The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. Th...The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.展开更多
Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differen...Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability.The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques.These methods can influence the cellular microenvironment,activate disparate signaling pathways,and induce different biological effects.“Epigenetic regulation”refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences,such as histone methylation.Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages.The most important sites of histone methylation in tooth organization were found to be H3K4,H3K9,and H3K27.Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites,generating distinct chromatin structures associated with specific downstream transcriptional states.Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications.A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation.Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4,H3K9,and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments.This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.展开更多
Background There is scarce data about comparisons between geriatric assessment tools in patients with aortic stenosis(AS).We aimed to describe the geriatric profile of patients with AS undergoing transcatheter aortic ...Background There is scarce data about comparisons between geriatric assessment tools in patients with aortic stenosis(AS).We aimed to describe the geriatric profile of patients with AS undergoing transcatheter aortic valve implantation(TAVI)and to analyze the ability of different tools for predicting clinical outcomes in this context.Methods This was a single center retrospective registry including patients with AS undergoing TAVI and surviving to hospital discharge.The primary endpoint was all-cause mortality or need for urgent readmission one year after TAVI.Results A total of 377 patients were included(mean age of 80.4 years).Most patients were independent or mildly dependent,with an optimal cognitive status.The proportion of frailty ranged from 17.6%to 49.8%.A total of 20 patients(5.3%)died and 110/377 patients(29.2%)died or were readmitted during follow up.Overall,most components of the geriatric assessment showed an association with clinical outcomes.Disability for instrumental activities showed a significant association with mortality and a strong association with the rate of mortality or readmission.The association between frailty and clinical outcomes was higher for short physical performance battery(SPPB),essential frailty toolset(EFT)and the frailty index based on comprehensive geriatric assessment(IF-VIG)and lower for Fried criteria and FRAIL scale.Conclusions AS patients from this series presented a good physical performance,optimal cognitive status and a reasonably low prevalence of frailty.The best predictive ability was observed for disability for instrumental activities and frailty as measured by the EFT,SPPB and the IF-VIG.展开更多
The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate ...The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate change on the structure,function,and services of the ecosystem.However,the spatial distribution and controlling factors of SOC and TN across various soil layers and vegetation types within this unique ecosystem remain inadequately understood.In this study,256 soil samples in 89 sites were collected from the Three River Headwaters Region(TRHR)in China to investigate SOC and TN and to explore the primary factors affecting their distribution,including soil,vegetation,climate,and geography factors.The results show that SOC and TN contents in 0-20,20-40,40-60,and 60-80 cm soil layers are 24.40,18.03,14.04,12.40 g/kg and 2.46,1.90,1.51,1.17 g/kg,respectively;with higher concentrations observed in the southeastern region compared to the northwest of the TRHR.One-way analysis of variance reveals that SOC and TN levels are elevated in the alpine meadow and the alpine shrub relative to the alpine steppe in the 0-60 cm soil layers.The structural equation model explores that soil water content is the main controlling factor affecting the variation of SOC and TN.Moreover,the geography,climate,and vegetation factors notably indirectly affect SOC and TN through soil factors.Therefore,it can effectively improve soil water and nutrient conditions through vegetation restoration,soil improvement,and grazing management,and the change of SOC and TN can be fully understood by establishing monitoring networks to better protect soil carbon and nitrogen.展开更多
