This paper focuses on the teaching of tea culture terminology translation against the backdrop of digital transformation in education.Based on the theory of pragmatic relevance,the research emphasizes shifting the foc...This paper focuses on the teaching of tea culture terminology translation against the backdrop of digital transformation in education.Based on the theory of pragmatic relevance,the research emphasizes shifting the focus of translation from static linguistic equivalence to more dynamic communicative effectiveness.This paper advocates the flexible application of various strategies.These include literal translation,free translation,transliteration with annotation,and adaptive translation based on the target audience’s cognitive context.The paper innovatively proposes digitally-enabled teaching implementation paths,including constructing modular online courses,building intelligent terminology case databases,conducting cloud-based workshops on translation,and implementing industry-academia collaborative project practices.These aim to reshape the teaching process utilizing digital technology,effectively cultivating higher vocational students’cultural communication abilities and practical translation skills,thereby providing high-quality language service talent support for the internationalization of Chinese tea culture.展开更多
Holography, which was invented by Dennis Gabor in 1948, offers an approach to reconstructing both the amplitude and phase information of a three-dimensional (3D) object [1]. Since its invention, the concept of hologra...Holography, which was invented by Dennis Gabor in 1948, offers an approach to reconstructing both the amplitude and phase information of a three-dimensional (3D) object [1]. Since its invention, the concept of holography has been widely used in various fields, such as microscopy [2], interferometry [3], ultrasonography [4], and holographic display [5]. Optical holography can be divided into two steps: recording and reconstruction. A conventional hologram is recorded onto a photosensitive film as the interference between an object beam carrying the 3D object information and a reference beam. Thereafter, the original object wavefront is reconstructed in the 3D image space by illuminating the reference beam on the recorded hologram.展开更多
To improve the efficiency of the management of large farms, a digitalized system of economic statistics is designed based on the Internet platform of the digitalized agricultural integrated system of Friendship Farm, ...To improve the efficiency of the management of large farms, a digitalized system of economic statistics is designed based on the Internet platform of the digitalized agricultural integrated system of Friendship Farm, the largest farm in the world. The system can also realize data storage by using the access databank technology. A dynamic website system, based on ASP technology, is used to implement the on-line inquiry of the statistical index of the agricultural economy and the diagrams of the index every year. Furthermore, it can provide the value of comprehensive indicators of farms' economic profits for every year and a trend chart of the comprehensive appraisal of economic development, by using principal component analysis. An early-warning indicator boundary is decided based on the majority principle. The system can realize the farm's terminal data input with effective data-collecting channels and a normative gathering scope and system. This system breaks through the stand-alone database system in agricultural digitalized research to realize the database system in the Internet environment by integrating the existing technologies in China. The system lays a foundation for the further integrated research on the network platform of the digitalized agricultural integrated system in Friendship Farm.展开更多
The health check up flow of digital hospital can be consulted with the assem bly line of industry factory.Because they have the following same features:highly specialized workstation, closeness and continuance,rhyth...The health check up flow of digital hospital can be consulted with the assem bly line of industry factory.Because they have the following same features:highly specialized workstation, closeness and continuance,rhythm,balanced production,continuous production.The essential prerequisites are as the follows:The inspecting item s and methods should be stable;advanced product mix and stable production design;standardized raw m aterial,consumption,procedure, inspection method;there are lots of request for health inspection;the customers move at the least unit;the space arrangement should be reasonable;the time arrangement should be proportion. With the com puter net,the digital inspection can achieves the raw material controlling accurately. The basis of check up line concerns about equipm ent,net and software,data collection,and per- sonnel.The group technology is used in the health inspection flow design of the digital hospital in the field of items custom ers and zone redivided.The digital assembly linem ic health inspect has the following stages:m ember registering,notice,check in,arrange order,tim e control,report,feed- back and analysis. The assem bly linemic has following advantages:increasing the productivity, the space utility,satisfaction of customer,fund returning,lowering the cost and ensuring the quality.展开更多
