BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited;however,the value of multi-parameter diffusion-weighted imaging(DWI)in the quantitative evalu...BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited;however,the value of multi-parameter diffusion-weighted imaging(DWI)in the quantitative evaluation of thyroid nodules has not been well determined.AIM To determine the utility of multi-parametric DWI including mono-exponential,biexponential,stretched exponential,and kurtosis models for the differentiation of thyroid lesions.METHODS Seventy-nine patients(62 with benign and 17 with malignant nodules)underwent multi-b value diffusion-weighted imaging of the thyroid.Multiple DWI parameters were obtained for statistical analysis.RESULTS Good agreement was found for diffusion parameters of thyroid nodules.Malignant lesions displayed lower diffusion parameters including apparent diffusion coefficient(ADC),the true diffusion coefficient(D),the perfusion fraction(f),the distributed diffusion coefficient(DDC),the intravoxel water diffusion heterogeneity(α)and kurtosis model-derived ADC(Dapp),and higher apparent diffusional kurtosis(Kapp)than benign entities(all P<0.01),except for the pseudodiffusion coefficient(D*)(P>0.05).The area under the ROC curve(AUC)of the ADC(0 and 1000)was not significantly different from that of the ADC(0 and 2000),ADC(0 to 2000),ADC(0 to 1000),D,DDC,Dapp and Kapp(all P>0.05),but was significantly higher than the AUC of D*,f andα(all P<0.05)for differentiating benign from malignant lesions.CONCLUSION Multiple DWI parameters including ADC,D,f,DDC,α,Dapp and Kapp could discriminate benign and malignant thyroid nodules.The metrics including D,DDC,Dapp and Kapp provide additional information with similar diagnostic performance of ADC,combination of these metrics may contribute to differentiate benign and malignant thyroid nodules.The ADC calculated with higher b values may not lead to improved diagnostic performance.展开更多
Diffusion-weighted imaging(DWI)as a new technique of magnetic resonance imaging(MRI)is used to detect focal hepatic lesions.This study was designed to evaluate the significance of DWI to differentiate focal hepatic le...Diffusion-weighted imaging(DWI)as a new technique of magnetic resonance imaging(MRI)is used to detect focal hepatic lesions.This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient(ADC)values.METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging(EPI)in 56 cases of small focal hepatic lesions,including hepatocellular carcinoma(11),hepatic metastatic tumor(15),hepatic cavernous hemangioma(14),and hepatic cyst(16).The ADC values of these lesions were calculated respectively.The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated.RESULTS:The mean ADC values(mm2/s)were(0.93±0.06)×10-3 in hepatocellular carcinomas,(1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas,and(3.18±0.33)×10-3 in hepatic cysts.The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively,which were significantly different(P<0.05).CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions.展开更多
AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography(DCE-US),following bolus injections of SonoVue.METHODS:The in vitro experiments w...AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography(DCE-US),following bolus injections of SonoVue.METHODS:The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank.In the in vivo experiments,B16F10 melanoma cells were xenografted to five nude mice.Both in vitro and in vivo,images were acquired following bolus injections of the ultrasound contrast agent SonoVue(Bracco,Milan,Italy) and using a Toshiba Aplio ultrasound scanner connected to a 2.9-5.8 MHz linear transducer(PZT,PLT 604AT probe)(Toshiba,Japan) allowing harmonic imaging("Vascular Recognition Imaging") involving linear raw data.A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute,Villejuif,France and used to evaluate seven perfusion parameters from time-intensity curves.Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation(CV).RESULTS:In vitro,different volumes of SonoVue were tested with the three phantoms:intra-operator variability was found to range from 2.33% to 23.72%.In vivo,experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%.In addition,the area under the curve(AUC) and the area under the wash-out(AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%.CONCLUSION:AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values.展开更多