Mice preantral follicles were cultured in vitro for 12 days to achieve metaphase Ⅱ （M Ⅱ ） oocytes. Oocyte growth differentiation factor-9 （GDF-9） gene expression was measured during different growth stages to ex...Mice preantral follicles were cultured in vitro for 12 days to achieve metaphase Ⅱ （M Ⅱ ） oocytes. Oocyte growth differentiation factor-9 （GDF-9） gene expression was measured during different growth stages to explore the relationship between oocyte maturation and GDF-9 gene expression. Preantral follicles of lO-day old mice were isolated from the ovaries and were cultured for 12 days. Oocytes from day 2 （D2）, D4, D6, D8, DIO, D12 cultured in vitro were named the in vitro group and oocytes of day 12 （D12）, D14, D16, D18, D20, D22 grown in vivo were named the in vivo group. Follicle survival, antrum formation and maturation rate were 89.5%, 51.8% and 56.6% respectively in follicles cultured in vitro. After RT-PCR and agarose gel electrophoresis, relative mRNA abundance of GDF-9 was measured in each group of oocytes. At day 8 - 12, the GDF-9 gene expression level of oocytes in vitro was significantly lower than that in vivo （P 〈 0.05）. We conclude that M Ⅱ oocytes can be obtained from in vitro culture of preantral follicles. The GDF- 9 gene expression of oocytes varies at different growth stages in vivo. The low expression of GDF-9 in oocytes cuhured in vitro may be the cause of their low developmental capacity.展开更多
Q:为什么无法从粒子物理出发推导出凝聚态物理?A:听过一个讲座,临结束时报告人问了一个问题:大家都知道“More is different”,那有人知道这篇文章还有一个副标题是什么吗?全场鸦雀无声。查阅后得知副标题是“Broken symmetry and the n...Q:为什么无法从粒子物理出发推导出凝聚态物理?A:听过一个讲座,临结束时报告人问了一个问题:大家都知道“More is different”,那有人知道这篇文章还有一个副标题是什么吗?全场鸦雀无声。查阅后得知副标题是“Broken symmetry and the nature of the hierarchical structure of science”,翻译过来就是“破缺的对称性与科学层级结构的本质”。展开更多
Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van Yüzü...Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van YüzüncüYıl University,Van,Turkey)Abstract:Quality assurance practices performed before treatment are believed to identify various potential errors.In this study,2-dimensional(2D)dosimetric results were analyzed by making some intentional mistakes in six different treatment plans.In this way,the detectability of errors was investigated.In all segments of all treatment plans,one of the multileaf collimators was kept fixed at different positions on the central axis.In addition to multileaf collimators error,gantry error was also examined in the study.The dose distribution results obtained by Treatment Planning System(TPS)were compared with those obtained by the 2D array device,both as local calculation and global calculation methods,using the gamma analysis method.When the results are examined in the case where the Multi-leaf collimators(MLC)is fixed at the 1 cm position.展开更多
Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this sys...Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.展开更多
Depression is a prevalent mental disorder that affects numerous individuals,manifesting as persistent anhedonia,sadness,and hopelessness.Despite extensive research,the exact causes and optimal treatment approaches for...Depression is a prevalent mental disorder that affects numerous individuals,manifesting as persistent anhedonia,sadness,and hopelessness.Despite extensive research,the exact causes and optimal treatment approaches for depression remain unclear.Extracellular vesicles(EVs),which carry biological molecules such as proteins,lipids,nucleic acids,and metabolites,have emerged as crucial players in both pathological and physiological processes.EVs derived from various sources exert distinct effects on depression.Specifically,EVs released by neurons,astrocytes,microglia,oligodendrocytes,immune cells,stem cells,and even bacteria contribute to the pathogenesis of depression.Moreover,there is growing interest in potential of EVs as diagnostic and therapeutic tools for depression.This review provides a comprehensive overview of recent research on EVs from different sources,their roles in depression,and their potential clinical applications.展开更多
MADRID and Beijing,though thousands of miles apart,have become a model for mutual learning between different civilizations through mutual respect and dialogue.In November,Spanish King Felipe VI will visit China.This w...MADRID and Beijing,though thousands of miles apart,have become a model for mutual learning between different civilizations through mutual respect and dialogue.In November,Spanish King Felipe VI will visit China.This will be another milestone in bilateral relations following the 2007 visit of former Spanish King Juan Carlos I to China and President Xi Jinping’s visit to Spain in 2018.展开更多
Reasonable greening design can effectively alleviate campus heat environment issues.This study uses the ENVI-met numerical model,along with in-situ observations and simulations,to analyze the thermal environment under...Reasonable greening design can effectively alleviate campus heat environment issues.This study uses the ENVI-met numerical model,along with in-situ observations and simulations,to analyze the thermal environment under three different greening schemes in typical areas of the Guangzhou University campus.The results indicate that the outdoor thermal environment is significantly influenced by the underlying surface materials and vegetation.The temperature of brick-paved surface is 0.9℃higher than that of natural soil surfaces under tree shade.Numerical simulations further confirm that increasing vegetation coverage effectively reduces outdoor air temperature.When the greening rate increases to 40%,the outdoor average temperature decreases by 0.7℃and relative humidity increases by approximately 4%,while wind speed remains minimal change.The cooling effect of vegetation is found to extend vertically to an altitude of 13 m.As the greening rate increases from 15%to 40%,the Mean Radiant Temperature(MRT)decreases from 50.6℃to 28.9℃,which is lower than the average ambient temperature,indicating improved thermal conditions.The Physiological Equivalent Temperature(PET)decreases from 40.2℃to 30.0℃,with the proportion of the areas classified as″very hot″reducing by 36.8%,significantly improving thermal comfort across most areas.Therefore,changing the ground material and greening landscape design can effectively alter the outdoor wind and thermal environment of the campus,thereby enhancing the thermal comfort for the campus community.展开更多