China is building a model project of digital government with the fully digitalized electronic invoices(FDEls)at the core.Through the"unified national e-invoice service platform",online invoice collection,aut...China is building a model project of digital government with the fully digitalized electronic invoices(FDEls)at the core.Through the"unified national e-invoice service platform",online invoice collection,automatic quota allocation and direct connection with enterprises can be achieved,which can reduce cost,enhance efficiency and promote digital transformation of enterprises.Relying on the precise supervision system of"data+rules,which covers hundreds of millions of trusted identity subjects,the platform can prevent and control risks in real time and align with international standards.The reform has achieved remarkable results:it has covered 95%of enterprises across the country,saved over RMB100 billion in costs annually,and reduced 30 billion paper invoices.Breakthrough innovations,including reconstructing the traditional invoice ecosystem,building the largest information technology innovation cloud platform and digital identity system,and promoting the internationalization of independent tax algorithms,have provided the Chinese solution for"data-driven tax governance"to the world,and contributed to high-quality development andhigh-levelopeningup.展开更多
Digital integrated circuits have significantly benefited from technology scaling down,while conventional analog integrated circuits suffer from more design constraints.In recent years,there has been strong research in...Digital integrated circuits have significantly benefited from technology scaling down,while conventional analog integrated circuits suffer from more design constraints.In recent years,there has been strong research interest in replacing conventional analog blocks with digitally-friendly and digitally-intensive alternatives,while signif-icant progress has been made.This paper reviews the existing digitalized analog integrated circuits,including amplifiers,analog-to-digital converters,phase-locked loops,and power supplies.Based on the review,the future development trends of the digitalized analog integrated circuits are derived.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
Some typical samples are used to explore the quantitative correlation with their features between a convective cloud and its rainfall field,with which to develop two morphological functions for the correlation and by ...Some typical samples are used to explore the quantitative correlation with their features between a convective cloud and its rainfall field,with which to develop two morphological functions for the correlation and by singling out their most suitable groups of parameters we propose a model for quantitatively estimating precipitation in the context o{ the in-advance recognition of meso-α convective system properties and its precipitating center.From the model fitting precision and forecasting accuracy we find that it is feasible to utilize geostationary meteorological satellite (GMS) digitalized imagery for estimating short-term rainfall in a quantitative manner.Also,evidence suggests that the model is supposed to be restricted in its applicability due to the fact that the employed samples are from rather typical rainfall events that are large-scale,slow-moving and have well-defined genesis and dissipative stages.展开更多
In the wave of digital and intelligent applications,artificial intelligence(AI)is transforming the development trajectories of industries across the globe.Traditional Chinese medicine(TCM),as a cultural treasure of th...In the wave of digital and intelligent applications,artificial intelligence(AI)is transforming the development trajectories of industries across the globe.Traditional Chinese medicine(TCM),as a cultural treasure of the Chinese nation,carries thousands of years of wisdom and practical experience.However,in the context of the rapid advancements in modern medicine and technology,TCM faces dual challenges:preserving its heritage while innovating.DeepSeek,a major achievement in the field of AI,offers a new opportunity for the development of TCM with its powerful technological capabilities.Exploring the integration of DeepSeek with TCM not only helps modernize the practice but also promises unique contributions to global health.展开更多
Pulse diagnosis equipment used in Traditional Chinese Medicine(TCM)has long been developed for collecting pulse information and in TCM research.However,it is still difficult to implement pulse taking automatically or ...Pulse diagnosis equipment used in Traditional Chinese Medicine(TCM)has long been developed for collecting pulse information and in TCM research.However,it is still difficult to implement pulse taking automatically or efficiently in clinical practice.Here,we present a digital protocol for TCM pulse information collection based on bionic pulse diagnosis equipment,which ensures high efficiency,reliability and data integrity of pulse diagnosis information.A four-degree-of-freedom pulse taking platform together with a wrist bracket can satisfy the spatial positioning and angle requirements for individually adaptive pulse acquisition.Three-dimensional reconstruction of a wrist surface and an image localization model are combined to provide coordinates of the acquisition position and detection direction automatically.Three series elastic joints can not only simulate the TCM pulse taking method that“Three