BACKGROUND Common variable immunodeficiency(CVID)is a primary antibody immunodeficiency disorder characterized by diminished IgG levels.Despite ongoing research,the precise pathogenesis of CVID remains unclear.Genetic...BACKGROUND Common variable immunodeficiency(CVID)is a primary antibody immunodeficiency disorder characterized by diminished IgG levels.Despite ongoing research,the precise pathogenesis of CVID remains unclear.Genetic factors account for only 10%-20%of cases,with an estimated incidence of 1 in 10000 to 1 in 100000,affecting individuals across all age groups.CASE SUMMARY We report the case of a 32-year-old man with CVID who presented with a chief complaint of“recurrent diarrhea and significant weight loss over the past 2 years”.Laboratory tests on admission showed fat droplets in stool,while other parameters were within normal ranges.Gastroscopy revealed a smooth gastric mucosa without bile retention or signs of Helicobacter pylori infection;however,the mucosa of the descending segment of the duodenum appeared rough.Further evaluation of the small intestine using computed tomography indicated no abnormalities.Finally,the whole-small bowel double-balloon enteroscopy(DBE)was performed,which revealed various phenotypic changes in the small intestinal mucosa.The patient was diagnosed with CVID,which improved after immunoglobulin therapy,with favorable follow-up outcomes.CONCLUSION Non-infectious enteropathy in CVID is rare.Therefore,DBE is essential for diagnosing small intestinal involvement in such cases.展开更多
Quantum entanglement, a fundamental concept in quantum mechanics, lies at the heart of many current and futurequantum technologies. A pivotal task is the generation and control of diverse quantum entangled states in a...Quantum entanglement, a fundamental concept in quantum mechanics, lies at the heart of many current and futurequantum technologies. A pivotal task is the generation and control of diverse quantum entangled states in a more compactand flexible manner. Here, we introduce an approach to achieve diverse path entanglement by exploiting the interactionbetween noncommutative metasurfaces and entangled photons. Different from other path entanglements, ourquantum path entanglement is evolution path entanglement of photons on Poincaré sphere. Due to quantum entanglementbetween idler photons and structured signal photons, evolution path of idler photons on the fundamental Poincarésphere can be nonlocally mirrored by structured signal photons on any higher-order Poincaré sphere, resulting in quantumpath entanglement. Benefiting from noncommutative metasurfaces, diverse quantum path entanglement can beswitched across different higher-order Poincaré spheres using distinct combination sequences of metasurfaces. Ourmethod allows for the tuning of diverse quantum path entanglement across a broad spectrum of quantum states, offeringa significant advancement in the manipulation of quantum entanglement.展开更多
A new macrofossil Lagerstatte was discovered from the uppermost Ediacaran Jiucheng Member at Jinning and Jiangchuan of the eastern Yunnan, yielding numerous diverse well-preserved thallophyte macrofossils. These inclu...A new macrofossil Lagerstatte was discovered from the uppermost Ediacaran Jiucheng Member at Jinning and Jiangchuan of the eastern Yunnan, yielding numerous diverse well-preserved thallophyte macrofossils. These include the previously-known representatives of vendobionts, Vendotaenia and Tyrasotaenia, and the biggish multicellular benthos such as Chuaria-like and Tawuia- like fossiis, as well as Longfengshaniaceaens with diverse holdfast structures. There are still some other problematic macrofossils with peculiar configurations as well as uncertain relatives. The distinct dominance of the giant, unbranching thallophytes occasionally with holdfast structures distinguishes this assemblage from the other Ediacaran macrofossil Lagerstattes in the Doushantuo Formation at Miaohe, Wenghui and Lantian, and the contemporary assemblage in the Shibantan Member of Dengying Formation, Yangtze Gorges area. This paper outlines the characteristics of some of the multicellular macrofossils from the Jiucheng Member at Jiangchuan. They include some macrofossils with different types of holdfast structure, larger Chuaria-like and Tawuia-like morphology and questionable affinities as well. The discovery of greater diverse macrofossil assemblages from the Jiucheng Member of eastern Yunnan has further indicated that an important diversification and evolutionary radiation of metaphytes took place in the latest Ediacaran time. This radiation of largescale, benthic metaphyte along with phytoplankton was likely important contributors to the early Cambrian explosion of metazoans.展开更多
In shale reservoirs,the organic pores with various structures formed during the thermal evolution of organic matter are the main storage site for adsorbed methane.However,in the process of thermal evolution,the adsorp...In shale reservoirs,the organic pores with various structures formed during the thermal evolution of organic matter are the main storage site for adsorbed methane.However,in the process of thermal evolution,the adsorption characteristics of methane in multi type and multi-scale organic matter pores have not been sufficiently studied.In this study,the molecular simulation method was used to study the adsorption characteristics of methane based on the geological conditions of Longmaxi Formation shale reservoir in Sichuan Basin,China.The results show that the characteristics of pore structure will affect the methane adsorption characteristics.The adsorption capacity of slit-pores for methane is much higher than that of cylindrical pores.The groove space inside the pore will change the density distribution of methane molecules in the pore,greatly improve the adsorption capacity of the pore,and increase the pressure sensitivity of the adsorption process.Although the variation of methane adsorption characteristics of different shapes is not consistent with pore size,all pores have the strongest methane adsorption capacity when the pore size is about 2 nm.In addition,the changes of temperature and pressure during the thermal evolution are also important factors to control the methane adsorption characteristics.The pore adsorption capacity first increases and then decreases with the increase of pressure,and increases with the increase of temperature.In the early stage of thermal evolution,pore adsorption capacity is strong and pressure sensitivity is weak;while in the late stage,it is on the contrary.展开更多