An expanding human population and technological progress demand clean and effective energy-storing systems.Within the realm of energy-storing devices,supercapacitors(SCs)have grabbed huge focus owing to their high-pow...An expanding human population and technological progress demand clean and effective energy-storing systems.Within the realm of energy-storing devices,supercapacitors(SCs)have grabbed huge focus owing to their high-power density,unique cycling stability,and fast charging discharging capabilities.Electrode material has a prominent impact on the effectiveness of SCs.Several types of electrode materials have been used,encompassing varied metal oxides,activated carbon,conducting polymers,and MOFs.Metal organic frameworks(MOFs)are considered emerging electrode candidates,which could be ascribed to the tunable porosity,large surface areas,and designed morphology.This review shows a detailed analysis of various mono-,bi-,and tri-metallic MOFs along with derivatives in SC applications,their structural characteristics,and synthetic strategies.It also critically evaluates MOFs potential to boost the SC's energy density,power density,stability,and conductivity.Also,it underscores their significance in the establishment of future-oriented energy storage applications.展开更多
Transition metal cobalt exhibits strong activation capabilities for alkanes,however,the instability of Co sites leads to sintering and coke deposition,resulting in rapid deactivation.Hierarchical zeolites,with their d...Transition metal cobalt exhibits strong activation capabilities for alkanes,however,the instability of Co sites leads to sintering and coke deposition,resulting in rapid deactivation.Hierarchical zeolites,with their diverse pore structures and high surface areas,are used to effectively anchor metals and enhance coke tolerance.Herein,a post-treatment method using an alkaline solution was employed to synthesize meso-microporous zeolite supports,which were subsequently loaded with Co species for propane dehydrogenation catalyst.The results indicate that the application of NaOH,an inorganic base,produces supports with a larger mesopore volume and more abundant hydroxyl nests compared to TPAOH,an organic base.UV-vis,Raman,and XPS analyses reveal that Co in the 0.5Co/SN-1-0.05 catalyst is mainly in the form of tetrahedral Co^(2+),which effectively activates C-H bonds.In contrast,the 0.5Co/S-1 catalyst contains mainly Co_(3)O_(4)species.Co^(2+)supported on hierarchical zeolites shows better propane conversion(58.6%)and propylene selectivity(>96%)compared to pure silica zeolites.Coke characterization indicates that hierarchical zeolites accumulate more coke,but it is mostly in the form of easily removable disordered carbon.The mesopores in the microporous zeolite support help disperse the active Co metal and facilitate coke removal during dehydrogenation,effectively preventing deactivation from sintering and coke coverage.展开更多
Understanding the characteristics of windsand flow field in the curve section of desert highway under different wind directions is helpful for reducing the wind-sand damage in the curve section.Therefore,taking the de...Understanding the characteristics of windsand flow field in the curve section of desert highway under different wind directions is helpful for reducing the wind-sand damage in the curve section.Therefore,taking the desert section of Wuma Expressway in Zhongwei city,Ningxia,China as the research background,the wind-sand flow field and sand accumulation phenomenon of concave surface plane curve embankment under different wind directions is calculated and analyzed by computational fluid dynamics(CFD)numerical simulation method.The results show that:(1)Under different wind directions,along the direction of the route,at the starting point of the route,the windward slope of the embankment is a circular arc section,which reduces the resistance of wind-sand flow and promotes the acceleration of sand particles.In the middle of the route,the low-speed area of the windward slope toe and the leeward slope toe is small;at the end of the route,the high-speed area on the shoulder side of the leeward road rises upward.(2)Under different wind directions,the smaller the angle between the wind direction and the route,the stronger the lateral transport effect on the wind-blown sand flow,and the more sand particles transported along the route direction.(3)Under different wind directions,in the concave windward horizontal curve,with the increase of the angle,the sand area on the top of the embankment shows an increasing trend.Whenα=30°,45°,60°,75°,the percentage of the sand area on the top of the embankment to the total embankment area is 0%,33.3%,64.4%,71.0%,respectively.(4)Under different wind directions,along the route direction,the sand transport efficiency of the concave surface upwind plane curve embankment shows a decreasing trend.In the case of a certain radius of the horizontal curve,the angle range between the wind direction and the concave horizontal curve route is recommended to be 30°-45°.展开更多
