Blood alcohol concentration (BAC) differs greatly among individuals, even when people of the same sex and age drink alcohol under the same drinking conditions. In this study, we investigated the main factors involved ...Blood alcohol concentration (BAC) differs greatly among individuals, even when people of the same sex and age drink alcohol under the same drinking conditions. In this study, we investigated the main factors involved in the internal reg-ulation of individual differences in BAC, focusing on the alcohol dehydrogenase 1B (ADH1B) genotype, blood acetal-dehyde concentration (BAcH), amount of habitual alcohol consumption, pharmacokinetic parameters of BAC, distribution volume of ethanol (Vd), and gastric emptying rate (GER) under the same drinking conditions. Twenty healthy Japanese males aged between 40 and 59 years old and having the aldehyde dehydrogenase 2 (ALDH2) genotype of ALDH 2*1/*2 were recruited for this study. The subjects were given 0.32 g ethanol/kg body weight in the form of commercially available beer (5%, v/v). The results showed that BAC-max differed greatly among individuals with a more than two-fold variation. When the BAC-time curve was compared among ADH1B genotypes (ADH1B*1/*1, *1/*2, and *2/*2), there were no differences in BAC among the genotypes. Although BAcH, monthly alcohol consumption, elimination rate of blood ethanol (β value) and ethanol disappearance rate from the body (EDR) can affect BAC, all of them had no correlations with BAC-max. However, Vd (liter/kg), ΔPlasma glucose concentration (ΔPGC = PGC30 min ? PGC0 min) and the serum concentration of gastric inhibitory polypeptide (GIP) did correlate with BAC-max. Model 2 in multiple linear regression analysis showed the optimal model for Vd and GIP with positive correlations with BAC-max. As GIP and ΔPGC are both reflected by gastric emptying rate (GER), we concluded that the individual differences in BAC after moderate drinking are mainly regulated by GER together with Vd. These findings demonstrate that together with body water content, the gastrointestinal tract plays an important role in the regulation of individual differences in BAC, involving first pass metabolism of ethanol.展开更多
Rubber-like materials that are commonly used in structural applications are modelled using hyperelastic material models.Most of the hyperelastic materials are nearly incompressible,which poses challenges,i.e.,volumetr...Rubber-like materials that are commonly used in structural applications are modelled using hyperelastic material models.Most of the hyperelastic materials are nearly incompressible,which poses challenges,i.e.,volumetric locking during numerical modelling.There exist many formulations in the context of the finite element method,among which the mixed displacementpressure formulation is robust.However,such a displacement-pressure formulation is less explored in meshfree methods,which mitigates the problem associated with mesh distortion during large deformation.This work addresses this issue of alleviating volumetric locking in the element-free Galerkin method(EFGM),which is one of the popular meshfree methods.A two-field mixed variational formulation using the perturbed Lagrangian approach within the EFGM framework is proposed for modelling nearly incompressible hyperelastic material models,such as Neo-Hookean and Mooney-Rivlin.Taking advantage of the meshless nature of the EFGM,this work introduces a unique approach by randomly distributing pressure nodes across the geometry,following specific guidelines.A wide spectrum of problems involving bending,tension,compression,and contact is solved using two approaches of the proposed displacement-pressure node formulation involving regular and irregular pressure node distribution.It is observed that both approaches give accurate results compared to the reference results,though the latter offers flexibility in the pressure nodal distribution.展开更多
Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in a...Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in alpine mountains with climate change.Hence,94 samples of river water were collected from 2018 to 2020 in the headwaters of the Shule River Basin to assess the nutrients spatiotemporal distribution and combined ap-proach of water quality index to assess water quality and potential sources.The findings depict that high nutrient concentrations were found to coincide with snowmelt and glacial meltwater and rainfall recharge periods,while total flux peaked from June to September due to increased runoff.Notably,total nitrogen(TN)concentrations were significantly higher near the town,primarily attributed to the replenishment of nitrate(NO_(3)^(‒)-N)from live-stock manure.The high total P(TP)was near the glacier,which was attributed to the transportation of glacial sediments into the river,and pH was another critical factor.N was the primary nutrient limiting factor for the growth of phytoplankton in river water.Although the migration and transport of nutrients have altered with climate change,river water quality is good in alpine mountains based on an overall evaluation.These findings contribute to enriching nutrient datasets and highlight the importance of water resource management and water quality assessment in sensitive and fragile alpine mountains.展开更多
Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the...Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the coordination with virtual power plants(VPPs).The proposed strategy improves systemflexibility and responsiveness by optimizing the power adjustment of flexible resources.In the proposed strategy,theGaussian Process Regression(GPR)is firstly employed to determine the adjustable range of aggregated power within the VPP,facilitating an assessment of its potential contribution to power supply support.Then,an optimal dispatch model based on a leader-follower game is developed to maximize the benefits of the VPP and flexible resources while guaranteeing the power balance at the same time.To solve the proposed optimal dispatch model efficiently,the constraints of the problem are reformulated and resolved using the Karush-Kuhn-Tucker(KKT)optimality conditions and linear programming duality theorem.The effectiveness of the strategy is illustrated through a detailed case study.展开更多
