVP-AgNPs) with two kinds of dosing regimens, continuous and one-time pulsed dosing, in different exposure media(deionized water and XiangJiang River water). There were a number of quite different experimental results(including 100% mortality of zebrafish,decline in the activity of enzymes, and lowest number and length of adventitious roots) in the one-time pulsed dosing regimen at high PVP-AgNP concentration exposure(HOE)compared to the three other treatments. Meanwhile, we determined that the concentration of leached silver ions from PVP-AgNPs was too low to play a role in zebrafish death. Those results showed that HOE led to a range of dramatic ecosystem impacts which were more destructive than those of other treatments. Moreover, compared with the continuous dosing regimen, despite the fact that higher toxicity was observed for HOE, there was little difference in the removal of total silver from the aquatic environment for the different dosing regimens. No obvious differences in ecological impacts were observed between different water columns under low concentration exposure. Overall, this work highlighted the fact that the toxicity of Ag NPs was impacted by different dosing regimens in different exposure media, which may be helpful for assessments of ecological impacts on aquatic environments.展开更多
The principle and working process of Vacuum Resin Shot Dosing Equipment(VRSDE) are analyzed and the characteristics of IP1612-220PLC (Programmable Logical Controller) areintroduced briefly at first. Then the authors d...The principle and working process of Vacuum Resin Shot Dosing Equipment(VRSDE) are analyzed and the characteristics of IP1612-220PLC (Programmable Logical Controller) areintroduced briefly at first. Then the authors discuss the flow of program, the assignment of PLCI/O ports, the wiring diagram, and the ladder logic program of the PLC control system of VRSDE indetail. Some application issues of the system are accounted for in addition. Finally, according tothe information acquired from users, the authors draw the conclusion: this system owns a highreliability and a-vailability and greatly improves the automatic degree of VRDE.展开更多
On the basis of the analysis of faults and their causes of vacuum resin shot dosing equipment, the fuzzy model of fault diagnosis for the equipment is constructed, and the fuzzy relationship matrix, the symptom fuzzy ...On the basis of the analysis of faults and their causes of vacuum resin shot dosing equipment, the fuzzy model of fault diagnosis for the equipment is constructed, and the fuzzy relationship matrix, the symptom fuzzy vector, the fuzzy compound arithmetic operator, and the diagnosis principle of the model are determined. Then the fault auto-diagnosis system for the equipment is designed , and the functions for real-time monitoring its operation condition and for fault auto diagosis are realized. Finally, the experiments of fault auto-diagnosis are conducted in practical production and the veracity of the system is verified.展开更多
Fe-based superconductors represent a fascinating class of materials,extensively studied for their complex interplay of superconductivity,magnetism,spin density waves,and nematicity,along with the interactions among th...Fe-based superconductors represent a fascinating class of materials,extensively studied for their complex interplay of superconductivity,magnetism,spin density waves,and nematicity,along with the interactions among these orders.An intriguing yet unexplained phenomenon observed in Fe-based superconductors is the emergence of superconductivity below 25K in the non-superconducting parent compound SrFe_(2)As_(2)following exposure to water at its surface.In this study,we employed in situ angle-resolved photoemission spectroscopy and low-energy electron diffraction to meticulously examine the electronic structure evolution of SrFe_(2)As_(2)upon in situ water dosing.Our findings indicate that water dosing markedly attenuates the spin density wave phase and surface Sr reconstruction while preserving the nematic order in SrFe_(2)As_(2).Furthermore,we detected an enhancement in the spectral weight of bands near the Fermi level.Our observations highlight the critical role of the intricate interplay among various orders induced by water dosing,which effectively modifies the band structure and favors the emergence of superconductivity in SrFe_(2)As_(2).展开更多
BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated r...BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated regimens.AIM To evaluate the efficacy,safety,and optimal dosing of vonoprazan(VPZ)-amoxicillin(AMO)dual therapy in a non-inferiority randomized trial for H.pylori eradication.METHODS In this multi-center,randomized trial conducted at 17 hospitals in Sichuan Province,China,1717 adults with confirmed infection were assigned(1:1:1)to 14-day regimens:(1)VPZ 20 mg BID+AMO 0.5 g QID;(2)0.75 g QID;or(3)1.0 g TID.The primary endpoint was the eradication rate based on intention-to-treat(ITT)and per-protocol(PP)analyses;secondary endpoints included adverse events(AEs)and treatment compliance.RESULTS Eradication rates were consistently high(92.35%-97.43%).In the 0.5 g QID group,ITT and PP eradication rates were 93.3%(95%CI:91.2-95.1)and 97.4%(95%CI:95.7-98.5),respectively,with no significant differences among groups(P>0.05).Compliance ranged from 98.1%to 98.3%,and AEs were infrequent(5.2%-7.5%),predominantly mild gastrointestinal symptoms,which occurred least often in the 0.5 g QID group.CONCLUSION VPZ-AMO dual therapy achieved excellent eradication,safety,and patient compliance.All regimens were similarly effective,whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability,supporting its use as a first-line option in high-prevalence settings.展开更多
The main objectives of this study were to investigate the distribution features of the ^(210)Po in abiotic(water and bottom sediments)and biotic(zooplankton,mollusks,fish)components of the North Crimean Canal(NCC)aqua...The main objectives of this study were to investigate the distribution features of the ^(210)Po in abiotic(water and bottom sediments)and biotic(zooplankton,mollusks,fish)components of the North Crimean Canal(NCC)aquatic ecosystem and adjacent irrigated soils as well as assessment of the doses received by water organisms from α-radiation of absorbed ^(210)Po.The samples were processed using standard radiochemical methods accepted in international practice.The activity of ^(210)Po in the samples was measured using the alpha-spectrometric OCTETE Plus complex(ORTEC-AMETEK,USA).The measurement error did not exceed 20%.Activity concentration of ^(210)Po in the studied objects decreased in the following rank:suspended matter(73.6 Bq/kg d.w.)>soils(32.5 Bq/kg d.w.)≈bottom sediments(32.1 Bq/kg d.w.)>mollusks(23.4 Bq/kg w.w.)>fish(6.4 Bq/kg w.w.).The ^(210)Po distribution coefficient(K_(d))values in water between suspended matter and its dissolved parts varied within the 1.4×10^(4)-1.4×10^(5) L/kg range.The concentration factors(CF)of ^(210)Po for hydrobionts of the NCC were in the range 10^(3)-10^(4) L/kg.The calculated absorbed radiation doses from ^(210)Po alpha radiation for the hydrobionts of the North Crimean Canal were significantly below the recommended dose limits.展开更多