The North China Plain(NCP)frequently experiences ozone pollution events,which are generally related to cross-border transport at multiple scales.However,current methods of calculating ozone transport are insufficient ...The North China Plain(NCP)frequently experiences ozone pollution events,which are generally related to cross-border transport at multiple scales.However,current methods of calculating ozone transport are insufficient to account for ozone transport at different altitudes.To further understand the characteristics of ozone transport,we applied theWeather Research and Forecasting(WRF)model and the Comprehensive Air Quality Model with Extensions(CAMx)based on flux calculation method.The results showed that the simulated flux calculation method was suitable for revealing the evolutionary trend of ozone fluxes.Monthly inflows,outflows,and total net fluxes ranged from-32985.45 to 37361.46 t/d and indicated strong transport and significant spatial and temporal variations of ozone in the urban boundary segments.Vertical distribution analysis of the net ozone fluxes demonstrated that the net fluxes varied with the altitude,and the altitude at which the corresponding peaks were located had a strong correlation with the neighborhood and season.It was noteworthy that there were three main transport directions throughout the year,namely northwest-southeast(NW-SE),southeast-northwest(SE-NW),and southwestnortheast(SW-NE).Additionally,the ozone flux was mainly affected by temperature,wind speed,and ozone concentration,with the correlation coefficient varying by season and altitude,up to 0.78.Moreover,the correlation analysis of ozone flux and wind direction in each city further verified the accuracy of the transport direction.This paper can provide scientific and technological support for the study of ozone generation mechanisms and the solution of urban/interregional ozone pollution problems.展开更多
BACKGROUND Repetitive transcranial magnetic stimulation(rTMS)entered clinical practice in China after 2000,first used in psychiatric surgery,and then in neurology and other disciplines.The First Hospital of Jiaxing in...BACKGROUND Repetitive transcranial magnetic stimulation(rTMS)entered clinical practice in China after 2000,first used in psychiatric surgery,and then in neurology and other disciplines.The First Hospital of Jiaxing introduced TMS in 2015.In practical applications,it has been found that different models of instruments and technical parameters can lead to differences in therapeutic efficacy.Therefore,our hospital selected the Danish TMS instrument,which ranks second in China,to test patients with schizophrenia from March 2021 to July 2021,with a focus on comparing the results at 5 Hz,10 Hz,and 15 Hz.The testing time is concentrated between 8:30 to 10:30 in the morning.A contingency plan was made for the quality after inspection before testing.Two evaluators independently control the quality of the contingency plan.The data is independently saved and proofread by two evaluators.The purpose of this study is to translate the research results into clinical practice and provide reference basis.AIM To investigate the effects of rehabilitation therapy using rTMS on the negative symptoms and event-related potential component of P300 in chronic schizophrenia.METHODS One hundred and five patients with chronic schizophrenia were randomly allocated to three groups based on the frequency of rTMS(5,10,or 15 Hz).The patients underwent five sessions of rTMS per week for 5 weeks.We compared the pre-and post-treatment P300 latency and scores for the Scale for Assessment of Negative Symptoms(SANS).RESULTS A significant decrease in SANS score after rTMS was observed in the 10-Hz group(P<0.05),which was not observed in the 5-Hz and 15-Hz groups.There was a significant increase in P300 amplitude in the 10-Hz group after rTMS treatment(P<0.05),but there was no significant change in P300 latency(P>0.05).The improvement of SANS score in the 10-Hz rTMS group was related to patient age and disease course.CONCLUSION rTMS at 10 Hz improved negative symptoms and cognitive function in chronic schizophrenia;however,further studies on the mechanism of action are required to validate our observations.展开更多
