Objective To obtain information on the distribution of serotypes and antimicrobial agent susceptibilities to group B streptococcus (GBS) strains isolated in Beijing area from 1991 to 1996. Methods Bacterial is...Objective To obtain information on the distribution of serotypes and antimicrobial agent susceptibilities to group B streptococcus (GBS) strains isolated in Beijing area from 1991 to 1996. Methods Bacterial isolates of GBS were obtained from vaginal and cervical tract of pregnant and nonpregnant women in Beijing Tian Tan Hospital by culture. A total of 76 GBS strains were identified finally by coagglutination. Serotyping was determined by Standard Lancefield method. Susceptibility to test agents was assessed by determining the minimal inhibitory concentrations (MICs) with agar dilution method that was established by the National Committee for Clinical Laboratory Standards (NCCLS). Results Seven serotypes were identified among 76 GBS strains isolates. Types Ⅱ (33%), Ⅲ (23%) and Ⅰa (16%) were the predominant serotypes in pregnant and nonpregnant women. MICs of penicillin G and ampicillin were ≤0.06 μg/ml. MICs of cephazolin, cefuroxime and cefoperozone were 0.003 μg/ml 0.06 μg/ml. MICs of erythromycin were 0.003 μg/ml 0.03 μg/ml. MICs of gentamycin were 1 μg/ml 32 μg/ml. MICs of amikacin were 4 μg/ml ≥64 μg/ml, nearly 12.8% and 40.4% of the strains were resistant to gentamycin and amikacin, respectively. Conclusions Our study provides useful epidemiologic data for preparation of GBS type specific vaccines which can prevent GBS infections and antimicrobial agents susceptibility patterns in China. Routine reports on GBS susceptibilities by clinical laboratories and continuous surveillance for changes in the susceptibility are of considerable clinical importance.展开更多
By analyzing the differences between binaural recording and real listening, it was deduced that there were some unrevealed auditory localization clues, and the sound pressure distribution pattern at the entrance of ea...By analyzing the differences between binaural recording and real listening, it was deduced that there were some unrevealed auditory localization clues, and the sound pressure distribution pattern at the entrance of ear canal was probably a clue. It was proved through the listening test that the unrevealed auditory localization clues really exist with the reduction to absurdity. And the effective frequency bands of the unrevealed localization clues were in- duced and summed. The result of finite element based simulations showed that the pressure distribution at the entrance of ear canal was non-uniform, and the pattern was related to the direction of sound source. And it was proved that the sound pressure distribution pattern at the entrance of the ear canal carried the sound source direction information and could be used as an unrevealed localization clue. The frequency bands in which the sound pressure distribution patterns had significant differences between front and back sound source directions were roughly matched with the effective frequency bands of unrevealed localization clues obtained from the listening tests. To some extent, it supports the pattern could be a kind of unrevealed auditory hypothesis that the sound pressure distribution localization clues.展开更多
文摘Objective To obtain information on the distribution of serotypes and antimicrobial agent susceptibilities to group B streptococcus (GBS) strains isolated in Beijing area from 1991 to 1996. Methods Bacterial isolates of GBS were obtained from vaginal and cervical tract of pregnant and nonpregnant women in Beijing Tian Tan Hospital by culture. A total of 76 GBS strains were identified finally by coagglutination. Serotyping was determined by Standard Lancefield method. Susceptibility to test agents was assessed by determining the minimal inhibitory concentrations (MICs) with agar dilution method that was established by the National Committee for Clinical Laboratory Standards (NCCLS). Results Seven serotypes were identified among 76 GBS strains isolates. Types Ⅱ (33%), Ⅲ (23%) and Ⅰa (16%) were the predominant serotypes in pregnant and nonpregnant women. MICs of penicillin G and ampicillin were ≤0.06 μg/ml. MICs of cephazolin, cefuroxime and cefoperozone were 0.003 μg/ml 0.06 μg/ml. MICs of erythromycin were 0.003 μg/ml 0.03 μg/ml. MICs of gentamycin were 1 μg/ml 32 μg/ml. MICs of amikacin were 4 μg/ml ≥64 μg/ml, nearly 12.8% and 40.4% of the strains were resistant to gentamycin and amikacin, respectively. Conclusions Our study provides useful epidemiologic data for preparation of GBS type specific vaccines which can prevent GBS infections and antimicrobial agents susceptibility patterns in China. Routine reports on GBS susceptibilities by clinical laboratories and continuous surveillance for changes in the susceptibility are of considerable clinical importance.
基金supported by the Science and Engineering Project of Communication University of China(3132016XNG1625)
文摘By analyzing the differences between binaural recording and real listening, it was deduced that there were some unrevealed auditory localization clues, and the sound pressure distribution pattern at the entrance of ear canal was probably a clue. It was proved through the listening test that the unrevealed auditory localization clues really exist with the reduction to absurdity. And the effective frequency bands of the unrevealed localization clues were in- duced and summed. The result of finite element based simulations showed that the pressure distribution at the entrance of ear canal was non-uniform, and the pattern was related to the direction of sound source. And it was proved that the sound pressure distribution pattern at the entrance of the ear canal carried the sound source direction information and could be used as an unrevealed localization clue. The frequency bands in which the sound pressure distribution patterns had significant differences between front and back sound source directions were roughly matched with the effective frequency bands of unrevealed localization clues obtained from the listening tests. To some extent, it supports the pattern could be a kind of unrevealed auditory hypothesis that the sound pressure distribution localization clues.