BACKGROUND Photon-counting detector(PCD)CT represents a transformative advancement in radiological imaging,offering superior spatial resolution,enhanced contrast-tonoise ratio,and reduced radiation dose compared with ...BACKGROUND Photon-counting detector(PCD)CT represents a transformative advancement in radiological imaging,offering superior spatial resolution,enhanced contrast-tonoise ratio,and reduced radiation dose compared with the conventional energyintegrating detector CT.AIM To evaluate PCD CT in oncologic imaging,focusing on its role in tumor detection,staging,and treatment response assessment.METHODS We performed a systematic PubMed search from January 1,2017 to December 31,2024,using the keywords“photon-counting CT”,“cancer”,and“tumor”to identify studies on its use in oncologic imaging.We included experimental studies on humans or human phantoms and excluded reviews,commentaries,editorials,non-English,animal,and non-experimental studies.Study selection followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Out of 175 initial studies,39 met the inclusion criteria after screening and full-text review.Data extraction focused on study type,country of origin,and oncologic applications of photon-counting CT.No formal risk of bias assessment was performed,and the review was not registered in PROSPERO as it did not include a meta-analysis.RESULTS Key findings highlighted the advantages of PCD CT in imaging renal masses,adrenal adenomas,ovarian cancer,breast cancer,prostate cancer,pancreatic tumors,hepatocellular carcinoma,metastases,multiple myeloma,and lung cancer.Additionally,PCD CT has demonstrated improved lesion characterization and enhanced diagnostic accuracy in oncology.Despite its promising capabilities challenges related to data processing,storage,and accessibility remain.CONCLUSION As PCD CT technology evolves,its integration into routine oncologic imaging has the potential to significantly enhance cancer diagnosis and patient management.展开更多
BACKGROUND Perioperative anesthesia management of obese patients presents significant challenges as traditional total body weight-based dosing fails to achieve optimal anesthetic effects due to altered pharmacokinetic...BACKGROUND Perioperative anesthesia management of obese patients presents significant challenges as traditional total body weight-based dosing fails to achieve optimal anesthetic effects due to altered pharmacokinetic characteristics including abnormal drug distribution and clearance.Rocuronium exhibits markedly different distribution patterns in obese patients,with conventional weight correction methods inadequately addressing individual muscle mass variations that critically influence drug distribution.AIM To investigate the quantitative relationship between skeletal muscle index(SMI)and rocuronium distribution volume in obese colorectal cancer patients,establish a population pharmacokinetic model,and develop individualized dosing strategies based on muscle mass.METHODS A retrospective cohort study was conducted,including 100 obese patients(body mass index≥30 kg/m^(2))who underwent elective radical colorectal cancer surgery at our hospital from June 2023 to January 2025.Skeletal muscle mass was measured using InBody 260 body composition analyzer and SMI was calculated to assess muscle mass,with male SMI<7.0 kg/m^(2) and female SMI<5.7 kg/m^(2)as diagnostic criteria for sarcopenia.Plasma rocuronium concentrations were detected by liquid chromatography-tandem mass spectrometry/mass spectrometry,and nonlinear mixed-effect modeling was used to establish population pharmacokinetic modeling.Stepwise regression was used to screen covariates,and dosing regimens were optimized through Monte Carlo simulation.The primary endpoint was targeted plasma concentration achievement rate,and the secondary endpoint was postoperative residual muscle relaxation incidence.RESULTS Among 100 patients,35(35.0%)had sarcopenia and 65(65.0%)did not.Patients in the sarcopenia group were older(64.1±9.8 years vs 54.2±10.9 years,P<0.001)and had significantly lower SMI(6.2±0.8 kg/m^(2)vs 8.4±1.2 kg/m^(2),P<0.001).SMI showed strong positive correlation with rocuronium steady-state distribution volume(r=0.718,P<0.001)and moderate negative correlation with clearance(r=-0.502,P<0.001).A two-compartment population pharmacokinetic model was successfully established,with SMI being the most important covariate affecting central compartment distribution volume(△OFV=-41.2,P<0.001).Model validation showed bootstrap successful convergence rate of 92.3%,and 92.1%of observed values fell within prediction intervals in predicted concentration versus predicted concentration.The SMI-based individualized dosing regimen improved target exposure achievement rate from 82.0%in traditional regimen to 93.5%(P=0.009),and reduced postoperative residual muscle relaxation incidence from 13.0%to 3.5%(P=0.018).The sarcopenia group showed the most significant improvement in achievement rate,from 71.4%to 93.8%(P=0.017).CONCLUSION SMI shows strong correlation with rocuronium distribution volume in obese colorectal cancer patients and is a key factor affecting drug distribution.SMI-based individualized dosing strategies can significantly improve target exposure achievement rate and reduce postoperative residual muscle relaxation incidence,providing scientific evidence for precision anesthesia management in obese patients.展开更多