Objective:This study aims to explore the benefit analysis of the same disease in different departments of public hospitals under the DIP payment method.Methods:This study is a retrospective analysis that selected clin...Objective:This study aims to explore the benefit analysis of the same disease in different departments of public hospitals under the DIP payment method.Methods:This study is a retrospective analysis that selected clinical data from patients who received treatment in the Department of Orthopedics and the Department of Acupuncture and Moxibustion at our hospital from January 1,2023,to December 31,2023.The study compared the costs of medications,examinations,treatments,laboratory tests,nursing and other expenses,and total treatment costs between the two departments.It analyzed the cost structure of the two departments and proposed further improvement suggestions.Results:The study results indicated that the total costs in the Department of Acupuncture and Moxibustion were significantly higher than those in the Department of Orthopedics.Among medication costs,the total medication costs in the Department of Orthopedics were higher than those in the Department of Acupuncture and Moxibustion,with costs for Western medicine,proprietary Chinese medicine,and herbal medicine all being higher(p<0.05).Regarding examination costs,consultation fees in the Department of Orthopedics were lower than those in the Department of Acupuncture and Moxibustion,while examination costs were higher(p<0.05).In terms of treatment costs,orthopedic treatment and surgical fees were higher than those in the Department of Acupuncture and Moxibustion(p<0.05).For laboratory test costs,orthopedic laboratory fees were significantly higher than those in the Department of Acupuncture and Moxibustion(p<0.05).Among nursing and other expenses,orthopedic blood transfusion,bed fees,and other expenses were higher than those in the Department of Acupuncture and Moxibustion,while nursing fees were lower(p<0.05).Conclusion:Treatment fees in the Department of Acupuncture and Moxibustion are the core and account for a relatively high proportion of the total costs.The benefits generated by the Department of Orthopedics are primarily derived from medication,examination,and laboratory fees,aligning with the characteristics of combining diagnosis,medication,and surgical intervention in orthopedic treatment.Consultation fees,nursing fees,and bed fees in the Department of Acupuncture and Moxibustion are higher than those in the Department of Orthopedics,indicating a longer treatment cycle in acupuncture,which warrants clinical attention.展开更多
In the frost-thaw region,prolonged freezethaw weathering can induce fracture and weaken rock masses,threatening engineering stability.While interbedded rock masses are common in such projects,their failure mechanisms ...In the frost-thaw region,prolonged freezethaw weathering can induce fracture and weaken rock masses,threatening engineering stability.While interbedded rock masses are common in such projects,their failure mechanisms remain insufficiently investigated in freezing and thawing environments.Therefore,this research establishes a particle flow code(PFC2D)model of interlayered rock masses with particular emphasis on the role of thickness variation.The analysis focuses on displacement,crack evolution,contact forces,and uniaxial compressive strength.The findings indicate that:(i)Completing 8 freeze-thaw cycles significantly increases displacement and contact forces,with crack growth accelerating markedly after 16 cycles.As the soft rock layer thickness ratio(Hs/H)increases,the peak contact force decreases by 18.3%,while the number of cracks rises by 48%.Once Hs/H exceeded 0.5,the rate of crack development decelerates.This reflects progressive bond degradation and damage accumulation:microscopic bonds weaken and rupture to form microcracks.Increased soft rock thickness promotes micro-damage accumulation,altering contact forces and intensifying degradation.(ii)Compressive cracks predominantly initiate in soft rock(limestone).After 20 cycles,cracking extends into the hard rock regions.As the Hs/H rises,compressive cracks first increase and then decline,with an overall reduction of 10.8%,while the compressive contact force exhibits a consistent downward trend.This trend indicates that freeze-thaw cycles cause severe microscopic degradation in soft rock,weakening its macroscopic strength and influencing compressive crack development.Increased soft rock thickness alters the stress state,thereby modifying crack propagation.(iii)Uniaxial compressive strength experiences a marked deterioration after 15 freeze-thaw cycles.It follows an exponential decay with increasing Hs/H,culminating in a total strength reduction of 76.9%.This demonstrates that freeze-thaw-induced microscopic damage deteriorates interparticle cohesion,reducing rock mass strength.A higher Hs/H ratio accelerates microscopic damage in the soft rock,causing cohesion to decay nonlinearly and macroscopic strength to drop exponentially.These results provide a theoretical basis for assessing the deformation and failure behaviors of rock masses under cyclic freeze-thaw action.展开更多
It has long been noticed that focus is able to influence the truth-conditions of coun-terfactual conditionals.Namely,stressing different parts of a counterfactual leads to distinct interpretations.However,existing the...It has long been noticed that focus is able to influence the truth-conditions of coun-terfactual conditionals.Namely,stressing different parts of a counterfactual leads to distinct interpretations.However,existing theories,such as those by von Finte1 and Rooth,fail to ad-equately account for this phenomenon.In this paper,I exposit the drawbacks of these theories and then propose a novel account,ie.the Good Question-Answer(GQA)view.The GQA account posits that focus triggers question-answer pairs,and pragmatic pressures conceming the adequacy of such question answer pairs in contexts are able to affect the truth-conditions of counterfactuals.I also argue for the GQA account by appeal to its theoretical virtues.展开更多
