Hepatocellular carcinoma(HCC)typically develops in the context of chronic liver disease,where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations.Epi...Hepatocellular carcinoma(HCC)typically develops in the context of chronic liver disease,where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations.Epigenetic regulation encompasses multiple mechanisms that govern the transcription machinery accessibility to DNA.This process is regulated by the addition and removal of covalent marks on chromatin,which can either affect DNA-histone interactions or serve as scaffolds for other proteins,among other mechanisms.Recent research has revealed that epigenetic alterations can disrupt chromatin homeostasis,redirecting transcriptional regulation to favour cancer-promoting states.Consequently,these alterations play a pivotal role in the acquisition of cancer hallmarks and provide insights into several biological processes involved in hepatocarcinogenesis.This review highlights the key epigenetic mechanisms underlying the development,progression and dissemination of HCC,with a particular focus on DNA methylation and histone post-translational modifications.This knowledge is relevant for guiding the development of innovative therapeutic approaches based on epigenetic modulators.展开更多
Dear Editor,Ovarian cancer is the leading cause of death among gynecologic malignancies,primarily due to metastatic disease,where current therapies are largely ineffective(5-year survival rate<25%).Epithelial-to-me...Dear Editor,Ovarian cancer is the leading cause of death among gynecologic malignancies,primarily due to metastatic disease,where current therapies are largely ineffective(5-year survival rate<25%).Epithelial-to-mesenchym al transition(EMT)is a critical process that confers metastatic plasticity to ovarian cancer cells,enabling aggressive peritoneal dissemination,and contributing to poor clinical outcomes.展开更多
基金funded by grants from PICT-2021-I-A-00975(GM,JB),PICT-2018-1036(JB)and PICT-2021-CAT-II-0012(GM,JB).
文摘Hepatocellular carcinoma(HCC)typically develops in the context of chronic liver disease,where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations.Epigenetic regulation encompasses multiple mechanisms that govern the transcription machinery accessibility to DNA.This process is regulated by the addition and removal of covalent marks on chromatin,which can either affect DNA-histone interactions or serve as scaffolds for other proteins,among other mechanisms.Recent research has revealed that epigenetic alterations can disrupt chromatin homeostasis,redirecting transcriptional regulation to favour cancer-promoting states.Consequently,these alterations play a pivotal role in the acquisition of cancer hallmarks and provide insights into several biological processes involved in hepatocarcinogenesis.This review highlights the key epigenetic mechanisms underlying the development,progression and dissemination of HCC,with a particular focus on DNA methylation and histone post-translational modifications.This knowledge is relevant for guiding the development of innovative therapeutic approaches based on epigenetic modulators.
基金supported by funding from the RGC Senior Research Fellow Scheme SRFS2223-7S05 to A.S.T.Wongfrom the“Laboratory for Synthetic Chemistry and Chemical Biology”under the Health@Inno HK Program launched by the Innovation and Technology Commission,Hong Kong SAR,China.
文摘Dear Editor,Ovarian cancer is the leading cause of death among gynecologic malignancies,primarily due to metastatic disease,where current therapies are largely ineffective(5-year survival rate<25%).Epithelial-to-mesenchym al transition(EMT)is a critical process that confers metastatic plasticity to ovarian cancer cells,enabling aggressive peritoneal dissemination,and contributing to poor clinical outcomes.
