Background:The rate of distant metastasis in patients with pancreatic neuroendocrine tumors(PNETs)is20%-50%at the time of initial diagnosis.However,whether tumor size can predict distant metastasis for PNETs remains u...Background:The rate of distant metastasis in patients with pancreatic neuroendocrine tumors(PNETs)is20%-50%at the time of initial diagnosis.However,whether tumor size can predict distant metastasis for PNETs remains unknown up to date.Methods:We used Surveillance,Epidemiology,and End Results(SEER)population-based data to collect6089 patients with PNETs from 2010 to 2019.The optimal cut-off point of tumor size to predict distant metastasis was calculated by Youden’s index.Multivariate logistic regression analysis was used to figure out the association between tumor size and distant metastasis patterns.Results:The most common metastatic site was liver(27.2%),followed by bone(3.0%),lung(2.3%)and brain(0.4%).Based on an optimal cut-off value of tumor size(25.5 mm)for predicting distant metastasis determined by Youden’s index,patients were categorized into groups of tumor size<25.5 mm and≥25.5 mm.Multivariate logistic regression analyses showed that,compared with<25.5 mm,tumor size≥25.5 mm was an independent risk predictor of overall distant metastasis[odds ratio(OR)=4.491,95%confidence interval(CI):3.724-5.416,P<0.001]and liver metastasis(OR=4.686,95%CI:3.886-5.651,P<0.001).Conclusions:Tumor size≥25.5 mm was significantly associated with more overall distant and liver metastases.Timely identification of distant metastasis for tumor size≥25.5 mm may provide survival benefit for timely and precise treatment.展开更多
Multi-angle statistical analysis of tropical cyclones(TCs)and their distant thermodynamic disturbances over Northwest Pacific from July to September during 2001-2020 was conducted.The results show that TCs could trigg...Multi-angle statistical analysis of tropical cyclones(TCs)and their distant thermodynamic disturbances over Northwest Pacific from July to September during 2001-2020 was conducted.The results show that TCs could trigger distant thermodynamic disturbances,which mainly caused an increase in air pressure and a rise in temperature in northern China.The distant thermodynamic disturbances triggered by TCs differed in spatial distribution and intensity in different months.In the same month,the spatial distribution of such disturbances triggered by high-intensity TCs was consistent with the overall pattern,and there was a significant increase in intensity and area.From the probability of TC activities and the significance test of variance of analysis under different levels of P-J index,it is found that TC activities could stimulate the increase of P-J teleconnection index.There was a significant positive correlation between them,which was accompanied by a step effect.展开更多
BACKGROUND Gastric cancer is the fifth most common cancer and the fourth leading cause of death worldwide.Most cases of newly diagnosed gastric cancer involve not only locally advanced tumor growth and regional lymph ...BACKGROUND Gastric cancer is the fifth most common cancer and the fourth leading cause of death worldwide.Most cases of newly diagnosed gastric cancer involve not only locally advanced tumor growth and regional lymph node metastases but also distant metastases.We report a rare case finding of a mass in the right inguinal area which is derived from gastric cancer.CASE SUMMARY A 68-year-old male initially diagnosed with an inguinal hernia presented with a 2 cm mass in the right inguinal area.Gastrointestinal symptoms led to the discovery of a stomach tumor.Biopsy confirmed gastrointestinal adenocarcinoma.The diagnosis was advanced gastric cancer with peritoneal dissemination,and the inguinal mass was due to direct infiltration.Due to gastrointestinal bleeding,the patient underwent palliative gastrectomy and lymph node dissection.Postoperatively,the patient received hyperthermic intraperitoneal chemotherapy and localized radiation therapy.CONCLUSION This case indicates that a systematic evaluation should be conducted during the initial consultation to explore the potential connection between unrecognized distant masses and the primary tumor.展开更多