Fluids generated from the source rocks containing various kerogen types at different thermal maturity stages control diagenetic processes and reservoir quality in adjacent sandstone reservoirs.This study focuses on th...Fluids generated from the source rocks containing various kerogen types at different thermal maturity stages control diagenetic processes and reservoir quality in adjacent sandstone reservoirs.This study focuses on the carbonate cements in the sandstones of the Lower Jurassic Yangxia Formation and the Ahe Formation in the Tarim Basin.Theδ^(18)O,δ^(13)C,and ^(87)Sr/^(86)Sr data indicate that low‑temperature ferroan calcite and manganoan calcite—characterized by strongly negativeδ^(13)C values and enrichment in light rare‑earth elements(LREEs)—record CO_(2) released during the thermal degradation of organic matter predominantly composed of Type III kerogen in coal‑bearing source rocks and of Type Ⅱ kerogen in mudstone source rocks,respectively.High‑temperature ferroan calcite and manganoan calcite,which exhibit similarly strongly negativeδ^(13)C values and enrichment in middle rare‑earth elements(MREEs),record organic acids and CO_(2) produced during the thermal decarboxylation of these same source rocks.The diagenetic fluid evolution sequence comprises early‑stage CO_(2) from thermal degradation of both coal‑bearing and mudstone source rocks;mid‑stage organic acids and CO_(2) from thermal decarboxylation of coal‑bearing source rocks;and late‑stage organic acids and CO_(2) from thermal decarboxylation of mudstone source rocks.Fluids generated during the thermal degradation of mudstone and coal‑bearing source rocks precipitated extensive calcite cements,leading to reservoir densification.Clumped isotope thermometry indicates that the primary generation periods of late‑stage mudstone‑derived fluids coincided with the formation of effective fractures.Feldspar dissolution along these fractures produced an interconnected network of fractures and dissolution pores,significantly enhancing reservoir quality in the Ahe Formation.展开更多
文摘The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.
基金supported by grants from the National Key Research and Development Program(2022YFA1104401)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-031 to Z.P.F.)grants from Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(NO.CXTD202204 to Z.P.F.).
文摘Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability.The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques.These methods can influence the cellular microenvironment,activate disparate signaling pathways,and induce different biological effects.“Epigenetic regulation”refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences,such as histone methylation.Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages.The most important sites of histone methylation in tooth organization were found to be H3K4,H3K9,and H3K27.Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites,generating distinct chromatin structures associated with specific downstream transcriptional states.Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications.A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation.Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4,H3K9,and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments.This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.
文摘Background There is scarce data about comparisons between geriatric assessment tools in patients with aortic stenosis(AS).We aimed to describe the geriatric profile of patients with AS undergoing transcatheter aortic valve implantation(TAVI)and to analyze the ability of different tools for predicting clinical outcomes in this context.Methods This was a single center retrospective registry including patients with AS undergoing TAVI and surviving to hospital discharge.The primary endpoint was all-cause mortality or need for urgent readmission one year after TAVI.Results A total of 377 patients were included(mean age of 80.4 years).Most patients were independent or mildly dependent,with an optimal cognitive status.The proportion of frailty ranged from 17.6%to 49.8%.A total of 20 patients(5.3%)died and 110/377 patients(29.2%)died or were readmitted during follow up.Overall,most components of the geriatric assessment showed an association with clinical outcomes.Disability for instrumental activities showed a significant association with mortality and a strong association with the rate of mortality or readmission.The association between frailty and clinical outcomes was higher for short physical performance battery(SPPB),essential frailty toolset(EFT)and the frailty index based on comprehensive geriatric assessment(IF-VIG)and lower for Fried criteria and FRAIL scale.Conclusions AS patients from this series presented a good physical performance,optimal cognitive status and a reasonably low prevalence of frailty.The best predictive ability was observed for disability for instrumental activities and frailty as measured by the EFT,SPPB and the IF-VIG.
