Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our pr...Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our previous study confirmed that inhalation of hydrogen gas can reduce the acute lung injury of ARDS,but the application of hydrogen has flammable and explosive safety concerns.Drinking hydrogen-rich liquid or inhaling hydrogen gas has been shown to play an important role in scavenging reactive oxygen species and maintaining mitochondrial quality control balance,thus improving ARDS in patients and animal models.Coral calcium hydrogenation(CCH)is a new solid molecular hydrogen carrier prepared from coral calcium(CC).Whether and how CCH affects acute lung injury in ARDS remains unstudied.In this study,we observed the therapeutic effect of CCH on lipopolysaccharide(LPS)induced acute lung injury in ARDS mice.The survival rate of mice treated with CCH and hydrogen inhalation was found to be comparable,demonstrating a significant improvement compared to the untreated ARDS model group.CCH treatment significantly reduced pulmonary hemorrhage and edema,and improved pulmonary function and local microcirculation in ARDS mice.CCH promoted mitochondrial peripheral division in the early course of ARDS by activating mitochondrial thioredoxin 2(Trx2),improved lung mitochondrial dysfunction induced by LPS,and reduced oxidative stress damage.The results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation.展开更多
The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor di...The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor division system covering vertical integration and horizontal complementarity of industrial chains.From the V-shaped development model in the twentieth century to the East Asian production network in the twenty-first century,the intra-industry and intra-product division of labor in the Asia-Pacific region has been ever deepening.However,due to the region’s high dependence on the U.S.market,the division of labor model in the Asia-Pacific suffers structural problems and is relatively fragile.Under the shock of Trump 1.0,countries in the Asia-Pacific region were forced to make adaptive adjustments,causing short-term turmoil in the regional economic order.Trump’s strong return in 2025,driven by the“America First”principle,brought forth a series of policies with strong unilateralism,isolationism and protectionism tendencies within just a few months。展开更多
Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane...Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.展开更多
WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphol...WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.展开更多
From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then...From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then proposes future prospects for them. The integration of theory and practice of "Production-Living-Ecology" Spaces is currently in a stage of in-depth exploration and practical application. Future research should fully recognize the importance and necessity of theoretical research on "Production-Living-Ecology" Spaces under the new situation, and consolidate the theoretical foundation for research on the development and protection of territorial space in the new era.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleoti...BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase(GTPase)and is implicated in various cancers.However,the role of RCC1 in HCC remains unex-plored.AIM To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.METHODS Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy.The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells.Furthermore,quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.RESULTS Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients.Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells,especially the proliferation of HCC cells,whereas RCC1 knockdown had the opposite effect.Mechanistically,we identied cell division cycle-associated(CDCA)8 as a downstream target of RCC1 in HCC.RCC1 overexpression markedly increased CDCA8 levels,consequently enhancing cell proliferation and survival in HCC cells.Additionally,we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.CONCLUSION Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target.展开更多
Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study perfor...Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.展开更多
Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a di...Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm work.The phenomenon has notably shaped the intergenerational division of labor(IDL)within households.However,it remains to be seen how farmers adjust their rice production systems in response to the IDL.The age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the IDL.Based on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service availability.Further analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational transfer.Monetary transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL households.This study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security.展开更多
The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and ma...The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and material mixing characteristics to improve the efficiency of thin-film evaporators.By using computational fluid dynamics(CFD)numerical simulation,the distribution pattern of the high-viscosity fluid flow field in the thin-film evaporators was obtained.It was found that the staggered interrupted blades could greatly promote material mixing and transportation,and impact the film formation of high-viscosity materials on the evaporator wall.Furthermore,a flow field state recognition method based on radial volume fraction statistics was proposed,and could quantitatively describe the internal flow field of thin-film evaporators.The method divides the high-viscosity materials in the thin-film evaporators into three flow states,the liquid film state,the exchange state and the liquid mass state.The three states of materials could be quantitatively described.The results show that the materials in the exchange state can connect the liquid film and the liquid mass,complete the material mixing and exchange,renew the liquid film,and maintain continuous and efficient liquid film evaporation.展开更多