A novel hood structure has been designed for the dust control system in the foundry in order to improve the working environment. A composite strategy has been applied for comparative analysis of the optimal venting vo...A novel hood structure has been designed for the dust control system in the foundry in order to improve the working environment. A composite strategy has been applied for comparative analysis of the optimal venting volume and the airflow distribution between the conventional hood and the novel one in this study. A Computational Fluid Dynamic (CFD) method is used to simulate the airflow fields and dust-polluted air moving paths. The CFD results show that a two-outlet hood, with one outlet located on the left of the hood, is better for improving dust-polluted air than the hood with one outlet only. It can be concluded that the number of the outlets as well as their location on the hood has a significant influence on the air flow pattern in the hood. The optimal venting volume is also a major consideration that is discussed in the study. The venting volume should be designed by considering both the effective level of air flow velocity around the dust source and the energy saving. The optimal airflow distribution may reduce the turbulence in the hood system.展开更多
Ionic strength conditions in distribution experiments with single ions are very important for evaluating their distribution properties. Distribution experiments of picrates (MPic) with M = Ag(I) and Li(I)-Cs(I) into o...Ionic strength conditions in distribution experiments with single ions are very important for evaluating their distribution properties. Distribution experiments of picrates (MPic) with M = Ag(I) and Li(I)-Cs(I) into o-dichlorobenzene (oDCBz) were performed at 298 K by changing volume ratios (Vorg/V) between water and oDCBz phases, where “org” shows an organic phase. Simultaneously, an analytic equation with the Vorg/V variation was derived in order to analyze such distribution systems. Additionally, the AgPic distribution into nitrobenzene (NB), dichloromethane, and 1,2-dichloroethene (DCE) and the NaB(C6H5) 4 (=NaBPh4) one into NB and DCE were studied at 298 K under the conditions of various Vorg/V values. So, extraction constants (Kex) for MPic into the org phases, their ion-pair formation constants (KMA,org) for MA = MPic in the org ones, and standard distribution constants () for the M(I) transfers between the water and org bulk phases with M = Ag and Li-Cs were determined at the distribution equilibrium potential (dep) of zero V between the bulk phases and also the Kex (NaA), KNaA,org, and values were done at A-=BPh-4. Here, the symbols Kex, KMA,org, and or were defined as [MA] org/[M+][A-], [MA] org/[M+]org [A-]org, and [M+]org/[M+] or [A-]org/[A-] at dep = 0, respectively. Especially, the ionic strength dependences of Kex and KMPic,org were examined at M = Li(I)-K(I) and org = oDCBz. From above, the conditional distribution constants, KD,BPh4 and KD,Cs, were classified by checking the experimental conditions of the I, Iorg, and dep values.展开更多
The apparent volume of distribution was defined for the first time as the phase volume that can hold the total amount of a substance at the measured phase substance concentration, in a system composed of two immiscibl...The apparent volume of distribution was defined for the first time as the phase volume that can hold the total amount of a substance at the measured phase substance concentration, in a system composed of two immiscible media that are in contact under conditions of constant phase volumes, at equilibrium. Its value is not affected by the total system solute mass and it only depends on the total system volume, the phase volumes and the affinity of the solute for the two phases in the system. Using this new concept of the apparent volume of distribution, we were able to demonstrate that under certain conditions compartment volumes in multi-compartment and multi-phasic pharmacokinetic models represent the actual physiological volumes of body fluids accessible by drugs. The classical pharmacokinetic models are now fully explained and can be used to provide accurate estimation of the pharmacokinetic parameters for hydrophilic drugs. In contrast, in the absence of tissue-plasma partition coefficients, lipophilic drugs that do not follow a one-compartment model are unlikely to be adequately described with classical multi-compartment pharmacokinetic models.展开更多
Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral ro...Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral routes of administration in an open two-compartment model. In a novel way, the apparent volume of distribution was estimated from a two-compartment model and found to be close to the total body water suggesting that Prazosin is distributed in all tissues both extracellularly and intracellularly. In addition, extracting the value of the apparent volume of distribution from a two-compartment model allowed comparative simulations in the one-compartment model. It is shown that dosage calculations of Prazosin intermittent infusion can be safely performed using the simpler one-compartment model equations. Lastly, several additional time-dependent pharmacokinetic parameters e.g., the peak time in the central and peripheral compartment and non-steady state and steady state peak concentration and AUC were determined using series equations for all three routes of administration, as a function of dose number and total time upon multiple drug administrations in the two-compartment model. It is also the first time that steady-state plasma drug concentration equations were derived in a two-compartment mammillary model.展开更多
This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the ...This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the mean oil volume fraction is up to 23.1%. A sensitivity coefficient back-projection (SBP) algorithm was adopted to reconstruct the flow distributions and a cross correlation method was applied to obtain the oil velocity distributions. The oil volume fraction and velocity distributions obtained from both measurement techniques were compared and good agreement was found, which indicates that the ERT tech- nique can be used to measure the low fraction oil-water flows. Finally, the factors affecting measurement precision were discussed.展开更多