fingers in a straight line,the middle finger determining the‘Guan’location and finger pulp pressing on the radial artery,”but also simultaneously carry out the force-controlled multi-gradient pressing process.In terms of pulse information integrity,this proposed protocol can generate rich pulse information,including basic individual information,pulse localization distribution,multi-gradient dynamic pulse force time series,and objective pulse parameters,which can help establish the fundamental data sets that are required as the pulse phenotype for subsequent comprehensive analysis of pulse diagnosis.The implementation of this scheme is beneficial to promote the standardization of the digitalized collection of pulse information,the effectiveness of detecting abnormal health status,and the promotion of the fundamental and clinical research of TCM,such as TCM pulse phenomics.展开更多
Digitization is the inevitable path for the natural development of traditional Chinese medicine(TCM)in the context of the Fourth Industrial Revolution.The goal of TCM digitization is to generate intelligence from numb...Digitization is the inevitable path for the natural development of traditional Chinese medicine(TCM)in the context of the Fourth Industrial Revolution.The goal of TCM digitization is to generate intelligence from numbers.Originating from the reasoning paradigm of Xiangshu(象数,image-number)or phenotype-numerology thinking,TCM came with a deep correlation of clinical observations with digits and laid a strong theoretical basis for digitization.The digitization of TCM should start from the clinical aspect,solve the problem of electronic medical records,achieve standardization and informatization,and on this basis,form a TCM knowledge base through knowledge-building.This process depends on the combined efforts of multiple disciplines such as medicine,mathematics,and engineering to achieve the digitization and intelligent transformation of TCM.This era calls for TCM to break down barriers,embrace opportunities,and move towards digitization.However,during the transformation,it should maintain its essence,avoid simplistic conversions,be guided by scientific value,leverage cutting-edge technologies,and enhance the depth and breadth of the interpretation of TCM connotations.The digitization of TCM will also improve its service capabilities,create an innovative digitally-intelligent TCM service platform,and contribute to the development of“Healthy China”initiatives with wisdom and solutions.展开更多
In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper...In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).展开更多
Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention...Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention and treatment.Methods:All studies were searched in online databases and grey literature,including PubMed(Medline),Web of Science,CINAHL,Scopus,IEEE Xplore Digital Library,Journal of Medical Internet Research(JMIR),MedNar,EBSco Open Dissertations.The search period is from inception to June 2023,and the languages are Finnish,English and Swedish.The research quality was evaluated using the web-based data management system Covidence for prevalence studies.The study protocol was registered with PROSPERO(registration number:CRD42021247595).Results:In this review,4,407 studies were screened,and 22 were included.These involved 3,433 participants and 264 child-parent pairs.The digital approaches included multicomponent elements like internet platforms,text messaging,video conferencing,online communities,wearable technology,and mobile apps,allowing one-way,two-way,and face-to-face interactions.Two studies showed statistically significant effects of treatment on BMI and waist-to-hip ratio.Most interventions reported positive outcomes,with no significant differences between groups,and none showed null effects during followup.Conclusions:Digital multicomponents like mobile apps and wearables can help obese children and adolescents adopt healthier lifestyles.While these interventions show promise for obesity management,further research is needed to assess their effectiveness,particularly regarding nurses'perspectives.展开更多
In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience...In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience of digital trade in the face of external crises is an important topic.Taking the backdrop of Sino-US trade friction,this paper constructs a resilience index system for digital trade.It utilizes entropy method,kernel density estimation,and ArcGIS mapping to calculate and visually analyze the resilience of China’s digital trade from 2017 to 2021.Additionally,a Tobit model is constructed to explore the main influencing factors of digital trade resilience patterns.The research findings indicate:1)temporally,during the period of Sino-US trade friction,China’s digital trade resilience shows an overall upward trend,but there are regional differences in resilience levels across the country,with a severe polarization phenomenon.2)Spatially,high resilience is observed in the eastern and central regions of China,while the western and northeastern regions exhibit low resilience.3)From a dimensional perspective,the resistance of digital trade resilience displays a spatial distribution of high values in the east and low values in the west.The recovery force is aggregated along coastal areas,and the renewal force tends to aggregate along the eastern coastline.4)Factors such as economic scale,industrial structure,urbanization rate,government fiscal expenditure,and technological talents significantly promote the enhancement of digital trade resilience.This study reveals the dynamic characteristics and influencing factors of digital trade resilience in responding to external shocks,providing theoretical basis and policy suggestions for enhancing digital trade resilience,and promoting high-quality economic development in China.展开更多
