This study investigates prescribed-time position tracking control for electromagnetic satellite formations subject to model uncertainties and external disturbances.Using the Clohessy-Wiltshire equations as the relativ...This study investigates prescribed-time position tracking control for electromagnetic satellite formations subject to model uncertainties and external disturbances.Using the Clohessy-Wiltshire equations as the relative motion dynamics model,a prescribed time output feedback control strategy is proposed.A prescribed-time extended state observer is designed to estimate the relative velocity and external disturbances.The disturbance estimates are then used as the feedforward component of the controller.Building on this framework,a novel prescribed-time active disturbance rejection control strategy for position tracking is developed via a backstepping control design.The convergence of the extended state observer and the stability of the closed-loop system are rigorously analyzed using Lyapunov stability theory.Numerical simulations are performed to validate the effectiveness of the proposed controller.展开更多
Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framew...Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framework that jointly designs distributed observers and local controllers to ensure robust formation control in the presence of external disturbances and sensor malfunctions.Treating the spacecraft formation as a single interconnected system,each spacecraft constructs a distributed observer that estimates the overall system state by incorporating both its own measurements and the predicted control information shared among the spacecraft.Based on the observer estimates,a local control law is synthesized to maintain the desired formation.Rigorous theoretical analysis and numerical simulations demonstrate that the proposed integrated approach effectively guarantees formation stability and resilience against sensor failures and disturbances.展开更多
Dynamic disturbances with various frequencies could trigger different failure modes of deep excavations.Superimposed on this static stress are dynamic disturbances due to various dynamic vibrations,e.g.excavation blas...Dynamic disturbances with various frequencies could trigger different failure modes of deep excavations.Superimposed on this static stress are dynamic disturbances due to various dynamic vibrations,e.g.excavation blasting,blasting,tunnel boring machine(TBM)vibration,rockburst wave,earthquakes.Specifically,these dynamic sources are characterized by a wide range of wave frequencies f,resulting in differences in failure modes.A series of true-triaxial compression tests were conducted on granite to simulate the excavation-induced stress path in three-dimensional(3D)stresses.Subsequently,a dynamic disturbance with various frequencies was applied to a cuboid specimen,to reveal the behavior associated with brittle failure.The dynamic disturbance with frequencies f of 5 Hz,10 Hz,and 40 Hz generates less disturbed energy components in the granite together with higher peak strength.However,dynamic disturbances with f of 20 Hz and 30 Hz resulted in a lower peak strength;the peak strength of the rock increases sp albeit it decreases at first,then increases.This U-shaped phenomenon relates to the natural frequency of the granite under such stress conditions.Different rock lithologies consisting of diverse mineral composition,respond differently to each sensitive resonance frequency.Interestingly,the weak disturbance stress with a high frequency f and low amplitude A increases the ratio of crack damage to peak strength(scd/sp)in the granite.This leads to the inhibition of the expansion of the granite during the dynamic disturbance process.Multiple penetrating tensileeshear cracks appear in the s3-direction as the disturbance frequency f increases.展开更多
Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam expl...Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.展开更多
This study investigated the effects of periodic high-frequency stress disturbances on the creep behavior of sandstone and analyzed the microstructural changes using nuclear magnetic resonance(NMR)technology.High-frequ...This study investigated the effects of periodic high-frequency stress disturbances on the creep behavior of sandstone and analyzed the microstructural changes using nuclear magnetic resonance(NMR)technology.High-frequency disturbance creep experiments were conducted on sandstone under different disturbance frequencies,disturbance cycles and loading stresses,and the following findings were obtained.Firstly,with the increase of loading stress and disturbance cycles,the total porosity increments,and damage value of sandstone increase,while the fractal dimension of sandstone pore structure presents the opposite trend.Secondly,during the disturbance creep process,the volumes of all three types of pores increase,but the proportion of micropores(T_(2)<10 ms)decreases,while the proportion of mesopores(10 ms<T_(2)<100 ms)and macropores(T_(2)>100 ms)increases.Thirdly,the fractal dimension difference has a good linear relationship with the damage,strain and porosity increment of sandstone during the disturbance creep process.Finally,the higher the disturbance frequency,the smaller the creep strain and creep strain rate during the steady-state creep stage.The study offers valuable theoretical insights for understanding rock creep behavior in complex stress environments.展开更多