Given the steady increase in use of alternative energy sources to supply part of the energy demand of the world, and considering that Mexico has enough wind resources to produce all the electricity required by the cou...Given the steady increase in use of alternative energy sources to supply part of the energy demand of the world, and considering that Mexico has enough wind resources to produce all the electricity required by the country, in this work, it is carried out the development of a system of wind resource assessment to determine the volume of water that a windmill pumping system can provide in a specific area. To this end, it has developed a computer program for wind resource assessment by measurements of wind speed, direction, temperature, barometric pressure and relative humidity. Measuring equipments were mounted in a wind measurement tower of 10 m high, within the premises of the University of Quintana Roo which is located along the coast. Until this day, there are records over a period of five months of the variables of wind speed, wind direction, temperature, relative humidity and atmospheric pressure. These variables were used for statistical calculations using the Weibull distributions. To give a better use of the calculated data, they were applied to the evaluation of a Pumping System.展开更多
In this paper,a large-scale experimental system was established to identify the migration and distribution laws of complex fracture proppant in shale reservoir volume fracturing.With this system,the effects of seconda...In this paper,a large-scale experimental system was established to identify the migration and distribution laws of complex fracture proppant in shale reservoir volume fracturing.With this system,the effects of secondary fracture angle,fluid displacement,proppant concentration and size,fracturing fluid viscosity and other factors on the migration and distribution of proppant were tested,and the migration and distribution of proppant in primary/secondary fractures were analyzed.The following results were obtained.First,the fluid flow pattern in fractures transforms gradually from laminar flow into turbulent flow with the increase of fracture supporting height.Second,the migration modes of proppant in fractures mainly include suspended migration and gliding migration.Third,the distribution form of proppant in primary fractures before branching is related to secondary fracture angle,fluid displacement and proppant concentration and size,among which the fluid displacement is the most important factor.Fourth,the mass ratio of proppant in primary fractures after branching is proportional to the secondary fracture angle,fluid displacement,fracturing fluid viscosity and proppant concentration and size,and is inversely proportional to the flow ratio between secondary fractures and primary fractures.Fifth,the mass ratio of proppant in secondary fractures after branching is proportional to fluid displacement,fracturing fluid viscosity and flow ratio between secondary fractures and primary fractures,and is inversely proportional to secondary fracture angle and proppant concentration and size.Sixth,the angle at the leading edge of proppant bank in the primary fractures after branching is proportional to the proppant concentration and size and the flow ratio between secondary fractures and primary fractures,but is inversely proportional to secondary fracture angle,fluid displacement and fracturing fluid viscosity.Seventh,the angle at the leading edge of proppant bank in the secondary fractures after branching is proportional to the secondary fracture angle and the proppant concentration and size,but is inversely proportional to the fluid displacement,fracturing fluid viscosity and flow ratio between secondary fractures and primary fractures.In conclusion,the research results can provide a theoretical support for proppant optimization and program design of shale reservoir volume fracturing.展开更多
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin a...The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.展开更多
We investigated the distribution and frequency of damage to tree stands adjacent to low-volume roads according to the type of hillside materials involved（soil or rock） and hillside gradient in mountainous forests of...We investigated the distribution and frequency of damage to tree stands adjacent to low-volume roads according to the type of hillside materials involved（soil or rock） and hillside gradient in mountainous forests of northern Iran. A total of 80 plots were systematically and randomly sampled to record damaged trees（bending,crushing and wounding） by class of hillside gradient and materials at the edge of road. Tree wounding and crushing at rock slopes was significantly greater than at hillsides with a mix of clay soil（p ／ 0.05）. Damage on hillsides with slope gradients[45% were 2, 8.5 and 2.3 times more frequent than on hillsides with slope gradient／15% for bending, crushing and wounding, respectively. The damage distribution varied according by type and the most frequent damage was tree wounding（p ／ 0.05）. The damage distribution was measured at distances of 4, 5 and 8 m from the road fillslope for tree bending, crushing and wounding, respectively. Using hydraulic excavators and physical barriers（wooden obstruction and synthetic holder） during earthworks for road construction could reduce these damage.展开更多
A method for packing irregular particles with a prescribed volume fraction is proposed.Furthermore,the generated granular material adheres to the prescribed statistical distribution and satisfies the desired complex s...A method for packing irregular particles with a prescribed volume fraction is proposed.Furthermore,the generated granular material adheres to the prescribed statistical distribution and satisfies the desired complex spatial arrangement.First,the irregular geometries of the realistic particles were obtained from the original particle images.Second,the Minkowski sum was used to check the overlap between irregular particles and place an irregular particle in contact with other particles.Third,the optimised advance front method(OAFM)generated irregular particle packing with the prescribed statistical dis-tribution and volume fraction based on the Minkowski sum.Moreover,the signed distance function was introduced to pack the particles in accordance with the desired spatial arrangement.Finally,seven biaxial tests were performed using the UDEC software,which demonstrated the accuracy and potential usefulness of the proposed method.It can model granular material efficiently and reflect the meso-structural characteristics of complex granular materials.This method has a wide range of applications where discrete modelling of granular media is necessary.展开更多
