Exploring a new and robust material for proton conduction is of significant importance to the scientific interest and technological importance.Polyoxometalates(POMs)are a class of molecular anion metal oxide clusters ...Exploring a new and robust material for proton conduction is of significant importance to the scientific interest and technological importance.Polyoxometalates(POMs)are a class of molecular anion metal oxide clusters with well-defined structures and diverse properties.Therefore,the design and synthesis of a POM-based material for proton conduction is extremely vital.Herein,a dimeric four tartaric acid-bridged tetra-Zr-incorporated arsenotungstate.展开更多
Decoupling electrical and thermal properties to enhance the figure of merit of thermoelectric materials underscores an in-depth understanding of the mechanisms that govern the transfer of charge carriers.Typically,a f...Decoupling electrical and thermal properties to enhance the figure of merit of thermoelectric materials underscores an in-depth understanding of the mechanisms that govern the transfer of charge carriers.Typically,a factor that contributes to the optimization of thermal conductivity is often found to be detrimental to the electrical transport properties.Here,we systematically investigated 26 dimeric MX_(2)-type compounds(where M represents a metal and X represents a nonmetal element)to explore the influence of the electronic configurations of metal cations on lattice thermal transport and thermoelectric performance using first-principles calculations.A principled scheme has been identified that the filled outer orbitals of the cation lead to a significantly lower lattice thermal conductivity compared to that of the partly occupied case for MX_(2),due to the much weakened bonds manifested by the shallow potential well,smaller interatomic force constants,and higher atomic displacement parameters.Based on these findings,we propose two ionic compounds,BaAs and BaSe_(2),to realize reasonable high electrical conductivities through the structural anisotropy caused by the inserted covalent X_(2) dimers while still maintaining the large lattice anharmonicity.The combined superior electrical and thermal properties of BaSe_(2) lead to a high n-type thermoelectric ZT value of 2.3 at 500 K.This work clarifies the structural origin of the heat transport properties of dimeric MX_(2)-type compounds and provides an insightful strategy for developing promising thermoelectric materials.展开更多
In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed ...In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from Inula Britannica(I.britannica).Seven novel sesquiterpenoid dimers inulabritanoids A−G(1−7)and two novel sesquiterpenoid monomers inulabritanoids H(8)and I(9)were isolated from I.britannica together with eighteen known compounds(10−27).The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance(NMR),high-resolution mass spectrometry(HR-MS),and electronic circular dichroism(ECD)spectra,complemented by quantum chemical calculations.Compounds 1,2,12,16,19,and 26 demonstrated inhibitory effects on NO production,with IC50 values of 3.65,5.48,3.29,6.91,3.12,and 5.67μmol·L^(−1),respectively.Mechanistic studies revealed that compound 1 inhibited IκB kinaseβ(IKKβ)phosphorylation,thereby blocking nuclear factorκB(NF-κB)nuclear translocation,and activated the kelch-like ECH-associated protein 1(Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2)signal pathway,leading to decreased expression of NADPH oxidase 2(NOX-2),inducible nitric oxide synthase(iNOS),tumor necrosis factorα(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),IL-1β,and IL-1αand increased expression of NAD(P)H:quinone oxidoreductase 1(NQO-1)and heme oxygenase-1(HO-1),thus exhibiting anti-inflammatory effects in vitro.These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development.展开更多
An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8...An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8.0Hz.Furthermore,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/L.The chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,respectively.All reported ambiguous structures were corrected by this pattern.Additionally,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.展开更多