基金supported by the National Science Foundation for Distinguished Young Scholars(No.42425107)Ecological Civilization Special Project of Key Research&and Development Program in Gansu Province(No.24YFFA009)the Top Talent Project of Gansu Province,Chinese Academy of Sciences Young Crossover Team Project(No.JCTD-2022-18)。
文摘The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate change on the structure,function,and services of the ecosystem.However,the spatial distribution and controlling factors of SOC and TN across various soil layers and vegetation types within this unique ecosystem remain inadequately understood.In this study,256 soil samples in 89 sites were collected from the Three River Headwaters Region(TRHR)in China to investigate SOC and TN and to explore the primary factors affecting their distribution,including soil,vegetation,climate,and geography factors.The results show that SOC and TN contents in 0-20,20-40,40-60,and 60-80 cm soil layers are 24.40,18.03,14.04,12.40 g/kg and 2.46,1.90,1.51,1.17 g/kg,respectively;with higher concentrations observed in the southeastern region compared to the northwest of the TRHR.One-way analysis of variance reveals that SOC and TN levels are elevated in the alpine meadow and the alpine shrub relative to the alpine steppe in the 0-60 cm soil layers.The structural equation model explores that soil water content is the main controlling factor affecting the variation of SOC and TN.Moreover,the geography,climate,and vegetation factors notably indirectly affect SOC and TN through soil factors.Therefore,it can effectively improve soil water and nutrient conditions through vegetation restoration,soil improvement,and grazing management,and the change of SOC and TN can be fully understood by establishing monitoring networks to better protect soil carbon and nitrogen.
文摘Mice preantral follicles were cultured in vitro for 12 days to achieve metaphase Ⅱ （M Ⅱ ） oocytes. Oocyte growth differentiation factor-9 （GDF-9） gene expression was measured during different growth stages to explore the relationship between oocyte maturation and GDF-9 gene expression. Preantral follicles of lO-day old mice were isolated from the ovaries and were cultured for 12 days. Oocytes from day 2 （D2）, D4, D6, D8, DIO, D12 cultured in vitro were named the in vitro group and oocytes of day 12 （D12）, D14, D16, D18, D20, D22 grown in vivo were named the in vivo group. Follicle survival, antrum formation and maturation rate were 89.5%, 51.8% and 56.6% respectively in follicles cultured in vitro. After RT-PCR and agarose gel electrophoresis, relative mRNA abundance of GDF-9 was measured in each group of oocytes. At day 8 - 12, the GDF-9 gene expression level of oocytes in vitro was significantly lower than that in vivo （P 〈 0.05）. We conclude that M Ⅱ oocytes can be obtained from in vitro culture of preantral follicles. The GDF- 9 gene expression of oocytes varies at different growth stages in vivo. The low expression of GDF-9 in oocytes cuhured in vitro may be the cause of their low developmental capacity.
文摘Q:为什么无法从粒子物理出发推导出凝聚态物理?A:听过一个讲座,临结束时报告人问了一个问题:大家都知道“More is different”,那有人知道这篇文章还有一个副标题是什么吗?全场鸦雀无声。查阅后得知副标题是“Broken symmetry and the nature of the hierarchical structure of science”,翻译过来就是“破缺的对称性与科学层级结构的本质”。
文摘Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van YüzüncüYıl University,Van,Turkey)Abstract:Quality assurance practices performed before treatment are believed to identify various potential errors.In this study,2-dimensional(2D)dosimetric results were analyzed by making some intentional mistakes in six different treatment plans.In this way,the detectability of errors was investigated.In all segments of all treatment plans,one of the multileaf collimators was kept fixed at different positions on the central axis.In addition to multileaf collimators error,gantry error was also examined in the study.The dose distribution results obtained by Treatment Planning System(TPS)were compared with those obtained by the 2D array device,both as local calculation and global calculation methods,using the gamma analysis method.When the results are examined in the case where the Multi-leaf collimators(MLC)is fixed at the 1 cm position.