In this study,the dosimetric characteristics(thickness applicability,preheating time,temperature and humidity dependence,in-batch uniformity,readout reproducibility,dose linearity,self-decay,and electron energy respon...In this study,the dosimetric characteristics(thickness applicability,preheating time,temperature and humidity dependence,in-batch uniformity,readout reproducibility,dose linearity,self-decay,and electron energy response)of engineered polycarbonate films irradiated with an electron beam(0–600 kGy)were investigated using photoluminescence spectroscopy.The results show a linear relationship between photoluminescence intensity and radiation dose when the thickness of the polycarbonate film is 0.3 mm.A higher fluorescence intensity can be obtained by preheating at 60℃ for 180 min before photoluminescence spectrum analysis.As the temperature during spectral testing and the ambient humidity(during and after irradiation)increased,the photoluminescence intensity of the polycarbonate films decreased.The photoluminescence intensity deviation of the polycarbonate films produced within the same batch at 100 kGy is 2.73%.After ten times of repeated excitations and readouts,the coefficients of variation in photoluminescence intensity are less than 8.6%,and the linear correlation coefficient between photoluminescence intensity and irradiation dose is 0.965 in the dose capture range of 20–600 kGy.Within 60 days of irradiation,the photoluminescence intensity of the polycarbonate film decreased to 60%of the initial value.The response of the 0.3 mm polycarbonate films to electron beams with energies exceeding 3.5 MeV does not differ significantly.This comprehensive analysis indicates the potential of polycarbonate films as a high-radiation dose detection material.展开更多
AIM: To compare(using the Ottawa Bowel Preparation Scale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the ...AIM: To compare(using the Ottawa Bowel Preparation Scale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the optimal preparation-to-colonoscopy interval.METHODS: Single-centre, prospective, randomized, investigator-blind stud in an academic tertiarycare centre. Two hundred patients requiring elective colonoscopy were assigned to receive one of the two preparation regimens(split vs morning) prior to colonoscopy. Main outcome measurements were bowel preparation quality and patient tolerability.RESULTS: Split-dose regimen resulted in better bowel preparation compared to morning regimen [Ottawascore mean 5.52(SD 1.23) vs 6.02(1.34); P = 0.017]. On subgroup analysis, for afternoon procedures, both the preparations were equally effective(P = 0.756). There was no difference in tolerability and compliance between the two regimens.CONCLUSION: Overall, previous evening- same morning split-dosing regimen results in better bowel cleansing for colonoscopy compared to morning preparation. For afternoon procedures, both schedules are equally effective; morning preparation may be more convenient to the patient.展开更多
The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system,...The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system, assessment computer. and the assessment operating code system. InSRDAAR-QNPP, the wind field of the surface and the lower levels are determined hourly by using amass consistent three-dimension diasnosis model with the topographic following coordinate system.A Lagrangin Puff model under changing meteorological condition is adopted for atmosphericdispersion, the correction for dry and wet depositions. physical decay and partial plume penetrationof the top inversion and the deviation of plume axis caused by complex terrain have been taken in-to account. The calculation domain areas include three square grid areas with the sideline 10 km, 40krn and 160 km and a grid interval 0.5 km, 2.0 km, 8.0 km respectively. Three exposure pathwaysare taken into account:the external exposure from immersion cloud and passing puff, the internalexposure from inhalation and the external exposure from contaminated ground. This system is ableto provide the results of concentration and dose distributions within 10 minutes after the data havebeen inputed.展开更多
Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced by many water utilities.Implementation of a sewer diversion provided the o...Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced by many water utilities.Implementation of a sewer diversion provided the opportunity to compare the effectiveness of magnesium hydroxide(Mg(OH)2)and two biological dosing compounds(Bioproducts A and B),with different modes of action(MOA),in a field-test across a large sewer network.Mg(OH)2 increases sewer p H allowing suppression of H2S release into the sewer environment while Bioproduct A acts to disrupt microbial communication through quorum sensing(QS),reducing biofilm integrity.Bioproduct B reduces H2S odors by scouring the sewer of fats,oils and grease(FOGs),which provide adhesion points for the microbial biofilm.Results revealed that only Mg(OH)2 altered the microbial community structure and reduced H2S emissions in a live sewer system,whilst Bioproducts A and B did not reduce H2S emissions or have an observable effect on the composition of the microbial community at the dosed site.Study results recommend in situ testing of dosing treatments before implementation across an operational system.展开更多
We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-wee...We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.展开更多
Restraining algal growth by algaecide has been studied by many researchers, but the dosing time has not yet been studied. In this study, we examined the appropriate dosing time of algaecide through a series of experim...Restraining algal growth by algaecide has been studied by many researchers, but the dosing time has not yet been studied. In this study, we examined the appropriate dosing time of algaecide through a series of experiments. In the experiments, the pH value of water is significantly affected by Microcystis aeruginosa, and the variation of the pH value is in favor of the growth of the alga. Therefore, using acid algaecide in the period with maximum pH values, i.e., the stable phase, would change the acidity-alkalinity of the water significantly, and would negatively affect algal growth. Acid algaecide does not eliminate the alga effectively if the acid algaecide is dosed in the logarithmic growth phase. Using acid algaecide in the decline phase after algal bloom not only is unfavorable for eliminating the alga, but also prolongs the decline phase, and even brings about next larger algal bloom.展开更多
Optically stimulated luminescence(OSL) reading systems are becoming smaller and capable of real-time detection. To improve real-time and multipurpose radiation dosimetry readings, we built a real-time continuous-wave(...Optically stimulated luminescence(OSL) reading systems are becoming smaller and capable of real-time detection. To improve real-time and multipurpose radiation dosimetry readings, we built a real-time continuous-wave(RCW) OSL reading system. This system is both small and lightweight, and it employs powerful laser excitation(478 mW/cm^2) at the dosimetry probe location. We investigate the possibility of using the RCW mode to read the radiation luminescence(RL) or OSL by using a singlecrystal Al_2O_3:C dosimeter in a low-dose-rate137 Cs y field.Our results indicate that the RL/OSL follows a stable and uniform distribution. The minimum detected doses associated with the RL, OSL, and RL + OSL signals are2.1 9 10^(-2), 3.17 9 10^(-1), and 5.7 9 10^(-2) l Gy, respectively. This device provides a framework for the future development of applications for practical radiation dose measurements.展开更多
Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quanti...Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quantitative and systematic analysis of data is necessary.Particularly,the FLASH effect response model to the dose or dose rate is still unclear.This study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal models.The data were modeled based on logistic regression analysis using the sigmoid function.The model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC curve.Results showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological endpoints.The dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 Gy.This study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.展开更多
The effects of potassium permanganate(KMnO_4)dosing position on the natural organic matter(NOM)removal as well as membrane fouling were investigated in the coagulation/ultrafiltration combined process.KMnO_4 oxidation...The effects of potassium permanganate(KMnO_4)dosing position on the natural organic matter(NOM)removal as well as membrane fouling were investigated in the coagulation/ultrafiltration combined process.KMnO_4 oxidation altered the NOM characteristics in terms of hydrophobicity and molecular weight,and destroyed humic substances originated from terraneous organisms in raw water.The optimal KMnO_4 dosage was 0.5 mg·L^(-1) in the peroxidation enhanced coagulation process with respect to the dissolved organic carbon(DOC)removal.When KMnO_4 was dosed into both upstream and downstream of coagulation,namely in the proposed twoposition dosing mode,coagulation and KMnO_4 oxidation worked individually on the apparent DOC removal.However,compared to the KMnO_4 addition prior to or after coagulation,the two-position dosing mode dramatically alleviated membrane fouling and reduced fouling irreversibility.This was attributed to the change of NOM characteristics as a result of KMnO_4 addition prior to coagulation and the presence of MnO_2 on membrane surface as a result of KMnO_4 addition prior to ultrafiltration.This work may provide useful information for the application of KMnO_4 oxidation in the coagulation/ultrafiltration combined system.展开更多
The formation of hydrogen sulfide in biofilms and sediments in sewer systems can cause severe pipe corrosions and health hazards, and requires expensive programs for its prevention. The aim of this study is to propose...The formation of hydrogen sulfide in biofilms and sediments in sewer systems can cause severe pipe corrosions and health hazards, and requires expensive programs for its prevention. The aim of this study is to propose a new control strategy and the optimal condition for sulfide elimination by intermittent nitrate dosing in sewer sediments. The study was carried out based on lab-scale experiments and batch tests using real sewer sediments. The intermittent nitrate dosing mode and the optimal control condition were investigated. The results indicated that the sulfide-intermittent-elimination strategy by nitrate dosing is advantageous for controlling sulfide accumulation in sewer sediment. The oxidation–reduction potential is a sensitive indicator parameter that can reflect the control effect and the minimum N/S（nitrate/sulfide）ratio with slight excess nitrate is necessary for optimal conditions of efficient sulfide control with lower carbon source loss. The optimal control condition is feasible for the sulfide elimination in sewer systems.展开更多
AIM To determine the preventive effect and safetyof proton pump inhibitors （PPIs） in low-dose aspirin（LDA）-associated gastrointestinal （GI） ulcers andbleeding.METHODS： We searched MEDLINE, EMBASE and theCochran...AIM To determine the preventive effect and safetyof proton pump inhibitors （PPIs） in low-dose aspirin（LDA）-associated gastrointestinal （GI） ulcers andbleeding.METHODS： We searched MEDLINE, EMBASE and theCochrane Controlled Trials Register from inception toDecember 2013, and checked conference abstracts ofrandomized controlled trials （RCTs） on the effect ofPPIs in reducing adverse GI events （hemorrhage, ulcer,perforation, or obstruction） in patients taking LDA.The preventive effects of PPIs were compared with thecontrol group [taking placebo, a cytoprotective agent,or an H2 receptor antagonist （H2RA）] in LDA-associatedupper GI injuries. The meta-analysis was performedusing RevMan 5.1 software.RESULTS： We evaluated 8780 participants in 10 RCTs.The meta-analysis showed that PPIs decreased the riskof LDA-associated upper GI ulcers （OR = 0.16; 95%CI：0.12-0.23） and bleeding （OR = 0.27; 95%CI： 0.16-0.43）compared with control. For patients treated with dualanti-platelet therapy of LDA and clopidogrel, PPIs wereable to prevent the LDA-associated GI bleeding （OR =0.36; 95%CI： 0.15-0.87） without increasing the riskof major adverse cardiovascular events （MACE） （OR =1.00; 95%CI： 0.76-1.31）. PPIs were superior to H2RAin prevention of LDA-associated GI ulcers （OR = 0.12;95%CI： 0.02-0.65） and bleeding （OR = 0.32; 95%CI：0.13-0.79）.CONCLUSION： PPIs are effective in preventing LDAassociatedupper GI ulcers and bleeding. Concomitantuse of PPI, LDA and clopidogrel did not increase therisk of MACE.展开更多
基金Supported by National Hi-tech Research and Development Program of China(863 Program,Grant No.2012AA111708)
文摘Selective Catalyst Reduction（SCR）Urea Dosing System（UDS）directly affects the system accuracy and the dynamic response performance of a vehicle.However,the UDS dynamic response is hard to keep up with the changes of the engine＇s operating conditions.That will lead to low NO_χconversion efficiency or NH_3 slip.In order to optimize the injection accuracy and the response speed of the UDS in dynamic conditions,an advanced control strategy based on an air-assisted volumetric UDS is presented.It covers the methods of flow compensation and switching working conditions.The strategy is authenticated on an UDS and tested in different dynamic conditions.The result shows that the control strategy discussed results in higher dynamic accuracy and faster dynamic response speed of UDS.The inject deviation range is improved from being between-8%and 10%to-4%and 2%and became more stable than before,and the dynamic response time was shortened from 200 ms to 150 ms.The ETC cycle result shows that after using the new strategy the NH_3 emission is reduced by 60%,and the NO_χemission remains almost unchanged.The trade-off between NO_χconversion efficiency and NH_3 slip is mitigated.The studied flow compensation and switching working conditions can improve the dynamic performance of the UDS significantly and make the UDS dynamic response keep up with the changes of the engine＇s operating conditions quickly.