The location of U-turn bays is an important consideration in indirect driveway left-turn treatments.In order to improve the performance of right-turns followed by U-turns（RTUTs）,this study evaluates the impacts of t...The location of U-turn bays is an important consideration in indirect driveway left-turn treatments.In order to improve the performance of right-turns followed by U-turns（RTUTs）,this study evaluates the impacts of the separation distances between driveway exits and downstream U-turn locations on the safety and operational performance of vehicles making RTUTs.Crash data are investigated at 179 selected roadway segments,and travel time data are measured using video cameras at 29 locations in the state of Florida,USA.Crash rate models and travel time models are developed based on data collected in the field.It is found that the separation distance between driveway exits and downstream U-turn locations significantly impacts the safety and operational performance of vehicles making right turns followed by U-turns.Based on the research results,the minimum and optimal separation distances between driveways and U-turn locations under different roadway conditions are determined to facilitate driver use of RTUTs.The results of this study can be used for future intersection improvement projects in China.展开更多
[Objective] The aim was to explore salt-resistant Spartina alterniflora and high-yield rice with germplasm resource in order to create new salt-resistant rice species with dual-purpose of food and forage. [Method] Fro...[Objective] The aim was to explore salt-resistant Spartina alterniflora and high-yield rice with germplasm resource in order to create new salt-resistant rice species with dual-purpose of food and forage. [Method] From 2009 to 2011, re- searches on distant hybridization of Spartina alterniflora and Oryza Sativa have been conducted with method of distant hybridization breeding. On the other hand, break- through and combination techniques （four selected one） were adopted to find the new rice species, including techniques of planting and selection in seashore, cyto- logical detection and selection, phenotype selection of backcross, and molecular marker assisted selection. [Result] Success rate of distant hybridization from 2009 to 2010 was 1.39%. RAPD molecular identification of 7C14 and rice female parent of Zhongxiang No.l, seed 2 was carried on with distant hybridization of male parent of Spartina altemiflora （H）. The results showed that bands same with Spartina alterni- flora parents were found in RH-1-10K205-7C14xH, RH-2-8K157-7C14xH, and RH-13- 9H5-Zhongxaing No.1 xH. Considering absent situation in rice parents, distant hy- bridization strains above were found with same parental genetic element as Spartina alterniflora. Female parent of rice 7K339, however, was under RAPD molecular identification with male parent of Spartina alterniflora. The result showed that bands same with Spartina alterniflora parents were found in RH-5-10K215, RH-6-8K48, RH- 12-9H9, RH-14-9H8 and RH-16-9H28. Considering absent situation in rice parents, distant hybridization strains above were found with same parental genetic element as Spartina altemiflora. Rest hybrid strains were found variance with Spartina alterniflora parents and rice parents in varying degrees. [Conclusion] New and excellent rice species of dual-purpose solves problem not only about salt-resistant species badly needed in coastal development and treatment of saline and alkaline land, but about fine fodder and roughage for herbivore, as well. What＇s more, this is of scientific significance in recourse utilization, efficiency improvement in agriculture, food security, and cultivation strategy.展开更多
[Objective] This study aimed to explore the germplasm resources of salt-tolerant Spartina,sweet-stalk Soughum bicolor and high-yield Oryza sativa for innovation of new germplasms of salt-tolerant and sweet-stalk Oryza...[Objective] This study aimed to explore the germplasm resources of salt-tolerant Spartina,sweet-stalk Soughum bicolor and high-yield Oryza sativa for innovation of new germplasms of salt-tolerant and sweet-stalk Oryza sativa with dual purpose of food and forage in sea beach.[Method] From 2009 to 2012,researches on distant hybridization of Spartina,Soughum bicolor and Oryza sativa had been carried out,and the RAPD molecular identification of obtained distant hybridization materials had been conducted.[Result] Experimental evidences of hybrid seed setting,transplanting and economic characters of hybrid materials were obtained;among the 14 hybrid materials for RAPD analysis,5 materials shared common bands with Spartina and Soughum bicolor parents,which were absent in Oryza sativa parent,indicating that the genetic component of Spartina and Soughum bicolor parents has been integrated into the 5 distant hybrids.[Conclusion] This study has important scientific significance in recourse utilization,agricultural efficiency improvement,food security,and cultivation strategy of China,showing broad application prospects.展开更多
基金supported by a grant from the National Natural Science Foundation of China(82173353)。
