Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascular diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was in...Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascular diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was initially and widely adopted in antimalarial treatments.As scientific research steadily progressed,its latent potential role in the cardiovascular system gradually captured the attention of the global scientific community.Artemisinin and its derivatives can reportedly play a protective role in the cardiovascular system through various mechanisms,including anti-inflammatory,anti-angiogenic,antioxidant,and anti-fibrotic effects,as well as the regulation of blood lipids and blood pressure.In particular,they have shown promising therapeutic effects in models of cardiovascular diseases such as atherosclerosis,myocardial ischaemia,and cardiac hypertrophy.In addition,artemisinin and its derivatives can improve cardiovascular function and prevent cardiovascular injury by regulating signalling pathways closely related to cardiovascular disease,such as AMPK and NF-kB.Although numerous ex vivo and in vivo experiments have verified the potential role of artemisinin in treating cardiovascular diseases,systematic studies to comprehensively elucidate its specific mechanism of action remain scarce.Further exploration of the precise roles of artemisinin and its derivatives in cardiovascular disease therapy,along with their potential clinical applications,could offer valuable insights for future research and treatment strategies.展开更多
With continuous advancements in early diagnosis and treatment strategies,the survival period of cancer patients has been well extended.However,cancer therapy-related cardiovascular toxicity(CTR-CVT)such as chemotherap...With continuous advancements in early diagnosis and treatment strategies,the survival period of cancer patients has been well extended.However,cancer therapy-related cardiovascular toxicity(CTR-CVT)such as chemotherapy,targeted therapy,immunotherapy,and radiotherapy has been increasing,with over40%of cancer deaths attributed to cardiovascular diseases,making it the second leading cause of death among cancer patients after recurrence and metastasis[1].展开更多
Motivated by the advancement of large language models,multiagent technology,and digital twins,digital skeletons are bringing new development opportunities in orthopedics.Data-driven deep learning(DL)network models can...Motivated by the advancement of large language models,multiagent technology,and digital twins,digital skeletons are bringing new development opportunities in orthopedics.Data-driven deep learning(DL)network models can effectively learn medical feature representations from multimodal and cross-scale datasets to accurately identify orthopedic diseases,making the most of the vast amount of medical imaging data and records collected over the years.Digital skeleton technology can be boosted by artificial intelligence(AI)to quickly and accurately identify common diseases and investigate the most difficult problems as researchers continue to integrate a wide range of DL techniques into orthopedic applications.展开更多
基金supported by the Youth Natural Science Foundation of Shandong Province(grant number:ZR2022QH340).
文摘Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascular diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was initially and widely adopted in antimalarial treatments.As scientific research steadily progressed,its latent potential role in the cardiovascular system gradually captured the attention of the global scientific community.Artemisinin and its derivatives can reportedly play a protective role in the cardiovascular system through various mechanisms,including anti-inflammatory,anti-angiogenic,antioxidant,and anti-fibrotic effects,as well as the regulation of blood lipids and blood pressure.In particular,they have shown promising therapeutic effects in models of cardiovascular diseases such as atherosclerosis,myocardial ischaemia,and cardiac hypertrophy.In addition,artemisinin and its derivatives can improve cardiovascular function and prevent cardiovascular injury by regulating signalling pathways closely related to cardiovascular disease,such as AMPK and NF-kB.Although numerous ex vivo and in vivo experiments have verified the potential role of artemisinin in treating cardiovascular diseases,systematic studies to comprehensively elucidate its specific mechanism of action remain scarce.Further exploration of the precise roles of artemisinin and its derivatives in cardiovascular disease therapy,along with their potential clinical applications,could offer valuable insights for future research and treatment strategies.
基金the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0502605)the National Natural Science Foundation of China(82374420 and 82174364)+1 种基金Beijing-tianjin-hebei Basic Research Cooperation project(J230033)TCM Theory Inheritance and Innovation Project of CACMS Innovation Fund(KYG-202403)。
文摘With continuous advancements in early diagnosis and treatment strategies,the survival period of cancer patients has been well extended.However,cancer therapy-related cardiovascular toxicity(CTR-CVT)such as chemotherapy,targeted therapy,immunotherapy,and radiotherapy has been increasing,with over40%of cancer deaths attributed to cardiovascular diseases,making it the second leading cause of death among cancer patients after recurrence and metastasis[1].
基金supported in part by the National Natural Science Foundation of China(82371957 and 82371956)the National Key R&D Program of China(2021YFC2501703 and 2021YFC2501701)+3 种基金Capital’s Funds for Health Improvement and Research(2024-1-1121)Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY2023-11 and JYY2023-8)Beijing Physician Scientist Training Project(BJPSTP-2024-08)Beijing Municipal Health Commission(BJRITO-RDP-2025).
文摘Motivated by the advancement of large language models,multiagent technology,and digital twins,digital skeletons are bringing new development opportunities in orthopedics.Data-driven deep learning(DL)network models can effectively learn medical feature representations from multimodal and cross-scale datasets to accurately identify orthopedic diseases,making the most of the vast amount of medical imaging data and records collected over the years.Digital skeleton technology can be boosted by artificial intelligence(AI)to quickly and accurately identify common diseases and investigate the most difficult problems as researchers continue to integrate a wide range of DL techniques into orthopedic applications.