基金supported by the National Natural Science Foundation of China (Nos.51579099,51521006,and 51508186)the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT-13R17)the Hunan Provincial Natural Science Foundation of China (No.2016JJ3076)
文摘Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In this study, comparative experiments were conducted to investigate the toxicological impacts of polyvinylpyrrolidone-coated silver nanoparticles(PVP-AgNPs) with two kinds of dosing regimens, continuous and one-time pulsed dosing, in different exposure media(deionized water and XiangJiang River water). There were a number of quite different experimental results(including 100% mortality of zebrafish,decline in the activity of enzymes, and lowest number and length of adventitious roots) in the one-time pulsed dosing regimen at high PVP-AgNP concentration exposure(HOE)compared to the three other treatments. Meanwhile, we determined that the concentration of leached silver ions from PVP-AgNPs was too low to play a role in zebrafish death. Those results showed that HOE led to a range of dramatic ecosystem impacts which were more destructive than those of other treatments. Moreover, compared with the continuous dosing regimen, despite the fact that higher toxicity was observed for HOE, there was little difference in the removal of total silver from the aquatic environment for the different dosing regimens. No obvious differences in ecological impacts were observed between different water columns under low concentration exposure. Overall, this work highlighted the fact that the toxicity of Ag NPs was impacted by different dosing regimens in different exposure media, which may be helpful for assessments of ecological impacts on aquatic environments.
文摘The principle and working process of Vacuum Resin Shot Dosing Equipment(VRSDE) are analyzed and the characteristics of IP1612-220PLC (Programmable Logical Controller) areintroduced briefly at first. Then the authors discuss the flow of program, the assignment of PLCI/O ports, the wiring diagram, and the ladder logic program of the PLC control system of VRSDE indetail. Some application issues of the system are accounted for in addition. Finally, according tothe information acquired from users, the authors draw the conclusion: this system owns a highreliability and a-vailability and greatly improves the automatic degree of VRDE.
文摘On the basis of the analysis of faults and their causes of vacuum resin shot dosing equipment, the fuzzy model of fault diagnosis for the equipment is constructed, and the fuzzy relationship matrix, the symptom fuzzy vector, the fuzzy compound arithmetic operator, and the diagnosis principle of the model are determined. Then the fault auto-diagnosis system for the equipment is designed , and the functions for real-time monitoring its operation condition and for fault auto diagosis are realized. Finally, the experiments of fault auto-diagnosis are conducted in practical production and the veracity of the system is verified.
基金supported by the National Nature Science Foundation of China[Grant Nos.92365204 and 12274298(Z.K.Liu)]the National Key R&D program of China[Grant No.2022YFA1604400/03(Z.K.Liu)]Zhangjiang Laboratory(Y.M.Zhang).The authors thank BL02B at the Shanghai Synchrotron Radiation Facility supported by the National Natural Science Foundation of China(Contract No.11227902).
文摘Fe-based superconductors represent a fascinating class of materials,extensively studied for their complex interplay of superconductivity,magnetism,spin density waves,and nematicity,along with the interactions among these orders.An intriguing yet unexplained phenomenon observed in Fe-based superconductors is the emergence of superconductivity below 25K in the non-superconducting parent compound SrFe_(2)As_(2)following exposure to water at its surface.In this study,we employed in situ angle-resolved photoemission spectroscopy and low-energy electron diffraction to meticulously examine the electronic structure evolution of SrFe_(2)As_(2)upon in situ water dosing.Our findings indicate that water dosing markedly attenuates the spin density wave phase and surface Sr reconstruction while preserving the nematic order in SrFe_(2)As_(2).Furthermore,we detected an enhancement in the spectral weight of bands near the Fermi level.Our observations highlight the critical role of the intricate interplay among various orders induced by water dosing,which effectively modifies the band structure and favors the emergence of superconductivity in SrFe_(2)As_(2).
基金Supported by Project Fund of the Health Commission of Sichuan Province,No.19PJ290。
文摘BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated regimens.AIM To evaluate the efficacy,safety,and optimal dosing of vonoprazan(VPZ)-amoxicillin(AMO)dual therapy in a non-inferiority randomized trial for H.pylori eradication.METHODS In this multi-center,randomized trial conducted at 17 hospitals in Sichuan Province,China,1717 adults with confirmed infection were assigned(1:1:1)to 14-day regimens:(1)VPZ 20 mg BID+AMO 0.5 g QID;(2)0.75 g QID;or(3)1.0 g TID.The primary endpoint was the eradication rate based on intention-to-treat(ITT)and per-protocol(PP)analyses;secondary endpoints included adverse events(AEs)and treatment compliance.RESULTS Eradication rates were consistently high(92.35%-97.43%).In the 0.5 g QID group,ITT and PP eradication rates were 93.3%(95%CI:91.2-95.1)and 97.4%(95%CI:95.7-98.5),respectively,with no significant differences among groups(P>0.05).Compliance ranged from 98.1%to 98.3%,and AEs were infrequent(5.2%-7.5%),predominantly mild gastrointestinal symptoms,which occurred least often in the 0.5 g QID group.CONCLUSION VPZ-AMO dual therapy achieved excellent eradication,safety,and patient compliance.All regimens were similarly effective,whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability,supporting its use as a first-line option in high-prevalence settings.