The Call of the Wild is one of the most famous novels written by Jack London.By borrowing vivid materials from his rich living experiences and diverse philosophies from different sources,he manages to make a dog named...The Call of the Wild is one of the most famous novels written by Jack London.By borrowing vivid materials from his rich living experiences and diverse philosophies from different sources,he manages to make a dog named Buck the hero,an impressive image which at tracts broad attention of both readers and critics.The writer intends to explore the author' s diverse philosophies,from the perspectives of Marxism,Darwinism,Social Darwinism and the Superman Theory respectively.And the writer will also point out this is caused by the col lision of different social ideas at that time.展开更多
The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the ang...The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the angle-dependent beampattern to an angle-time-range-dependent three-dimensional function by modulating the frequencies/time delays/phases across different transmit antenna elements.In this respect,extra Degrees-of-Freedom(DOFs)in the range domain are achieved,which opens up an innovative way to fulfil the tasks with enhanced system performance by jointly using the angle and range information.This paper summaries the developments of waveform diverse radars,including the Frequency Diverse Array(FDA),the Space-Time-CirculatingArray(STCA),and the Element-Pulse-Coding(EPC)frameworks,with emphasis on the analysis of the range-dependent beampattern from the basic properties upon how it is controlled.Moreover,the most recent advances of utilizing such a range-dependent beampattern in target detection,parameter estimation and identifiability,clutter suppression,jammer suppression and Synthetic Aperture Radar(SAR)imaging are discussed.展开更多
Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA i...Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA is range-angle-time-dependent transmit beampattern and its underlying properties are continuously revealed in the research.The formulation and exploitation of the transmit diversity with a frequency increment is the fundamental principle,which brings extra degrees-of-freedom(DOFs)in the transmit dimension.As the FDA radar carries additional information in range,it provides more flexibility in signal processing and also brings in new technical issues.This article overviews the state-of-the-art in FDA radar area and its applications,mainly based on the progress in our group.There are two main catalogs in FDA radar area,namely coherent FDA and FDA-MIMO(multiple-input multiple-output)radars.Potential applications including target parameter estimation,ambiguous clutter suppression,and deceptive jammer suppression are discussed.展开更多
The seriously range-ambiguous clutter is one of the main problems in clutter suppression for hypersonic vehicle-borne forward-looking radar. An approach based on the frequency diverse array (FDA) technique is proposed...The seriously range-ambiguous clutter is one of the main problems in clutter suppression for hypersonic vehicle-borne forward-looking radar. An approach based on the frequency diverse array (FDA) technique is proposed to mitigate the range ambiguous clutter. The frequency increment is designed to distinguish the clutter at ambiguous ranges and suppress the clutter by using a subspace projection algorithm. On the platform with high altitude or limited array antennas, the proposed method performs better for its independence of the elevation degrees-of-freedom (DOF). Finally, simulation results verify the effectiveness of the proposed method.展开更多
Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been...Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.展开更多
Due to the rapid development of electronic countermeasures(ECMs),the corresponding means of electronic counter countermeasures(ECCMs)are urgently needed.In this paper,an act-ive anti-jamming method based on frequency ...Due to the rapid development of electronic countermeasures(ECMs),the corresponding means of electronic counter countermeasures(ECCMs)are urgently needed.In this paper,an act-ive anti-jamming method based on frequency diverse array radar is proposed.By deriving the closed form of the phase center in a uniform line array FDA,we establish a model of the FDA signal based on adaptive weights and derive the effect of active anti-jamming in this regime.The pro-posed active anti-jamming method makes it difficult for jammers to detect or locate our radar.Fur-thermore,the effectiveness of the two frequency increment schemes in terms of anti-jamming is ana-lyzed by comparing the deviation of phase center.Finally,the simulation results verify the effective-ness and superiority of the proposed method.展开更多