Ternary strategy with a suitable third component is a successful strategy to improve the photovoltaic performance of organic solar cells(OSCs).Very recently,Y-series based giant molecule acceptors or oligomerized acce...Ternary strategy with a suitable third component is a successful strategy to improve the photovoltaic performance of organic solar cells(OSCs).Very recently,Y-series based giant molecule acceptors or oligomerized acceptors have emerged as promising materials for achieving highly efficient and stable binary OSCs,while application as third component for ternary OSCs is limited.Here a novelπ-extended giant dimeric acceptor,GDF,is developed based on central Y series core fusion and rigid BDT as linker,and then incorporated into the state-of-the-art PM1:PC6 system to construct ternary OSCs.The GDF has a near planar backbone,resulting in increasedπ-conjugation,excellent crystallinity,and good electron transport capacity.When GDF is introduced into the PM1:PC6 system,it ensues in a cascade like the lowest unoccupied molecular orbitals(LUMO)energy level alignment,a complementary absorption band with PM1 and PC6,higher and balanced hole and electron mobility,slightly smaller domain size,and a higher exciton dissociation probability for PM1:PC6:GDF(1:1.1:0.1)blend film.As a consequence,the PM1:PC6:GDF(1:1.1:0.1)ternary OSC achieves a champion PCE of 19.22%,with a significantly higher open-circuit voltage and short-circuit current density,compared to 18.45%for the PM1:PC6(1:1.2)binary OSC.Our findings show that employing aπ-extended giant dimeric acceptor as a third component significantly improves the photovoltaic performance of ternary OSCs.展开更多
A new dimeric phthalide named Z, Z＇-3.3＇a, 7.7＇a-diligustilide was isolated from the roots of Angelica sinensis. Its structure was determined using spectroscopic methods and X-ray crystallographic diffraction analy...A new dimeric phthalide named Z, Z＇-3.3＇a, 7.7＇a-diligustilide was isolated from the roots of Angelica sinensis. Its structure was determined using spectroscopic methods and X-ray crystallographic diffraction analysis.展开更多
A new dimeric psoralen-type furanocoumarin, notopterol-（18-O-20＇）-notopol （1）, was isolated from Notopterygium incisum for the first time and its structure was elucidated by spectroscopic methods.
The viscoelastic micelle systems formed by novel anionic-nonionic dimeric surfactant and conventional cationic surfactant cetyltrimethylammonium(1631) were studied.The viscoelasticity,thixotropy,flow curves and consti...The viscoelastic micelle systems formed by novel anionic-nonionic dimeric surfactant and conventional cationic surfactant cetyltrimethylammonium(1631) were studied.The viscoelasticity,thixotropy,flow curves and constitutive equation for the novel viscoelastic micelle systems were investigated.The results show that the micelle systems possess viscoelasticity,thixotropy,and shear thinning property.Some micelle systems possess hysteresis loops showing both viscoelasticity and thixotropy.It is proved that the flow curves are characterized by the co-rotational Jeffreys constitutive equation correctly.展开更多
Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretat...Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.展开更多
The formation of coordinated dimeric complexes bridged by axial ligands on surface is observed with the help of a 1,3,5-tris（10-carboxydecyloxy）benzene（TCDB） template through scanning tunneling microscopy（STM）. ...The formation of coordinated dimeric complexes bridged by axial ligands on surface is observed with the help of a 1,3,5-tris（10-carboxydecyloxy）benzene（TCDB） template through scanning tunneling microscopy（STM）. STM images of molecular adlayers of zinc tetraphenylporphyrin（Zn TPP）, zinc phthalocyanine（Zn Pc）, and their mixture are reported. Zn TPP and Zn Pc can spontaneously form highly an ordered structure with a 1：1 molar ratio, which is different from that of individual Zn Pc. The coordinated bimolecular complexes bridged with axial ligands, simply as Zn Pc–DPP–Zn TPP and Zn Pc–DPE–Zn Pc, are presented and the corresponding surface structures are compared. Zn Pc and Zn TPP can be connected by an axial ligand DPP and formed assembled structures out of surface. Two types of arrays with entirely new structure are obtained for the Zn Pc–DPE–Zn Pc complex. These bridged hybrid complexes provide an example of design of self-organized crystals on the basis of coordination through non-covalent interactions.展开更多
A novel dimeric eremophilane, ligulolide B, was isolated from the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structure was elucidated by various spectroscopic methods including ...A novel dimeric eremophilane, ligulolide B, was isolated from the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structure was elucidated by various spectroscopic methods including intensive 2D NMR techniques （^1H-^1H COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESI-MS.展开更多
Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of t...Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.展开更多
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a...Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.展开更多
To search naturally occurring interleukin-1β(IL-1β) inhibitors,biscaesalmins A(1) and B(2),two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton,have been isolated from the traditio...To search naturally occurring interleukin-1β(IL-1β) inhibitors,biscaesalmins A(1) and B(2),two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton,have been isolated from the traditional Chinese medicine Kushilian(Caesalpinia minax).Their full structures were determined by comprehensive spectroscopic analysis and quantum chemical TD-DFT(time-dependent density functional theory) calculation.Biosynthetically,1 and 2 were formed via an intermolecular [4+2]Diels-Alder cycloaddition of two monomers,affording an additional six-membered carbon ring linkage.Compounds 1 and 2 inhibited nitric oxide production on lipopolysaccharide-stimulated THP-1 macrophages,with IC_(50) values being at 1.20±0.23 and 2.30±0.15 μmol/L,respectively.Furthermore,compound 1 inhibited NLRP3(NOD-,LRR-and pyrin domain-containing protein 3) inflammasomemediated IL-1β production and blocked the migration of macrophages towards adipocyte conditioned medium.Biscaesalmins A and B might be candidates for treating inflammation-related metabolic diseases.展开更多
Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,a...Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,and poor cellular internalization.Herein,we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loading of CPT for cancer therapy.This self-assembled micelle possesses the following essential components for CPT:(1)pH-sensitive PEG(OHC-PEG-CHO)for prolonging blood circulation and allowing biocompatibility by shielding the cationic micelles,which can be detached under the tumor acidic microenvironment and facilitates the cellular uptake;(2)polypeptide polylysine-polyphenylalanine(PKF)synthesized via ring-opening polymerization for micelle formation and CPT analogue loading;(3)dimeric CPT(DCPT)with redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor sites.Interestingly,the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular internalization when compared with the spherical blank PKF micelles.Also,the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle formation.In conclusion,this work provides a promising strategy facilitating the safety and effective application of CPT in cancer therapy.展开更多
Although many plasmonic nanosenosrs have been established for the detection of mercury(Ⅱ)(Hg^(2+)),few of them is feasible for analyzing natural samples with very complex matrices because of insufficient method selec...Although many plasmonic nanosenosrs have been established for the detection of mercury(Ⅱ)(Hg^(2+)),few of them is feasible for analyzing natural samples with very complex matrices because of insufficient method selectivity.To address this challenge,we propose an epitaxial and lattice-mismatch approach to the synthesis of a unique Au/Ag_(2)S dimeric nanostructure,which consists of an Au segment with excellent plasmonic characteristics,and a highly stable Ag_(2)S portion with minimum solubility product (K_(sp)(Ag_(2)S)=6.3×10^(-50)).The detection relies on the chemical conversion of Ag_(2)S to HgS when reacting with Hg^(2+),resulting in a red shift in the absorption band of the connecting Au NPs.The concurrent color changes of the solution from gray purple to dark green and finally to navy correlate well with Hg^(2+)concentration,thus enables UV-vis quantitation and a naked-eye readout of the Hg^(2+)concentration.This method exhibits superior selectivity towards Hg^(2+) over other interfering ions tested because Hg^(2+) is the only ion that can react with Ag_(2)S to form HgS with even smaller solubility product (K_(sp)(HgS)=4×10^(-53)).The detection limit of this method is 1.21μmol/L,calculated by the signal-to-noise of 3.The practicability of the method was verified by analyzing the Hg^(2+)in sewage water samples without sample pretreatment with satisfactory recoveries (93.1%-102.8%) and relative standard deviations (1.38%-2.89%).We believe this method holds great potential for on-the-spot detection of Hg^(2+) in environmental water samples with complex matrices.展开更多