文摘Background:The rate of distant metastasis in patients with pancreatic neuroendocrine tumors(PNETs)is20%-50%at the time of initial diagnosis.However,whether tumor size can predict distant metastasis for PNETs remains unknown up to date.Methods:We used Surveillance,Epidemiology,and End Results(SEER)population-based data to collect6089 patients with PNETs from 2010 to 2019.The optimal cut-off point of tumor size to predict distant metastasis was calculated by Youden’s index.Multivariate logistic regression analysis was used to figure out the association between tumor size and distant metastasis patterns.Results:The most common metastatic site was liver(27.2%),followed by bone(3.0%),lung(2.3%)and brain(0.4%).Based on an optimal cut-off value of tumor size(25.5 mm)for predicting distant metastasis determined by Youden’s index,patients were categorized into groups of tumor size<25.5 mm and≥25.5 mm.Multivariate logistic regression analyses showed that,compared with<25.5 mm,tumor size≥25.5 mm was an independent risk predictor of overall distant metastasis[odds ratio(OR)=4.491,95%confidence interval(CI):3.724-5.416,P<0.001]and liver metastasis(OR=4.686,95%CI:3.886-5.651,P<0.001).Conclusions:Tumor size≥25.5 mm was significantly associated with more overall distant and liver metastases.Timely identification of distant metastasis for tumor size≥25.5 mm may provide survival benefit for timely and precise treatment.
基金the National Natural Science Foundation of China(42305011).
文摘Multi-angle statistical analysis of tropical cyclones(TCs)and their distant thermodynamic disturbances over Northwest Pacific from July to September during 2001-2020 was conducted.The results show that TCs could trigger distant thermodynamic disturbances,which mainly caused an increase in air pressure and a rise in temperature in northern China.The distant thermodynamic disturbances triggered by TCs differed in spatial distribution and intensity in different months.In the same month,the spatial distribution of such disturbances triggered by high-intensity TCs was consistent with the overall pattern,and there was a significant increase in intensity and area.From the probability of TC activities and the significance test of variance of analysis under different levels of P-J index,it is found that TC activities could stimulate the increase of P-J teleconnection index.There was a significant positive correlation between them,which was accompanied by a step effect.
文摘BACKGROUND Gastric cancer is the fifth most common cancer and the fourth leading cause of death worldwide.Most cases of newly diagnosed gastric cancer involve not only locally advanced tumor growth and regional lymph node metastases but also distant metastases.We report a rare case finding of a mass in the right inguinal area which is derived from gastric cancer.CASE SUMMARY A 68-year-old male initially diagnosed with an inguinal hernia presented with a 2 cm mass in the right inguinal area.Gastrointestinal symptoms led to the discovery of a stomach tumor.Biopsy confirmed gastrointestinal adenocarcinoma.The diagnosis was advanced gastric cancer with peritoneal dissemination,and the inguinal mass was due to direct infiltration.Due to gastrointestinal bleeding,the patient underwent palliative gastrectomy and lymph node dissection.Postoperatively,the patient received hyperthermic intraperitoneal chemotherapy and localized radiation therapy.CONCLUSION This case indicates that a systematic evaluation should be conducted during the initial consultation to explore the potential connection between unrecognized distant masses and the primary tumor.
文摘The location of U-turn bays is an important consideration in indirect driveway left-turn treatments.In order to improve the performance of right-turns followed by U-turns（RTUTs）,this study evaluates the impacts of the separation distances between driveway exits and downstream U-turn locations on the safety and operational performance of vehicles making RTUTs.Crash data are investigated at 179 selected roadway segments,and travel time data are measured using video cameras at 29 locations in the state of Florida,USA.Crash rate models and travel time models are developed based on data collected in the field.It is found that the separation distance between driveway exits and downstream U-turn locations significantly impacts the safety and operational performance of vehicles making right turns followed by U-turns.Based on the research results,the minimum and optimal separation distances between driveways and U-turn locations under different roadway conditions are determined to facilitate driver use of RTUTs.The results of this study can be used for future intersection improvement projects in China.