Two kinds of iterative methods are designed to solve the linear system of equations, we obtain a new interpretation in terms of a geometric concept. Therefore, we have a better insight into the essence of the iterativ...Two kinds of iterative methods are designed to solve the linear system of equations, we obtain a new interpretation in terms of a geometric concept. Therefore, we have a better insight into the essence of the iterative methods and provide a reference for further study and design. Finally, a new iterative method is designed named as the diverse relaxation parameter of the SOR method which, in particular, demonstrates the geometric characteristics. Many examples prove that the method is quite effective.展开更多
The high-power laser energy research(HiPER)project was a European project for demonstrating the feasibility of inertial fusion energy based on using direct-drive targets in a shock ignition scheme using a drywall evac...The high-power laser energy research(HiPER)project was a European project for demonstrating the feasibility of inertial fusion energy based on using direct-drive targets in a shock ignition scheme using a drywall evacuated chamber.HiPER was intended to drive the transition from a scientific proof of principle to a demonstration power plant in Europe.The project was divided into three realistic scenarios(Experimental,Prototype,and Demo)to help identify open problems and select appropriate technologies to solve them.One of the problems identified was the lack of appropriate plasma-facing materials(PFMs)for the reaction chamber.Therefore,a major challenge was to develop radiation-resistant materials able to withstand the large thermal loads and radiation in these reactors.In this paper,we describe the main threats that coarse-grained Wwould face in the diverse HiPER scenarios.Based on purely thermomechanical considerations,theWlifetimes for the HiPER Prototype and Demo scenarios are limited by fatigue to 14000 h and 28 h,respectively.The combined effects of thermal load and atomistic damage significantly reduce these lifetimes to just∼1000 shots for the Experimental scenario and a few minutes and seconds for the Prototype and Demo scenarios,respectively.Thus,coarse-grainedWis not an appropriatePFMfor the Prototype or Demo scenarios.Therefore,alternatives to this material need to be identified.Here,we review some of the different approaches that are being investigated,highlight the work done to characterize these new materials,and suggest further experiments.展开更多
New armament systems are subjected to the method for dealing with multi-stage system reliability-growth statistical problems of diverse population in order to improve reliability before starting mass production. Aimin...New armament systems are subjected to the method for dealing with multi-stage system reliability-growth statistical problems of diverse population in order to improve reliability before starting mass production. Aiming at the test process which is high expense and small sample-size in the development of complex system, the specific methods are studied on how to process the statistical information of Bayesian reliability growth regarding diverse populations. Firstly, according to the characteristics of reliability growth during product development, the Bayesian method is used to integrate the testing information of multi-stage and the order relations of distribution parameters. And then a Gamma-Beta prior distribution is proposed based on non-homogeneous Poisson process（NHPP） corresponding to the reliability growth process. The posterior distribution of reliability parameters is obtained regarding different stages of product, and the reliability parameters are evaluated based on the posterior distribution. Finally, Bayesian approach proposed in this paper for multi-stage reliability growth test is applied to the test process which is small sample-size in the astronautics filed. The results of a numerical example show that the presented model can make use of the diverse information synthetically, and pave the way for the application of the Bayesian model for multi-stage reliability growth test evaluation with small sample-size. The method is useful for evaluating multi-stage system reliability and making reliability growth plan rationally.展开更多
The isolation of high quality RNA is a crucial technique in plant molecular biology. The quality of RNA determines the reliability of downstream process like real time PCR. In this paper, we reported a high quality RN...The isolation of high quality RNA is a crucial technique in plant molecular biology. The quality of RNA determines the reliability of downstream process like real time PCR. In this paper, we reported a high quality RNA extraction protocol for a variety of plant species. Our protocol is time effective than traditional RNA extraction methods. The method takes only an hour to complete the procedure. Spectral measurement and electrophoresis were used to demonstrate RNA quality and quantity. The extracted RNA was further used for cDNA synthesis, expression analysis and copy number determination through Real Time PCR. The results indicate that RNA was of good quality and fit for real time PCR. This high throughput plant RNA extraction protocol can be used to isolate high quality RNA from diverse plants for real time PCR and other downstream applications.展开更多