The storage, longitudinal distribution and recruitment processes of in-stream large wood (LW) were studied comparing channel segments draining four Chilean mountain catchments with different land use. The segments wer...The storage, longitudinal distribution and recruitment processes of in-stream large wood (LW) were studied comparing channel segments draining four Chilean mountain catchments with different land use. The segments were divided into relatively uniform reaches of different lengths and surveyed for LW (piece dimensions, position in the channel, orientation to flow and aggregation) and stream morphology (slope and bank full channel width and depth) characterizations. LW volume stored in the Pichun, El Toro and Vuelta de Zorra study channels are within the range informed in international researches from streams draining catchments with similar forest covers. However, the 1057 m3/ha of LW stored in Tres Arroyos is extremely high and in the same order of magnitude than the reports from old-growth forests in the Pacific Northwest of USA. The size of the area that can potentially provide wood to streams depends on the wood supply mechanisms within any catchment, and the LW stored in the study segments increases as the size of this area increases. This study aims to contribute to the knowledge on the effects of LW in mountain channels, gathering new information and expanding investigations developed in Chile since 2008. This research was carried out within the framework of Project FONDECYT 11106209.展开更多
This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de...This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.展开更多
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci...The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.展开更多
As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limite...As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric pollutants.To address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May 2022.The monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station data.Temporally,there were pronounced seasonal variations in air pollutants.Spatially,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial emissions.The study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in summer.In spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two rings.This study offers data support for formulating the next phase of air pollution control measures in urban areas.展开更多
The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality d...The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality deterioration and posing a risk to public health.An in-situ scanning vibrating electrode technique(SVET)with micron-scale resolution,microscopic scale detection and water quality analysis were used to investigate the corrosion behavior and metal release from DPs throughout the whole CML failure process.Metal pollutants release occurred at three different stages of CML failure process,and there are potential risks of water quality deterioration exceeding the maximum allowable levels set by national standards in the partial failure stage and lining peeling stage.Furthermore,the effects of water chemistry(Cl^(−),SO_(4)^(2−),NO_(3)−,and Ca^(2+))on corrosion scale growth and iron release activity,were investigated during the CML partial failure stage.Results showed that the CML failure process in DPs was accelerated by the autocatalysis of localized corrosion.Cl^(−)was found to damage the uncorroded metal surface,while SO_(4)^(2−)mainly dissolved the corrosion scale surface,increasing iron release.Both the oxidation of NO_(3)−and selective sedimentation of Ca2+were found to enhance the stability of corrosion scales and inhibit iron release.展开更多
Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution character...Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries.展开更多
文摘Blood alcohol concentration (BAC) differs greatly among individuals, even when people of the same sex and age drink alcohol under the same drinking conditions. In this study, we investigated the main factors involved in the internal reg-ulation of individual differences in BAC, focusing on the alcohol dehydrogenase 1B (ADH1B) genotype, blood acetal-dehyde concentration (BAcH), amount of habitual alcohol consumption, pharmacokinetic parameters of BAC, distribution volume of ethanol (Vd), and gastric emptying rate (GER) under the same drinking conditions. Twenty healthy Japanese males aged between 40 and 59 years old and having the aldehyde dehydrogenase 2 (ALDH2) genotype of ALDH 2*1/*2 were recruited for this study. The subjects were given 0.32 g ethanol/kg body weight in the form of commercially available beer (5%, v/v). The results showed that BAC-max differed greatly among individuals with a more than two-fold variation. When the BAC-time curve was compared among ADH1B genotypes (ADH1B*1/*1, *1/*2, and *2/*2), there were no differences in BAC among the genotypes. Although BAcH, monthly alcohol consumption, elimination rate of blood ethanol (β value) and ethanol disappearance rate from the body (EDR) can affect BAC, all of them had no correlations with BAC-max. However, Vd (liter/kg), ΔPlasma glucose concentration (ΔPGC = PGC30 min ? PGC0 min) and the serum concentration of gastric inhibitory polypeptide (GIP) did correlate with BAC-max. Model 2 in multiple linear regression analysis showed the optimal model for Vd and GIP with positive correlations with BAC-max. As GIP and ΔPGC are both reflected by gastric emptying rate (GER), we concluded that the individual differences in BAC after moderate drinking are mainly regulated by GER together with Vd. These findings demonstrate that together with body water content, the gastrointestinal tract plays an important role in the regulation of individual differences in BAC, involving first pass metabolism of ethanol.
