Acupuncture therapy is widely used in the clinic,and its therapeutic effects have been proven by numerous studies.The dose–effect relationship of acupuncture is a fundamental aspect of the acupuncture research system...Acupuncture therapy is widely used in the clinic,and its therapeutic effects have been proven by numerous studies.The dose–effect relationship of acupuncture is a fundamental aspect of the acupuncture research system.Recent studies found that different acupuncture dosages altered study results directly,indicating the importance of screening the optimal stimulation dosage.However,the system for studying the acupuncture dose–effect relationship is still in its infancy,and the methodology of the system needs to be improved.This review aimed to define the factors impacting acupuncture“dosage”and“effect,”and to improve the methodological system for research on the dose–effect relationship of acupuncture.By summarizing the current findings of acupuncture dose–effect studies,we discussed the vital acupuncture parameters and methodological problems that influence the relationship between acupuncture dosage and its effects.These factors consist of specific influencing factors(acupoint selection,acupuncture manipulation parameters,de qi response)and nonspecific influencing factors(comparison selection,blinding procedure,patient expectancy).Our perspectives offer suggestions for the design of acupuncture dosage–effect trials.Further studies need to be conducted to establish the methodological system and provide systematic evidence of the acupuncture dose–effect relationship.展开更多
Polybrominated diphenyl ethers (PBDEs) used as flame retardants are widely used in a variety of consumer products, like textiles, foam and building materials. They are persistent in the environment, and increasing lev...Polybrominated diphenyl ethers (PBDEs) used as flame retardants are widely used in a variety of consumer products, like textiles, foam and building materials. They are persistent in the environment, and increasing levels of PBDEs have been found both biota and human tissue samples. In the present study we examined the dose-dependent effects of pentabrominated diphenyl ether (PBDE-99) on the serum hormone and histology of reproductive system in male rats. 40 health 4-week-old SD rats were divided into 4 groups randomly. The treated rats were orally administered with BDE-99 at the dose of 60,120 or 180 mg/kg, while controls received equal volume of corn oil. We examined the changes of serum hormone levels, histopathology, and PCNA after 30 days exposure to BDE-99. With increasing doses of BDE-99, testis organ coefficient increased, serum hormone levels lower, PCNA positive expression reduced, and the degeneration of seminiferous epithelium were revealed in treated group. These indicators with significant dose-effect relationship showed that BDE-99 can reduce the serum sex hormone levels and cause severe degeneration of seminiferous epithelium.展开更多
目的:全面回顾了不同运动方式在老年肌少症防治中的干预效果,重点关注抗阻运动的剂量效应,旨在为肌少症防治的运动干预临床实践提供精准化策略。方法:通过检索PubMed、Web of Science、中国知网等数据库,筛选近期相关随机对照试验(RCT)...目的:全面回顾了不同运动方式在老年肌少症防治中的干预效果,重点关注抗阻运动的剂量效应,旨在为肌少症防治的运动干预临床实践提供精准化策略。方法:通过检索PubMed、Web of Science、中国知网等数据库,筛选近期相关随机对照试验(RCT)、系统综述和Meta分析,针对不同运动方式对肌少症的防治效果及抗阻运动剂量效应进行分析。结论:不同运动方式在肌少症防治中表现出差异化特征与互补效应,抗阻运动在提升肌肉质量和力量方面疗效显著;有氧运动通过改善代谢与心肺功能,延缓肌少症进展;多组分运动通过整合多重效应,全面优化身体功能;全身振动训练(WBVT)与血流限制训练(BFRT)可为体力受限人群提供安全、可行的替代方案。抗阻运动是老年肌少症运动干预的核心手段,60%~80%1RM、每周2~3次、多组数高量抗阻运动方案在提升肌肉质量和力量上效果最优;30%~40%1RM单组数低量抗阻运动方案亦可获益,适合虚弱或初练者。应依据个体基线、恢复能力,在兼顾有效性、安全性和依从性的基础上,构建精准化、可长期执行的抗阻运动方案,并联合其他运动模式,实现老年肌少症最佳干预效果。展开更多