Background： Many tree species in tropical forests have distributions tracking local ridge-slope-valley topography. Previous work in a 50-ha plot in Korup National Park, Cameroon, demonstrated that 272 species, or 63%...Background： Many tree species in tropical forests have distributions tracking local ridge-slope-valley topography. Previous work in a 50-ha plot in Korup National Park, Cameroon, demonstrated that 272 species, or 63% of those tested, were significantly associated with topography. Methods： We used two censuses of 329,000 trees ≥1 cm dbh to examine demographic variation at this site that would account for those observed habitat preferences. We tested two predictions. First, within a given topographic habitat, species specializing on that habitat （＇residents＇） should outperform species that are specialists of other habitats （＇foreigners＇）. Second, across different topographic habitats, species should perform best in the habitat on which they specialize （＇home＇） compared to other habitats （＇away＇）. Species＇ performance was estimated using growth and mortality rates. Results： In hierarchical models with species identity as a random effect, we found no evidence of a demographic advantage to resident species. Indeed, growth rates were most often higher for foreign species. Similarly, comparisons of species on their home vs. away habitats revealed no sign of a performance advantage on the home habitat. Conclusions＂ We reject the hypothesis that species distributions along a ridge-valley catena at Korup are caused by species differences in trees _〉1 cm dbh. Since there must be a demographic cause for habitat specialization, we offer three alternatives. First, the demographic advantage specialists have at home occurs at the reproductive or seedling stage, in sizes smaller than we census in the forest plot. Second, species may have higher performance on their preferred habitat when density is low, but when population builds up, there are negative density-dependent feedbacks that reduce performance. Third, demographic filtering may be produced by extreme environmental conditions that we did not observe during the census interval.展开更多
Older adult falls are a significant public health problem,but one that is amenable to preventive interventions.1,2 Despite the progress made in identifying risk factors,developing efficacious health-related interventi...Older adult falls are a significant public health problem,but one that is amenable to preventive interventions.1,2 Despite the progress made in identifying risk factors,developing efficacious health-related interventions,and promoting evidencebased programs in the community,much work remains before these strategies are broadly available and effectively used to reduce fall-related injuries.3 As Newton and ScottFindlay4 have pointed out,the translation of basic scientific knowledge into clinical studies,and the transformation of clinical studies into improvements in health services and public health practices,remain major obstacles to widespread adoption.展开更多
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes.Although therapeutics specifically targeting known causal mutations may rescue individual types of...Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes.Although therapeutics specifically targeting known causal mutations may rescue individual types of ALS, these approaches cannottreat most cases since they have unknown genetic etiology. Thus, there is a pressing need for therapeutic strategies that rescuemultiple forms of ALS. Here, we show that pharmacological inhibition of PIKFYVE kinase activates an unconventional proteinclearance mechanism involving exocytosis of aggregation-prone proteins. Reducing PIKFYVE activity ameliorates ALSpathology and extends survival of animal models and patient-derived motor neurons representing diverse forms of ALS includingC9ORF72, TARDBP, FUS, and sporadic. These findings highlight a potential approach for mitigating ALS pathogenesis that doesnot require stimulating macroautophagy or the ubiquitin-proteosome system.展开更多
This paper studies chirped optical solitons in nonlinear optical fibers.However,we obtain diverse soliton solutions and new chirped bright and dark solitons,trigonometric function solutions and rational solutions by a...This paper studies chirped optical solitons in nonlinear optical fibers.However,we obtain diverse soliton solutions and new chirped bright and dark solitons,trigonometric function solutions and rational solutions by adopting two formal integration methods.The obtained results take into account the different conditions set on the parameters of the nonlinear ordinary differential equation of the new extended direct algebraic equation method.These results are more general compared to Hadi et al(2018 Optik 172545–53)and Yakada et al(2019 Optik197163108).展开更多
Public vehicle seats are used under diverse conditions, therefore, the design of these seats is desired to be universal design. In the past study, seat swing function used in public vehicle seats, and it was optimized...Public vehicle seats are used under diverse conditions, therefore, the design of these seats is desired to be universal design. In the past study, seat swing function used in public vehicle seats, and it was optimized from the mechanical aspect under diverse conditions. Seat swing function is the function to prevent hip-sliding force, which causes sitting uncomfortable feeling. Recent study clarified that the reduction of blood flow in the legs causes physiological dysfunction, which is one of the causes of Long Flight Thrombosis, and the social issue. Thus, in the design of seat swing function, it is necessary to consider not only mechanical aspects but also physiological aspects. For the universal design of seat swing function considering the physiological aspect （blood flow）, the influence of blood flow on seat swing function in diverse conditions was analyzed. The method of this study was measuring blood flow and body pressure distribution on seat cushion of seat swing function under diverse conditions. From the analysis, it was indicated that it was necessary to reduce the compressive force behind the knees of the user conditions; the short physique and the high weight physique in standard sitting posture, for the universal design of seat swing function to prevent reduction of blood flow in the legs.展开更多
基金Supported by National Natural Science Foundation of China,No.82360120Ten Thousand Doctor Plan in Yunnan Province,No.YNWRMY-2018-020Yunnan Provincial Key Laboratory of Clinical Virology,No.202205AG070053-07.
