To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded i...To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded inconsistent results.[2,3]Consequently,it remains unclear which of the various antidepressant categories may affect stroke.Thus,the rational use of antidepressants is important for reducing stroke risk and recurrence,while offering candidate therapeutic targets.Drug-target Mendelian randomization(MR)analysis,which uses genetic variants located in or near the region of drug target genes as proxies for drug effects,is a promising tool for identifying causal links between drug targets and diseases.展开更多
文摘To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded inconsistent results.[2,3]Consequently,it remains unclear which of the various antidepressant categories may affect stroke.Thus,the rational use of antidepressants is important for reducing stroke risk and recurrence,while offering candidate therapeutic targets.Drug-target Mendelian randomization(MR)analysis,which uses genetic variants located in or near the region of drug target genes as proxies for drug effects,is a promising tool for identifying causal links between drug targets and diseases.