Near-space airship is a frontier and hotspot in current military research and development,and the near-space composite propeller is the key technology for its development.In order to obtain higher aerodynamic efficien...Near-space airship is a frontier and hotspot in current military research and development,and the near-space composite propeller is the key technology for its development.In order to obtain higher aerodynamic efficiency at an altitude of 22 km,a certain near-space composite propeller is designed as a long and slender aerodynamic shape with a 10 m diameter,which brings many challenges to the composite structure design.The initial design is obtained by the composite structure variable stiffness design method using based on fixed region division blending model.However,it weighs 23.142 kg,exceeding the required 20 kg.In order to meet the structural design requirements of the propeller,a variable stiffness design method using the adaptive region division blending model is proposed in this paper.Compared with the methods using the fixed region division blending model,this method optimizes region division,stacking thickness and stacking sequence in a single level,considering the coupling effect among them.Through a more refined region division,this method can provide a more optimal design for composite tapered structures.Additionally,to improve the efficiency of optimization subjected to manufacturing constraints,a hierarchical penalty function is proposed to quickly filter out the solutions that do not meet manufacturing constraints.The above methods combined with a Genetic Algorithm(GA)using specific encoding are adopted to optimize the near-space composite propeller.The optimal design of the structure weighs 18.831 kg,with all manufacturing constraints and all structural response constraints being satisfied.Compared with the initial design,the optimal design has a more refined region division,and achieves a weight reduction of 18.6%.This demonstrates that a refined region division can significantly improve the mechanical performance of the composite tapered structure.展开更多
The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zamb...The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zambezi Delta basin,it has a low gravity anomaly,and the existing seismic survey lines do not cover the whole basin;therefore,it is difficult to interpret the structural characteristics of the whole basin based solely on gravity or seismic data.Based on satellite altimetry gravity anomaly data,this study infers the distribution characteristics of faults in the Zambezi Delta basin by using the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)technique.Then,constrained by seismic data,the gravity anomaly at the Moho interface is extracted by using the fast forward method of the double-interface model of the gravity anomaly,and this anomaly is then removed from the Bouguer gravity anomaly to obtain the sedimentary layer gravity anomaly.The thickness of the sedimentary strata is obtained by inversing the sedimentary basement depth of the whole basin.Then,uplifts and depressions are divided based on a sedimentary layer thickness of 3 km.This research demonstrates that the Zambezi Delta basin mainly features nearly SN-trending and NE-trending faults and that these faults exhibit east-west partitioning.The nearly SN-trending strike-slip faults controlled the sedimentary development of the basin,and the NE-trending tensile faults may have acted as migration channels for oil,gas and magma.The“overcompensation”effect of the Moho interface gravity anomaly on the gravity anomaly of the sedimentary layer is caused by the depression of the Moho interface beneath the Beira High,which results in a low gravity anomaly value for the Beira High.The pattern of uplifts and depressions trends NE and has the structural characteristics of east-west blocks.展开更多
BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a pot...BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely understood.AIM To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC development.METHODS Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down CDC25C.Subsequently,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in vivo.Cell proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,respectively.The expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western blotting.Additionally,apoptosis was investigated using flow cytometry,qRT-PCR,and western blotting.RESULTS CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in mice.CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC cells.CONCLUSION The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signaling pathway.展开更多
This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularl...This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.展开更多
Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out cons...Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.展开更多
In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the l...In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).展开更多