文摘BACKGROUND Common variable immunodeficiency(CVID)is a primary antibody immunodeficiency disorder characterized by diminished IgG levels.Despite ongoing research,the precise pathogenesis of CVID remains unclear.Genetic factors account for only 10%-20%of cases,with an estimated incidence of 1 in 10000 to 1 in 100000,affecting individuals across all age groups.CASE SUMMARY We report the case of a 32-year-old man with CVID who presented with a chief complaint of“recurrent diarrhea and significant weight loss over the past 2 years”.Laboratory tests on admission showed fat droplets in stool,while other parameters were within normal ranges.Gastroscopy revealed a smooth gastric mucosa without bile retention or signs of Helicobacter pylori infection;however,the mucosa of the descending segment of the duodenum appeared rough.Further evaluation of the small intestine using computed tomography indicated no abnormalities.Finally,the whole-small bowel double-balloon enteroscopy(DBE)was performed,which revealed various phenotypic changes in the small intestinal mucosa.The patient was diagnosed with CVID,which improved after immunoglobulin therapy,with favorable follow-up outcomes.CONCLUSION Non-infectious enteropathy in CVID is rare.Therefore,DBE is essential for diagnosing small intestinal involvement in such cases.
基金supports from National Natural Science Foundation of China(Grant No.12174097).
文摘Quantum entanglement, a fundamental concept in quantum mechanics, lies at the heart of many current and futurequantum technologies. A pivotal task is the generation and control of diverse quantum entangled states in a more compactand flexible manner. Here, we introduce an approach to achieve diverse path entanglement by exploiting the interactionbetween noncommutative metasurfaces and entangled photons. Different from other path entanglements, ourquantum path entanglement is evolution path entanglement of photons on Poincaré sphere. Due to quantum entanglementbetween idler photons and structured signal photons, evolution path of idler photons on the fundamental Poincarésphere can be nonlocally mirrored by structured signal photons on any higher-order Poincaré sphere, resulting in quantumpath entanglement. Benefiting from noncommutative metasurfaces, diverse quantum path entanglement can beswitched across different higher-order Poincaré spheres using distinct combination sequences of metasurfaces. Ourmethod allows for the tuning of diverse quantum path entanglement across a broad spectrum of quantum states, offeringa significant advancement in the manipulation of quantum entanglement.
基金supported by the Key Laboratory of Stratigraphy and Paleontology,Chinese Academy of Geological Sciences(Grant No.JB0705)the Institute of Geology,Chinese Academy of Geological Sciences(Grant No.J0716)+1 种基金the National Natural Science Foundation of China(Grant Nos.40272015,40672022)the China Geology Survey Grant(Grant Nos.1212010511607,200213000042)
文摘A new macrofossil Lagerstatte was discovered from the uppermost Ediacaran Jiucheng Member at Jinning and Jiangchuan of the eastern Yunnan, yielding numerous diverse well-preserved thallophyte macrofossils. These include the previously-known representatives of vendobionts, Vendotaenia and Tyrasotaenia, and the biggish multicellular benthos such as Chuaria-like and Tawuia- like fossiis, as well as Longfengshaniaceaens with diverse holdfast structures. There are still some other problematic macrofossils with peculiar configurations as well as uncertain relatives. The distinct dominance of the giant, unbranching thallophytes occasionally with holdfast structures distinguishes this assemblage from the other Ediacaran macrofossil Lagerstattes in the Doushantuo Formation at Miaohe, Wenghui and Lantian, and the contemporary assemblage in the Shibantan Member of Dengying Formation, Yangtze Gorges area. This paper outlines the characteristics of some of the multicellular macrofossils from the Jiucheng Member at Jiangchuan. They include some macrofossils with different types of holdfast structure, larger Chuaria-like and Tawuia-like morphology and questionable affinities as well. The discovery of greater diverse macrofossil assemblages from the Jiucheng Member of eastern Yunnan has further indicated that an important diversification and evolutionary radiation of metaphytes took place in the latest Ediacaran time. This radiation of largescale, benthic metaphyte along with phytoplankton was likely important contributors to the early Cambrian explosion of metazoans.