By using computer imaging analysis system combined with light microscopy, the glomeruli lesions on biopsy specimens sections were quantitatively analysed. The patholoical changes of mesangial proliferative glomerulone...By using computer imaging analysis system combined with light microscopy, the glomeruli lesions on biopsy specimens sections were quantitatively analysed. The patholoical changes of mesangial proliferative glomerulonephritis (MsPGN) in children were quantitatively evaluated and the correlation between the mesangial matrix area (MA) and some clinical data were also analysed. The results indicated that the levels of various glomerular parameters in MsPGN group were higher than those of normal controls. No correlation was found between MA and 24 h urinary protein excretion, but a negative correlation was revealed between MA and estimated GFR. MA was also correlated with the duration of MsPGN recovery. It was suggested that the quantitative analysis of glomerular parameters by computer is a reproducible methods. The parameter of MA may be used for evaluation of the renal function, determination of the duration of therapy and evaluation of prognosis of MsPGN in children.展开更多
目的分析动态增强磁共振成像(dynamic contrast enhanced magnetic resonance imaging,DCE-MRI)定量参数与表观扩散系数(apparent diffusion coefficient,ADC)联合诊断外周带前列腺癌的价值。方法选取2022年4月—2024年4月丹江口市第一...目的分析动态增强磁共振成像(dynamic contrast enhanced magnetic resonance imaging,DCE-MRI)定量参数与表观扩散系数(apparent diffusion coefficient,ADC)联合诊断外周带前列腺癌的价值。方法选取2022年4月—2024年4月丹江口市第一医院收治的168例患者为研究对象,其中83例外周带前列腺癌患者纳入观察组,85例前列腺炎患者纳入对照组,另将同期于丹江口市第一医院行体检的88名健康体检者纳入健康组,均行DCE-MRI、扩散加权成像(diffusion weighted imaging,DWI)扫描,对比3组速率常数(rate constant,K_(ep))、容积转运常数(volume transfer constant,K_(trans))、血管外细胞外间隙体积分数(fractional extravascular extracellular space volume,V_(e))及ADC值;另描绘受试者工作曲线(receiver operating characteristic curve,ROC),分析K_(ep)、K_(trans)、V_(e)及ADC值单独或联合诊断外周带前列腺癌的价值。结果观察组的K_(ep)为(0.78±0.16)min、K_(trans)为(0.61±0.13)min,高于对照组的(0.53±0.10)min、(0.28±0.05)min,健康组的(0.14±0.02)min、(0.18±0.01)min,差异有统计学意义(P<0.001);观察组的V_(e)为(0.14±0.02)、ADC为(0.82±0.19)×10^(-3)mm^(2)/s,低于对照组的(0.18±0.02)、(1.06±0.18)×10^(-3)mm^(2)/s,健康组的(0.38±0.06)、(1.34±0.15)×10^(-3)mm^(2)/s,差异有统计学意义(P<0.001)。ROC结果显示,K_(ep)、K_(trans)、V_(e)及ADC值联合诊断外周带前列腺癌的曲线下面积(area under the curve,AUC)高于四者单一诊断(P<0.001)。结论DCE-MRI定量参数联合ADC可有效地诊断出外周带前列腺癌,存在一定的诊断价值。展开更多
合成MRI(synthetic magnetic resonance imaging,SyMRI)是一种新兴的定量MRI技术,可通过单次扫描获取多对比度图像,实现与传统MRI等效的诊断效能。近年来,SyMRI技术日趋成熟,图像质量不断提高,在中枢神经系统、乳腺、骨肌系统、腹部等...合成MRI(synthetic magnetic resonance imaging,SyMRI)是一种新兴的定量MRI技术,可通过单次扫描获取多对比度图像,实现与传统MRI等效的诊断效能。近年来,SyMRI技术日趋成熟,图像质量不断提高,在中枢神经系统、乳腺、骨肌系统、腹部等全身多部位疾病中的应用越来越广。SyMRI突出优势在于突破了传统MRI对多序列扫描的依赖,显著缩短扫描时间,基于定量序列测量组织固有特性,实现组织参数的定量比较。本文就SyMRI基本原理、可行性验证及图像质量评价、临床应用等方面展开综述,旨在为各系统疾病的精准化诊疗拓展新的检查思路。展开更多
基金Supported by the Health Commission of Zhejiang Province,No.2019KY690。
文摘BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited;however,the value of multi-parameter diffusion-weighted imaging(DWI)in the quantitative evaluation of thyroid nodules has not been well determined.AIM To determine the utility of multi-parametric DWI including mono-exponential,biexponential,stretched exponential,and kurtosis models for the differentiation of thyroid lesions.METHODS Seventy-nine patients(62 with benign and 17 with malignant nodules)underwent multi-b value diffusion-weighted imaging of the thyroid.Multiple DWI parameters were obtained for statistical analysis.RESULTS Good agreement was found for diffusion parameters of thyroid nodules.Malignant lesions displayed lower diffusion parameters including apparent diffusion coefficient(ADC),the true diffusion coefficient(D),the perfusion fraction(f),the distributed diffusion coefficient(DDC),the intravoxel water diffusion heterogeneity(α)and kurtosis model-derived ADC(Dapp),and higher apparent diffusional kurtosis(Kapp)than benign entities(all P<0.01),except for the pseudodiffusion coefficient(D*)(P>0.05).The area under the ROC curve(AUC)of the ADC(0 and 1000)was not significantly different from that of the ADC(0 and 2000),ADC(0 to 2000),ADC(0 to 1000),D,DDC,Dapp and Kapp(all P>0.05),but was significantly higher than the AUC of D*,f andα(all P<0.05)for differentiating benign from malignant lesions.CONCLUSION Multiple DWI parameters including ADC,D,f,DDC,α,Dapp and Kapp could discriminate benign and malignant thyroid nodules.The metrics including D,DDC,Dapp and Kapp provide additional information with similar diagnostic performance of ADC,combination of these metrics may contribute to differentiate benign and malignant thyroid nodules.The ADC calculated with higher b values may not lead to improved diagnostic performance.
基金This study was supported by the Natural Science Foundation of Guangdong Province,China(No.101595 and No.32830).
