This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the l...This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the lagoon, which include factors such as size, depth, water quality, and ecosystem composition. Secondly, the influence of precipitation on the water volume in the lagoon will be examined. This analysis involves assessing historical rainfall patterns in the region, as well as the amount and frequency of precipitation during the 2021 flood event. Thirdly, the hydrogeologic and geologic conditions of the lagoon will be evaluated. This involves examining factors such as the type and structure of the soil and bedrock, the presence of aquifers or other underground water sources, and the movement of water through the surrounding landscape. Finally, the study seeks to assess the risk of future flooding in Tasi-Tolu Lagoon, based on the insights gained from the previous analyses. Overall, this study’s goal is to provide a comprehensive understanding of the hydrogeological factors that contribute to flooding in Tasi-Tolu Lagoon. This knowledge could be used to inform flood mitigation strategies or to improve our ability to predict and respond to future flooding events in the region.展开更多
Introduction Idiosyncratic drug-induced liver injury(DILI),particularly with anti-epileptics,occasionally may occur in the setting of severe cutaneous adverse reactions with eosinophilia and systemic symptoms(DRESS),o...Introduction Idiosyncratic drug-induced liver injury(DILI),particularly with anti-epileptics,occasionally may occur in the setting of severe cutaneous adverse reactions with eosinophilia and systemic symptoms(DRESS),often with a cholestatic pattern of injury,including rarely vanishing bile ducts syndrome(VBDS)[1].DILIDRESS can progress from mild damage to fatal cases,with an estimated mortality that ranges from 1.7%to 8%[2].展开更多
Background and Aims:Drug-induced liver injury with autoimmune features(AI-DILI)mimics the clinical presentation,and laboratory and pathologic features of idiopathic autoimmune hepatitis(AIH).We aimed to identify histo...Background and Aims:Drug-induced liver injury with autoimmune features(AI-DILI)mimics the clinical presentation,and laboratory and pathologic features of idiopathic autoimmune hepatitis(AIH).We aimed to identify histopathologic hallmarks to differentiate these entities.Methods:All liver biopsies archived for the past 10 years were reviewed retrospectively to identify cases of recently detected liver injury associated with predominantly lymphoplasmacytic interphase hepatitis,positive markers for liver autoimmunity,and negative tests for viral hepatitis.Twenty cases were divided into AIH(n=12)or AI-DILI(n=8)groups.Blind qualitative evaluation of necroinflammatory changes and liver fibrosis were performed according to the Scheuer scoring system.Cellular densities were determined using ImageJ(V1.51t,National Institutes of Health,Bethesda,MD,USA).Fibrosis was assessed on Masson trichrome-stained slides,and collagen deposition was estimated following a protocol of color deconvolution.Results:Necroinflammatory changes as well as densities(portal and lobular)of neutrophils and eosinophils,intracellular cholestasis,and regenerative changes did not differ between the two groups(P≥0.05).Neutrophil densities but not eosinophils showed a positive correlation with the severity of hepatocellular damage(r=0.6and 0.58,vs.alanine aminotransferase,P<0.05).Ceroidladen macrophages but not histiocytic aggregates appeared to be more common in AI-DILI(P<0.05).AIH patients presented more often with evidence of chronic damage,including higher scores of fibrosis and collagen deposition,in comparison to AI-DILI(P<0.05).Conclusions:Although there is no histologic feature pathognomonic for AI-DILI or AIH,advanced stages of liver fibrosis can be used to support the diagnosis of AIH in some cases.Definitive diagnosis of AI-DILI requires follow-up and demonstration of complete remission after drug withdrawal with no need for immunosuppression.展开更多
Dear editor,We are writing to give a response to the article titled“Focusing on women with DILI and their outcomes,appropriately intervening early”(Sun X et al.,2024)recently published in your journal.The article fo...Dear editor,We are writing to give a response to the article titled“Focusing on women with DILI and their outcomes,appropriately intervening early”(Sun X et al.,2024)recently published in your journal.The article focused on the susceptibility and prognosis of females with drug-induced liver injury,exploring three main points:First,there is a higher prevalence of drug-induced liver injury(DILI)in females due to gender differences in drug sensitivity,metabolism,and immune responses.展开更多
Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced li...Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced liver injury(DILI)in patients with psoriasis and to establish a risk prediction model via machine learning.Methods:A total of 6,303 participants were selected,all of whom answered questions regarding psoriasis and drug use.Chronic DILI was diagnosed on the basis of persistent abnormalities in the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(TBIL)levels.Multiple logistic regression and other methods have been employed in different models to explore the relationship between psoriasis and chronic DILI.Potential confounding factors(age,sex,ethnicity,household income,education,alcohol consumption,smoking,and body mass index(BMI))were controlled.Results:After controlling for potential confounding factors,the results revealed a significant positive correlation between psoriasis and chronic DILI,and an optimal predictive model was generated on the basis of diabetes status and BMI.Conclusion:Patients with psoriasis appear to be at increased risk of chronic DILI.More prospective studies are needed to confirm this clinical correlation.展开更多
文摘This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the lagoon, which include factors such as size, depth, water quality, and ecosystem composition. Secondly, the influence of precipitation on the water volume in the lagoon will be examined. This analysis involves assessing historical rainfall patterns in the region, as well as the amount and frequency of precipitation during the 2021 flood event. Thirdly, the hydrogeologic and geologic conditions of the lagoon will be evaluated. This involves examining factors such as the type and structure of the soil and bedrock, the presence of aquifers or other underground water sources, and the movement of water through the surrounding landscape. Finally, the study seeks to assess the risk of future flooding in Tasi-Tolu Lagoon, based on the insights gained from the previous analyses. Overall, this study’s goal is to provide a comprehensive understanding of the hydrogeological factors that contribute to flooding in Tasi-Tolu Lagoon. This knowledge could be used to inform flood mitigation strategies or to improve our ability to predict and respond to future flooding events in the region.