As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division...As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division gene, are involved in plastid division process of plant cells. Antisense and sense expression constructions were employed to investigate the functions of the two ftsZ genes, NtFtsZ1 and NtFtsZ2, in transgenic Nicotiana tabacum L. plants. Although antisense expression of,NtFtsZs reduced the native protein level obviously, the size and number of chloroplasts in transgenic tobacco plants had no effect. In contrast, overexpression of NtFtsZs in transgenic plants strikingly changed the number and morphology of chloroplasts. Even only 1 - 2 huge chloroplasts could be seen in the mesophyll cells of some overexpression transgenic plants. Analyses of chloroplast ultrastructures and chlorophyll content of different transgenic plants suggested that NtFtsZs gene have no direct influence on the normal development and function of chloroplasts. ne changes in chloroplast morphology must be a compensation for the change in chloroplast number. The different phenotypes of chloroplasts in antisense and sense transgenic plants implied that different members from the same ftsZ gene family may have similar function in controlling plastid division. Meanwhile, the changes of chloroplast morphology in sense transgenic plants represented the possible plastoskeleton function of ftsZ in higher plant.展开更多
Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method w...Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method will not be effective when the ground roll wave and the effective signal have the same frequency bands because of overlapping. The radial trace transform （RTT） considers the apparent velocity difference between the effective signal and the ground roll wave to suppress the latter, but affects the low-frequency components of the former. This study proposes a ground roll wave suppression method by combining the wavelet frequency division and the RTT based on the difference between the ground roll wave velocity and the effective signal and their energy difference in the wavelet domain, thus making full use of the advantages of both methods. First, we decompose the seismic data into different frequency bands through wavelet transform. Second, the RTT and low-cut filtering are applied to the low-frequency band, where the ground roll waves are appearing. Third, we reconstruct the seismic record without ground roll waves by using the inverse RTT and the remaining frequency bands. The proposed method not only improves the ground roll wave suppression, but also protects the signal integrity. The numerical simulation and real seismic data processing results suggest that the proposed method has a strong ability to denoise while preserving the amplitude.展开更多
The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was...The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was equal to or greater than the rate of 3% was taken as standards to define wheat drought disaster years.The average reduction ratio of production in the wheat drought years in Hebei-Shandong-Henan was calculated.The frequency distribution rule of wheat in different drought disaster strength of winter wheat in Hebei-Shandong-Henan was analyzed.According to the conception and calculation method of drought disaster risk index of winter wheat,the regional distribution law of drought disaster risk index of winter wheat was analyzed.The division technical methods of winter wheat drought disaster risk zones in Hebei-Shandong-Henan under the irrigated conditions were put forward.Taking the average reduction rate of production in drought years,drought disaster risk index and precipitation of winter wheat in growth periods as indices,using the statistical analysis and overlay function of GIS,the production reduction risk of winter wheat caused by drought disaster in winter wheat zones of Hebei-Shandong-Henan was divided and evaluated.The risk evaluation of production reduction of winter wheat in different risk zones under different climate conditions was realized.The disaster prevention and mitigation measures of winter wheat drought were given.展开更多
基金supported by the Nanjing Medical Science and Technology Development Project,China(Project No.:YKK23221)Open Project of Immune Cell Translational Research Center of Jiangning Hospital,Nanjing Medical University,China(Project No.:JNYYZXKY202216)+1 种基金General Project of Medical Education Collaborative Innovation Fund of Jiangsu University,China(Project No.:JDYY2023094)China Red Cross Foundation Medical Empowerment Charity Special Fund Project(Project No.:CRCF-YXFN-202302028).
文摘Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our previous study confirmed that inhalation of hydrogen gas can reduce the acute lung injury of ARDS,but the application of hydrogen has flammable and explosive safety concerns.Drinking hydrogen-rich liquid or inhaling hydrogen gas has been shown to play an important role in scavenging reactive oxygen species and maintaining mitochondrial quality control balance,thus improving ARDS in patients and animal models.Coral calcium hydrogenation(CCH)is a new solid molecular hydrogen carrier prepared from coral calcium(CC).Whether and how CCH affects acute lung injury in ARDS remains unstudied.In this study,we observed the therapeutic effect of CCH on lipopolysaccharide(LPS)induced acute lung injury in ARDS mice.The survival rate of mice treated with CCH and hydrogen inhalation was found to be comparable,demonstrating a significant improvement compared to the untreated ARDS model group.CCH treatment significantly reduced pulmonary hemorrhage and edema,and improved pulmonary function and local microcirculation in ARDS mice.CCH promoted mitochondrial peripheral division in the early course of ARDS by activating mitochondrial thioredoxin 2(Trx2),improved lung mitochondrial dysfunction induced by LPS,and reduced oxidative stress damage.The results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation.