Deep tight reservoirs exhibit complex stress and seepage fields due to varying pore structures,thus the seepage characteristics are significant for enhancing oil production.This study conducted triaxial compression an...Deep tight reservoirs exhibit complex stress and seepage fields due to varying pore structures,thus the seepage characteristics are significant for enhancing oil production.This study conducted triaxial compression and permeability tests to investigate the mechanical and seepage properties of tight sandstone.A digital core of tight sandstone was built using Computed Tomography(CT)scanning,which was divided into matrix and pore phases by a pore equivalent diameter threshold.A fluid-solid coupling model was established to investigate the seepage characteristics at micro-scale.The results showed that increasing the confining pressure decreased porosity,permeability,and flow velocity,with the pore phase becoming the dominant seepage channel.Cracks and large pores closed first under increasing pressure,resulted in a steep drop in permeability.However,permeability slightly decreased under high confining pressure,which followed a first-order exponential function.Flow velocity increased with seepage pressure.And the damage mainly occurred in stress-concentration regions under low seepage pressure.Seepage behavior followed linear Darcy flow,the damage emerged at seepage entrances under high pressure,which decreased rock elastic modulus and significantly increased permeability.展开更多
Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and ta...Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.展开更多
Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale who...Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale whole slide images(WSIs)features to predict the response to breast cancer NAC more finely.Methods:This work collected 1,670 whole slide images for training and validation sets,internal testing sets,external testing sets,and prospective testing sets of the weakly-supervised deep learning-based multi-task model(DLMM)in predicting treatment response and pCR to NAC.Our approach models two-by-two feature interactions across scales by employing concatenate fusion of single-scale feature representations,and controls the expressiveness of each representation via a gating-based attention mechanism.Results:In the retrospective analysis,DLMM exhibited excellent predictive performance for the prediction of treatment response,with area under the receiver operating characteristic curves(AUCs)of 0.869[95%confidence interval(95%CI):0.806−0.933]in the internal testing set and 0.841(95%CI:0.814−0.867)in the external testing sets.For the pCR prediction task,DLMM reached AUCs of 0.865(95%CI:0.763−0.964)in the internal testing and 0.821(95%CI:0.763−0.878)in the pooled external testing set.In the prospective testing study,DLMM also demonstrated favorable predictive performance,with AUCs of 0.829(95%CI:0.754−0.903)and 0.821(95%CI:0.692−0.949)in treatment response and pCR prediction,respectively.DLMM significantly outperformed the baseline models in all testing sets(P<0.05).Heatmaps were employed to interpret the decision-making basis of the model.Furthermore,it was discovered that high DLMM scores were associated with immune-related pathways and cells in the microenvironment during biological basis exploration.Conclusions:The DLMM represents a valuable tool that aids clinicians in selecting personalized treatment strategies for breast cancer patients.展开更多
基金Special Project of Higher Education in the 2023,Educational Science Planning Project of the Leading Group Office of the Guangdong Provincial Educational Science Planning,“Research on the New Forms of Foreign Language Teaching in Guangdong Higher Vocational Colleges under the Background of Education Digitization”(Project No.:2023GXJK1052)。
文摘This paper focuses on the teaching of tea culture terminology translation against the backdrop of digital transformation in education.Based on the theory of pragmatic relevance,the research emphasizes shifting the focus of translation from static linguistic equivalence to more dynamic communicative effectiveness.This paper advocates the flexible application of various strategies.These include literal translation,free translation,transliteration with annotation,and adaptive translation based on the target audience’s cognitive context.The paper innovatively proposes digitally-enabled teaching implementation paths,including constructing modular online courses,building intelligent terminology case databases,conducting cloud-based workshops on translation,and implementing industry-academia collaborative project practices.These aim to reshape the teaching process utilizing digital technology,effectively cultivating higher vocational students’cultural communication abilities and practical translation skills,thereby providing high-quality language service talent support for the internationalization of Chinese tea culture.