The crystal and molecular structure of copper(Ⅱ) dimeric complex of S-methyl-B-N-(pyridine N-oxide-2-ylmethylidene) dithiocarbazate with acetonitrile, [CuL (CH3CN)]2 (ClO4)2, was determined by X-ray diffraction. The ...The crystal and molecular structure of copper(Ⅱ) dimeric complex of S-methyl-B-N-(pyridine N-oxide-2-ylmethylidene) dithiocarbazate with acetonitrile, [CuL (CH3CN)]2 (ClO4)2, was determined by X-ray diffraction. The complex crystalizes in monoclinic system with space group P21/n, a= 7. 685(2), 6=20.160(6), c= 10. 847(5) A ,B = 107.89(3), Z=2,Dc=1.788 g/cm3, F(000) = 835. 8, u= 18. 17 cm-1(Moka,R= 0. 057.Each Cu(Ⅱ) ion in the complex is surrounded by a distorted square pyramidal. The basal plane is comprised of S, N and O atoms of one ligand together with a N atom of the solvent--acetonitrile, while the axial position is occupied by the S atom of the other ligand. The bond length of Cu-S(bridging) is 3. 038A . and Cu-Cu distance is 3. 700A.展开更多
Erratum to:Nat.Prod.Bioprospect.(2015)5:77–82 DOI 10.1007/s13659-015-0054-6 In the HTML version of the original publication,the graphical abstract was inadvertently omitted.The graphical abstract is given in this er...Erratum to:Nat.Prod.Bioprospect.(2015)5:77–82 DOI 10.1007/s13659-015-0054-6 In the HTML version of the original publication,the graphical abstract was inadvertently omitted.The graphical abstract is given in this erratum.展开更多
The dimeric dipeptide mimetics of the brain derived neurotrophic factor (BDNF) loops 1 and 4 and nerve growth factor (NGF) loop 4 were designed and synthesized at the Zakusov Research Institute of Pharmacology. There ...The dimeric dipeptide mimetics of the brain derived neurotrophic factor (BDNF) loops 1 and 4 and nerve growth factor (NGF) loop 4 were designed and synthesized at the Zakusov Research Institute of Pharmacology. There are respectively bis-(N-monosuccinyl-L-methionyl-L-serine) heptamethylenediamide(GSB-214), bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106) and bis-(N-monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2). All of the ob-tained compounds activated a corresponding specific NGF or BDNF tyrosine kinase receptor (TrkA or TrkB), but had different postreceptor signaling patterns. GSB-106 activated the ERK and AKT, whereas GSB-214 and GK-2 only activated the AKT kinase. Here we report a comparative analysis of neuroprotective activity of these dipeptides in a model of ischemic stroke induced by transient middle cerebral artery occlusion (MCAO). The all three dimeric dipeptides showed a statistically significant decrease of infarct volumes with the treatment beginning 4 hour after surgery. In the experiment with BDNF mimetics, GSB-106 reduced this volume by 66% and GSB-214 by 26%. NGF GK-2 reduced the cerebral infarct volume by 45%. Thus, BDNF mimetic, which activated both the ERK and AKT, and NGF mimetic, which selectively activated PI3K/AKT, showed high neuroprotective efficacy. In addition, we studied neuroprotective effects of GK-2 at the beginning of the treatment 6, 8 and 24 hours after reperfusion. The neuroprotective effect of GK-2 persisted in all these conditions. The effectiveness of GK-2 at a delayed start of administration suggests that the dipeptide has neuroregenerative properties. The results obtained suggest a potential role for the dimeric dipeptide NGF and BDNF mimetics as therapeutic agents useful in the treatment of a stroke.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22071043 and 22203027)Shanxi Province Science Foundation(No.202303021211194)the program for the(Reserved)Discipline Leaders of Taiyuan Institute of Technology.
文摘Exploring a new and robust material for proton conduction is of significant importance to the scientific interest and technological importance.Polyoxometalates(POMs)are a class of molecular anion metal oxide clusters with well-defined structures and diverse properties.Therefore,the design and synthesis of a POM-based material for proton conduction is extremely vital.Herein,a dimeric four tartaric acid-bridged tetra-Zr-incorporated arsenotungstate.
基金financial support from the Natural Science Foundation of China(No.11904089,12174092,11674087)the Overseas Expertise Introduction Center for Discipline Innovation(D18025)+1 种基金the Program for Key Research and Development of Science and Technology in Hubei Province(grant No.2023BEB002)supported by the Young Science Foundation of Hubei University(Grant No.430/184303000047).