文摘The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor division system covering vertical integration and horizontal complementarity of industrial chains.From the V-shaped development model in the twentieth century to the East Asian production network in the twenty-first century,the intra-industry and intra-product division of labor in the Asia-Pacific region has been ever deepening.However,due to the region’s high dependence on the U.S.market,the division of labor model in the Asia-Pacific suffers structural problems and is relatively fragile.Under the shock of Trump 1.0,countries in the Asia-Pacific region were forced to make adaptive adjustments,causing short-term turmoil in the regional economic order.Trump’s strong return in 2025,driven by the“America First”principle,brought forth a series of policies with strong unilateralism,isolationism and protectionism tendencies within just a few months。
基金support from the National Nat-ural Science Foundation of China(Grant No.12474199)the Fundamental Research Funds for Central Universities of China(Grant No.20720240144),and 111 Project(B16029).
文摘Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.
文摘WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.
基金Supported by Open Experimental Project in 2024 of Chuzhou University"Construction of Land and Space Planning System under the Background of Ecological Civilization"Humanities and Social Sciences Research Project Key Project of Anhui University in 2023"Digital Enabling Anhui Rural Human Settlements Environment Comprehensive Renovation Promotion Mechanism and Policy Optimization Research"(2023AH051571)+1 种基金Scientific Research Project of Chuzhou University"Research on the Mode,Mechanism and Promotion Path of Coordinated Development of Villages and Towns in the Suburbs of Metropolis from the Perspective of Three-dimensional Structure"(2023qd63)Digital Technology and Rural Revitalization Anhui Key Laboratory of Philosophy and Social Sciences 2024 Open Fund"Research on the Development Path and Supporting System of Rural Industry Driven by Digital Technology"(ZSKF202408).
文摘From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then proposes future prospects for them. The integration of theory and practice of "Production-Living-Ecology" Spaces is currently in a stage of in-depth exploration and practical application. Future research should fully recognize the importance and necessity of theoretical research on "Production-Living-Ecology" Spaces under the new situation, and consolidate the theoretical foundation for research on the development and protection of territorial space in the new era.
基金Supported by the National Natural Science Foundation of China,No.82002940 and No.82203336Shaanxi Natural Science Foundation,No.2023-JC-YB-166.
文摘BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase(GTPase)and is implicated in various cancers.However,the role of RCC1 in HCC remains unex-plored.AIM To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.METHODS Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy.The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells.Furthermore,quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.RESULTS Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients.Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells,especially the proliferation of HCC cells,whereas RCC1 knockdown had the opposite effect.Mechanistically,we identied cell division cycle-associated(CDCA)8 as a downstream target of RCC1 in HCC.RCC1 overexpression markedly increased CDCA8 levels,consequently enhancing cell proliferation and survival in HCC cells.Additionally,we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.CONCLUSION Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target.
基金Postdoctoral Research Foundation of China (2021M700608)Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission (cstc2021jcyj-bsh0047)+1 种基金Scientific Project Supported by the Bureau of Planning and Natural Resources, Chongqing (2301DH09002)Sichuan Transportation Science and Technology Project (2018ZL-01)。
文摘Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.
基金supported by the National Natural Science Foundation of China(42207529)the China Postdoctoral Science Foundation(2022M721289).
文摘Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm work.The phenomenon has notably shaped the intergenerational division of labor(IDL)within households.However,it remains to be seen how farmers adjust their rice production systems in response to the IDL.The age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the IDL.Based on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service availability.Further analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational transfer.Monetary transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL households.This study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security.