基金supported by the Russian Science Foundation,grant number 23-26-00128,“The role of the irrigation system of the North Crimean Canal in the transfer of long-lived radionuclides of Chernobyl origin,heavy metals,as well as hydrocarbons from the Dnieper water to irrigated farmlands of the Crimea.”。
文摘The main objectives of this study were to investigate the distribution features of the ^(210)Po in abiotic(water and bottom sediments)and biotic(zooplankton,mollusks,fish)components of the North Crimean Canal(NCC)aquatic ecosystem and adjacent irrigated soils as well as assessment of the doses received by water organisms from α-radiation of absorbed ^(210)Po.The samples were processed using standard radiochemical methods accepted in international practice.The activity of ^(210)Po in the samples was measured using the alpha-spectrometric OCTETE Plus complex(ORTEC-AMETEK,USA).The measurement error did not exceed 20%.Activity concentration of ^(210)Po in the studied objects decreased in the following rank:suspended matter(73.6 Bq/kg d.w.)>soils(32.5 Bq/kg d.w.)≈bottom sediments(32.1 Bq/kg d.w.)>mollusks(23.4 Bq/kg w.w.)>fish(6.4 Bq/kg w.w.).The ^(210)Po distribution coefficient(K_(d))values in water between suspended matter and its dissolved parts varied within the 1.4×10^(4)-1.4×10^(5) L/kg range.The concentration factors(CF)of ^(210)Po for hydrobionts of the NCC were in the range 10^(3)-10^(4) L/kg.The calculated absorbed radiation doses from ^(210)Po alpha radiation for the hydrobionts of the North Crimean Canal were significantly below the recommended dose limits.
文摘BACKGROUND Photon-counting detector(PCD)CT represents a transformative advancement in radiological imaging,offering superior spatial resolution,enhanced contrast-tonoise ratio,and reduced radiation dose compared with the conventional energyintegrating detector CT.AIM To evaluate PCD CT in oncologic imaging,focusing on its role in tumor detection,staging,and treatment response assessment.METHODS We performed a systematic PubMed search from January 1,2017 to December 31,2024,using the keywords“photon-counting CT”,“cancer”,and“tumor”to identify studies on its use in oncologic imaging.We included experimental studies on humans or human phantoms and excluded reviews,commentaries,editorials,non-English,animal,and non-experimental studies.Study selection followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Out of 175 initial studies,39 met the inclusion criteria after screening and full-text review.Data extraction focused on study type,country of origin,and oncologic applications of photon-counting CT.No formal risk of bias assessment was performed,and the review was not registered in PROSPERO as it did not include a meta-analysis.RESULTS Key findings highlighted the advantages of PCD CT in imaging renal masses,adrenal adenomas,ovarian cancer,breast cancer,prostate cancer,pancreatic tumors,hepatocellular carcinoma,metastases,multiple myeloma,and lung cancer.Additionally,PCD CT has demonstrated improved lesion characterization and enhanced diagnostic accuracy in oncology.Despite its promising capabilities challenges related to data processing,storage,and accessibility remain.CONCLUSION As PCD CT technology evolves,its integration into routine oncologic imaging has the potential to significantly enhance cancer diagnosis and patient management.
文摘BACKGROUND Perioperative anesthesia management of obese patients presents significant challenges as traditional total body weight-based dosing fails to achieve optimal anesthetic effects due to altered pharmacokinetic characteristics including abnormal drug distribution and clearance.Rocuronium exhibits markedly different distribution patterns in obese patients,with conventional weight correction methods inadequately addressing individual muscle mass variations that critically influence drug distribution.AIM To investigate the quantitative relationship between skeletal muscle index(SMI)and rocuronium distribution volume in obese colorectal cancer patients,establish a population pharmacokinetic model,and develop individualized dosing strategies based on muscle mass.METHODS A retrospective cohort study was conducted,including 100 obese patients(body mass index≥30 kg/m^(2))who underwent elective radical colorectal cancer surgery at our hospital from June 2023 to January 2025.Skeletal muscle mass was measured using InBody 260 body composition analyzer and SMI was calculated to assess muscle mass,with male SMI<7.0 kg/m^(2) and female SMI<5.7 kg/m^(2)as diagnostic criteria for sarcopenia.Plasma rocuronium concentrations were detected by liquid chromatography-tandem mass spectrometry/mass spectrometry,and nonlinear mixed-effect modeling was used to establish population pharmacokinetic modeling.Stepwise regression was used to screen covariates,and dosing regimens were optimized through Monte Carlo simulation.The primary endpoint was targeted plasma concentration achievement rate,and the secondary endpoint was postoperative residual muscle relaxation incidence.RESULTS Among 100 patients,35(35.0%)had sarcopenia and 65(65.0%)did not.Patients in the sarcopenia group were older(64.1±9.8 years vs 54.2±10.9 years,P<0.001)and had significantly lower SMI(6.2±0.8 kg/m^(2)vs 8.4±1.2 kg/m^(2),P<0.001).SMI showed strong positive correlation with rocuronium steady-state distribution volume(r=0.718,P<0.001)and moderate negative correlation with clearance(r=-0.502,P<0.001).A two-compartment population pharmacokinetic model was successfully established,with SMI being the most important covariate affecting central compartment distribution volume(△OFV=-41.2,P<0.001).Model validation showed bootstrap successful convergence rate of 92.3%,and 92.1%of observed values fell within prediction intervals in predicted concentration versus predicted concentration.The SMI-based individualized dosing regimen improved target exposure achievement rate from 82.0%in traditional regimen to 93.5%(P=0.009),and reduced postoperative residual muscle relaxation incidence from 13.0%to 3.5%(P=0.018).The sarcopenia group showed the most significant improvement in achievement rate,from 71.4%to 93.8%(P=0.017).CONCLUSION SMI shows strong correlation with rocuronium distribution volume in obese colorectal cancer patients and is a key factor affecting drug distribution.SMI-based individualized dosing strategies can significantly improve target exposure achievement rate and reduce postoperative residual muscle relaxation incidence,providing scientific evidence for precision anesthesia management in obese patients.
