Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear me...Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).展开更多
Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc ...Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc is composed of three parts:the inner nucleus pulposus(NP),the outer annulus fibrosus(AF),and the superior and inferior cartilage endplates(CEPs).Degeneration of IVDs is a primary contributor to various spinal disorders,such as cervical spondylosis,low back pain,and lumbar disc herniation,all of which lead to a significant reduction in the quality of life of patients and impose a substantial economic burden.In China,IVD degeneration(IVDD)is the third most common chronic disease following hypertension and diabetes,highlighting the widespread impact of IVDD on public health.1 Non-degenerated adult IVDs are devoid of a vascular system within。展开更多
Adipose tissue is a heterogeneous,dynamic,and metabolically active tissue that orchestrates systematic metabolic homeostasis by regulating thermogenesis,immune responses,and endocrine signaling[1–4].Adipose tissue is...Adipose tissue is a heterogeneous,dynamic,and metabolically active tissue that orchestrates systematic metabolic homeostasis by regulating thermogenesis,immune responses,and endocrine signaling[1–4].Adipose tissue is a multicellular tissue with multiple cell types,including mature adipocytes,adipogenic stem and progenitor cells(ASPCs),immune cells,endothelial cells,and Schwann cells[5].Dysregulation in adipose tissue is associated with a broad spectrum of metabolic disorders,such as obesity,type 2 diabetes,and cardiovascular disease[6,7].A comprehensive characterization of the cellular composition and functional states of adipose tissue is therefore essential for advancing the understanding of the physiological and pathological mechanisms underlying metabolic diseases.The advent of single-cell and single-nucleus transcriptomic(single-cell RNA sequencing[scRNA-seq]and single-nucleus RNA sequencing[snRNA-seq])technologies has provided unprecedented resolution to tackle this challenge.展开更多
基金supported by the National Natural Science Foundation of China(82104138)the Zhejiang Provincial Natural Science Foundation of China(LY24H310003).
文摘Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).
基金supported by the National Natural Science Foundation of China,China(82472505,82472498,82272549,82072488,82102620,and 82170255)the National Key Research and Development plan,Ministry of Science and Technology of the People’s Republic of China(2022YFC2407203)+2 种基金the Young Health Talents of Shanghai Municipal Health Commission,China(2022YQ011)the China Medical Education Association(2023-020)and the Youth Talent Project of Huashan Hospital(30302164006).
文摘Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc is composed of three parts:the inner nucleus pulposus(NP),the outer annulus fibrosus(AF),and the superior and inferior cartilage endplates(CEPs).Degeneration of IVDs is a primary contributor to various spinal disorders,such as cervical spondylosis,low back pain,and lumbar disc herniation,all of which lead to a significant reduction in the quality of life of patients and impose a substantial economic burden.In China,IVD degeneration(IVDD)is the third most common chronic disease following hypertension and diabetes,highlighting the widespread impact of IVDD on public health.1 Non-degenerated adult IVDs are devoid of a vascular system within。
文摘Adipose tissue is a heterogeneous,dynamic,and metabolically active tissue that orchestrates systematic metabolic homeostasis by regulating thermogenesis,immune responses,and endocrine signaling[1–4].Adipose tissue is a multicellular tissue with multiple cell types,including mature adipocytes,adipogenic stem and progenitor cells(ASPCs),immune cells,endothelial cells,and Schwann cells[5].Dysregulation in adipose tissue is associated with a broad spectrum of metabolic disorders,such as obesity,type 2 diabetes,and cardiovascular disease[6,7].A comprehensive characterization of the cellular composition and functional states of adipose tissue is therefore essential for advancing the understanding of the physiological and pathological mechanisms underlying metabolic diseases.The advent of single-cell and single-nucleus transcriptomic(single-cell RNA sequencing[scRNA-seq]and single-nucleus RNA sequencing[snRNA-seq])technologies has provided unprecedented resolution to tackle this challenge.