基金This work was supported by the National Natural Science Foundation of China(Nos.41772141,41972171)the Natural Science Foundation of Jiangsu Province(BK20181362),the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘In shale reservoirs,the organic pores with various structures formed during the thermal evolution of organic matter are the main storage site for adsorbed methane.However,in the process of thermal evolution,the adsorption characteristics of methane in multi type and multi-scale organic matter pores have not been sufficiently studied.In this study,the molecular simulation method was used to study the adsorption characteristics of methane based on the geological conditions of Longmaxi Formation shale reservoir in Sichuan Basin,China.The results show that the characteristics of pore structure will affect the methane adsorption characteristics.The adsorption capacity of slit-pores for methane is much higher than that of cylindrical pores.The groove space inside the pore will change the density distribution of methane molecules in the pore,greatly improve the adsorption capacity of the pore,and increase the pressure sensitivity of the adsorption process.Although the variation of methane adsorption characteristics of different shapes is not consistent with pore size,all pores have the strongest methane adsorption capacity when the pore size is about 2 nm.In addition,the changes of temperature and pressure during the thermal evolution are also important factors to control the methane adsorption characteristics.The pore adsorption capacity first increases and then decreases with the increase of pressure,and increases with the increase of temperature.In the early stage of thermal evolution,pore adsorption capacity is strong and pressure sensitivity is weak;while in the late stage,it is on the contrary.
文摘The Call of the Wild is one of the most famous novels written by Jack London.By borrowing vivid materials from his rich living experiences and diverse philosophies from different sources,he manages to make a dog named Buck the hero,an impressive image which at tracts broad attention of both readers and critics.The writer intends to explore the author' s diverse philosophies,from the perspectives of Marxism,Darwinism,Social Darwinism and the Superman Theory respectively.And the writer will also point out this is caused by the col lision of different social ideas at that time.
基金supported in part by the National Nature Science Foundation of China(Nos.62101402,61931016,62071344)China Postdoctoral Science Foundation(Nos.2021TQ0261,2021M702547)Young Elite Scientists Sponsorship Program by CAST(2021QNRC001).
文摘The transmit antenna beampattern of the phased array radar is only a function of angle,limiting its ability to discriminate the targets from the same direction.Recently,the waveform diverse array radars expand the angle-dependent beampattern to an angle-time-range-dependent three-dimensional function by modulating the frequencies/time delays/phases across different transmit antenna elements.In this respect,extra Degrees-of-Freedom(DOFs)in the range domain are achieved,which opens up an innovative way to fulfil the tasks with enhanced system performance by jointly using the angle and range information.This paper summaries the developments of waveform diverse radars,including the Frequency Diverse Array(FDA),the Space-Time-CirculatingArray(STCA),and the Element-Pulse-Coding(EPC)frameworks,with emphasis on the analysis of the range-dependent beampattern from the basic properties upon how it is controlled.Moreover,the most recent advances of utilizing such a range-dependent beampattern in target detection,parameter estimation and identifiability,clutter suppression,jammer suppression and Synthetic Aperture Radar(SAR)imaging are discussed.
基金This work was supported in part by the National Natural Science Foundation of China(NSFC)(Nos.61931016,62071344 and 61911530246)the Key Laboratory Equipment Advanced Research Fund(No.6142206200210).
文摘Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA is range-angle-time-dependent transmit beampattern and its underlying properties are continuously revealed in the research.The formulation and exploitation of the transmit diversity with a frequency increment is the fundamental principle,which brings extra degrees-of-freedom(DOFs)in the transmit dimension.As the FDA radar carries additional information in range,it provides more flexibility in signal processing and also brings in new technical issues.This article overviews the state-of-the-art in FDA radar area and its applications,mainly based on the progress in our group.There are two main catalogs in FDA radar area,namely coherent FDA and FDA-MIMO(multiple-input multiple-output)radars.Potential applications including target parameter estimation,ambiguous clutter suppression,and deceptive jammer suppression are discussed.
基金supported by the National Natural Science Foundation of China(61301282)
文摘The seriously range-ambiguous clutter is one of the main problems in clutter suppression for hypersonic vehicle-borne forward-looking radar. An approach based on the frequency diverse array (FDA) technique is proposed to mitigate the range ambiguous clutter. The frequency increment is designed to distinguish the clutter at ambiguous ranges and suppress the clutter by using a subspace projection algorithm. On the platform with high altitude or limited array antennas, the proposed method performs better for its independence of the elevation degrees-of-freedom (DOF). Finally, simulation results verify the effectiveness of the proposed method.
文摘Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.
基金the National Natural Science Foundation of China(No.61971438)the Natural Science Founda-tion of Shaanxi Province(No.2019JM-155).
