Proteolytic processing of the transmembrane amyloid precursor protein (APP) to aggregation-prone amyloid-β (Aβ) peptide underlies the development of Alzheimer’s disease.
To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation ha...To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation has been implicated in numerous disease processes,particularly in tumorigenesis.Lung cancer is the leading cause of cancer-related mortality worldwide.Most patients with lung cancer are diagnosed at an advanced stage,which poses grave risks to their lives.O-GlcNAcylation facilitates cancer cell adaption to adverse environments,playing a critical role in the onset and progression of lung cancer.This article provides a brief overview of O-GlcNAcylation properties and recent advancements in its study across various diseases,with a particular focus on lung cancer.展开更多
文摘Proteolytic processing of the transmembrane amyloid precursor protein (APP) to aggregation-prone amyloid-β (Aβ) peptide underlies the development of Alzheimer’s disease.
基金National Natural Science Foundation of China(No.82000052)Sichuan Science and Technology Program(2022YFS0632)joint foundation of Luzhou Government and Southwest Medical University(Nos.2020LZXNYDJ11,2021LZXNYD-J25)
文摘To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation has been implicated in numerous disease processes,particularly in tumorigenesis.Lung cancer is the leading cause of cancer-related mortality worldwide.Most patients with lung cancer are diagnosed at an advanced stage,which poses grave risks to their lives.O-GlcNAcylation facilitates cancer cell adaption to adverse environments,playing a critical role in the onset and progression of lung cancer.This article provides a brief overview of O-GlcNAcylation properties and recent advancements in its study across various diseases,with a particular focus on lung cancer.
