Objective To analyze the gamma band effective connectiviyty characteristicsof theprefrontal-striatal circuitry in bipolar disorder patients with and without a history of manic episodes,as well as in major depressive d...Objective To analyze the gamma band effective connectiviyty characteristicsof theprefrontal-striatal circuitry in bipolar disorder patients with and without a history of manic episodes,as well as in major depressive disorder patients,during the recognition of positive emotional faces,this study aims to identify unique neurophysiological features that may aid in the early detection of bipolar disorder.Methods This retrospective study collected clinical data and magnetoencephalography(MEG)imaging data from patients performing a positive emotional face recognition task at the Affiliated Brain Hospital of Nanjing Medical University from May 2009 to December 2019.The study included 75 patients with major depressive disorder and 29 patients with bipolar disorder in a depressive episode(rBD group).Concurrently,39 age-and gender-matched healthy controls(HC group)were recruited.After a follow-up period of at least 5 years,23 out of the 75 patients with major depressive disorder converted to bipolar disorder(ctBD group),while the remaining 52 who did not convert maintained a diagnosis of major depressive disorder.Results There were statistically significant differences in gamma-band effective connectivity in the prefrontal-striatal circuit when recognizing positive emotional faces among the converted to bipolar disorder(ctBD),raw bipolar disorder,major depressive disorder,and HC groups(H=9.04,10.30,8.30,13.43,14.38,12.62,9.82,8.94,24.62,7.89,18.53,9.97,9.58,12.79,P<0.05).The ctBD group,rBD group,and major depressive group all showed reduction in effective connectivity from the right orbital inferior frontal gyrus(ORBinf.R)to the left orbital inferior frontal gyrus(ORBinf.L)[Z=-1.98,-3.38,-2.88],from the right orbital inferior frontal gyrus to the right ventral striatum(VS.R)(Z=-2.05,-2.76,-2.11;P<0.05)and from the left ventral striatum(VS.L)to the left orbital middle frontal gyrus(ORBmid.L)(Z=-2.76,-1.98,-2.43;P<0.05).Among the disease groups,the ctBD group showed significantly enhanced effective connectivity strength compared to the major depressive group from the right amygdala(AMYG.R)to the left orbital inferior frontal gyrus(0.04(0.03,0.08)),from the right amygdala to the left ventral striatum(0.05(0.03,0.09)),and from the right ventral striatum to the right anterior cingulate and paracingulate gyri(ACG.R)(0.04(0.02,0.08))(Z=4.17,3.70,3.35;P<0.001).The ctBD group also exhibited enhanced effective connectivity compared to the rBD group from ORBinf.R to the ACG.R,fron the AMYG.R to the ORBinf.L,from the AMYG.R to the VS.L,and from the VS.R to the ACG.R(Z=2.05,4.61,3.60,3.04;P<0.05).The rBD group demonstrated reduced effective connectivity compared to the major depressive disorder group from the right orbital middle frontal gyrus(ORBmid.R)to the left anterior cingulate and paracingulate gyri(ACG.L),ORBinf.R to the ACG.R and from the ORBinf.R to the AMYG.R(Z=-2.12,-2.40,-2.22;P<0.05).Conclusion There are significant differences in the gamma-band effective connectivity characteristics of the prefrontal-striatal pathway when recognizing positive emotional faces between patients with bipolar disorder in depressive episodes and those with depression,as well as differences between bipolar depressed patients with and without a history of manic episodes.展开更多
文摘Objective To analyze the gamma band effective connectiviyty characteristicsof theprefrontal-striatal circuitry in bipolar disorder patients with and without a history of manic episodes,as well as in major depressive disorder patients,during the recognition of positive emotional faces,this study aims to identify unique neurophysiological features that may aid in the early detection of bipolar disorder.Methods This retrospective study collected clinical data and magnetoencephalography(MEG)imaging data from patients performing a positive emotional face recognition task at the Affiliated Brain Hospital of Nanjing Medical University from May 2009 to December 2019.The study included 75 patients with major depressive disorder and 29 patients with bipolar disorder in a depressive episode(rBD group).Concurrently,39 age-and gender-matched healthy controls(HC group)were recruited.After a follow-up period of at least 5 years,23 out of the 75 patients with major depressive disorder converted to bipolar disorder(ctBD group),while the remaining 52 who did not convert maintained a diagnosis of major depressive disorder.Results There were statistically significant differences in gamma-band effective connectivity in the prefrontal-striatal circuit when recognizing positive emotional faces among the converted to bipolar disorder(ctBD),raw bipolar disorder,major depressive disorder,and HC groups(H=9.04,10.30,8.30,13.43,14.38,12.62,9.82,8.94,24.62,7.89,18.53,9.97,9.58,12.79,P<0.05).The ctBD group,rBD group,and major depressive group all showed reduction in effective connectivity from the right orbital inferior frontal gyrus(ORBinf.R)to the left orbital inferior frontal gyrus(ORBinf.L)[Z=-1.98,-3.38,-2.88],from the right orbital inferior frontal gyrus to the right ventral striatum(VS.R)(Z=-2.05,-2.76,-2.11;P<0.05)and from the left ventral striatum(VS.L)to the left orbital middle frontal gyrus(ORBmid.L)(Z=-2.76,-1.98,-2.43;P<0.05).Among the disease groups,the ctBD group showed significantly enhanced effective connectivity strength compared to the major depressive group from the right amygdala(AMYG.R)to the left orbital inferior frontal gyrus(0.04(0.03,0.08)),from the right amygdala to the left ventral striatum(0.05(0.03,0.09)),and from the right ventral striatum to the right anterior cingulate and paracingulate gyri(ACG.R)(0.04(0.02,0.08))(Z=4.17,3.70,3.35;P<0.001).The ctBD group also exhibited enhanced effective connectivity compared to the rBD group from ORBinf.R to the ACG.R,fron the AMYG.R to the ORBinf.L,from the AMYG.R to the VS.L,and from the VS.R to the ACG.R(Z=2.05,4.61,3.60,3.04;P<0.05).The rBD group demonstrated reduced effective connectivity compared to the major depressive disorder group from the right orbital middle frontal gyrus(ORBmid.R)to the left anterior cingulate and paracingulate gyri(ACG.L),ORBinf.R to the ACG.R and from the ORBinf.R to the AMYG.R(Z=-2.12,-2.40,-2.22;P<0.05).Conclusion There are significant differences in the gamma-band effective connectivity characteristics of the prefrontal-striatal pathway when recognizing positive emotional faces between patients with bipolar disorder in depressive episodes and those with depression,as well as differences between bipolar depressed patients with and without a history of manic episodes.