文摘Decoupling electrical and thermal properties to enhance the figure of merit of thermoelectric materials underscores an in-depth understanding of the mechanisms that govern the transfer of charge carriers.Typically,a factor that contributes to the optimization of thermal conductivity is often found to be detrimental to the electrical transport properties.Here,we systematically investigated 26 dimeric MX_(2)-type compounds(where M represents a metal and X represents a nonmetal element)to explore the influence of the electronic configurations of metal cations on lattice thermal transport and thermoelectric performance using first-principles calculations.A principled scheme has been identified that the filled outer orbitals of the cation lead to a significantly lower lattice thermal conductivity compared to that of the partly occupied case for MX_(2),due to the much weakened bonds manifested by the shallow potential well,smaller interatomic force constants,and higher atomic displacement parameters.Based on these findings,we propose two ionic compounds,BaAs and BaSe_(2),to realize reasonable high electrical conductivities through the structural anisotropy caused by the inserted covalent X_(2) dimers while still maintaining the large lattice anharmonicity.The combined superior electrical and thermal properties of BaSe_(2) lead to a high n-type thermoelectric ZT value of 2.3 at 500 K.This work clarifies the structural origin of the heat transport properties of dimeric MX_(2)-type compounds and provides an insightful strategy for developing promising thermoelectric materials.
基金supported by the National Natural Science Foundation of China(Nos.82274069,82030116,and 82141212)the Young Scientific and Technological Talents(Level Two)in Tianjin(No.QN20230212)+1 种基金Tianjin Education Commission Research Program Project(No.2024KJ004)the Eaglet Plan Project of Tianjin University of Traditional Chinese Medicine(No.XJS2024101).
文摘In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from Inula Britannica(I.britannica).Seven novel sesquiterpenoid dimers inulabritanoids A−G(1−7)and two novel sesquiterpenoid monomers inulabritanoids H(8)and I(9)were isolated from I.britannica together with eighteen known compounds(10−27).The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance(NMR),high-resolution mass spectrometry(HR-MS),and electronic circular dichroism(ECD)spectra,complemented by quantum chemical calculations.Compounds 1,2,12,16,19,and 26 demonstrated inhibitory effects on NO production,with IC50 values of 3.65,5.48,3.29,6.91,3.12,and 5.67μmol·L^(−1),respectively.Mechanistic studies revealed that compound 1 inhibited IκB kinaseβ(IKKβ)phosphorylation,thereby blocking nuclear factorκB(NF-κB)nuclear translocation,and activated the kelch-like ECH-associated protein 1(Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2)signal pathway,leading to decreased expression of NADPH oxidase 2(NOX-2),inducible nitric oxide synthase(iNOS),tumor necrosis factorα(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),IL-1β,and IL-1αand increased expression of NAD(P)H:quinone oxidoreductase 1(NQO-1)and heme oxygenase-1(HO-1),thus exhibiting anti-inflammatory effects in vitro.These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development.
基金funded by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-028).
文摘An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8.0Hz.Furthermore,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/L.The chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,respectively.All reported ambiguous structures were corrected by this pattern.Additionally,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.