To address the issue that hybrid flow shop production struggles to handle order disturbance events,a dynamic scheduling model was constructed.The model takes minimizing the maximum makespan,delivery time deviation,and...To address the issue that hybrid flow shop production struggles to handle order disturbance events,a dynamic scheduling model was constructed.The model takes minimizing the maximum makespan,delivery time deviation,and scheme deviation degree as the optimization objectives.An adaptive dynamic scheduling strategy based on the degree of order disturbance is proposed.An improved multi-objective Grey Wolf(IMOGWO)optimization algorithm is designed by combining the“job-machine”two-layer encoding strategy,the timing-driven two-stage decoding strategy,the opposition-based learning initialization population strategy,the POX crossover strategy,the dualoperation dynamic mutation strategy,and the variable neighborhood search strategy for problem solving.A variety of test cases with different scales were designed,and ablation experiments were conducted to verify the effectiveness of the improved strategies.The results show that each improved strategy can effectively enhance the performance of the IMOGWO.Additionally,performance analysis was conducted by comparing the proposed algorithm with three mature and classical algorithms.The results demonstrate that the proposed algorithm exhibits superior performance in solving the hybrid flow-shop scheduling problem(HFSP).Case validations were conducted for different types of order disturbance scenarios.The results demonstrate that the proposed adaptive dynamic scheduling strategy and the IMOGWO algorithm can effectively address order disturbance events.They enable rapid response to order disturbance while ensuring the stability of the production system.展开更多
Myelin,made by oligodendrocytes(OLs)in the central nervous system(CNS),is essential for neural transmission.In particular,myelin facilitates communication across the long connections between different brain regions th...Myelin,made by oligodendrocytes(OLs)in the central nervous system(CNS),is essential for neural transmission.In particular,myelin facilitates communication across the long connections between different brain regions that form the white matter.Myelinated segments also provide metabolic intermediates to axons,supporting their demanding energetic needs.Genetic disorders that disrupt myelin formation result in progressive neurologic degeneration.展开更多
The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses ...The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.展开更多
A better understanding of the structure and dynamics of disturbed forests is key for forecasting their future successional trajectories.Despite vulnerability of subalpine forests to warming climate,little is known as ...A better understanding of the structure and dynamics of disturbed forests is key for forecasting their future successional trajectories.Despite vulnerability of subalpine forests to warming climate,little is known as to how their community composition has responded to disturbances and climate warming over decades.Before the 1970s,subalpine forests on the southeastern Qinghai-Tibet Plateau mainly experienced logging and fire,but afterwards they were more impacted by climate warming.Thus,they provide an excellent setting to test whether disturbances and climate warming led to changes in forest structure.Based on the analysis of 3145 forest inventory plots at 4-to 5-year resolution,we found that spruce-fir forests shifted to pine and broadleaved forests since the early 1970s.Such a turnover in species composition mainly occurred in the 1994e1998 period.By strongly altering site conditions,disturbances in concert with climate warming reshuffle community composition to warm-adapted broadleaf-pine species.Thus,moderate disturbances shifted forest composition through a gradual loss of resilience of spruce-fir forests.Shifts in these foundation species will have profound impacts on ecosystem functions and services.In the future,broadleaved forests could expand more rapidly than evergreen needle-leaved forests under moderate warming scenarios.In addition to climate,the effects of anthropogenic disturbances on subalpine forests should be considered in adaptive forest management and in projections of future forest changes.展开更多