基金Supported by National Natural Science Foundation of China(31072064)Foundation Project of Self-reliant Innovation for Agricultural Science and Technology,Supporting Project for Exploration and Research of Jiangsu Province in2011(TCX(11)4133,CX(11)4060)~~
文摘[Objective] The aim was to explore salt-resistant Spartina alterniflora and high-yield rice with germplasm resource in order to create new salt-resistant rice species with dual-purpose of food and forage. [Method] From 2009 to 2011, re- searches on distant hybridization of Spartina alterniflora and Oryza Sativa have been conducted with method of distant hybridization breeding. On the other hand, break- through and combination techniques （four selected one） were adopted to find the new rice species, including techniques of planting and selection in seashore, cyto- logical detection and selection, phenotype selection of backcross, and molecular marker assisted selection. [Result] Success rate of distant hybridization from 2009 to 2010 was 1.39%. RAPD molecular identification of 7C14 and rice female parent of Zhongxiang No.l, seed 2 was carried on with distant hybridization of male parent of Spartina altemiflora （H）. The results showed that bands same with Spartina alterni- flora parents were found in RH-1-10K205-7C14xH, RH-2-8K157-7C14xH, and RH-13- 9H5-Zhongxaing No.1 xH. Considering absent situation in rice parents, distant hy- bridization strains above were found with same parental genetic element as Spartina alterniflora. Female parent of rice 7K339, however, was under RAPD molecular identification with male parent of Spartina alterniflora. The result showed that bands same with Spartina alterniflora parents were found in RH-5-10K215, RH-6-8K48, RH- 12-9H9, RH-14-9H8 and RH-16-9H28. Considering absent situation in rice parents, distant hybridization strains above were found with same parental genetic element as Spartina altemiflora. Rest hybrid strains were found variance with Spartina alterniflora parents and rice parents in varying degrees. [Conclusion] New and excellent rice species of dual-purpose solves problem not only about salt-resistant species badly needed in coastal development and treatment of saline and alkaline land, but about fine fodder and roughage for herbivore, as well. What＇s more, this is of scientific significance in recourse utilization, efficiency improvement in agriculture, food security, and cultivation strategy.
基金Supported by Natural Science Foundation of Jiangsu Province"Exploration and Innovation of Salt-tolerant and Sweet-stalk Rice Germplasm Resources with Dual Purpose of Food and Forage in Sea Beach"(BK2010270)Application Research Project from Nantong Municipal Science and Technology Bureau"Study on Molecular Breeding Technology for Salt-tolerant and Sweet-stalk Superior Forage Rice in Sea Beach"(BK2011006)~~
文摘[Objective] This study aimed to explore the germplasm resources of salt-tolerant Spartina,sweet-stalk Soughum bicolor and high-yield Oryza sativa for innovation of new germplasms of salt-tolerant and sweet-stalk Oryza sativa with dual purpose of food and forage in sea beach.[Method] From 2009 to 2012,researches on distant hybridization of Spartina,Soughum bicolor and Oryza sativa had been carried out,and the RAPD molecular identification of obtained distant hybridization materials had been conducted.[Result] Experimental evidences of hybrid seed setting,transplanting and economic characters of hybrid materials were obtained;among the 14 hybrid materials for RAPD analysis,5 materials shared common bands with Spartina and Soughum bicolor parents,which were absent in Oryza sativa parent,indicating that the genetic component of Spartina and Soughum bicolor parents has been integrated into the 5 distant hybrids.[Conclusion] This study has important scientific significance in recourse utilization,agricultural efficiency improvement,food security,and cultivation strategy of China,showing broad application prospects.