基金National Natural Science Foundation of China(Nos.51905089 and 52075093)Special Fund for Basic Research and Operating Costs of Central Colleges and Universities,China(No.22320D-31)Open Fund for National Key Laboratory of Tribology of Tsinghua University,China(No.SKLTKF20B05)。
文摘The flow field and flow state of thin-film evaporators are complex,and it is significant to effectively divide and quantify the flow field and flow state,as well as to study the internal flow field distribution and material mixing characteristics to improve the efficiency of thin-film evaporators.By using computational fluid dynamics(CFD)numerical simulation,the distribution pattern of the high-viscosity fluid flow field in the thin-film evaporators was obtained.It was found that the staggered interrupted blades could greatly promote material mixing and transportation,and impact the film formation of high-viscosity materials on the evaporator wall.Furthermore,a flow field state recognition method based on radial volume fraction statistics was proposed,and could quantitatively describe the internal flow field of thin-film evaporators.The method divides the high-viscosity materials in the thin-film evaporators into three flow states,the liquid film state,the exchange state and the liquid mass state.The three states of materials could be quantitatively described.The results show that the materials in the exchange state can connect the liquid film and the liquid mass,complete the material mixing and exchange,renew the liquid film,and maintain continuous and efficient liquid film evaporation.
基金This study was co-supported by stable funding from the National Key Laboratory of Aerofoil and Grille Aerodynamics,China.
文摘Near-space airship is a frontier and hotspot in current military research and development,and the near-space composite propeller is the key technology for its development.In order to obtain higher aerodynamic efficiency at an altitude of 22 km,a certain near-space composite propeller is designed as a long and slender aerodynamic shape with a 10 m diameter,which brings many challenges to the composite structure design.The initial design is obtained by the composite structure variable stiffness design method using based on fixed region division blending model.However,it weighs 23.142 kg,exceeding the required 20 kg.In order to meet the structural design requirements of the propeller,a variable stiffness design method using the adaptive region division blending model is proposed in this paper.Compared with the methods using the fixed region division blending model,this method optimizes region division,stacking thickness and stacking sequence in a single level,considering the coupling effect among them.Through a more refined region division,this method can provide a more optimal design for composite tapered structures.Additionally,to improve the efficiency of optimization subjected to manufacturing constraints,a hierarchical penalty function is proposed to quickly filter out the solutions that do not meet manufacturing constraints.The above methods combined with a Genetic Algorithm(GA)using specific encoding are adopted to optimize the near-space composite propeller.The optimal design of the structure weighs 18.831 kg,with all manufacturing constraints and all structural response constraints being satisfied.Compared with the initial design,the optimal design has a more refined region division,and achieves a weight reduction of 18.6%.This demonstrates that a refined region division can significantly improve the mechanical performance of the composite tapered structure.
基金The Petrochina Basic Prospective Science and Technology Research Project–Overseas deepwater ultra-deepwater oil and gas exploration technology research topic,under contract No.2021DJ2403。
文摘The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zambezi Delta basin,it has a low gravity anomaly,and the existing seismic survey lines do not cover the whole basin;therefore,it is difficult to interpret the structural characteristics of the whole basin based solely on gravity or seismic data.Based on satellite altimetry gravity anomaly data,this study infers the distribution characteristics of faults in the Zambezi Delta basin by using the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)technique.Then,constrained by seismic data,the gravity anomaly at the Moho interface is extracted by using the fast forward method of the double-interface model of the gravity anomaly,and this anomaly is then removed from the Bouguer gravity anomaly to obtain the sedimentary layer gravity anomaly.The thickness of the sedimentary strata is obtained by inversing the sedimentary basement depth of the whole basin.Then,uplifts and depressions are divided based on a sedimentary layer thickness of 3 km.This research demonstrates that the Zambezi Delta basin mainly features nearly SN-trending and NE-trending faults and that these faults exhibit east-west partitioning.The nearly SN-trending strike-slip faults controlled the sedimentary development of the basin,and the NE-trending tensile faults may have acted as migration channels for oil,gas and magma.The“overcompensation”effect of the Moho interface gravity anomaly on the gravity anomaly of the sedimentary layer is caused by the depression of the Moho interface beneath the Beira High,which results in a low gravity anomaly value for the Beira High.The pattern of uplifts and depressions trends NE and has the structural characteristics of east-west blocks.
