Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder whose mechanisms underlying remain incompletely understood,particularly the role of glial cells.This study investigated the impact of ALS-a...Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder whose mechanisms underlying remain incompletely understood,particularly the role of glial cells.This study investigated the impact of ALS-associated genes on distinct glial populations in Drosophila.We assessed motor function and lifespan,revealing significant sexual dimorphism,with males generally showing greater declines.Our findings also underscore the importance of glial cells,particularly subperineurial glia(SPG)in the male leg femur,and provides valuable insights into the complex interplay between glial cells and ALS-associated genes.展开更多
基金supported by University of Ottawa Startup grant to WJK, University of Ottawa Brain and Mind Research Institute/Center for Neural Dynamics Open call project grant to WJK, University of Ottawa Interdisciplinary Research Group Funding Opportunity (IRGFO stream 1 and 2) Grant to WJK, Mitacs Globalink Research Internship Program grant to WJK, and Startup funds from HIT Center for Life Science to WJKsupported by a Brain Pool Program by National Research Foundation in Korea to WJK, Burroughs Wellcome Fund Collaborative Research Travel Grants 1017486 to WJK, NVIDIA Academic Hardware Grant Program to WJK.
文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder whose mechanisms underlying remain incompletely understood,particularly the role of glial cells.This study investigated the impact of ALS-associated genes on distinct glial populations in Drosophila.We assessed motor function and lifespan,revealing significant sexual dimorphism,with males generally showing greater declines.Our findings also underscore the importance of glial cells,particularly subperineurial glia(SPG)in the male leg femur,and provides valuable insights into the complex interplay between glial cells and ALS-associated genes.