基金supported by the Yunnan Fundamental Research Project(202301BF070001-009,KC-22222357)the Sichuan Science and Technology Program(2023NSFSC0990)the School of Materials Science and Engineering,Jiangsu Engineering Laboratory of Light-Electricity-Heat Energy-Converting Materials and Applications。
文摘Ternary strategy with a suitable third component is a successful strategy to improve the photovoltaic performance of organic solar cells(OSCs).Very recently,Y-series based giant molecule acceptors or oligomerized acceptors have emerged as promising materials for achieving highly efficient and stable binary OSCs,while application as third component for ternary OSCs is limited.Here a novelπ-extended giant dimeric acceptor,GDF,is developed based on central Y series core fusion and rigid BDT as linker,and then incorporated into the state-of-the-art PM1:PC6 system to construct ternary OSCs.The GDF has a near planar backbone,resulting in increasedπ-conjugation,excellent crystallinity,and good electron transport capacity.When GDF is introduced into the PM1:PC6 system,it ensues in a cascade like the lowest unoccupied molecular orbitals(LUMO)energy level alignment,a complementary absorption band with PM1 and PC6,higher and balanced hole and electron mobility,slightly smaller domain size,and a higher exciton dissociation probability for PM1:PC6:GDF(1:1.1:0.1)blend film.As a consequence,the PM1:PC6:GDF(1:1.1:0.1)ternary OSC achieves a champion PCE of 19.22%,with a significantly higher open-circuit voltage and short-circuit current density,compared to 18.45%for the PM1:PC6(1:1.2)binary OSC.Our findings show that employing aπ-extended giant dimeric acceptor as a third component significantly improves the photovoltaic performance of ternary OSCs.
基金financially supported by the General Fund of National Natural Science Foundation of China(No.30472160).
文摘A new dimeric phthalide named Z, Z＇-3.3＇a, 7.7＇a-diligustilide was isolated from the roots of Angelica sinensis. Its structure was determined using spectroscopic methods and X-ray crystallographic diffraction analysis.
基金in part,by NSFC grants(No.90713040,30640068),MOST(No.2003CB716601),NCET grant(No.NCET-06-0422)STCSM grants(No.06DZ19002,06PJ14033,07DZ22006).The authors are grateful to Dr.Jiang-Nan Peng and Prof.Mark T.Hamann(Department of Pharmacognosy,The University of Mississippi),Prof.Jian-Ming Yue(Shanghai Institute of Materia Medica),and Prof.Zheng Zhao(Shanghai Key Laboratory of Brain Functional Genomics)for their assistance of the measurement of MS spectral data.The authors wish to thank Prof.Jian-Wei Chen(Nanjing University of Traditional Chinese Medicine)for the plant identification.
文摘A new dimeric psoralen-type furanocoumarin, notopterol-（18-O-20＇）-notopol （1）, was isolated from Notopterygium incisum for the first time and its structure was elucidated by spectroscopic methods.
基金Project(20276016) supported by the National Natural Science Foundation of China
文摘The viscoelastic micelle systems formed by novel anionic-nonionic dimeric surfactant and conventional cationic surfactant cetyltrimethylammonium(1631) were studied.The viscoelasticity,thixotropy,flow curves and constitutive equation for the novel viscoelastic micelle systems were investigated.The results show that the micelle systems possess viscoelasticity,thixotropy,and shear thinning property.Some micelle systems possess hysteresis loops showing both viscoelasticity and thixotropy.It is proved that the flow curves are characterized by the co-rotational Jeffreys constitutive equation correctly.
基金financial support of the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09301001-001,2015ZX09103002)the National Natural Science Fundation of China(Nos.81302657,81473112,81573305)
文摘Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.
基金supported by the National Basic Research Program of China (No. 2013CB934200)National Basic Research Program of China (No. 2012CB933001)+1 种基金The Chinese Academy of Sciences (No. YZ201318)the National Natural Science Foundation of China (Nos. 21472029, 51173031, 91127043, 51203030, 51463002)
文摘The formation of coordinated dimeric complexes bridged by axial ligands on surface is observed with the help of a 1,3,5-tris（10-carboxydecyloxy）benzene（TCDB） template through scanning tunneling microscopy（STM）. STM images of molecular adlayers of zinc tetraphenylporphyrin（Zn TPP）, zinc phthalocyanine（Zn Pc）, and their mixture are reported. Zn TPP and Zn Pc can spontaneously form highly an ordered structure with a 1：1 molar ratio, which is different from that of individual Zn Pc. The coordinated bimolecular complexes bridged with axial ligands, simply as Zn Pc–DPP–Zn TPP and Zn Pc–DPE–Zn Pc, are presented and the corresponding surface structures are compared. Zn Pc and Zn TPP can be connected by an axial ligand DPP and formed assembled structures out of surface. Two types of arrays with entirely new structure are obtained for the Zn Pc–DPE–Zn Pc complex. These bridged hybrid complexes provide an example of design of self-organized crystals on the basis of coordination through non-covalent interactions.