Obtaining high-quality 10000-meter-deep seafloor sediment samples is the prerequisite and foundation for conducting deep-sea geological and environmental scientific research.The bottom structure of the deep seafloor i...Obtaining high-quality 10000-meter-deep seafloor sediment samples is the prerequisite and foundation for conducting deep-sea geological and environmental scientific research.The bottom structure of the deep seafloor is complex,and the physical and mechanical properties and disturbance resistance of sediments of different lithologies vary greatly,so the sediment sampler inevitably disturbs the sediments during the sampling process and affects the quality of the sediment samples.A new type of deep-sea sediment pressure retaining sampler is introduced,the force state and elastic–plastic state of the sampler destroying sediments are analyzed,the radial disturbance model of sediment coring based on the spherical cavity expansion theory is established,and the radius of sediments undergoing plastic deformation around the spherical holes is used as an index for evaluating the radial disturbance of sediments.The distribution of stress and strain fields in the sediments during the expansion of the spherical cavity and the influencing factors of the radius of the radially disturbed region(plastic region)are analyzed using an arithmetic example,and the influence law is analyzed.A sediment disturbance experimental platform was built indoors to simulate the sediment coring process.The radial stress field and pore water pressure of the sediment during the coring process were monitored by sensors arranged inside the sediment,and the results of indoor tests verified the correctness of the perturbation theory model.The sampler was carried aboard the deep-sea manned submersible FENDOUZHE and conducted on-site tests at depths of 9298.4 and 9142.8 m in the Kuril-Kamchatka Trench.Pressure-preserved sediment samples were retrieved,with preservation rates of 94.21%and 92.02%,respectively,which are much higher than the current technical indicator of 80%of pressure-holding ratio for deep-sea sediments.The retrieved sediments have obvious stratification characteristics and little disturbance.展开更多
Aircraft disturbs the adjacent atmospheric environment in flight,forming spatial distribution features of atmospheric density that differ from the natural background,which may potentially be utilized as tracer charact...Aircraft disturbs the adjacent atmospheric environment in flight,forming spatial distribution features of atmospheric density that differ from the natural background,which may potentially be utilized as tracer characteristics to introduce new technologies for indirectly sensing the presence of aircraft.In this paper,the concept of a long-range aircraft detection based on the atmospheric disturbance density field is proposed,and the detection mode of tomographic imaging of the scattering light of an atmospheric disturbance flow field is designed.By modeling the spatial distribution of the disturbance density field,the scattered echo signal images of active light towards the disturbance field at long distance are simulated.On this basis,the characteristics of the disturbance optical signal at the optimal detection resolution are analyzed.The results show that the atmospheric disturbance flow field of the supersonic aircraft presents circular in the light-scattering echo images.The disturbance signal can be further highlighted by differential processing of the adjacent scattering images.As the distance behind the aircraft increases,the diffusion range of the disturbance signal increases,and the signal intensity and contrast with the background decrease.Under the ground-based observation conditions of the aircraft at a height of 10000 m,a Mach number of1.6,and a detection distance of 100 km,the contrast between the disturbance signal and the back-ground was 30 d B at a distance of one time from the rear of the fuselage,and the diffusion diameter of the disturbance signal was 50 m.At a distance eight times the length of the aircraft,the contrast decreased to 10 dB,and the diameter increased to 290 m.The contrast was reduced to 3 dB at a distance nine times the length of the aircraft,and the diameter was diffused to 310 m.These results indicate the possibility of long-range aircraft detection based on the characteristics of the atmospheric density field.展开更多
BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral...BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.展开更多
A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source di...A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical...Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.展开更多
Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability ...Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of forests.At the same time,detailed accounts of disturbances and forest responses are not yet well quantified in Asia.This study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast Asia.This approach allowed us to detect forest disturbance and quantify the resilience after disturbance.Results showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by disturbances.Specifically,95%of forests had robust resilience and could recover from disturbance within a few decades.The resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance magnitude.In summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two decades.The authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in 2022.The findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.展开更多