文摘Due to the rapid development of electronic countermeasures(ECMs),the corresponding means of electronic counter countermeasures(ECCMs)are urgently needed.In this paper,an act-ive anti-jamming method based on frequency diverse array radar is proposed.By deriving the closed form of the phase center in a uniform line array FDA,we establish a model of the FDA signal based on adaptive weights and derive the effect of active anti-jamming in this regime.The pro-posed active anti-jamming method makes it difficult for jammers to detect or locate our radar.Fur-thermore,the effectiveness of the two frequency increment schemes in terms of anti-jamming is ana-lyzed by comparing the deviation of phase center.Finally,the simulation results verify the effective-ness and superiority of the proposed method.
基金Supported by the National Natural Science Foundation of China(61272300)
文摘Two kinds of iterative methods are designed to solve the linear system of equations, we obtain a new interpretation in terms of a geometric concept. Therefore, we have a better insight into the essence of the iterative methods and provide a reference for further study and design. Finally, a new iterative method is designed named as the diverse relaxation parameter of the SOR method which, in particular, demonstrates the geometric characteristics. Many examples prove that the method is quite effective.
基金This research was supported by Comunidad de Madrid(Grant No.S2018/EMT-4437)the Ministerio de Economıa y Competitividad of Spain(Grant No.PID2019-105325RB-C32)(Radiafus-V)+1 种基金EUROFUSION(WPENR:Enabling ResearchGrant No.ENRIFE19.CCFE-01).
文摘The high-power laser energy research(HiPER)project was a European project for demonstrating the feasibility of inertial fusion energy based on using direct-drive targets in a shock ignition scheme using a drywall evacuated chamber.HiPER was intended to drive the transition from a scientific proof of principle to a demonstration power plant in Europe.The project was divided into three realistic scenarios(Experimental,Prototype,and Demo)to help identify open problems and select appropriate technologies to solve them.One of the problems identified was the lack of appropriate plasma-facing materials(PFMs)for the reaction chamber.Therefore,a major challenge was to develop radiation-resistant materials able to withstand the large thermal loads and radiation in these reactors.In this paper,we describe the main threats that coarse-grained Wwould face in the diverse HiPER scenarios.Based on purely thermomechanical considerations,theWlifetimes for the HiPER Prototype and Demo scenarios are limited by fatigue to 14000 h and 28 h,respectively.The combined effects of thermal load and atomistic damage significantly reduce these lifetimes to just∼1000 shots for the Experimental scenario and a few minutes and seconds for the Prototype and Demo scenarios,respectively.Thus,coarse-grainedWis not an appropriatePFMfor the Prototype or Demo scenarios.Therefore,alternatives to this material need to be identified.Here,we review some of the different approaches that are being investigated,highlight the work done to characterize these new materials,and suggest further experiments.
基金supported by Sustentation Program of National Ministries and Commissions of China (Grant No. 51319030302 and Grant No. 9140A19030506KG0166)
文摘New armament systems are subjected to the method for dealing with multi-stage system reliability-growth statistical problems of diverse population in order to improve reliability before starting mass production. Aiming at the test process which is high expense and small sample-size in the development of complex system, the specific methods are studied on how to process the statistical information of Bayesian reliability growth regarding diverse populations. Firstly, according to the characteristics of reliability growth during product development, the Bayesian method is used to integrate the testing information of multi-stage and the order relations of distribution parameters. And then a Gamma-Beta prior distribution is proposed based on non-homogeneous Poisson process（NHPP） corresponding to the reliability growth process. The posterior distribution of reliability parameters is obtained regarding different stages of product, and the reliability parameters are evaluated based on the posterior distribution. Finally, Bayesian approach proposed in this paper for multi-stage reliability growth test is applied to the test process which is small sample-size in the astronautics filed. The results of a numerical example show that the presented model can make use of the diverse information synthetically, and pave the way for the application of the Bayesian model for multi-stage reliability growth test evaluation with small sample-size. The method is useful for evaluating multi-stage system reliability and making reliability growth plan rationally.
文摘The isolation of high quality RNA is a crucial technique in plant molecular biology. The quality of RNA determines the reliability of downstream process like real time PCR. In this paper, we reported a high quality RNA extraction protocol for a variety of plant species. Our protocol is time effective than traditional RNA extraction methods. The method takes only an hour to complete the procedure. Spectral measurement and electrophoresis were used to demonstrate RNA quality and quantity. The extracted RNA was further used for cDNA synthesis, expression analysis and copy number determination through Real Time PCR. The results indicate that RNA was of good quality and fit for real time PCR. This high throughput plant RNA extraction protocol can be used to isolate high quality RNA from diverse plants for real time PCR and other downstream applications.
