Adolescents represent a significant proportion of global psychiatric morbidity,with approximately 10%–20%affected by mental disorders,primarily including major depressive disorder(MDD),bipolar disorder(BD),and schizo...Adolescents represent a significant proportion of global psychiatric morbidity,with approximately 10%–20%affected by mental disorders,primarily including major depressive disorder(MDD),bipolar disorder(BD),and schizophrenia(SZ)[1,2].These mental disorders exhibit distinct clinical presentations compared with adult forms,including prominent somatic symptoms in MDD[3],rapid mood cycling in BD[4],and insidious onset in SZ[5].The symptom-based Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5)framework faces challenges in differentiating these mental disorders because of overlapping manifestations and developmental heterogeneity[6],necessitating biologically anchored classification frameworks.展开更多
基金supported by the Ministry of Science and Technology of China(2022YFA0806000)the National Natural Science Foundation of China Grants(32150005)+3 种基金the Clinical Research Operating Fund of Central High level hospitals(2022-PUMCH-E-001)the Medical and Scientific Innovation Project of the Chinese Academy of Medical Sciences(2022-12M-1-004)the Talent Program of the Chinese Academy of Medical Sciences(2022-RC310-10)Research Funds from the Health@InnoHK Program launched by the Innovation Technology Commission of the Hong Kong Special Administrative Region,and STI2030-Major Projects(2022ZD0212900).
文摘Adolescents represent a significant proportion of global psychiatric morbidity,with approximately 10%–20%affected by mental disorders,primarily including major depressive disorder(MDD),bipolar disorder(BD),and schizophrenia(SZ)[1,2].These mental disorders exhibit distinct clinical presentations compared with adult forms,including prominent somatic symptoms in MDD[3],rapid mood cycling in BD[4],and insidious onset in SZ[5].The symptom-based Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5)framework faces challenges in differentiating these mental disorders because of overlapping manifestations and developmental heterogeneity[6],necessitating biologically anchored classification frameworks.