基金support from the Australian Research Council (ARC) through the Discovery Project (DP180102402)support from a scholarship from theChina Scholarship Council (201706190189)financial support from the Humboldt Research Fellowship from the Alexander von Humboldt Foundation
文摘Holography, which was invented by Dennis Gabor in 1948, offers an approach to reconstructing both the amplitude and phase information of a three-dimensional (3D) object [1]. Since its invention, the concept of holography has been widely used in various fields, such as microscopy [2], interferometry [3], ultrasonography [4], and holographic display [5]. Optical holography can be divided into two steps: recording and reconstruction. A conventional hologram is recorded onto a photosensitive film as the interference between an object beam carrying the 3D object information and a reference beam. Thereafter, the original object wavefront is reconstructed in the 3D image space by illuminating the reference beam on the recorded hologram.
基金The Key Technologies R& D Program of Heilongjiang Province (No.GB06B601)
文摘To improve the efficiency of the management of large farms, a digitalized system of economic statistics is designed based on the Internet platform of the digitalized agricultural integrated system of Friendship Farm, the largest farm in the world. The system can also realize data storage by using the access databank technology. A dynamic website system, based on ASP technology, is used to implement the on-line inquiry of the statistical index of the agricultural economy and the diagrams of the index every year. Furthermore, it can provide the value of comprehensive indicators of farms' economic profits for every year and a trend chart of the comprehensive appraisal of economic development, by using principal component analysis. An early-warning indicator boundary is decided based on the majority principle. The system can realize the farm's terminal data input with effective data-collecting channels and a normative gathering scope and system. This system breaks through the stand-alone database system in agricultural digitalized research to realize the database system in the Internet environment by integrating the existing technologies in China. The system lays a foundation for the further integrated research on the network platform of the digitalized agricultural integrated system in Friendship Farm.
文摘The health check up flow of digital hospital can be consulted with the assem bly line of industry factory.Because they have the following same features:highly specialized workstation, closeness and continuance,rhythm,balanced production,continuous production.The essential prerequisites are as the follows:The inspecting item s and methods should be stable;advanced product mix and stable production design;standardized raw m aterial,consumption,procedure, inspection method;there are lots of request for health inspection;the customers move at the least unit;the space arrangement should be reasonable;the time arrangement should be proportion. With the com puter net,the digital inspection can achieves the raw material controlling accurately. The basis of check up line concerns about equipm ent,net and software,data collection,and per- sonnel.The group technology is used in the health inspection flow design of the digital hospital in the field of items custom ers and zone redivided.The digital assembly linem ic health inspect has the following stages:m ember registering,notice,check in,arrange order,tim e control,report,feed- back and analysis. The assem bly linemic has following advantages:increasing the productivity, the space utility,satisfaction of customer,fund returning,lowering the cost and ensuring the quality.
