In Mexico, digitalis was known since the 16th century and was used to treat patients with bloating, and it was not until the 20th century that it began to be used as a medicine for heart failure. In conjunction with d...In Mexico, digitalis was known since the 16th century and was used to treat patients with bloating, and it was not until the 20th century that it began to be used as a medicine for heart failure. In conjunction with diuretics. Digitalis was later used in combination individualized with the new medications, for this purpose and research has shown that the combination of medications on an individualized basis is what is currently successfully available for the medical treatment of heart failure.展开更多
The article focuses on the influence of operator and process safety and the trends of robotics and digitalisation on a ladle slide gate that was introduced to the market 6 years ago[1].After more than 50 installations...The article focuses on the influence of operator and process safety and the trends of robotics and digitalisation on a ladle slide gate that was introduced to the market 6 years ago[1].After more than 50 installations,customer experience was gathered and new features were added to a system upgrade.These upgrades are related to safety,ease of operation,and low operational costs.Especially a newly introduced“open check”feature increases the confidence level of the operators and can boost performance.With growing requirements to increase safety for people and processes in the ladle preparation area and on the continuous casting floor,automation has become increasingly important in steel plants.A slide gate prototype is currently underway to launch an innovative new gate design striving for full automation.Several critical process steps are already available and successfully used in the steel plants,such as cylinder connection,slag detection integration,and ladle gate preparation area automation.Fully automated operation will be followed by digitalisation,allowing for tracking of performance,safety,and quality.This paper summarises new features available for slide gates and outlines individual initiatives towards fully automated operation and data acquisition examples of digitalisation.展开更多
We previously developed an HPLC method for determination of lanatoside C, digoxin and α-acetyldigoxin in digitalis glycosides isolated from Digitalis lanata leaves. Here, we present an improved HPLC-UV method to dete...We previously developed an HPLC method for determination of lanatoside C, digoxin and α-acetyldigoxin in digitalis glycosides isolated from Digitalis lanata leaves. Here, we present an improved HPLC-UV method to determine those compounds and deslanoside. We used the improved method to examine the effects of various pretreatments on the amounts of the four compounds isolated from the leaves, with the aim of maximizing the yield of digoxin. Leaves were extracted with 50% methanol, followed by clean-up on a Sep-Pak C18 cartridge prior to HPLC analysis. The amounts of lanatoside C, digoxin and α-acetyldigoxin per 100 mg of the leaves without pretreatment were 115.6, 7.45 and 23.8 μg, respectively (deslanoside was not detected). Pretreatment with acetic acid, which activated deglucosylation mediated by digilanidase present in the leaves, increased the amounts of digoxin and α-acetyldigoxin, while lanatoside C and deslanoside were not detected. Pretreatment with sodium methoxide, which hydrolyzed lanatoside C to deslanoside, increased the yields of deslanoside and digoxin, while lanatoside C and α-acetyldigoxin were not detected. The combination of both pretreatments afforded only digoxin in a yield of 115.1 μg/100 mg leaves. Use of the combined pretreatments appears to be effective for maximizing the yield of digoxin from the leaves.展开更多
https://www.sciencedirect.com/journal/energy-and-buildings/vol/336/suppl/C Volume 336,1 June 2025[OA](1)Advancing energy renovations through digitalisation:A critical review of EU policies and instruments by Sun-Ah Hw...https://www.sciencedirect.com/journal/energy-and-buildings/vol/336/suppl/C Volume 336,1 June 2025[OA](1)Advancing energy renovations through digitalisation:A critical review of EU policies and instruments by Sun-Ah Hwang,Sultan etin,Henk Visscher,et al,Article 115627.展开更多
文章旨在对比分析国内外数字化设计在非物质文化遗产数字化保护领域的发展态势与未来趋势,为我国非遗数字化保护设计的发展路径提供参考框架。研究基于CNKI与Web of Science数据库相关文献,借助CiteSpace工具,从年度发文量、研究机构、...文章旨在对比分析国内外数字化设计在非物质文化遗产数字化保护领域的发展态势与未来趋势,为我国非遗数字化保护设计的发展路径提供参考框架。研究基于CNKI与Web of Science数据库相关文献,借助CiteSpace工具,从年度发文量、研究机构、关键词共现与突现等维度,深入分析发文网络、机构分布、学科领域、期刊偏好、研究焦点及其演进趋势。综合国内外研究热点与发展趋势可知,尽管非遗数字化保护设计已取得一定成果,但仍面临诸多挑战与局限。结合当前研究重点与中国国情,从技术创新、研究对象拓展、研究领域深化、内容导向优化与教育培养强化五个方面,对其未来发展进行了前瞻性预测。研究者可据此进一步挖掘非遗数字化保护的文化内涵与技术价值,推动该领域迈向更全面、深入的发展阶段。展开更多
Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extra...Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in Chinese medicine. This manuscript presents two studies that were conducted to optimize the cultivation conditions for digoxin production in the TCM Mao Hua Yan Di Huang in a greenhouse under GAP conditions.Methods: Two experiments were designed in which 4 growth conditions were compared. Levels of digoxin, gitoxin, digitoxin, α-acetyldigoxin, β-acetyl-digoxin were measured using HPLC-UV and compared between the conditions.Results: Normal soil, no CO_2 enrichment combined with a cold shock was found to be the optimal condition for producing digoxin in the first experiment. Gitoxin content was significantly lower in plants grown in this condition. Mechanical stress as well as the time of harvesting showed no statistically significant differences in the production of cardenolides. In the second experiment the optimal condition was found to be a combination of cold nights, sun screen, fertilizer use and no milled soil.Conclusion: This study shows that digoxin production can be increased by controlling the growth conditions of D. lanata Ehrh. The effect of cold was important in both experiments for improving digoxin production. Cultivating Chinese herbal medicines in optimized greenhouse conditions might be an economically attractive alternative to regular open air cultivation.展开更多
文摘In Mexico, digitalis was known since the 16th century and was used to treat patients with bloating, and it was not until the 20th century that it began to be used as a medicine for heart failure. In conjunction with diuretics. Digitalis was later used in combination individualized with the new medications, for this purpose and research has shown that the combination of medications on an individualized basis is what is currently successfully available for the medical treatment of heart failure.