1Introduction To date,in model-based gait-planning methods,the dynamics of the center of mass(COM)of bipedal robots have been analyzed by establishing their linear inverted pendulum model(LIPM)or extended forms(Owaki ...1Introduction To date,in model-based gait-planning methods,the dynamics of the center of mass(COM)of bipedal robots have been analyzed by establishing their linear inverted pendulum model(LIPM)or extended forms(Owaki et al.,2010;Englsberger et al.,2015;Xie et al.,2020).With regard to model-based gait-generation methods for uphill and downhill terrain,Kuo(2007)simulated human gait using an inverted pendulum,which provided a circular trajectory for the COM rather than a horizontal trajectory.He found that a horizontal COM trajectory consumed more muscle energy.Massah et al.(2012)utilized a 3D LIPM and the concept of zero moment point(ZMP).They developed a trajectory planner using the semi-elliptical motion equations of an NAO humanoid robot and simulated walking on various sloped terrains using the Webots platform.展开更多
The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scena...The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scenarios.In this context,two critical issues emerge:the gravitational pull caused by adding a potential energy term in the robot dynamics,which drives the vehicle downhill,and several positioning errors due to vibrations and slippage of the Mecanum wheel.To address these challenges,this work presents an Active Disturbance Rejection Control(ADRC)-based framework designed to enable accurate tracking on inclined surfaces,despite the compounded effects of gravitational forces and slippage.Unlike conventional controllers,the proposed method requires minimal model knowledge while actively compensates for unknown dynamics and external disturbances in real time.A complete theoretical formulation is provided,supported by numerical simulations and comprehensive experimental validation.Results demonstrate that the ADRC structure significantly outperforms not only the traditional proportional-integral-derivative(PID)control but also a robust variant of PID combined with a Quasi-Sliding Mode control(PID-QSMC)strategy,achieving superior tracking.Notably,this study offers an important experimental validation of ADRC for Mecanum-wheeled robots operating on inclined surfaces.It contributes a practical and scalable solution to extend their operational capabilities beyond flat environments.展开更多
Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal b...Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.展开更多
To address the issue of disturbance compensation deviation in linear active disturbance rejection control(LADRC),a linear active disturbance rejection control method with reference to the integral chain model(LADRC-R)...To address the issue of disturbance compensation deviation in linear active disturbance rejection control(LADRC),a linear active disturbance rejection control method with reference to the integral chain model(LADRC-R)is proposed.By constructing an ideal control reference model,a dynamic correlation between output deviation and uncompensated disturbances is established,and a dual-loop compensation mechanism is designed.Based on theoretical analysis and frequency-domain characteristics of typical first/second-order systems,this method maintains the parameter-tuning advantages of LADRC while reducing disturbance effects by 50%and introducing no phase lag during low-frequency disturbance suppression.Simulations on second-order systems verify its robustness under parameter perturbations,gain mismatch,and complex disturbances,and an optimized design scheme for the deviation compensator is proposed to suppress discontinuous measurement noise interference.Finally,the engineering effectiveness of this method in precision motion control is validated on an electromagnetic suspension platform,providing a new approach to improving the control performance of LADRC in environments with uncertain disturbances.展开更多
文摘This study investigates prescribed-time position tracking control for electromagnetic satellite formations subject to model uncertainties and external disturbances.Using the Clohessy-Wiltshire equations as the relative motion dynamics model,a prescribed time output feedback control strategy is proposed.A prescribed-time extended state observer is designed to estimate the relative velocity and external disturbances.The disturbance estimates are then used as the feedforward component of the controller.Building on this framework,a novel prescribed-time active disturbance rejection control strategy for position tracking is developed via a backstepping control design.The convergence of the extended state observer and the stability of the closed-loop system are rigorously analyzed using Lyapunov stability theory.Numerical simulations are performed to validate the effectiveness of the proposed controller.