基金the National Institutes of Health award U01 TW03004 under the NIH-NSF-USDA funded International Cooperative Biodiversity Groups programfinancial support from the U.S. Agency for International Development’s Central Africa Regional Program for the Environment and the Smithsonian Tropical Research Institute+3 种基金Financial support for the 2008 recensus was provided by the Frank Levinson Family Foundationsupported by U.S. National Science Foundation award DEB-9806828provided by the Bioresources Development and Conservation Programme-Cameroonthe WWF Korup Project
文摘Background： Many tree species in tropical forests have distributions tracking local ridge-slope-valley topography. Previous work in a 50-ha plot in Korup National Park, Cameroon, demonstrated that 272 species, or 63% of those tested, were significantly associated with topography. Methods： We used two censuses of 329,000 trees ≥1 cm dbh to examine demographic variation at this site that would account for those observed habitat preferences. We tested two predictions. First, within a given topographic habitat, species specializing on that habitat （＇residents＇） should outperform species that are specialists of other habitats （＇foreigners＇）. Second, across different topographic habitats, species should perform best in the habitat on which they specialize （＇home＇） compared to other habitats （＇away＇）. Species＇ performance was estimated using growth and mortality rates. Results： In hierarchical models with species identity as a random effect, we found no evidence of a demographic advantage to resident species. Indeed, growth rates were most often higher for foreign species. Similarly, comparisons of species on their home vs. away habitats revealed no sign of a performance advantage on the home habitat. Conclusions＂ We reject the hypothesis that species distributions along a ridge-valley catena at Korup are caused by species differences in trees _〉1 cm dbh. Since there must be a demographic cause for habitat specialization, we offer three alternatives. First, the demographic advantage specialists have at home occurs at the reproductive or seedling stage, in sizes smaller than we census in the forest plot. Second, species may have higher performance on their preferred habitat when density is low, but when population builds up, there are negative density-dependent feedbacks that reduce performance. Third, demographic filtering may be produced by extreme environmental conditions that we did not observe during the census interval.
文摘Older adult falls are a significant public health problem,but one that is amenable to preventive interventions.1,2 Despite the progress made in identifying risk factors,developing efficacious health-related interventions,and promoting evidencebased programs in the community,much work remains before these strategies are broadly available and effectively used to reduce fall-related injuries.3 As Newton and ScottFindlay4 have pointed out,the translation of basic scientific knowledge into clinical studies,and the transformation of clinical studies into improvements in health services and public health practices,remain major obstacles to widespread adoption.
文摘Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes.Although therapeutics specifically targeting known causal mutations may rescue individual types of ALS, these approaches cannottreat most cases since they have unknown genetic etiology. Thus, there is a pressing need for therapeutic strategies that rescuemultiple forms of ALS. Here, we show that pharmacological inhibition of PIKFYVE kinase activates an unconventional proteinclearance mechanism involving exocytosis of aggregation-prone proteins. Reducing PIKFYVE activity ameliorates ALSpathology and extends survival of animal models and patient-derived motor neurons representing diverse forms of ALS includingC9ORF72, TARDBP, FUS, and sporadic. These findings highlight a potential approach for mitigating ALS pathogenesis that doesnot require stimulating macroautophagy or the ubiquitin-proteosome system.
文摘This paper studies chirped optical solitons in nonlinear optical fibers.However,we obtain diverse soliton solutions and new chirped bright and dark solitons,trigonometric function solutions and rational solutions by adopting two formal integration methods.The obtained results take into account the different conditions set on the parameters of the nonlinear ordinary differential equation of the new extended direct algebraic equation method.These results are more general compared to Hadi et al(2018 Optik 172545–53)and Yakada et al(2019 Optik197163108).
文摘Public vehicle seats are used under diverse conditions, therefore, the design of these seats is desired to be universal design. In the past study, seat swing function used in public vehicle seats, and it was optimized from the mechanical aspect under diverse conditions. Seat swing function is the function to prevent hip-sliding force, which causes sitting uncomfortable feeling. Recent study clarified that the reduction of blood flow in the legs causes physiological dysfunction, which is one of the causes of Long Flight Thrombosis, and the social issue. Thus, in the design of seat swing function, it is necessary to consider not only mechanical aspects but also physiological aspects. For the universal design of seat swing function considering the physiological aspect （blood flow）, the influence of blood flow on seat swing function in diverse conditions was analyzed. The method of this study was measuring blood flow and body pressure distribution on seat cushion of seat swing function under diverse conditions. From the analysis, it was indicated that it was necessary to reduce the compressive force behind the knees of the user conditions; the short physique and the high weight physique in standard sitting posture, for the universal design of seat swing function to prevent reduction of blood flow in the legs.