文摘The article focuses on the influence of operator and process safety and the trends of robotics and digitalisation on a ladle slide gate that was introduced to the market 6 years ago[1].After more than 50 installations,customer experience was gathered and new features were added to a system upgrade.These upgrades are related to safety,ease of operation,and low operational costs.Especially a newly introduced“open check”feature increases the confidence level of the operators and can boost performance.With growing requirements to increase safety for people and processes in the ladle preparation area and on the continuous casting floor,automation has become increasingly important in steel plants.A slide gate prototype is currently underway to launch an innovative new gate design striving for full automation.Several critical process steps are already available and successfully used in the steel plants,such as cylinder connection,slag detection integration,and ladle gate preparation area automation.Fully automated operation will be followed by digitalisation,allowing for tracking of performance,safety,and quality.This paper summarises new features available for slide gates and outlines individual initiatives towards fully automated operation and data acquisition examples of digitalisation.
文摘We previously developed an HPLC method for determination of lanatoside C, digoxin and α-acetyldigoxin in digitalis glycosides isolated from Digitalis lanata leaves. Here, we present an improved HPLC-UV method to determine those compounds and deslanoside. We used the improved method to examine the effects of various pretreatments on the amounts of the four compounds isolated from the leaves, with the aim of maximizing the yield of digoxin. Leaves were extracted with 50% methanol, followed by clean-up on a Sep-Pak C18 cartridge prior to HPLC analysis. The amounts of lanatoside C, digoxin and α-acetyldigoxin per 100 mg of the leaves without pretreatment were 115.6, 7.45 and 23.8 μg, respectively (deslanoside was not detected). Pretreatment with acetic acid, which activated deglucosylation mediated by digilanidase present in the leaves, increased the amounts of digoxin and α-acetyldigoxin, while lanatoside C and deslanoside were not detected. Pretreatment with sodium methoxide, which hydrolyzed lanatoside C to deslanoside, increased the yields of deslanoside and digoxin, while lanatoside C and α-acetyldigoxin were not detected. The combination of both pretreatments afforded only digoxin in a yield of 115.1 μg/100 mg leaves. Use of the combined pretreatments appears to be effective for maximizing the yield of digoxin from the leaves.
文摘The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore our gains and losses from digitalisation.
文摘https://www.sciencedirect.com/journal/energy-and-buildings/vol/336/suppl/C Volume 336,1 June 2025[OA](1)Advancing energy renovations through digitalisation:A critical review of EU policies and instruments by Sun-Ah Hwang,Sultan etin,Henk Visscher,et al,Article 115627.
文摘文章旨在对比分析国内外数字化设计在非物质文化遗产数字化保护领域的发展态势与未来趋势,为我国非遗数字化保护设计的发展路径提供参考框架。研究基于CNKI与Web of Science数据库相关文献,借助CiteSpace工具,从年度发文量、研究机构、关键词共现与突现等维度,深入分析发文网络、机构分布、学科领域、期刊偏好、研究焦点及其演进趋势。综合国内外研究热点与发展趋势可知,尽管非遗数字化保护设计已取得一定成果,但仍面临诸多挑战与局限。结合当前研究重点与中国国情,从技术创新、研究对象拓展、研究领域深化、内容导向优化与教育培养强化五个方面,对其未来发展进行了前瞻性预测。研究者可据此进一步挖掘非遗数字化保护的文化内涵与技术价值,推动该领域迈向更全面、深入的发展阶段。
基金the city of Emmen, the province Drenthe (KEI program)"Kenniscentrum plantenstoffen"+1 种基金"LTO Noord Projecten" in the Netherlandspartly funded by Boehringer Ingelheim Pharma Gmb H & Co.KG
文摘Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in Chinese medicine. This manuscript presents two studies that were conducted to optimize the cultivation conditions for digoxin production in the TCM Mao Hua Yan Di Huang in a greenhouse under GAP conditions.Methods: Two experiments were designed in which 4 growth conditions were compared. Levels of digoxin, gitoxin, digitoxin, α-acetyldigoxin, β-acetyl-digoxin were measured using HPLC-UV and compared between the conditions.Results: Normal soil, no CO_2 enrichment combined with a cold shock was found to be the optimal condition for producing digoxin in the first experiment. Gitoxin content was significantly lower in plants grown in this condition. Mechanical stress as well as the time of harvesting showed no statistically significant differences in the production of cardenolides. In the second experiment the optimal condition was found to be a combination of cold nights, sun screen, fertilizer use and no milled soil.Conclusion: This study shows that digoxin production can be increased by controlling the growth conditions of D. lanata Ehrh. The effect of cold was important in both experiments for improving digoxin production. Cultivating Chinese herbal medicines in optimized greenhouse conditions might be an economically attractive alternative to regular open air cultivation.