文摘China is building a model project of digital government with the fully digitalized electronic invoices(FDEls)at the core.Through the"unified national e-invoice service platform",online invoice collection,automatic quota allocation and direct connection with enterprises can be achieved,which can reduce cost,enhance efficiency and promote digital transformation of enterprises.Relying on the precise supervision system of"data+rules,which covers hundreds of millions of trusted identity subjects,the platform can prevent and control risks in real time and align with international standards.The reform has achieved remarkable results:it has covered 95%of enterprises across the country,saved over RMB100 billion in costs annually,and reduced 30 billion paper invoices.Breakthrough innovations,including reconstructing the traditional invoice ecosystem,building the largest information technology innovation cloud platform and digital identity system,and promoting the internationalization of independent tax algorithms,have provided the Chinese solution for"data-driven tax governance"to the world,and contributed to high-quality development andhigh-levelopeningup.
基金supported by the National Natural Science Foundation of China(62021004,62022065,92164301).
文摘Digital integrated circuits have significantly benefited from technology scaling down,while conventional analog integrated circuits suffer from more design constraints.In recent years,there has been strong research interest in replacing conventional analog blocks with digitally-friendly and digitally-intensive alternatives,while signif-icant progress has been made.This paper reviews the existing digitalized analog integrated circuits,including amplifiers,analog-to-digital converters,phase-locked loops,and power supplies.Based on the review,the future development trends of the digitalized analog integrated circuits are derived.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
文摘Some typical samples are used to explore the quantitative correlation with their features between a convective cloud and its rainfall field,with which to develop two morphological functions for the correlation and by singling out their most suitable groups of parameters we propose a model for quantitatively estimating precipitation in the context o{ the in-advance recognition of meso-α convective system properties and its precipitating center.From the model fitting precision and forecasting accuracy we find that it is feasible to utilize geostationary meteorological satellite (GMS) digitalized imagery for estimating short-term rainfall in a quantitative manner.Also,evidence suggests that the model is supposed to be restricted in its applicability due to the fact that the employed samples are from rather typical rainfall events that are large-scale,slow-moving and have well-defined genesis and dissipative stages.
文摘In the wave of digital and intelligent applications,artificial intelligence(AI)is transforming the development trajectories of industries across the globe.Traditional Chinese medicine(TCM),as a cultural treasure of the Chinese nation,carries thousands of years of wisdom and practical experience.However,in the context of the rapid advancements in modern medicine and technology,TCM faces dual challenges:preserving its heritage while innovating.DeepSeek,a major achievement in the field of AI,offers a new opportunity for the development of TCM with its powerful technological capabilities.Exploring the integration of DeepSeek with TCM not only helps modernize the practice but also promises unique contributions to global health.
基金supported by the Shanghai 2021 Science and Technology Innovation Action Plan Project(Grant No.21S31902500)the Independent Deployment of Scientific Research Projects of Jihua Laboratory(Grant No.X190051TB190)the National Natural Science Foundation of China(Grant No.U1913216).
文摘Pulse diagnosis equipment used in Traditional Chinese Medicine(TCM)has long been developed for collecting pulse information and in TCM research.However,it is still difficult to implement pulse taking automatically or efficiently in clinical practice.Here,we present a digital protocol for TCM pulse information collection based on bionic pulse diagnosis equipment,which ensures high efficiency,reliability and data integrity of pulse diagnosis information.A four-degree-of-freedom pulse taking platform together with a wrist bracket can satisfy the spatial positioning and angle requirements for individually adaptive pulse acquisition.Three-dimensional reconstruction of a wrist surface and an image localization model are combined to provide coordinates of the acquisition position and detection direction automatically.Three series elastic joints can not only simulate the TCM pulse taking method that“Three fingers in a straight line,the middle finger determining the‘Guan’location and finger pulp pressing on the radial artery,”but also simultaneously carry out the force-controlled multi-gradient pressing process.In terms of pulse information integrity,this proposed protocol can generate rich pulse information,including basic individual information,pulse localization distribution,multi-gradient dynamic pulse force time series,and objective pulse parameters,which can help establish the fundamental data sets that are required as the pulse phenotype for subsequent comprehensive analysis of pulse diagnosis.The implementation of this scheme is beneficial to promote the standardization of the digitalized collection of pulse information,the effectiveness of detecting abnormal health status,and the promotion of the fundamental and clinical research of TCM,such as TCM pulse phenomics.