基金supported by the National Natural Science Foundation of China(62088101,62522307,62273045,U2341213)Beijing Nova Program(20230484481)。
文摘Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framework that jointly designs distributed observers and local controllers to ensure robust formation control in the presence of external disturbances and sensor malfunctions.Treating the spacecraft formation as a single interconnected system,each spacecraft constructs a distributed observer that estimates the overall system state by incorporating both its own measurements and the predicted control information shared among the spacecraft.Based on the observer estimates,a local control law is synthesized to maintain the desired formation.Rigorous theoretical analysis and numerical simulations demonstrate that the proposed integrated approach effectively guarantees formation stability and resilience against sensor failures and disturbances.
基金supported by the National Natural Science Foundation of China(Grant Nos.52222810 and 52178383).
文摘Dynamic disturbances with various frequencies could trigger different failure modes of deep excavations.Superimposed on this static stress are dynamic disturbances due to various dynamic vibrations,e.g.excavation blasting,blasting,tunnel boring machine(TBM)vibration,rockburst wave,earthquakes.Specifically,these dynamic sources are characterized by a wide range of wave frequencies f,resulting in differences in failure modes.A series of true-triaxial compression tests were conducted on granite to simulate the excavation-induced stress path in three-dimensional(3D)stresses.Subsequently,a dynamic disturbance with various frequencies was applied to a cuboid specimen,to reveal the behavior associated with brittle failure.The dynamic disturbance with frequencies f of 5 Hz,10 Hz,and 40 Hz generates less disturbed energy components in the granite together with higher peak strength.However,dynamic disturbances with f of 20 Hz and 30 Hz resulted in a lower peak strength;the peak strength of the rock increases sp albeit it decreases at first,then increases.This U-shaped phenomenon relates to the natural frequency of the granite under such stress conditions.Different rock lithologies consisting of diverse mineral composition,respond differently to each sensitive resonance frequency.Interestingly,the weak disturbance stress with a high frequency f and low amplitude A increases the ratio of crack damage to peak strength(scd/sp)in the granite.This leads to the inhibition of the expansion of the granite during the dynamic disturbance process.Multiple penetrating tensileeshear cracks appear in the s3-direction as the disturbance frequency f increases.
基金supported by the operating fund of Key Laboratory of Nuclear Power Systems and Equipment(Shanghai Jiao Tong University),Ministry of Education,China,the Natural Science Foundation of Shanghai Municipality(25ZR1402177)the National Natural Science Foundation of China(12105167)。
文摘Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.
基金supported by National Natural Science Foundation of China(Grant No.52404074)the National Key Research and Development Program(Fund for Young Scientists)(Grant No.2021YFC2900400)Postdoctoral Science Foundation of China(Grant No.2024M761706).
文摘This study investigated the effects of periodic high-frequency stress disturbances on the creep behavior of sandstone and analyzed the microstructural changes using nuclear magnetic resonance(NMR)technology.High-frequency disturbance creep experiments were conducted on sandstone under different disturbance frequencies,disturbance cycles and loading stresses,and the following findings were obtained.Firstly,with the increase of loading stress and disturbance cycles,the total porosity increments,and damage value of sandstone increase,while the fractal dimension of sandstone pore structure presents the opposite trend.Secondly,during the disturbance creep process,the volumes of all three types of pores increase,but the proportion of micropores(T_(2)<10 ms)decreases,while the proportion of mesopores(10 ms<T_(2)<100 ms)and macropores(T_(2)>100 ms)increases.Thirdly,the fractal dimension difference has a good linear relationship with the damage,strain and porosity increment of sandstone during the disturbance creep process.Finally,the higher the disturbance frequency,the smaller the creep strain and creep strain rate during the steady-state creep stage.The study offers valuable theoretical insights for understanding rock creep behavior in complex stress environments.
基金funded by National Key Research and Development Program Projects of China under Grant No.2020YFB1713500.