基金supported by the Foundation for the"Bairen Jihua"of Chinese Academy of Sciences(CAS)in 2000the National Natural Science Foundation of China(NNSFC 20021001,20372029,20475057).
文摘A novel dimeric eremophilane, ligulolide B, was isolated from the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structure was elucidated by various spectroscopic methods including intensive 2D NMR techniques （^1H-^1H COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESI-MS.
基金the foundations from NSFC(81373291)the National Science and Technology Support Program of China(2013BAI11B02)the Young Academic Leader Raising Foundation of Yunnan Province(No.2009CI073)。
文摘Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.
基金Poly U(G-YBGQ G-SB81+3 种基金 G-YZ95)the Research Grant Council of Hong Kong(15101014)ITSP-Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/012/16GD)Shenzhen Basic Research Program(JCYJ20160331141459373)
文摘Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.
基金the financial support of the Science and Technology Development Fund,Macao SAR (No.FDCT 0031/2019/ A1)the National Natural Science Foundation of China (Nos. 81872754 and 81872756)University of Macao,Macao SAR (Nos.MYRG2017-00109-ICMS and MYRG2018-00037-ICMS)。
文摘To search naturally occurring interleukin-1β(IL-1β) inhibitors,biscaesalmins A(1) and B(2),two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton,have been isolated from the traditional Chinese medicine Kushilian(Caesalpinia minax).Their full structures were determined by comprehensive spectroscopic analysis and quantum chemical TD-DFT(time-dependent density functional theory) calculation.Biosynthetically,1 and 2 were formed via an intermolecular [4+2]Diels-Alder cycloaddition of two monomers,affording an additional six-membered carbon ring linkage.Compounds 1 and 2 inhibited nitric oxide production on lipopolysaccharide-stimulated THP-1 macrophages,with IC_(50) values being at 1.20±0.23 and 2.30±0.15 μmol/L,respectively.Furthermore,compound 1 inhibited NLRP3(NOD-,LRR-and pyrin domain-containing protein 3) inflammasomemediated IL-1β production and blocked the migration of macrophages towards adipocyte conditioned medium.Biscaesalmins A and B might be candidates for treating inflammation-related metabolic diseases.
基金supported by the National Natural Science Foundation of China (51922111)the Science and Technology Development Fund, Macao SAR (File no. 0124/2019/A3)+1 种基金the University of Macao (File no. MYRG2022-00203-ICMS)Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials (2019B121205002)
文摘Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,and poor cellular internalization.Herein,we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loading of CPT for cancer therapy.This self-assembled micelle possesses the following essential components for CPT:(1)pH-sensitive PEG(OHC-PEG-CHO)for prolonging blood circulation and allowing biocompatibility by shielding the cationic micelles,which can be detached under the tumor acidic microenvironment and facilitates the cellular uptake;(2)polypeptide polylysine-polyphenylalanine(PKF)synthesized via ring-opening polymerization for micelle formation and CPT analogue loading;(3)dimeric CPT(DCPT)with redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor sites.Interestingly,the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular internalization when compared with the spherical blank PKF micelles.Also,the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle formation.In conclusion,this work provides a promising strategy facilitating the safety and effective application of CPT in cancer therapy.