基金Special Funds of the National Natural Science Foundation of China(T2341006).
文摘Digitization is the inevitable path for the natural development of traditional Chinese medicine(TCM)in the context of the Fourth Industrial Revolution.The goal of TCM digitization is to generate intelligence from numbers.Originating from the reasoning paradigm of Xiangshu(象数,image-number)or phenotype-numerology thinking,TCM came with a deep correlation of clinical observations with digits and laid a strong theoretical basis for digitization.The digitization of TCM should start from the clinical aspect,solve the problem of electronic medical records,achieve standardization and informatization,and on this basis,form a TCM knowledge base through knowledge-building.This process depends on the combined efforts of multiple disciplines such as medicine,mathematics,and engineering to achieve the digitization and intelligent transformation of TCM.This era calls for TCM to break down barriers,embrace opportunities,and move towards digitization.However,during the transformation,it should maintain its essence,avoid simplistic conversions,be guided by scientific value,leverage cutting-edge technologies,and enhance the depth and breadth of the interpretation of TCM connotations.The digitization of TCM will also improve its service capabilities,create an innovative digitally-intelligent TCM service platform,and contribute to the development of“Healthy China”initiatives with wisdom and solutions.
文摘In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).
文摘Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention and treatment.Methods:All studies were searched in online databases and grey literature,including PubMed(Medline),Web of Science,CINAHL,Scopus,IEEE Xplore Digital Library,Journal of Medical Internet Research(JMIR),MedNar,EBSco Open Dissertations.The search period is from inception to June 2023,and the languages are Finnish,English and Swedish.The research quality was evaluated using the web-based data management system Covidence for prevalence studies.The study protocol was registered with PROSPERO(registration number:CRD42021247595).Results:In this review,4,407 studies were screened,and 22 were included.These involved 3,433 participants and 264 child-parent pairs.The digital approaches included multicomponent elements like internet platforms,text messaging,video conferencing,online communities,wearable technology,and mobile apps,allowing one-way,two-way,and face-to-face interactions.Two studies showed statistically significant effects of treatment on BMI and waist-to-hip ratio.Most interventions reported positive outcomes,with no significant differences between groups,and none showed null effects during followup.Conclusions:Digital multicomponents like mobile apps and wearables can help obese children and adolescents adopt healthier lifestyles.While these interventions show promise for obesity management,further research is needed to assess their effectiveness,particularly regarding nurses'perspectives.
基金Under the auspices of National Natural Science Foundation of China(No.42471205)the General Scientific Research Project of Zhejiang Provincial Department of Education(No.2024JYTYB12)the Philosophy and Social Science Planning Project of Zhejiang Province(No.23NDJC109YB)。
文摘In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience of digital trade in the face of external crises is an important topic.Taking the backdrop of Sino-US trade friction,this paper constructs a resilience index system for digital trade.It utilizes entropy method,kernel density estimation,and ArcGIS mapping to calculate and visually analyze the resilience of China’s digital trade from 2017 to 2021.Additionally,a Tobit model is constructed to explore the main influencing factors of digital trade resilience patterns.The research findings indicate:1)temporally,during the period of Sino-US trade friction,China’s digital trade resilience shows an overall upward trend,but there are regional differences in resilience levels across the country,with a severe polarization phenomenon.2)Spatially,high resilience is observed in the eastern and central regions of China,while the western and northeastern regions exhibit low resilience.3)From a dimensional perspective,the resistance of digital trade resilience displays a spatial distribution of high values in the east and low values in the west.The recovery force is aggregated along coastal areas,and the renewal force tends to aggregate along the eastern coastline.4)Factors such as economic scale,industrial structure,urbanization rate,government fiscal expenditure,and technological talents significantly promote the enhancement of digital trade resilience.This study reveals the dynamic characteristics and influencing factors of digital trade resilience in responding to external shocks,providing theoretical basis and policy suggestions for enhancing digital trade resilience,and promoting high-quality economic development in China.
