OBJECTIVE:To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate(DMPS)on neurological Wilson's disease(WD)in patients.METHODS:We retrospectively evaluated the clinical records of 125 WD...OBJECTIVE:To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate(DMPS)on neurological Wilson's disease(WD)in patients.METHODS:We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone.All patients had a history of neurological deterioration during their diseases courses.The clinical efficacies,adverse reactions,and results of the various hematological and biochemical investigations were recorded for statistical analysis.RESULTS:92.30%(60 patients)of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paral-leled by a significantly improved GAS score.Meanwhile,the WBC and PLT counts stabilized,liver function and renal function were improved or remained stable.The combined therapy also obviously promoted the 24-h urinary copper excretion.In particular,only 30.76%of the WD patients experienced mild adverse reactions,including neurological deterioration in 5 patients(7.69%),hepatic worsening in 1 subject(1.89%),which was less frequently than those in the control group treated with DMPS only.CONCLUSION:Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms.展开更多
基金Supported by National Natural Science Foundation of China(No.81673811,81473534,81774299)
文摘OBJECTIVE:To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate(DMPS)on neurological Wilson's disease(WD)in patients.METHODS:We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone.All patients had a history of neurological deterioration during their diseases courses.The clinical efficacies,adverse reactions,and results of the various hematological and biochemical investigations were recorded for statistical analysis.RESULTS:92.30%(60 patients)of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paral-leled by a significantly improved GAS score.Meanwhile,the WBC and PLT counts stabilized,liver function and renal function were improved or remained stable.The combined therapy also obviously promoted the 24-h urinary copper excretion.In particular,only 30.76%of the WD patients experienced mild adverse reactions,including neurological deterioration in 5 patients(7.69%),hepatic worsening in 1 subject(1.89%),which was less frequently than those in the control group treated with DMPS only.CONCLUSION:Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms.