文摘Diffusion-weighted imaging(DWI)as a new technique of magnetic resonance imaging(MRI)is used to detect focal hepatic lesions.This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient(ADC)values.METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging(EPI)in 56 cases of small focal hepatic lesions,including hepatocellular carcinoma(11),hepatic metastatic tumor(15),hepatic cavernous hemangioma(14),and hepatic cyst(16).The ADC values of these lesions were calculated respectively.The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated.RESULTS:The mean ADC values(mm2/s)were(0.93±0.06)×10-3 in hepatocellular carcinomas,(1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas,and(3.18±0.33)×10-3 in hepatic cysts.The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively,which were significantly different(P<0.05).CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions.
文摘AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography(DCE-US),following bolus injections of SonoVue.METHODS:The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank.In the in vivo experiments,B16F10 melanoma cells were xenografted to five nude mice.Both in vitro and in vivo,images were acquired following bolus injections of the ultrasound contrast agent SonoVue(Bracco,Milan,Italy) and using a Toshiba Aplio ultrasound scanner connected to a 2.9-5.8 MHz linear transducer(PZT,PLT 604AT probe)(Toshiba,Japan) allowing harmonic imaging("Vascular Recognition Imaging") involving linear raw data.A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute,Villejuif,France and used to evaluate seven perfusion parameters from time-intensity curves.Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation(CV).RESULTS:In vitro,different volumes of SonoVue were tested with the three phantoms:intra-operator variability was found to range from 2.33% to 23.72%.In vivo,experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%.In addition,the area under the curve(AUC) and the area under the wash-out(AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%.CONCLUSION:AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values.
文摘By using computer imaging analysis system combined with light microscopy, the glomeruli lesions on biopsy specimens sections were quantitatively analysed. The patholoical changes of mesangial proliferative glomerulonephritis (MsPGN) in children were quantitatively evaluated and the correlation between the mesangial matrix area (MA) and some clinical data were also analysed. The results indicated that the levels of various glomerular parameters in MsPGN group were higher than those of normal controls. No correlation was found between MA and 24 h urinary protein excretion, but a negative correlation was revealed between MA and estimated GFR. MA was also correlated with the duration of MsPGN recovery. It was suggested that the quantitative analysis of glomerular parameters by computer is a reproducible methods. The parameter of MA may be used for evaluation of the renal function, determination of the duration of therapy and evaluation of prognosis of MsPGN in children.
文摘目的分析动态增强磁共振成像(dynamic contrast enhanced magnetic resonance imaging,DCE-MRI)定量参数与表观扩散系数(apparent diffusion coefficient,ADC)联合诊断外周带前列腺癌的价值。方法选取2022年4月—2024年4月丹江口市第一医院收治的168例患者为研究对象,其中83例外周带前列腺癌患者纳入观察组,85例前列腺炎患者纳入对照组,另将同期于丹江口市第一医院行体检的88名健康体检者纳入健康组,均行DCE-MRI、扩散加权成像(diffusion weighted imaging,DWI)扫描,对比3组速率常数(rate constant,K_(ep))、容积转运常数(volume transfer constant,K_(trans))、血管外细胞外间隙体积分数(fractional extravascular extracellular space volume,V_(e))及ADC值;另描绘受试者工作曲线(receiver operating characteristic curve,ROC),分析K_(ep)、K_(trans)、V_(e)及ADC值单独或联合诊断外周带前列腺癌的价值。结果观察组的K_(ep)为(0.78±0.16)min、K_(trans)为(0.61±0.13)min,高于对照组的(0.53±0.10)min、(0.28±0.05)min,健康组的(0.14±0.02)min、(0.18±0.01)min,差异有统计学意义(P<0.001);观察组的V_(e)为(0.14±0.02)、ADC为(0.82±0.19)×10^(-3)mm^(2)/s,低于对照组的(0.18±0.02)、(1.06±0.18)×10^(-3)mm^(2)/s,健康组的(0.38±0.06)、(1.34±0.15)×10^(-3)mm^(2)/s,差异有统计学意义(P<0.001)。ROC结果显示,K_(ep)、K_(trans)、V_(e)及ADC值联合诊断外周带前列腺癌的曲线下面积(area under the curve,AUC)高于四者单一诊断(P<0.001)。结论DCE-MRI定量参数联合ADC可有效地诊断出外周带前列腺癌,存在一定的诊断价值。
文摘合成MRI(synthetic magnetic resonance imaging,SyMRI)是一种新兴的定量MRI技术,可通过单次扫描获取多对比度图像,实现与传统MRI等效的诊断效能。近年来,SyMRI技术日趋成熟,图像质量不断提高,在中枢神经系统、乳腺、骨肌系统、腹部等全身多部位疾病中的应用越来越广。SyMRI突出优势在于突破了传统MRI对多序列扫描的依赖,显著缩短扫描时间,基于定量序列测量组织固有特性,实现组织参数的定量比较。本文就SyMRI基本原理、可行性验证及图像质量评价、临床应用等方面展开综述,旨在为各系统疾病的精准化诊疗拓展新的检查思路。