目的:探讨针灸次数与颈性眩晕(CV)疗效之间的量效关系。方法:检索建库至2024年6月28日中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、Web of Science、Pub Med中针灸治疗CV的随机对照试验...目的:探讨针灸次数与颈性眩晕(CV)疗效之间的量效关系。方法:检索建库至2024年6月28日中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、Web of Science、Pub Med中针灸治疗CV的随机对照试验文献,研究对象采用单纯针灸治疗,选穴以“百会-风池-颈夹脊”为核心处方,结局指标包括颈性眩晕症状与功能评估量表(ESCV)评分及椎-基底动脉平均血流速度。采用Cochrane偏倚风险评估工具2.0评价其文献质量,通过Stata17.0软件中稳健误差元回归(REMR)方法进行针灸次数与疗效间的量效Meta回归分析。结果:共纳入19篇文献,试验组共747例患者。10次针灸治疗后,患者ESCV评分升高至20.29(95%CI:16.77,23.80),治疗前后ESCV差值为4.60(95%CI:2.59,6.60),ESCV评分改善率为0.36(95%CI:0.26,0.46);20次针灸治疗后,ESCV评分提高至21.55(95%CI:18.87,24.22),ESCV评分差值为5.42(95%CI:3.87,6.97),ESCV评分改善率为0.39(95%CI:0.31,0.48)。10次针灸治疗后,左侧椎动脉(LVA)平均血流速度改善率为0.08(95%CI:0.05,0.12),右侧椎动脉(RVA)平均血流速度改善率为0.09(95%CI:0.05,0.12),基底动脉(BA)平均血流速度改善率为0.11(95%CI:0.06,0.15);14次针灸治疗后,LVA、RVA、BA平均血流速度改善率均达到最高值:LVA[0.09(95%CI:0.06,0.12)]、RVA[0.10(95%CI:0.07,0.13)]、BA[0.12(95%CI:0.07,0.16)]。结论:针灸次数与CV疗效之间存在非线性的量效关系,推荐14次为最佳针灸治疗次数。展开更多
Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefl...Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefly the researches in the last 10 years on its chemical compositions,effective ingredients for improving cardiac function,dose-effect relationship in treating CHF,and adverse reactions that occurred in clinical practice.展开更多
基金funded by the Ministry of Science and Technology of the People’s Republic of ChinaNational Key Research and Development Program(2010CB530506,2018YFC1706001,2019YFC0840709)+2 种基金Tianjin Municipal Science and Technology BureauTianjin Science and Technology Plan Project(18PTLCSY00060)the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Exploration and Innovation Project(YB202112)
文摘Acupuncture therapy is widely used in the clinic,and its therapeutic effects have been proven by numerous studies.The dose–effect relationship of acupuncture is a fundamental aspect of the acupuncture research system.Recent studies found that different acupuncture dosages altered study results directly,indicating the importance of screening the optimal stimulation dosage.However,the system for studying the acupuncture dose–effect relationship is still in its infancy,and the methodology of the system needs to be improved.This review aimed to define the factors impacting acupuncture“dosage”and“effect,”and to improve the methodological system for research on the dose–effect relationship of acupuncture.By summarizing the current findings of acupuncture dose–effect studies,we discussed the vital acupuncture parameters and methodological problems that influence the relationship between acupuncture dosage and its effects.These factors consist of specific influencing factors(acupoint selection,acupuncture manipulation parameters,de qi response)and nonspecific influencing factors(comparison selection,blinding procedure,patient expectancy).Our perspectives offer suggestions for the design of acupuncture dosage–effect trials.Further studies need to be conducted to establish the methodological system and provide systematic evidence of the acupuncture dose–effect relationship.
