Vaccines are critical tools in controlling infectious diseases,yet traditional production methods face significant challenges,in-cluding high costs,complex infrastructure requirements,and re-liance on cold-chain logis...Vaccines are critical tools in controlling infectious diseases,yet traditional production methods face significant challenges,in-cluding high costs,complex infrastructure requirements,and re-liance on cold-chain logistics.These limitations restrict vaccine access,especially in low-resource regions,and were starkly ex-posed during the COVID-19 pandemic,underscoring the need for innovative vaccine platforms.Plant-derived vaccines,in which antigenic proteins are produced in plants using recombinant DNA technology,represent a promising alternative.Nicotiana benthamiana,a close relative of common tobacco,is among the most widely used plant hosts because of its fast growth,ease of genetic manipulation,and suitability for transient expres-sion systems(Song et al.,2024).In addition,edible crops such as tomato and lettuce offer potential platforms for oral vaccines,while cereal crops such as rice and maize are being explored for thermostable formulations that bypass refrigeration requirements.展开更多
Microneedles have shown considerable potential in treating ocular diseases,yet enhancing their architecture and functionality to improve therapeutic efficacy poses marked challenges.Here,inspired by the antioxidant st...Microneedles have shown considerable potential in treating ocular diseases,yet enhancing their architecture and functionality to improve therapeutic efficacy poses marked challenges.Here,inspired by the antioxidant strategy of blueberries and the wet adhesive mechanism of clingfish,we construct hierarchical and multifunctional microneedles.These microneedles possess both wet adhesive and antioxidant properties,making them highly effective for ocular wound healing.Constructed using polyacrylic acid-N-hydroxysuccinimide-based hydrogel with hexagonal structures,these generated microneedles ensure strong adhesion in wet environments.Furthermore,by incorporating proanthocyanidins(pAc)into the tips,the microneedle is imparted with excellent competence to scavenge reactive oxygen species(ROS).In the rat model of ocular alkali burns,the designed microneedle not only exhibited robust adhesion and desirable antioxidant properties in the moist ocular environment but also facilitated sustained drug release and effective treatment.These results suggest that our bioinspired microneedles with multifunctional properties offer substantial advancement over conventional approaches,positioning them as promising candidates for versatile wound healing applications.展开更多
Introduction:Metabolic health status plays a central role in the development of a broad spectrum of chronic diseases.Yet existing assessment approaches rely on comparatively complex measurement techniques,which constr...Introduction:Metabolic health status plays a central role in the development of a broad spectrum of chronic diseases.Yet existing assessment approaches rely on comparatively complex measurement techniques,which constrain their widespread adoption and limits their utility in population-based metabolic health management.Methods:The research employed a two-phase approach to construct a metabolic health index.We conducted a Delphi consultation to define and prioritize key metabolic health indicators,then drew on data from the China Chronic Disease and Risk Factor Surveillance,linked to the national mortality surveillance system,and built Cox proportional hazards models to estimate indicator-specific weights.Using these weights,we developed the Metabolic Health Index(MHI)and established a classification system to stratify metabolic health subtypes.We subsequently analyzed MHI score distributions and subtype prevalence across population subgroups.Results:The Delphi process identified 11 indicators for inclusion in the model:age,smoking,alcohol consumption,body-mass index,waist-toheight ratio,fasting blood glucose,blood pressure,blood lipids,serum uric acid,metabolic-associated fatty liver disease,and family history of metabolic diseases.Applying the classification system,we identified 13 metabolic health subtypes across 7 categories.MHI scores declined with age,and females consistently outscored males across all age groups.Over half of the participants(54.5%)had relatively high MHI scores,and the proportion with higher scores decreased with age.Conclusion:The MHI converts population health data into a quantitative metric for assessing metabolic health in adults and provides a practical approach for public health practice across diverse regions and settings.展开更多
基金supported by the Science and Technology Foundation of Beijing Life Science Academy(2024200CB0110)the Natural Science Foundation of Shandong Province,China(ZR2024QC068).
文摘Vaccines are critical tools in controlling infectious diseases,yet traditional production methods face significant challenges,in-cluding high costs,complex infrastructure requirements,and re-liance on cold-chain logistics.These limitations restrict vaccine access,especially in low-resource regions,and were starkly ex-posed during the COVID-19 pandemic,underscoring the need for innovative vaccine platforms.Plant-derived vaccines,in which antigenic proteins are produced in plants using recombinant DNA technology,represent a promising alternative.Nicotiana benthamiana,a close relative of common tobacco,is among the most widely used plant hosts because of its fast growth,ease of genetic manipulation,and suitability for transient expres-sion systems(Song et al.,2024).In addition,edible crops such as tomato and lettuce offer potential platforms for oral vaccines,while cereal crops such as rice and maize are being explored for thermostable formulations that bypass refrigeration requirements.
基金supported by the National Key Re search and Development Program of China(2020YFA0908200)the National Natural Science Foundation of China(82101184)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2024A1515010457)the Shenzhen Medical Research Fund(A2303017)the Shenzhen Science and Technology Program(JCYJ20210324133214038 and JCYJ20210324102809024).
文摘Microneedles have shown considerable potential in treating ocular diseases,yet enhancing their architecture and functionality to improve therapeutic efficacy poses marked challenges.Here,inspired by the antioxidant strategy of blueberries and the wet adhesive mechanism of clingfish,we construct hierarchical and multifunctional microneedles.These microneedles possess both wet adhesive and antioxidant properties,making them highly effective for ocular wound healing.Constructed using polyacrylic acid-N-hydroxysuccinimide-based hydrogel with hexagonal structures,these generated microneedles ensure strong adhesion in wet environments.Furthermore,by incorporating proanthocyanidins(pAc)into the tips,the microneedle is imparted with excellent competence to scavenge reactive oxygen species(ROS).In the rat model of ocular alkali burns,the designed microneedle not only exhibited robust adhesion and desirable antioxidant properties in the moist ocular environment but also facilitated sustained drug release and effective treatment.These results suggest that our bioinspired microneedles with multifunctional properties offer substantial advancement over conventional approaches,positioning them as promising candidates for versatile wound healing applications.
基金Non-communicable Chronic Diseases-National Science and Technology Major Project(2025ZD0550501).
文摘Introduction:Metabolic health status plays a central role in the development of a broad spectrum of chronic diseases.Yet existing assessment approaches rely on comparatively complex measurement techniques,which constrain their widespread adoption and limits their utility in population-based metabolic health management.Methods:The research employed a two-phase approach to construct a metabolic health index.We conducted a Delphi consultation to define and prioritize key metabolic health indicators,then drew on data from the China Chronic Disease and Risk Factor Surveillance,linked to the national mortality surveillance system,and built Cox proportional hazards models to estimate indicator-specific weights.Using these weights,we developed the Metabolic Health Index(MHI)and established a classification system to stratify metabolic health subtypes.We subsequently analyzed MHI score distributions and subtype prevalence across population subgroups.Results:The Delphi process identified 11 indicators for inclusion in the model:age,smoking,alcohol consumption,body-mass index,waist-toheight ratio,fasting blood glucose,blood pressure,blood lipids,serum uric acid,metabolic-associated fatty liver disease,and family history of metabolic diseases.Applying the classification system,we identified 13 metabolic health subtypes across 7 categories.MHI scores declined with age,and females consistently outscored males across all age groups.Over half of the participants(54.5%)had relatively high MHI scores,and the proportion with higher scores decreased with age.Conclusion:The MHI converts population health data into a quantitative metric for assessing metabolic health in adults and provides a practical approach for public health practice across diverse regions and settings.
