Marine natural products represent an important class of biologically active compounds critical for drug discovery.To date,17 marine-derived drugs,including trabectedin and eribulin,have been approved by the US FDA for...Marine natural products represent an important class of biologically active compounds critical for drug discovery.To date,17 marine-derived drugs,including trabectedin and eribulin,have been approved by the US FDA for clinical use and 33 others are in clinical trials[1].However,their medicinal investigation and clinical trials are often hampered by the scarcity of natural sources and by the difficulties of their harvesting in the delicate marine environment.Therefore,efficient and scalable approaches for the synthesis of promising marine natural products are essential to overcome supply issues for drug development.展开更多
文摘Marine natural products represent an important class of biologically active compounds critical for drug discovery.To date,17 marine-derived drugs,including trabectedin and eribulin,have been approved by the US FDA for clinical use and 33 others are in clinical trials[1].However,their medicinal investigation and clinical trials are often hampered by the scarcity of natural sources and by the difficulties of their harvesting in the delicate marine environment.Therefore,efficient and scalable approaches for the synthesis of promising marine natural products are essential to overcome supply issues for drug development.