文摘Introduction Idiosyncratic drug-induced liver injury(DILI),particularly with anti-epileptics,occasionally may occur in the setting of severe cutaneous adverse reactions with eosinophilia and systemic symptoms(DRESS),often with a cholestatic pattern of injury,including rarely vanishing bile ducts syndrome(VBDS)[1].DILIDRESS can progress from mild damage to fatal cases,with an estimated mortality that ranges from 1.7%to 8%[2].
文摘Background and Aims:Drug-induced liver injury with autoimmune features(AI-DILI)mimics the clinical presentation,and laboratory and pathologic features of idiopathic autoimmune hepatitis(AIH).We aimed to identify histopathologic hallmarks to differentiate these entities.Methods:All liver biopsies archived for the past 10 years were reviewed retrospectively to identify cases of recently detected liver injury associated with predominantly lymphoplasmacytic interphase hepatitis,positive markers for liver autoimmunity,and negative tests for viral hepatitis.Twenty cases were divided into AIH(n=12)or AI-DILI(n=8)groups.Blind qualitative evaluation of necroinflammatory changes and liver fibrosis were performed according to the Scheuer scoring system.Cellular densities were determined using ImageJ(V1.51t,National Institutes of Health,Bethesda,MD,USA).Fibrosis was assessed on Masson trichrome-stained slides,and collagen deposition was estimated following a protocol of color deconvolution.Results:Necroinflammatory changes as well as densities(portal and lobular)of neutrophils and eosinophils,intracellular cholestasis,and regenerative changes did not differ between the two groups(P≥0.05).Neutrophil densities but not eosinophils showed a positive correlation with the severity of hepatocellular damage(r=0.6and 0.58,vs.alanine aminotransferase,P<0.05).Ceroidladen macrophages but not histiocytic aggregates appeared to be more common in AI-DILI(P<0.05).AIH patients presented more often with evidence of chronic damage,including higher scores of fibrosis and collagen deposition,in comparison to AI-DILI(P<0.05).Conclusions:Although there is no histologic feature pathognomonic for AI-DILI or AIH,advanced stages of liver fibrosis can be used to support the diagnosis of AIH in some cases.Definitive diagnosis of AI-DILI requires follow-up and demonstration of complete remission after drug withdrawal with no need for immunosuppression.
基金funded by Capital’s Funds for Health Improvement and Research of Beijing Municipal Health Commission(2024-2-5068)PLA General Hospital Youth Independent Innovation Science Fund project(22QNCZ023).
文摘Dear editor,We are writing to give a response to the article titled“Focusing on women with DILI and their outcomes,appropriately intervening early”(Sun X et al.,2024)recently published in your journal.The article focused on the susceptibility and prognosis of females with drug-induced liver injury,exploring three main points:First,there is a higher prevalence of drug-induced liver injury(DILI)in females due to gender differences in drug sensitivity,metabolism,and immune responses.
基金supported by the Natural Science Foundation of Anhui Province(240808QH272).
文摘Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced liver injury(DILI)in patients with psoriasis and to establish a risk prediction model via machine learning.Methods:A total of 6,303 participants were selected,all of whom answered questions regarding psoriasis and drug use.Chronic DILI was diagnosed on the basis of persistent abnormalities in the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(TBIL)levels.Multiple logistic regression and other methods have been employed in different models to explore the relationship between psoriasis and chronic DILI.Potential confounding factors(age,sex,ethnicity,household income,education,alcohol consumption,smoking,and body mass index(BMI))were controlled.Results:After controlling for potential confounding factors,the results revealed a significant positive correlation between psoriasis and chronic DILI,and an optimal predictive model was generated on the basis of diabetes status and BMI.Conclusion:Patients with psoriasis appear to be at increased risk of chronic DILI.More prospective studies are needed to confirm this clinical correlation.