基金supported by the DST-SERB and VSSC,ISRO of the project titled“Functionality Enhancement through Design and Development of Advanced Finite Element Algorithms for STR tools”under IMPRINT.IIC(IMP/2019/000276)scheme.
文摘Rubber-like materials that are commonly used in structural applications are modelled using hyperelastic material models.Most of the hyperelastic materials are nearly incompressible,which poses challenges,i.e.,volumetric locking during numerical modelling.There exist many formulations in the context of the finite element method,among which the mixed displacementpressure formulation is robust.However,such a displacement-pressure formulation is less explored in meshfree methods,which mitigates the problem associated with mesh distortion during large deformation.This work addresses this issue of alleviating volumetric locking in the element-free Galerkin method(EFGM),which is one of the popular meshfree methods.A two-field mixed variational formulation using the perturbed Lagrangian approach within the EFGM framework is proposed for modelling nearly incompressible hyperelastic material models,such as Neo-Hookean and Mooney-Rivlin.Taking advantage of the meshless nature of the EFGM,this work introduces a unique approach by randomly distributing pressure nodes across the geometry,following specific guidelines.A wide spectrum of problems involving bending,tension,compression,and contact is solved using two approaches of the proposed displacement-pressure node formulation involving regular and irregular pressure node distribution.It is observed that both approaches give accurate results compared to the reference results,though the latter offers flexibility in the pressure nodal distribution.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(No.2019QZKK0208)the National Natural Science Foundation of China(Nos.42171148 and 42330512)the Key R&D Project from the Science and Technology Department of Tibet(No.XZ202501ZY0030).
文摘Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in alpine mountains with climate change.Hence,94 samples of river water were collected from 2018 to 2020 in the headwaters of the Shule River Basin to assess the nutrients spatiotemporal distribution and combined ap-proach of water quality index to assess water quality and potential sources.The findings depict that high nutrient concentrations were found to coincide with snowmelt and glacial meltwater and rainfall recharge periods,while total flux peaked from June to September due to increased runoff.Notably,total nitrogen(TN)concentrations were significantly higher near the town,primarily attributed to the replenishment of nitrate(NO_(3)^(‒)-N)from live-stock manure.The high total P(TP)was near the glacier,which was attributed to the transportation of glacial sediments into the river,and pH was another critical factor.N was the primary nutrient limiting factor for the growth of phytoplankton in river water.Although the migration and transport of nutrients have altered with climate change,river water quality is good in alpine mountains based on an overall evaluation.These findings contribute to enriching nutrient datasets and highlight the importance of water resource management and water quality assessment in sensitive and fragile alpine mountains.
基金supported by the Science and Technology Project of Sichuan Electric Power Company“Power Supply Guarantee Strategy for Urban Distribution Networks Considering Coordination with Virtual Power Plant during Extreme Weather Event”(No.521920230003).
文摘Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the coordination with virtual power plants(VPPs).The proposed strategy improves systemflexibility and responsiveness by optimizing the power adjustment of flexible resources.In the proposed strategy,theGaussian Process Regression(GPR)is firstly employed to determine the adjustable range of aggregated power within the VPP,facilitating an assessment of its potential contribution to power supply support.Then,an optimal dispatch model based on a leader-follower game is developed to maximize the benefits of the VPP and flexible resources while guaranteeing the power balance at the same time.To solve the proposed optimal dispatch model efficiently,the constraints of the problem are reformulated and resolved using the Karush-Kuhn-Tucker(KKT)optimality conditions and linear programming duality theorem.The effectiveness of the strategy is illustrated through a detailed case study.