文摘To address the issue that hybrid flow shop production struggles to handle order disturbance events,a dynamic scheduling model was constructed.The model takes minimizing the maximum makespan,delivery time deviation,and scheme deviation degree as the optimization objectives.An adaptive dynamic scheduling strategy based on the degree of order disturbance is proposed.An improved multi-objective Grey Wolf(IMOGWO)optimization algorithm is designed by combining the“job-machine”two-layer encoding strategy,the timing-driven two-stage decoding strategy,the opposition-based learning initialization population strategy,the POX crossover strategy,the dualoperation dynamic mutation strategy,and the variable neighborhood search strategy for problem solving.A variety of test cases with different scales were designed,and ablation experiments were conducted to verify the effectiveness of the improved strategies.The results show that each improved strategy can effectively enhance the performance of the IMOGWO.Additionally,performance analysis was conducted by comparing the proposed algorithm with three mature and classical algorithms.The results demonstrate that the proposed algorithm exhibits superior performance in solving the hybrid flow-shop scheduling problem(HFSP).Case validations were conducted for different types of order disturbance scenarios.The results demonstrate that the proposed adaptive dynamic scheduling strategy and the IMOGWO algorithm can effectively address order disturbance events.They enable rapid response to order disturbance while ensuring the stability of the production system.
基金support held by JPA,Collaborative Network Award BRAVEinMS,Grant/Award Number:PA-1604-08492(MG)from the Multiple Sclerosis Society of Canada,Grant/Award Number:1038154(to TEK).
文摘Myelin,made by oligodendrocytes(OLs)in the central nervous system(CNS),is essential for neural transmission.In particular,myelin facilitates communication across the long connections between different brain regions that form the white matter.Myelinated segments also provide metabolic intermediates to axons,supporting their demanding energetic needs.Genetic disorders that disrupt myelin formation result in progressive neurologic degeneration.
基金supported by the National Key R&D Program of China(No.2021YFB2011300)the Special Funds Project for the Transformation of Scientific and Technological Achievements of Jiangsu Province,China(No.BA2023039)+1 种基金the National Natural Science Foundation of China(No.52075262)the Fundamental Research Funds for the Central Universities,China(No.30922010706).
文摘The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.
基金supported by the National Natural Science Foundation of China(42030508)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0301)the Key technology research and development projects in Xizang Autonomous Regions(XZ202101ZY0005G).
文摘A better understanding of the structure and dynamics of disturbed forests is key for forecasting their future successional trajectories.Despite vulnerability of subalpine forests to warming climate,little is known as to how their community composition has responded to disturbances and climate warming over decades.Before the 1970s,subalpine forests on the southeastern Qinghai-Tibet Plateau mainly experienced logging and fire,but afterwards they were more impacted by climate warming.Thus,they provide an excellent setting to test whether disturbances and climate warming led to changes in forest structure.Based on the analysis of 3145 forest inventory plots at 4-to 5-year resolution,we found that spruce-fir forests shifted to pine and broadleaved forests since the early 1970s.Such a turnover in species composition mainly occurred in the 1994e1998 period.By strongly altering site conditions,disturbances in concert with climate warming reshuffle community composition to warm-adapted broadleaf-pine species.Thus,moderate disturbances shifted forest composition through a gradual loss of resilience of spruce-fir forests.Shifts in these foundation species will have profound impacts on ecosystem functions and services.In the future,broadleaved forests could expand more rapidly than evergreen needle-leaved forests under moderate warming scenarios.In addition to climate,the effects of anthropogenic disturbances on subalpine forests should be considered in adaptive forest management and in projections of future forest changes.
基金supported by the National Key Research and Development Program of China(Nos.2023YFC2809304 and 2022YFC2805904).