文摘Polybrominated diphenyl ethers (PBDEs) used as flame retardants are widely used in a variety of consumer products, like textiles, foam and building materials. They are persistent in the environment, and increasing levels of PBDEs have been found both biota and human tissue samples. In the present study we examined the dose-dependent effects of pentabrominated diphenyl ether (PBDE-99) on the serum hormone and histology of reproductive system in male rats. 40 health 4-week-old SD rats were divided into 4 groups randomly. The treated rats were orally administered with BDE-99 at the dose of 60,120 or 180 mg/kg, while controls received equal volume of corn oil. We examined the changes of serum hormone levels, histopathology, and PCNA after 30 days exposure to BDE-99. With increasing doses of BDE-99, testis organ coefficient increased, serum hormone levels lower, PCNA positive expression reduced, and the degeneration of seminiferous epithelium were revealed in treated group. These indicators with significant dose-effect relationship showed that BDE-99 can reduce the serum sex hormone levels and cause severe degeneration of seminiferous epithelium.
文摘目的:全面回顾了不同运动方式在老年肌少症防治中的干预效果,重点关注抗阻运动的剂量效应,旨在为肌少症防治的运动干预临床实践提供精准化策略。方法:通过检索PubMed、Web of Science、中国知网等数据库,筛选近期相关随机对照试验(RCT)、系统综述和Meta分析,针对不同运动方式对肌少症的防治效果及抗阻运动剂量效应进行分析。结论:不同运动方式在肌少症防治中表现出差异化特征与互补效应,抗阻运动在提升肌肉质量和力量方面疗效显著;有氧运动通过改善代谢与心肺功能,延缓肌少症进展;多组分运动通过整合多重效应,全面优化身体功能;全身振动训练(WBVT)与血流限制训练(BFRT)可为体力受限人群提供安全、可行的替代方案。抗阻运动是老年肌少症运动干预的核心手段,60%~80%1RM、每周2~3次、多组数高量抗阻运动方案在提升肌肉质量和力量上效果最优;30%~40%1RM单组数低量抗阻运动方案亦可获益,适合虚弱或初练者。应依据个体基线、恢复能力,在兼顾有效性、安全性和依从性的基础上,构建精准化、可长期执行的抗阻运动方案,并联合其他运动模式,实现老年肌少症最佳干预效果。
文摘目的:探讨针灸次数与颈性眩晕(CV)疗效之间的量效关系。方法:检索建库至2024年6月28日中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、Web of Science、Pub Med中针灸治疗CV的随机对照试验文献,研究对象采用单纯针灸治疗,选穴以“百会-风池-颈夹脊”为核心处方,结局指标包括颈性眩晕症状与功能评估量表(ESCV)评分及椎-基底动脉平均血流速度。采用Cochrane偏倚风险评估工具2.0评价其文献质量,通过Stata17.0软件中稳健误差元回归(REMR)方法进行针灸次数与疗效间的量效Meta回归分析。结果:共纳入19篇文献,试验组共747例患者。10次针灸治疗后,患者ESCV评分升高至20.29(95%CI:16.77,23.80),治疗前后ESCV差值为4.60(95%CI:2.59,6.60),ESCV评分改善率为0.36(95%CI:0.26,0.46);20次针灸治疗后,ESCV评分提高至21.55(95%CI:18.87,24.22),ESCV评分差值为5.42(95%CI:3.87,6.97),ESCV评分改善率为0.39(95%CI:0.31,0.48)。10次针灸治疗后,左侧椎动脉(LVA)平均血流速度改善率为0.08(95%CI:0.05,0.12),右侧椎动脉(RVA)平均血流速度改善率为0.09(95%CI:0.05,0.12),基底动脉(BA)平均血流速度改善率为0.11(95%CI:0.06,0.15);14次针灸治疗后,LVA、RVA、BA平均血流速度改善率均达到最高值:LVA[0.09(95%CI:0.06,0.12)]、RVA[0.10(95%CI:0.07,0.13)]、BA[0.12(95%CI:0.07,0.16)]。结论:针灸次数与CV疗效之间存在非线性的量效关系,推荐14次为最佳针灸治疗次数。
文摘Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefly the researches in the last 10 years on its chemical compositions,effective ingredients for improving cardiac function,dose-effect relationship in treating CHF,and adverse reactions that occurred in clinical practice.