基金supported by the National Natural Science Foundation of China(No.12305385)Key Projects of Scientific Research of the Hunan Provincial Department of Education(22A0310)the Research Startup Project of University of South China(220XQD025).
文摘In this study,the dosimetric characteristics(thickness applicability,preheating time,temperature and humidity dependence,in-batch uniformity,readout reproducibility,dose linearity,self-decay,and electron energy response)of engineered polycarbonate films irradiated with an electron beam(0–600 kGy)were investigated using photoluminescence spectroscopy.The results show a linear relationship between photoluminescence intensity and radiation dose when the thickness of the polycarbonate film is 0.3 mm.A higher fluorescence intensity can be obtained by preheating at 60℃ for 180 min before photoluminescence spectrum analysis.As the temperature during spectral testing and the ambient humidity(during and after irradiation)increased,the photoluminescence intensity of the polycarbonate films decreased.The photoluminescence intensity deviation of the polycarbonate films produced within the same batch at 100 kGy is 2.73%.After ten times of repeated excitations and readouts,the coefficients of variation in photoluminescence intensity are less than 8.6%,and the linear correlation coefficient between photoluminescence intensity and irradiation dose is 0.965 in the dose capture range of 20–600 kGy.Within 60 days of irradiation,the photoluminescence intensity of the polycarbonate film decreased to 60%of the initial value.The response of the 0.3 mm polycarbonate films to electron beams with energies exceeding 3.5 MeV does not differ significantly.This comprehensive analysis indicates the potential of polycarbonate films as a high-radiation dose detection material.
文摘AIM: To compare(using the Ottawa Bowel Preparation Scale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the optimal preparation-to-colonoscopy interval.METHODS: Single-centre, prospective, randomized, investigator-blind stud in an academic tertiarycare centre. Two hundred patients requiring elective colonoscopy were assigned to receive one of the two preparation regimens(split vs morning) prior to colonoscopy. Main outcome measurements were bowel preparation quality and patient tolerability.RESULTS: Split-dose regimen resulted in better bowel preparation compared to morning regimen [Ottawascore mean 5.52(SD 1.23) vs 6.02(1.34); P = 0.017]. On subgroup analysis, for afternoon procedures, both the preparations were equally effective(P = 0.756). There was no difference in tolerability and compliance between the two regimens.CONCLUSION: Overall, previous evening- same morning split-dosing regimen results in better bowel cleansing for colonoscopy compared to morning preparation. For afternoon procedures, both schedules are equally effective; morning preparation may be more convenient to the patient.
文摘The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system, assessment computer. and the assessment operating code system. InSRDAAR-QNPP, the wind field of the surface and the lower levels are determined hourly by using amass consistent three-dimension diasnosis model with the topographic following coordinate system.A Lagrangin Puff model under changing meteorological condition is adopted for atmosphericdispersion, the correction for dry and wet depositions. physical decay and partial plume penetrationof the top inversion and the deviation of plume axis caused by complex terrain have been taken in-to account. The calculation domain areas include three square grid areas with the sideline 10 km, 40krn and 160 km and a grid interval 0.5 km, 2.0 km, 8.0 km respectively. Three exposure pathwaysare taken into account:the external exposure from immersion cloud and passing puff, the internalexposure from inhalation and the external exposure from contaminated ground. This system is ableto provide the results of concentration and dose distributions within 10 minutes after the data havebeen inputed.
基金supported by an Australian Postgraduate Award at La Trobe Universityadditional financial support from industry collaborators Western Water
文摘Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced by many water utilities.Implementation of a sewer diversion provided the opportunity to compare the effectiveness of magnesium hydroxide(Mg(OH)2)and two biological dosing compounds(Bioproducts A and B),with different modes of action(MOA),in a field-test across a large sewer network.Mg(OH)2 increases sewer p H allowing suppression of H2S release into the sewer environment while Bioproduct A acts to disrupt microbial communication through quorum sensing(QS),reducing biofilm integrity.Bioproduct B reduces H2S odors by scouring the sewer of fats,oils and grease(FOGs),which provide adhesion points for the microbial biofilm.Results revealed that only Mg(OH)2 altered the microbial community structure and reduced H2S emissions in a live sewer system,whilst Bioproducts A and B did not reduce H2S emissions or have an observable effect on the composition of the microbial community at the dosed site.Study results recommend in situ testing of dosing treatments before implementation across an operational system.
文摘We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.
基金supported by the Special Fund for Public Welfare Industry of Ministry of Water Resources of China(Grant No.200801001)National Science and Technology Major Projects of China(Grant No.2012ZX07506003-4)Central Public-interest Scientific Institution Basal Research Fund(Grants No.Y110002 and Y110005)
文摘Restraining algal growth by algaecide has been studied by many researchers, but the dosing time has not yet been studied. In this study, we examined the appropriate dosing time of algaecide through a series of experiments. In the experiments, the pH value of water is significantly affected by Microcystis aeruginosa, and the variation of the pH value is in favor of the growth of the alga. Therefore, using acid algaecide in the period with maximum pH values, i.e., the stable phase, would change the acidity-alkalinity of the water significantly, and would negatively affect algal growth. Acid algaecide does not eliminate the alga effectively if the acid algaecide is dosed in the logarithmic growth phase. Using acid algaecide in the decline phase after algal bloom not only is unfavorable for eliminating the alga, but also prolongs the decline phase, and even brings about next larger algal bloom.
