Diffuse optical spectroscopy is a relatively new,noninvasive and nonionizing technique for breast cancer diagnosis.In the present study,we have introduced a novel handheld diffuse optical breast scan(DOB-Scan)probe to...Diffuse optical spectroscopy is a relatively new,noninvasive and nonionizing technique for breast cancer diagnosis.In the present study,we have introduced a novel handheld diffuse optical breast scan(DOB-Scan)probe to measure optical properties of the breast in vivo and create functional and compositional images of the tissue.In addition,the probe gives more information about breast tissue's constituents,which helps distinguish a healthy and cancerous tissue.Two symmetrical light sources,each including four different wavelengths,are used to illuminate the breast tissue.A high-resolution linear array detector measures the intensity of the back-scattered photons at different radial destinations from the illumination sources on the surface of the breast tissue,and a unique image reconstruction algorithm is used to create four cross-sectional images for four different wavelengths.Different fromfiber optic-based illumination techniques,the proposed method in this paper integrates multi-wavelength light-emitting diodes to act as pencil beam sources into a scattering medium like breast tissue.This unique design and its compact structure reduce the complexity,size and cost of a potential probe.Although the introduced technique miniaturizes the probe,this study points to the reliability of this technique in the phantom study and clinical breast imaging.We have received ethical approval to test the DOB-Scan probe on patients and we are currently testing the DOB-Scan probe on subjects who are diagnosed with breast cancer.展开更多
Diffuse Optical Spectroscopy(DOS)is a promising non-invasive and non-ionizing technique for breast anomaly detection.In this study,we have developed a new handheld DOS probe to measure optical properties of breast tis...Diffuse Optical Spectroscopy(DOS)is a promising non-invasive and non-ionizing technique for breast anomaly detection.In this study,we have developed a new handheld DOS probe to measure optical properties of breast tissue.In the proposed probe,the breast tissue is illuminated with four near infrared(NIR)wavelengths light emitting diodes(LED),which are encapsulated in a package(eLEDs),and two PIN photodiodes measure the intensity of the scattered photons at two di®erent locations.The proposed technique of using eLEDs is introduced,in order to have a multi-wavelength pointed-beam illumination source instead of using the laser-coupledflberoptic technique,which increases the complexity,size,and cost of the probe.Despite the fact that the proposed technique miniaturizes the probe and reduces the complexity of the DOS,the study proves that it is accurate and reliable in measuring optical properties of the tissue.The measurements are performed at the rate of 10 Hz which is suitable for dynamic measurement of biological activity,in-vivo.The multi-spectral evaluation algorithm is used to reconstruct four main absorber concentrations in the breast including oxy-hemoglobin(cHb),deoxy-hemoglobin(cHbO_(2)),water(cH2O),fat(cFat),and average scattering coeficient of the medium,as well as concentration changes in Hb(cHb)and HbO_(2)(cHbO_(2)).Although the probe is designed for breast cancer diagnosis,it can be used in a wide range of applications for both static and dynamic measurements such as functional brain imaging.A series of phantoms,comprised of Delrinr,Intralipidr,PierceTM and Black ink,are used to verify performance of the device.The probe will be tested on human subjects,in-vivo,in the next phase.展开更多
Silver nanoclusters（NCs） embedded in soda-lime glass was synthesized by the electric fieldassisted diffusion（EFAD） and successive annealing. The samples were characterized by UV-Vis absorption spectroscopy, photol...Silver nanoclusters（NCs） embedded in soda-lime glass was synthesized by the electric fieldassisted diffusion（EFAD） and successive annealing. The samples were characterized by UV-Vis absorption spectroscopy, photoluminescence spectroscopy, X-ray photoelectron spectroscopy（XPS）, and lifetime measurements. The experimental results show that the growth of silver clusters is favored by the annealing temperature and dwell time. The as-diffused and annealed glass samples show photoluminescence around 550 nm under UV excitation, which can be associated with the presence of L-center and Ag3~＋ cluster. And the increasing of the annealing temperature and dwell time results in an appearance of the SPR peak and the decreasing of the luminescence intensities because the Ag3~＋ clusters grow up into the Ag nanoparticles.展开更多
基金The Natural Sciences and Engineering Research Council of Canada(NSERC)provided partialfi-nancial support for this project.The authors thank Dr.Rhonda Janzen(with the Jim Pattison Outpatient Care and Surgery Center),Dr.Mojgan Jenab,M.Sc.student Zahra Haeiri(both from SFU)for conducting the clinical test,Sepideh M.Moqadam for her input in case design and M.Sc.student Mi Zhou at SFU to review and edit the paper.