基金supported by the Shanghai Leading Academic Discipline Project(B604)the Henan Science and Technology Breakthrough Major Project(102102210440)+1 种基金the High School Funding Scheme for Key Young Teachersthe Education Department of Henan Province,2010
文摘A novel hood structure has been designed for the dust control system in the foundry in order to improve the working environment. A composite strategy has been applied for comparative analysis of the optimal venting volume and the airflow distribution between the conventional hood and the novel one in this study. A Computational Fluid Dynamic (CFD) method is used to simulate the airflow fields and dust-polluted air moving paths. The CFD results show that a two-outlet hood, with one outlet located on the left of the hood, is better for improving dust-polluted air than the hood with one outlet only. It can be concluded that the number of the outlets as well as their location on the hood has a significant influence on the air flow pattern in the hood. The optimal venting volume is also a major consideration that is discussed in the study. The venting volume should be designed by considering both the effective level of air flow velocity around the dust source and the energy saving. The optimal airflow distribution may reduce the turbulence in the hood system.
文摘Ionic strength conditions in distribution experiments with single ions are very important for evaluating their distribution properties. Distribution experiments of picrates (MPic) with M = Ag(I) and Li(I)-Cs(I) into o-dichlorobenzene (oDCBz) were performed at 298 K by changing volume ratios (Vorg/V) between water and oDCBz phases, where “org” shows an organic phase. Simultaneously, an analytic equation with the Vorg/V variation was derived in order to analyze such distribution systems. Additionally, the AgPic distribution into nitrobenzene (NB), dichloromethane, and 1,2-dichloroethene (DCE) and the NaB(C6H5) 4 (=NaBPh4) one into NB and DCE were studied at 298 K under the conditions of various Vorg/V values. So, extraction constants (Kex) for MPic into the org phases, their ion-pair formation constants (KMA,org) for MA = MPic in the org ones, and standard distribution constants () for the M(I) transfers between the water and org bulk phases with M = Ag and Li-Cs were determined at the distribution equilibrium potential (dep) of zero V between the bulk phases and also the Kex (NaA), KNaA,org, and values were done at A-=BPh-4. Here, the symbols Kex, KMA,org, and or were defined as [MA] org/[M+][A-], [MA] org/[M+]org [A-]org, and [M+]org/[M+] or [A-]org/[A-] at dep = 0, respectively. Especially, the ionic strength dependences of Kex and KMPic,org were examined at M = Li(I)-K(I) and org = oDCBz. From above, the conditional distribution constants, KD,BPh4 and KD,Cs, were classified by checking the experimental conditions of the I, Iorg, and dep values.
文摘The apparent volume of distribution was defined for the first time as the phase volume that can hold the total amount of a substance at the measured phase substance concentration, in a system composed of two immiscible media that are in contact under conditions of constant phase volumes, at equilibrium. Its value is not affected by the total system solute mass and it only depends on the total system volume, the phase volumes and the affinity of the solute for the two phases in the system. Using this new concept of the apparent volume of distribution, we were able to demonstrate that under certain conditions compartment volumes in multi-compartment and multi-phasic pharmacokinetic models represent the actual physiological volumes of body fluids accessible by drugs. The classical pharmacokinetic models are now fully explained and can be used to provide accurate estimation of the pharmacokinetic parameters for hydrophilic drugs. In contrast, in the absence of tissue-plasma partition coefficients, lipophilic drugs that do not follow a one-compartment model are unlikely to be adequately described with classical multi-compartment pharmacokinetic models.
文摘Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral routes of administration in an open two-compartment model. In a novel way, the apparent volume of distribution was estimated from a two-compartment model and found to be close to the total body water suggesting that Prazosin is distributed in all tissues both extracellularly and intracellularly. In addition, extracting the value of the apparent volume of distribution from a two-compartment model allowed comparative simulations in the one-compartment model. It is shown that dosage calculations of Prazosin intermittent infusion can be safely performed using the simpler one-compartment model equations. Lastly, several additional time-dependent pharmacokinetic parameters e.g., the peak time in the central and peripheral compartment and non-steady state and steady state peak concentration and AUC were determined using series equations for all three routes of administration, as a function of dose number and total time upon multiple drug administrations in the two-compartment model. It is also the first time that steady-state plasma drug concentration equations were derived in a two-compartment mammillary model.
基金Project (No. 15933) supported by the Royal Society-Chinese Acad-emy of Sciences Joint Project
文摘This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the mean oil volume fraction is up to 23.1%. A sensitivity coefficient back-projection (SBP) algorithm was adopted to reconstruct the flow distributions and a cross correlation method was applied to obtain the oil velocity distributions. The oil volume fraction and velocity distributions obtained from both measurement techniques were compared and good agreement was found, which indicates that the ERT tech- nique can be used to measure the low fraction oil-water flows. Finally, the factors affecting measurement precision were discussed.
