Cp^*Co(Ⅲ)-catalyzed direct C—H amidation of azines has been developed.This co nversion could proceed smoothly in the absence of external oxidants,acids or bases,with excellent regioselectivity and broad functional g...Cp^*Co(Ⅲ)-catalyzed direct C—H amidation of azines has been developed.This co nversion could proceed smoothly in the absence of external oxidants,acids or bases,with excellent regioselectivity and broad functional group tolerance,CO2 was released as the sole byproduct,thus providing an environmentally benign amidation process.The products obtained are important intermediates in organic synthesis.展开更多
High atomic economy is an aspirational target of the construction functional organic molecules,which is one of the core contents of green chemistry.The visible-light-driven copper-catalyzed synthesis of hydroxamates f...High atomic economy is an aspirational target of the construction functional organic molecules,which is one of the core contents of green chemistry.The visible-light-driven copper-catalyzed synthesis of hydroxamates from dioxazolones has been reported.This reaction possesses high atom economy,a catalyst loading as low as 5 mol%,mild reaction conditions,and a broad substrate scope with excellent yields.A mechanistic study reveals that cleavage of C-O bond might be involved in the reaction.展开更多
A copper-catalyzed tandem click/amidation reaction involving various alkynes,azides,and dioxazolones has been developed for the synthesis of fully substituted 5-amide-1,2,3-triazoles.The key step in this reaction is t...A copper-catalyzed tandem click/amidation reaction involving various alkynes,azides,and dioxazolones has been developed for the synthesis of fully substituted 5-amide-1,2,3-triazoles.The key step in this reaction is the interception of the in situ-formed cuprate-triazole intermediate with N-acyl nitrenes,which are generated from dioxazolones.The choice of precursor for the N-acyl nitrenes plays a crucial role in the success of the reaction.This method is characterized by a broad substrate scope,mild reaction conditions,and complete regioselectivity.展开更多
基金the Ministry of Science and Technology of China(No.2016YFE0132600)Henan Center for Outstanding Overseas Scientists(No.GZS2020001)。
文摘Cp^*Co(Ⅲ)-catalyzed direct C—H amidation of azines has been developed.This co nversion could proceed smoothly in the absence of external oxidants,acids or bases,with excellent regioselectivity and broad functional group tolerance,CO2 was released as the sole byproduct,thus providing an environmentally benign amidation process.The products obtained are important intermediates in organic synthesis.
文摘High atomic economy is an aspirational target of the construction functional organic molecules,which is one of the core contents of green chemistry.The visible-light-driven copper-catalyzed synthesis of hydroxamates from dioxazolones has been reported.This reaction possesses high atom economy,a catalyst loading as low as 5 mol%,mild reaction conditions,and a broad substrate scope with excellent yields.A mechanistic study reveals that cleavage of C-O bond might be involved in the reaction.
基金support from Natural Science Foundation of China and Shandong Province(Nos.22471143 and ZR2020QB012)the Taishan Scholar award of Shandong Province.
文摘A copper-catalyzed tandem click/amidation reaction involving various alkynes,azides,and dioxazolones has been developed for the synthesis of fully substituted 5-amide-1,2,3-triazoles.The key step in this reaction is the interception of the in situ-formed cuprate-triazole intermediate with N-acyl nitrenes,which are generated from dioxazolones.The choice of precursor for the N-acyl nitrenes plays a crucial role in the success of the reaction.This method is characterized by a broad substrate scope,mild reaction conditions,and complete regioselectivity.