文摘Diffuse optical spectroscopy is a relatively new,noninvasive and nonionizing technique for breast cancer diagnosis.In the present study,we have introduced a novel handheld diffuse optical breast scan(DOB-Scan)probe to measure optical properties of the breast in vivo and create functional and compositional images of the tissue.In addition,the probe gives more information about breast tissue's constituents,which helps distinguish a healthy and cancerous tissue.Two symmetrical light sources,each including four different wavelengths,are used to illuminate the breast tissue.A high-resolution linear array detector measures the intensity of the back-scattered photons at different radial destinations from the illumination sources on the surface of the breast tissue,and a unique image reconstruction algorithm is used to create four cross-sectional images for four different wavelengths.Different fromfiber optic-based illumination techniques,the proposed method in this paper integrates multi-wavelength light-emitting diodes to act as pencil beam sources into a scattering medium like breast tissue.This unique design and its compact structure reduce the complexity,size and cost of a potential probe.Although the introduced technique miniaturizes the probe,this study points to the reliability of this technique in the phantom study and clinical breast imaging.We have received ethical approval to test the DOB-Scan probe on patients and we are currently testing the DOB-Scan probe on subjects who are diagnosed with breast cancer.
文摘Diffuse Optical Spectroscopy(DOS)is a promising non-invasive and non-ionizing technique for breast anomaly detection.In this study,we have developed a new handheld DOS probe to measure optical properties of breast tissue.In the proposed probe,the breast tissue is illuminated with four near infrared(NIR)wavelengths light emitting diodes(LED),which are encapsulated in a package(eLEDs),and two PIN photodiodes measure the intensity of the scattered photons at two di®erent locations.The proposed technique of using eLEDs is introduced,in order to have a multi-wavelength pointed-beam illumination source instead of using the laser-coupledflberoptic technique,which increases the complexity,size,and cost of the probe.Despite the fact that the proposed technique miniaturizes the probe and reduces the complexity of the DOS,the study proves that it is accurate and reliable in measuring optical properties of the tissue.The measurements are performed at the rate of 10 Hz which is suitable for dynamic measurement of biological activity,in-vivo.The multi-spectral evaluation algorithm is used to reconstruct four main absorber concentrations in the breast including oxy-hemoglobin(cHb),deoxy-hemoglobin(cHbO_(2)),water(cH2O),fat(cFat),and average scattering coeficient of the medium,as well as concentration changes in Hb(cHb)and HbO_(2)(cHbO_(2)).Although the probe is designed for breast cancer diagnosis,it can be used in a wide range of applications for both static and dynamic measurements such as functional brain imaging.A series of phantoms,comprised of Delrinr,Intralipidr,PierceTM and Black ink,are used to verify performance of the device.The probe will be tested on human subjects,in-vivo,in the next phase.
基金Funded by the Shanghai Science and Technology Committee(12nm0504700)
文摘Silver nanoclusters（NCs） embedded in soda-lime glass was synthesized by the electric fieldassisted diffusion（EFAD） and successive annealing. The samples were characterized by UV-Vis absorption spectroscopy, photoluminescence spectroscopy, X-ray photoelectron spectroscopy（XPS）, and lifetime measurements. The experimental results show that the growth of silver clusters is favored by the annealing temperature and dwell time. The as-diffused and annealed glass samples show photoluminescence around 550 nm under UV excitation, which can be associated with the presence of L-center and Ag3~＋ cluster. And the increasing of the annealing temperature and dwell time results in an appearance of the SPR peak and the decreasing of the luminescence intensities because the Ag3~＋ clusters grow up into the Ag nanoparticles.
