Methyl 3-trimethylsilylpropargyl carbonate reacted with dinucleophiles under the catalysis of palladium(0) complex to give the corresponding desilylated annulation products.
Phosphine-catalyzed[5+1]annulation reaction of Morita-Baylis-Hillman(MBH)carbonates with 1,3-dicarbonyl compounds has been developed,producing biologically interesting spirocyclohexene derivatives in high yields with ...Phosphine-catalyzed[5+1]annulation reaction of Morita-Baylis-Hillman(MBH)carbonates with 1,3-dicarbonyl compounds has been developed,producing biologically interesting spirocyclohexene derivatives in high yields with moderate to excellent diastereoselectivities.The annulation was achieved through sequential 1,6-conjugate addition/nucleophilic substution reaction of phosphine ylides with dinucleophiles.展开更多
The reaction of 3-（1-hydropolyfluoroalkenyl）-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was investigated. 7-Fluoroalkyl-2,3-dihydro- 1,4-diazepine[ 1,2-d]quinazolin- 11-ones 2, 2-fluoroalkylisoxazolo[3,2-b]...The reaction of 3-（1-hydropolyfluoroalkenyl）-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was investigated. 7-Fluoroalkyl-2,3-dihydro- 1,4-diazepine[ 1,2-d]quinazolin- 11-ones 2, 2-fluoroalkylisoxazolo[3,2-b]quinazolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane, hydroxylamine hydrochloride and 1,2-diaminobenzene respectively.展开更多
文摘Methyl 3-trimethylsilylpropargyl carbonate reacted with dinucleophiles under the catalysis of palladium(0) complex to give the corresponding desilylated annulation products.
文摘Phosphine-catalyzed[5+1]annulation reaction of Morita-Baylis-Hillman(MBH)carbonates with 1,3-dicarbonyl compounds has been developed,producing biologically interesting spirocyclohexene derivatives in high yields with moderate to excellent diastereoselectivities.The annulation was achieved through sequential 1,6-conjugate addition/nucleophilic substution reaction of phosphine ylides with dinucleophiles.
基金Project supported by the National Natural Science Foundation of China （No. 20172065）.
文摘The reaction of 3-（1-hydropolyfluoroalkenyl）-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was investigated. 7-Fluoroalkyl-2,3-dihydro- 1,4-diazepine[ 1,2-d]quinazolin- 11-ones 2, 2-fluoroalkylisoxazolo[3,2-b]quinazolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane, hydroxylamine hydrochloride and 1,2-diaminobenzene respectively.