基金supported by the National Natural Science Foundation of China(No.21876206)the Key Fundamental Project of Shandong Natural Science Foundation(No.ZR2020ZD13)+1 种基金the Science and Technology Projects of Qingdao(No.21–1–4-sf-7-nsh)the Youth Innovation and Technology project of Universities in Shandong Province(No.2020KJC007)。
文摘Although many plasmonic nanosenosrs have been established for the detection of mercury(Ⅱ)(Hg^(2+)),few of them is feasible for analyzing natural samples with very complex matrices because of insufficient method selectivity.To address this challenge,we propose an epitaxial and lattice-mismatch approach to the synthesis of a unique Au/Ag_(2)S dimeric nanostructure,which consists of an Au segment with excellent plasmonic characteristics,and a highly stable Ag_(2)S portion with minimum solubility product (K_(sp)(Ag_(2)S)=6.3×10^(-50)).The detection relies on the chemical conversion of Ag_(2)S to HgS when reacting with Hg^(2+),resulting in a red shift in the absorption band of the connecting Au NPs.The concurrent color changes of the solution from gray purple to dark green and finally to navy correlate well with Hg^(2+)concentration,thus enables UV-vis quantitation and a naked-eye readout of the Hg^(2+)concentration.This method exhibits superior selectivity towards Hg^(2+) over other interfering ions tested because Hg^(2+) is the only ion that can react with Ag_(2)S to form HgS with even smaller solubility product (K_(sp)(HgS)=4×10^(-53)).The detection limit of this method is 1.21μmol/L,calculated by the signal-to-noise of 3.The practicability of the method was verified by analyzing the Hg^(2+)in sewage water samples without sample pretreatment with satisfactory recoveries (93.1%-102.8%) and relative standard deviations (1.38%-2.89%).We believe this method holds great potential for on-the-spot detection of Hg^(2+) in environmental water samples with complex matrices.
文摘The crystal and molecular structure of copper(Ⅱ) dimeric complex of S-methyl-B-N-(pyridine N-oxide-2-ylmethylidene) dithiocarbazate with acetonitrile, [CuL (CH3CN)]2 (ClO4)2, was determined by X-ray diffraction. The complex crystalizes in monoclinic system with space group P21/n, a= 7. 685(2), 6=20.160(6), c= 10. 847(5) A ,B = 107.89(3), Z=2,Dc=1.788 g/cm3, F(000) = 835. 8, u= 18. 17 cm-1(Moka,R= 0. 057.Each Cu(Ⅱ) ion in the complex is surrounded by a distorted square pyramidal. The basal plane is comprised of S, N and O atoms of one ligand together with a N atom of the solvent--acetonitrile, while the axial position is occupied by the S atom of the other ligand. The bond length of Cu-S(bridging) is 3. 038A . and Cu-Cu distance is 3. 700A.
文摘Erratum to:Nat.Prod.Bioprospect.(2015)5:77–82 DOI 10.1007/s13659-015-0054-6 In the HTML version of the original publication,the graphical abstract was inadvertently omitted.The graphical abstract is given in this erratum.
文摘The dimeric dipeptide mimetics of the brain derived neurotrophic factor (BDNF) loops 1 and 4 and nerve growth factor (NGF) loop 4 were designed and synthesized at the Zakusov Research Institute of Pharmacology. There are respectively bis-(N-monosuccinyl-L-methionyl-L-serine) heptamethylenediamide(GSB-214), bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106) and bis-(N-monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2). All of the ob-tained compounds activated a corresponding specific NGF or BDNF tyrosine kinase receptor (TrkA or TrkB), but had different postreceptor signaling patterns. GSB-106 activated the ERK and AKT, whereas GSB-214 and GK-2 only activated the AKT kinase. Here we report a comparative analysis of neuroprotective activity of these dipeptides in a model of ischemic stroke induced by transient middle cerebral artery occlusion (MCAO). The all three dimeric dipeptides showed a statistically significant decrease of infarct volumes with the treatment beginning 4 hour after surgery. In the experiment with BDNF mimetics, GSB-106 reduced this volume by 66% and GSB-214 by 26%. NGF GK-2 reduced the cerebral infarct volume by 45%. Thus, BDNF mimetic, which activated both the ERK and AKT, and NGF mimetic, which selectively activated PI3K/AKT, showed high neuroprotective efficacy. In addition, we studied neuroprotective effects of GK-2 at the beginning of the treatment 6, 8 and 24 hours after reperfusion. The neuroprotective effect of GK-2 persisted in all these conditions. The effectiveness of GK-2 at a delayed start of administration suggests that the dipeptide has neuroregenerative properties. The results obtained suggest a potential role for the dimeric dipeptide NGF and BDNF mimetics as therapeutic agents useful in the treatment of a stroke.