文摘Given the steady increase in use of alternative energy sources to supply part of the energy demand of the world, and considering that Mexico has enough wind resources to produce all the electricity required by the country, in this work, it is carried out the development of a system of wind resource assessment to determine the volume of water that a windmill pumping system can provide in a specific area. To this end, it has developed a computer program for wind resource assessment by measurements of wind speed, direction, temperature, barometric pressure and relative humidity. Measuring equipments were mounted in a wind measurement tower of 10 m high, within the premises of the University of Quintana Roo which is located along the coast. Until this day, there are records over a period of five months of the variables of wind speed, wind direction, temperature, relative humidity and atmospheric pressure. These variables were used for statistical calculations using the Weibull distributions. To give a better use of the calculated data, they were applied to the evaluation of a Pumping System.
基金supported by the Science Foundation for Young Scientists of National Natural Science Foundation of China,“Study on the Diversion and Distribution Mechanisms of Proppant for“Multi-Stage And Multi-Cluster”Fracturing by Shale Horizontal Well”(Grant No.51604050)the Chongqing Science and Technology Innovation Project for People's Livelihood,“Research&Development of Instruments for Evaluating the Migration and Distribution of Proppant for“Multi-Stage And Multi-Cluster”Fracturing by Shale Horizontal Well”(Grant No.cstc2016shmszx90003).
文摘In this paper,a large-scale experimental system was established to identify the migration and distribution laws of complex fracture proppant in shale reservoir volume fracturing.With this system,the effects of secondary fracture angle,fluid displacement,proppant concentration and size,fracturing fluid viscosity and other factors on the migration and distribution of proppant were tested,and the migration and distribution of proppant in primary/secondary fractures were analyzed.The following results were obtained.First,the fluid flow pattern in fractures transforms gradually from laminar flow into turbulent flow with the increase of fracture supporting height.Second,the migration modes of proppant in fractures mainly include suspended migration and gliding migration.Third,the distribution form of proppant in primary fractures before branching is related to secondary fracture angle,fluid displacement and proppant concentration and size,among which the fluid displacement is the most important factor.Fourth,the mass ratio of proppant in primary fractures after branching is proportional to the secondary fracture angle,fluid displacement,fracturing fluid viscosity and proppant concentration and size,and is inversely proportional to the flow ratio between secondary fractures and primary fractures.Fifth,the mass ratio of proppant in secondary fractures after branching is proportional to fluid displacement,fracturing fluid viscosity and flow ratio between secondary fractures and primary fractures,and is inversely proportional to secondary fracture angle and proppant concentration and size.Sixth,the angle at the leading edge of proppant bank in the primary fractures after branching is proportional to the proppant concentration and size and the flow ratio between secondary fractures and primary fractures,but is inversely proportional to secondary fracture angle,fluid displacement and fracturing fluid viscosity.Seventh,the angle at the leading edge of proppant bank in the secondary fractures after branching is proportional to the secondary fracture angle and the proppant concentration and size,but is inversely proportional to the fluid displacement,fracturing fluid viscosity and flow ratio between secondary fractures and primary fractures.In conclusion,the research results can provide a theoretical support for proppant optimization and program design of shale reservoir volume fracturing.
基金supported by the National Natural Science Foundation of China,Nos.32070534(to WY),32370567(to WY),82371874(to XL),81830032(to XL),82071421(to SL)Key Field Research and Development Program of Guangdong Province,No.2018B030337001(to XL)+2 种基金Guangzhou Key Research Program on Brain Science,No.202007030008(to XL)Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(to XL)Guangdong Basic and Applied Basic Research Foundation,Nos.2022A1515012301(to WY),2023B1515020031(to WY).
文摘The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.
文摘We investigated the distribution and frequency of damage to tree stands adjacent to low-volume roads according to the type of hillside materials involved（soil or rock） and hillside gradient in mountainous forests of northern Iran. A total of 80 plots were systematically and randomly sampled to record damaged trees（bending,crushing and wounding） by class of hillside gradient and materials at the edge of road. Tree wounding and crushing at rock slopes was significantly greater than at hillsides with a mix of clay soil（p ／ 0.05）. Damage on hillsides with slope gradients[45% were 2, 8.5 and 2.3 times more frequent than on hillsides with slope gradient／15% for bending, crushing and wounding, respectively. The damage distribution varied according by type and the most frequent damage was tree wounding（p ／ 0.05）. The damage distribution was measured at distances of 4, 5 and 8 m from the road fillslope for tree bending, crushing and wounding, respectively. Using hydraulic excavators and physical barriers（wooden obstruction and synthetic holder） during earthworks for road construction could reduce these damage.