文摘Obtaining high-quality 10000-meter-deep seafloor sediment samples is the prerequisite and foundation for conducting deep-sea geological and environmental scientific research.The bottom structure of the deep seafloor is complex,and the physical and mechanical properties and disturbance resistance of sediments of different lithologies vary greatly,so the sediment sampler inevitably disturbs the sediments during the sampling process and affects the quality of the sediment samples.A new type of deep-sea sediment pressure retaining sampler is introduced,the force state and elastic–plastic state of the sampler destroying sediments are analyzed,the radial disturbance model of sediment coring based on the spherical cavity expansion theory is established,and the radius of sediments undergoing plastic deformation around the spherical holes is used as an index for evaluating the radial disturbance of sediments.The distribution of stress and strain fields in the sediments during the expansion of the spherical cavity and the influencing factors of the radius of the radially disturbed region(plastic region)are analyzed using an arithmetic example,and the influence law is analyzed.A sediment disturbance experimental platform was built indoors to simulate the sediment coring process.The radial stress field and pore water pressure of the sediment during the coring process were monitored by sensors arranged inside the sediment,and the results of indoor tests verified the correctness of the perturbation theory model.The sampler was carried aboard the deep-sea manned submersible FENDOUZHE and conducted on-site tests at depths of 9298.4 and 9142.8 m in the Kuril-Kamchatka Trench.Pressure-preserved sediment samples were retrieved,with preservation rates of 94.21%and 92.02%,respectively,which are much higher than the current technical indicator of 80%of pressure-holding ratio for deep-sea sediments.The retrieved sediments have obvious stratification characteristics and little disturbance.
文摘Aircraft disturbs the adjacent atmospheric environment in flight,forming spatial distribution features of atmospheric density that differ from the natural background,which may potentially be utilized as tracer characteristics to introduce new technologies for indirectly sensing the presence of aircraft.In this paper,the concept of a long-range aircraft detection based on the atmospheric disturbance density field is proposed,and the detection mode of tomographic imaging of the scattering light of an atmospheric disturbance flow field is designed.By modeling the spatial distribution of the disturbance density field,the scattered echo signal images of active light towards the disturbance field at long distance are simulated.On this basis,the characteristics of the disturbance optical signal at the optimal detection resolution are analyzed.The results show that the atmospheric disturbance flow field of the supersonic aircraft presents circular in the light-scattering echo images.The disturbance signal can be further highlighted by differential processing of the adjacent scattering images.As the distance behind the aircraft increases,the diffusion range of the disturbance signal increases,and the signal intensity and contrast with the background decrease.Under the ground-based observation conditions of the aircraft at a height of 10000 m,a Mach number of1.6,and a detection distance of 100 km,the contrast between the disturbance signal and the back-ground was 30 d B at a distance of one time from the rear of the fuselage,and the diffusion diameter of the disturbance signal was 50 m.At a distance eight times the length of the aircraft,the contrast decreased to 10 dB,and the diameter increased to 290 m.The contrast was reduced to 3 dB at a distance nine times the length of the aircraft,and the diameter was diffused to 310 m.These results indicate the possibility of long-range aircraft detection based on the characteristics of the atmospheric density field.
基金Supported by the Shaanxi Provincial Key Research and Development Plan Project,No.2020ZDLSF01-02.
文摘BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.
基金co-supported by the National Key R&D Program of China(No.2023YFB4704400)the Zhejiang Provincial Natural Science Foundation of China(No.LQ24F030012)the National Natural Science Foundation of China General Project(No.62373033)。
文摘A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
基金supported by the National Natural Science Foundation of China(Nos.52177059 and 52407064).
文摘Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.
基金jointly supported by the National Natural Science Foundation of China [grant number 42265012]the Funding by the Fengyun Application Pioneering Project [grant number FY-APP-ZX-2022.0221]。
文摘Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of forests.At the same time,detailed accounts of disturbances and forest responses are not yet well quantified in Asia.This study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast Asia.This approach allowed us to detect forest disturbance and quantify the resilience after disturbance.Results showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by disturbances.Specifically,95%of forests had robust resilience and could recover from disturbance within a few decades.The resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance magnitude.In summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two decades.The authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in 2022.The findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.