基金Supported by Natural Science Foundation of Guangxi Zhuang Autonomous Region,China,No.2023GXNSFAA026070 and No.2018GXNSFAA281071.
文摘BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely understood.AIM To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC development.METHODS Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down CDC25C.Subsequently,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in vivo.Cell proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,respectively.The expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western blotting.Additionally,apoptosis was investigated using flow cytometry,qRT-PCR,and western blotting.RESULTS CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in mice.CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC cells.CONCLUSION The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signaling pathway.
文摘This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.
文摘Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.
文摘In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).
文摘As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division gene, are involved in plastid division process of plant cells. Antisense and sense expression constructions were employed to investigate the functions of the two ftsZ genes, NtFtsZ1 and NtFtsZ2, in transgenic Nicotiana tabacum L. plants. Although antisense expression of,NtFtsZs reduced the native protein level obviously, the size and number of chloroplasts in transgenic tobacco plants had no effect. In contrast, overexpression of NtFtsZs in transgenic plants strikingly changed the number and morphology of chloroplasts. Even only 1 - 2 huge chloroplasts could be seen in the mesophyll cells of some overexpression transgenic plants. Analyses of chloroplast ultrastructures and chlorophyll content of different transgenic plants suggested that NtFtsZs gene have no direct influence on the normal development and function of chloroplasts. ne changes in chloroplast morphology must be a compensation for the change in chloroplast number. The different phenotypes of chloroplasts in antisense and sense transgenic plants implied that different members from the same ftsZ gene family may have similar function in controlling plastid division. Meanwhile, the changes of chloroplast morphology in sense transgenic plants represented the possible plastoskeleton function of ftsZ in higher plant.
基金supported by the National Science and Technology Major Project(No.2011ZX05007-006)the 973 Program of China(No.2013CB228604)the major Project of Petrochina(No.2014B-0610)
文摘Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method will not be effective when the ground roll wave and the effective signal have the same frequency bands because of overlapping. The radial trace transform （RTT） considers the apparent velocity difference between the effective signal and the ground roll wave to suppress the latter, but affects the low-frequency components of the former. This study proposes a ground roll wave suppression method by combining the wavelet frequency division and the RTT based on the difference between the ground roll wave velocity and the effective signal and their energy difference in the wavelet domain, thus making full use of the advantages of both methods. First, we decompose the seismic data into different frequency bands through wavelet transform. Second, the RTT and low-cut filtering are applied to the low-frequency band, where the ground roll waves are appearing. Third, we reconstruct the seismic record without ground roll waves by using the inverse RTT and the remaining frequency bands. The proposed method not only improves the ground roll wave suppression, but also protects the signal integrity. The numerical simulation and real seismic data processing results suggest that the proposed method has a strong ability to denoise while preserving the amplitude.
基金Supported by The Ministry of Finance,Meteorological Industry Spe-cific(GYHY200706030)China Meteorological Administration 2009 Budget Item(CMATG2009M32)~~
文摘The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was equal to or greater than the rate of 3% was taken as standards to define wheat drought disaster years.The average reduction ratio of production in the wheat drought years in Hebei-Shandong-Henan was calculated.The frequency distribution rule of wheat in different drought disaster strength of winter wheat in Hebei-Shandong-Henan was analyzed.According to the conception and calculation method of drought disaster risk index of winter wheat,the regional distribution law of drought disaster risk index of winter wheat was analyzed.The division technical methods of winter wheat drought disaster risk zones in Hebei-Shandong-Henan under the irrigated conditions were put forward.Taking the average reduction rate of production in drought years,drought disaster risk index and precipitation of winter wheat in growth periods as indices,using the statistical analysis and overlay function of GIS,the production reduction risk of winter wheat caused by drought disaster in winter wheat zones of Hebei-Shandong-Henan was divided and evaluated.The risk evaluation of production reduction of winter wheat in different risk zones under different climate conditions was realized.The disaster prevention and mitigation measures of winter wheat drought were given.
