Dear Editor,Male infertility comprises 50%of infertility cases globally,and one of the most severe forms is non-obstructive azoospermia(NOA),which affects approximately 10%–15%of infertile men.1 Genetic factors play ...Dear Editor,Male infertility comprises 50%of infertility cases globally,and one of the most severe forms is non-obstructive azoospermia(NOA),which affects approximately 10%–15%of infertile men.1 Genetic factors play an important role in the pathogenesis of NOA.Recent research progress has increasingly elucidated the pathogenesis of NOA.Multiple studies,particularly those using whole-exome sequencing,have identified an increasing number of pathogenic genes,including meiosis specific with OB-fold(MEIOB),telomere repeat binding bouquet formation protein 1(TERB1),and ubiquitin-specific peptidase 26(USP26)2–4 associated with NOA.These findings have greatly advanced our understanding of the molecular mechanisms underlying the failure of spermatogenesis.However,the genetic etiology of NOA for a considerable number of patients remains to be identified.展开更多
基金supported by Fundamental Research Funds for the Central Institutes(2023GJZD01).
文摘Dear Editor,Male infertility comprises 50%of infertility cases globally,and one of the most severe forms is non-obstructive azoospermia(NOA),which affects approximately 10%–15%of infertile men.1 Genetic factors play an important role in the pathogenesis of NOA.Recent research progress has increasingly elucidated the pathogenesis of NOA.Multiple studies,particularly those using whole-exome sequencing,have identified an increasing number of pathogenic genes,including meiosis specific with OB-fold(MEIOB),telomere repeat binding bouquet formation protein 1(TERB1),and ubiquitin-specific peptidase 26(USP26)2–4 associated with NOA.These findings have greatly advanced our understanding of the molecular mechanisms underlying the failure of spermatogenesis.However,the genetic etiology of NOA for a considerable number of patients remains to be identified.