基金financially supported by the National Natural Science Foundation of China(Nos.42272153 and 42472195)the Research Fund of PetroChina Tarim Oilfield Company(No.671023060003)the Research Fund of China National Petroleum Corporation Limited(No.2023ZZ16YJ04).
文摘Deep tight reservoirs exhibit complex stress and seepage fields due to varying pore structures,thus the seepage characteristics are significant for enhancing oil production.This study conducted triaxial compression and permeability tests to investigate the mechanical and seepage properties of tight sandstone.A digital core of tight sandstone was built using Computed Tomography(CT)scanning,which was divided into matrix and pore phases by a pore equivalent diameter threshold.A fluid-solid coupling model was established to investigate the seepage characteristics at micro-scale.The results showed that increasing the confining pressure decreased porosity,permeability,and flow velocity,with the pore phase becoming the dominant seepage channel.Cracks and large pores closed first under increasing pressure,resulted in a steep drop in permeability.However,permeability slightly decreased under high confining pressure,which followed a first-order exponential function.Flow velocity increased with seepage pressure.And the damage mainly occurred in stress-concentration regions under low seepage pressure.Seepage behavior followed linear Darcy flow,the damage emerged at seepage entrances under high pressure,which decreased rock elastic modulus and significantly increased permeability.
基金Science and Technology strategic cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University (2019LZXNYD-P01DUAN)National Key R&D Program of China (2024YFC3505400)Regional Key R&D Program of Ningxia Hui Autonomous Region (2024BEG01003)。
文摘Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.
基金supported by the National Natural Science Foundation of China(No.82371933)the National Natural Science Foundation of Shandong Province of China(No.ZR2021MH120)+1 种基金the Taishan Scholars Project(No.tsqn202211378)the Shandong Provincial Natural Science Foundation for Excellent Young Scholars(No.ZR2024YQ075).
文摘Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale whole slide images(WSIs)features to predict the response to breast cancer NAC more finely.Methods:This work collected 1,670 whole slide images for training and validation sets,internal testing sets,external testing sets,and prospective testing sets of the weakly-supervised deep learning-based multi-task model(DLMM)in predicting treatment response and pCR to NAC.Our approach models two-by-two feature interactions across scales by employing concatenate fusion of single-scale feature representations,and controls the expressiveness of each representation via a gating-based attention mechanism.Results:In the retrospective analysis,DLMM exhibited excellent predictive performance for the prediction of treatment response,with area under the receiver operating characteristic curves(AUCs)of 0.869[95%confidence interval(95%CI):0.806−0.933]in the internal testing set and 0.841(95%CI:0.814−0.867)in the external testing sets.For the pCR prediction task,DLMM reached AUCs of 0.865(95%CI:0.763−0.964)in the internal testing and 0.821(95%CI:0.763−0.878)in the pooled external testing set.In the prospective testing study,DLMM also demonstrated favorable predictive performance,with AUCs of 0.829(95%CI:0.754−0.903)and 0.821(95%CI:0.692−0.949)in treatment response and pCR prediction,respectively.DLMM significantly outperformed the baseline models in all testing sets(P<0.05).Heatmaps were employed to interpret the decision-making basis of the model.Furthermore,it was discovered that high DLMM scores were associated with immune-related pathways and cells in the microenvironment during biological basis exploration.Conclusions:The DLMM represents a valuable tool that aids clinicians in selecting personalized treatment strategies for breast cancer patients.