基金supported by the National Natural Science Foundation of China(No.12332023)the Zhejiang Provincial Natural Science Foundation of China(No.LY23E050010).
文摘1Introduction To date,in model-based gait-planning methods,the dynamics of the center of mass(COM)of bipedal robots have been analyzed by establishing their linear inverted pendulum model(LIPM)or extended forms(Owaki et al.,2010;Englsberger et al.,2015;Xie et al.,2020).With regard to model-based gait-generation methods for uphill and downhill terrain,Kuo(2007)simulated human gait using an inverted pendulum,which provided a circular trajectory for the COM rather than a horizontal trajectory.He found that a horizontal COM trajectory consumed more muscle energy.Massah et al.(2012)utilized a 3D LIPM and the concept of zero moment point(ZMP).They developed a trajectory planner using the semi-elliptical motion equations of an NAO humanoid robot and simulated walking on various sloped terrains using the Webots platform.
文摘The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scenarios.In this context,two critical issues emerge:the gravitational pull caused by adding a potential energy term in the robot dynamics,which drives the vehicle downhill,and several positioning errors due to vibrations and slippage of the Mecanum wheel.To address these challenges,this work presents an Active Disturbance Rejection Control(ADRC)-based framework designed to enable accurate tracking on inclined surfaces,despite the compounded effects of gravitational forces and slippage.Unlike conventional controllers,the proposed method requires minimal model knowledge while actively compensates for unknown dynamics and external disturbances in real time.A complete theoretical formulation is provided,supported by numerical simulations and comprehensive experimental validation.Results demonstrate that the ADRC structure significantly outperforms not only the traditional proportional-integral-derivative(PID)control but also a robust variant of PID combined with a Quasi-Sliding Mode control(PID-QSMC)strategy,achieving superior tracking.Notably,this study offers an important experimental validation of ADRC for Mecanum-wheeled robots operating on inclined surfaces.It contributes a practical and scalable solution to extend their operational capabilities beyond flat environments.
基金supported by grants from Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA22096018(to JY)Guangxi Key Research and Development Program,No.AB22080053(to DD)+6 种基金Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA23023004(to MZ)the National Natural Science Foundation of China,Nos.82260021(to MZ),82060315(to DD)the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2021GXNSFBA220007(to GD)Clinical Research Center For Medical Imaging in Hunan Province,No.2020SK4001(to JL)Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection in Hunan Province,No.2020SK3006(to JL)Science and Technology Innovation Program of Hunan Province,No.2021RC4016(to JL)Key Project of the Natural Science Foundation of Hunan Province,No.2024JJ3041(to JL).
文摘Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.
基金supported by the National Natural Science Foundation of China(Nos.62063009,52262050)the National Key Research and Development Program during the 14th 5-Year Plan(No.2023YFB4302100)the Major Science and Technology Research and Development Special Project in Jiangxi Province(No.20232ACE01011).
文摘To address the issue of disturbance compensation deviation in linear active disturbance rejection control(LADRC),a linear active disturbance rejection control method with reference to the integral chain model(LADRC-R)is proposed.By constructing an ideal control reference model,a dynamic correlation between output deviation and uncompensated disturbances is established,and a dual-loop compensation mechanism is designed.Based on theoretical analysis and frequency-domain characteristics of typical first/second-order systems,this method maintains the parameter-tuning advantages of LADRC while reducing disturbance effects by 50%and introducing no phase lag during low-frequency disturbance suppression.Simulations on second-order systems verify its robustness under parameter perturbations,gain mismatch,and complex disturbances,and an optimized design scheme for the deviation compensator is proposed to suppress discontinuous measurement noise interference.Finally,the engineering effectiveness of this method in precision motion control is validated on an electromagnetic suspension platform,providing a new approach to improving the control performance of LADRC in environments with uncertain disturbances.