基金The authors would like to acknowledge the financial support provided by the National Key R&D Program of China(Grant No.2018YFC1504802)the National Natural Science Foundation of China(Grant Nos.41972266,12102230).
文摘A method for packing irregular particles with a prescribed volume fraction is proposed.Furthermore,the generated granular material adheres to the prescribed statistical distribution and satisfies the desired complex spatial arrangement.First,the irregular geometries of the realistic particles were obtained from the original particle images.Second,the Minkowski sum was used to check the overlap between irregular particles and place an irregular particle in contact with other particles.Third,the optimised advance front method(OAFM)generated irregular particle packing with the prescribed statistical dis-tribution and volume fraction based on the Minkowski sum.Moreover,the signed distance function was introduced to pack the particles in accordance with the desired spatial arrangement.Finally,seven biaxial tests were performed using the UDEC software,which demonstrated the accuracy and potential usefulness of the proposed method.It can model granular material efficiently and reflect the meso-structural characteristics of complex granular materials.This method has a wide range of applications where discrete modelling of granular media is necessary.
文摘The storage, longitudinal distribution and recruitment processes of in-stream large wood (LW) were studied comparing channel segments draining four Chilean mountain catchments with different land use. The segments were divided into relatively uniform reaches of different lengths and surveyed for LW (piece dimensions, position in the channel, orientation to flow and aggregation) and stream morphology (slope and bank full channel width and depth) characterizations. LW volume stored in the Pichun, El Toro and Vuelta de Zorra study channels are within the range informed in international researches from streams draining catchments with similar forest covers. However, the 1057 m3/ha of LW stored in Tres Arroyos is extremely high and in the same order of magnitude than the reports from old-growth forests in the Pacific Northwest of USA. The size of the area that can potentially provide wood to streams depends on the wood supply mechanisms within any catchment, and the LW stored in the study segments increases as the size of this area increases. This study aims to contribute to the knowledge on the effects of LW in mountain channels, gathering new information and expanding investigations developed in Chile since 2008. This research was carried out within the framework of Project FONDECYT 11106209.
基金supported by Poongsan-KAIST Future Research Center Projectthe fund support provided by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Grant No.2023R1A2C2005661)。
文摘This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.
基金the National Natural Science:Foundation of China(52375370)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University(2023-DXSSKF-Z02)+2 种基金the Nat-ural Science Foundation of Shanxi(202103021224049)GDAS Projects of International cooperation platform of Sci-ence and Technology(2022GDASZH-2022010203-003)Guangdong province Science and Technology Plan Projects(2023B1212060045).
文摘The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.
基金supported by the National Natural Science Foundation of China(Nos.U19A2044,42105132,42030609,41975037,and 42105133)the National Key Research and Development Program of China(No.2022YFC3703502)+1 种基金the Plan for Anhui Major Provincial Science&Technology Project(No.202203a07020003)Hefei Ecological Environment Bureau Project(No.2020BFFFD01804).
文摘As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric pollutants.To address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May 2022.The monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station data.Temporally,there were pronounced seasonal variations in air pollutants.Spatially,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial emissions.The study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in summer.In spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two rings.This study offers data support for formulating the next phase of air pollution control measures in urban areas.
基金supported by the National Natural Science Foundation of China(Nos.51808158,52170101,and 52200116)Tianjin Natural Science Foundation(No.23JCYBJC00640).
文摘The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality deterioration and posing a risk to public health.An in-situ scanning vibrating electrode technique(SVET)with micron-scale resolution,microscopic scale detection and water quality analysis were used to investigate the corrosion behavior and metal release from DPs throughout the whole CML failure process.Metal pollutants release occurred at three different stages of CML failure process,and there are potential risks of water quality deterioration exceeding the maximum allowable levels set by national standards in the partial failure stage and lining peeling stage.Furthermore,the effects of water chemistry(Cl^(−),SO_(4)^(2−),NO_(3)−,and Ca^(2+))on corrosion scale growth and iron release activity,were investigated during the CML partial failure stage.Results showed that the CML failure process in DPs was accelerated by the autocatalysis of localized corrosion.Cl^(−)was found to damage the uncorroded metal surface,while SO_(4)^(2−)mainly dissolved the corrosion scale surface,increasing iron release.Both the oxidation of NO_(3)−and selective sedimentation of Ca2+were found to enhance the stability of corrosion scales and inhibit iron release.
基金supported by the National Key Research and Development Program of China(No.2019YFC1804501)the National Natural Science Foundation of China(Nos.42122056 and U1901210)+2 种基金Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020063)the Key Research and Development Program of Guangdong Province(No.2021B1111380003)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Z032).
文摘Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries.