基金supported by the International Fusion Reactor Experiment Program(No.2014GB112004)
文摘Optically stimulated luminescence(OSL) reading systems are becoming smaller and capable of real-time detection. To improve real-time and multipurpose radiation dosimetry readings, we built a real-time continuous-wave(RCW) OSL reading system. This system is both small and lightweight, and it employs powerful laser excitation(478 mW/cm^2) at the dosimetry probe location. We investigate the possibility of using the RCW mode to read the radiation luminescence(RL) or OSL by using a singlecrystal Al_2O_3:C dosimeter in a low-dose-rate137 Cs y field.Our results indicate that the RL/OSL follows a stable and uniform distribution. The minimum detected doses associated with the RL, OSL, and RL + OSL signals are2.1 9 10^(-2), 3.17 9 10^(-1), and 5.7 9 10^(-2) l Gy, respectively. This device provides a framework for the future development of applications for practical radiation dose measurements.
基金supported by the National Key R&D Program of China(No.2022YFC2402300)National Natural Science Foundation of China(No.12075330)。
文摘Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quantitative and systematic analysis of data is necessary.Particularly,the FLASH effect response model to the dose or dose rate is still unclear.This study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal models.The data were modeled based on logistic regression analysis using the sigmoid function.The model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC curve.Results showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological endpoints.The dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 Gy.This study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.
基金Supported by the National Natural Science Foundation of China(51478314,51638011)the National Key Project for Research and Development Program of China(2016YFC0400503)+1 种基金the Natural Science Foundation of Tianjin(14JCQNJC09000)Science and Technology Research Projects of Colleges and Universities of Hebei Province(QN2015122)
文摘The effects of potassium permanganate(KMnO_4)dosing position on the natural organic matter(NOM)removal as well as membrane fouling were investigated in the coagulation/ultrafiltration combined process.KMnO_4 oxidation altered the NOM characteristics in terms of hydrophobicity and molecular weight,and destroyed humic substances originated from terraneous organisms in raw water.The optimal KMnO_4 dosage was 0.5 mg·L^(-1) in the peroxidation enhanced coagulation process with respect to the dissolved organic carbon(DOC)removal.When KMnO_4 was dosed into both upstream and downstream of coagulation,namely in the proposed twoposition dosing mode,coagulation and KMnO_4 oxidation worked individually on the apparent DOC removal.However,compared to the KMnO_4 addition prior to or after coagulation,the two-position dosing mode dramatically alleviated membrane fouling and reduced fouling irreversibility.This was attributed to the change of NOM characteristics as a result of KMnO_4 addition prior to coagulation and the presence of MnO_2 on membrane surface as a result of KMnO_4 addition prior to ultrafiltration.This work may provide useful information for the application of KMnO_4 oxidation in the coagulation/ultrafiltration combined system.
基金supported by the National Natural Science Foundation of China (No. 50908131)the Major Science and Technology Program for Water Pollution Control and Treatment of China (No. 2011ZX07301-002)Tsinghua University Initiative Scientific Research Program (No.20121087922)
文摘The formation of hydrogen sulfide in biofilms and sediments in sewer systems can cause severe pipe corrosions and health hazards, and requires expensive programs for its prevention. The aim of this study is to propose a new control strategy and the optimal condition for sulfide elimination by intermittent nitrate dosing in sewer sediments. The study was carried out based on lab-scale experiments and batch tests using real sewer sediments. The intermittent nitrate dosing mode and the optimal control condition were investigated. The results indicated that the sulfide-intermittent-elimination strategy by nitrate dosing is advantageous for controlling sulfide accumulation in sewer sediment. The oxidation–reduction potential is a sensitive indicator parameter that can reflect the control effect and the minimum N/S（nitrate/sulfide）ratio with slight excess nitrate is necessary for optimal conditions of efficient sulfide control with lower carbon source loss. The optimal control condition is feasible for the sulfide elimination in sewer systems.
文摘AIM To determine the preventive effect and safetyof proton pump inhibitors （PPIs） in low-dose aspirin（LDA）-associated gastrointestinal （GI） ulcers andbleeding.METHODS： We searched MEDLINE, EMBASE and theCochrane Controlled Trials Register from inception toDecember 2013, and checked conference abstracts ofrandomized controlled trials （RCTs） on the effect ofPPIs in reducing adverse GI events （hemorrhage, ulcer,perforation, or obstruction） in patients taking LDA.The preventive effects of PPIs were compared with thecontrol group [taking placebo, a cytoprotective agent,or an H2 receptor antagonist （H2RA）] in LDA-associatedupper GI injuries. The meta-analysis was performedusing RevMan 5.1 software.RESULTS： We evaluated 8780 participants in 10 RCTs.The meta-analysis showed that PPIs decreased the riskof LDA-associated upper GI ulcers （OR = 0.16; 95%CI：0.12-0.23） and bleeding （OR = 0.27; 95%CI： 0.16-0.43）compared with control. For patients treated with dualanti-platelet therapy of LDA and clopidogrel, PPIs wereable to prevent the LDA-associated GI bleeding （OR =0.36; 95%CI： 0.15-0.87） without increasing the riskof major adverse cardiovascular events （MACE） （OR =1.00; 95%CI： 0.76-1.31）. PPIs were superior to H2RAin prevention of LDA-associated GI ulcers （OR = 0.12;95%CI： 0.02-0.65） and bleeding （OR = 0.32; 95%CI：0.13-0.79）.CONCLUSION： PPIs are effective in preventing LDAassociatedupper GI ulcers and bleeding. Concomitantuse of PPI, LDA and clopidogrel did not increase therisk of MACE.