基金supported by the Natural Science Foundation of Hunan Province,China(Grant Nos.2023JJ50178 and 2023JJ50194)the Excellent Youth Project of Hunan Provincial Department of Education(Grant No.23B0542).
文摘Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.
基金Supported by Gusu Talent program,No.(2023)105Suzhou Science and Technology Development Plan Program,No.SKY2023228+2 种基金Project of Medical Research Fund of Jiangsu Provincial Health Commission,No.Z2023043Suzhou Clinical Medical Center for Mood Disorders,No.Szlcyxzx202109Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116.
文摘Depression is a prevalent mental disorder that affects numerous individuals,manifesting as persistent anhedonia,sadness,and hopelessness.Despite extensive research,the exact causes and optimal treatment approaches for depression remain unclear.Extracellular vesicles(EVs),which carry biological molecules such as proteins,lipids,nucleic acids,and metabolites,have emerged as crucial players in both pathological and physiological processes.EVs derived from various sources exert distinct effects on depression.Specifically,EVs released by neurons,astrocytes,microglia,oligodendrocytes,immune cells,stem cells,and even bacteria contribute to the pathogenesis of depression.Moreover,there is growing interest in potential of EVs as diagnostic and therapeutic tools for depression.This review provides a comprehensive overview of recent research on EVs from different sources,their roles in depression,and their potential clinical applications.
文摘MADRID and Beijing,though thousands of miles apart,have become a model for mutual learning between different civilizations through mutual respect and dialogue.In November,Spanish King Felipe VI will visit China.This will be another milestone in bilateral relations following the 2007 visit of former Spanish King Juan Carlos I to China and President Xi Jinping’s visit to Spain in 2018.
基金Science and Technology Research Project of Guang-dong Meteorological Bureau(GRMC2022M21)Guangdong Basic and Applied Basic Research Foundation(2023A1515012240)Research Project of Guangzhou Meteor-ological Bureau(M202218)。
文摘Reasonable greening design can effectively alleviate campus heat environment issues.This study uses the ENVI-met numerical model,along with in-situ observations and simulations,to analyze the thermal environment under three different greening schemes in typical areas of the Guangzhou University campus.The results indicate that the outdoor thermal environment is significantly influenced by the underlying surface materials and vegetation.The temperature of brick-paved surface is 0.9℃higher than that of natural soil surfaces under tree shade.Numerical simulations further confirm that increasing vegetation coverage effectively reduces outdoor air temperature.When the greening rate increases to 40%,the outdoor average temperature decreases by 0.7℃and relative humidity increases by approximately 4%,while wind speed remains minimal change.The cooling effect of vegetation is found to extend vertically to an altitude of 13 m.As the greening rate increases from 15%to 40%,the Mean Radiant Temperature(MRT)decreases from 50.6℃to 28.9℃,which is lower than the average ambient temperature,indicating improved thermal conditions.The Physiological Equivalent Temperature(PET)decreases from 40.2℃to 30.0℃,with the proportion of the areas classified as″very hot″reducing by 36.8%,significantly improving thermal comfort across most areas.Therefore,changing the ground material and greening landscape design can effectively alter the outdoor wind and thermal environment of the campus,thereby enhancing the thermal comfort for the campus community.
文摘An expanding human population and technological progress demand clean and effective energy-storing systems.Within the realm of energy-storing devices,supercapacitors(SCs)have grabbed huge focus owing to their high-power density,unique cycling stability,and fast charging discharging capabilities.Electrode material has a prominent impact on the effectiveness of SCs.Several types of electrode materials have been used,encompassing varied metal oxides,activated carbon,conducting polymers,and MOFs.Metal organic frameworks(MOFs)are considered emerging electrode candidates,which could be ascribed to the tunable porosity,large surface areas,and designed morphology.This review shows a detailed analysis of various mono-,bi-,and tri-metallic MOFs along with derivatives in SC applications,their structural characteristics,and synthetic strategies.It also critically evaluates MOFs potential to boost the SC's energy density,power density,stability,and conductivity.Also,it underscores their significance in the establishment of future-oriented energy storage applications.
基金supported by the National Natural Science Foundation of China(Nos.22035009,22178381)the National Key R&D Program of China(Nos.2021YFA1501301,2021YFC2901100)the State Key Laboratory of Heavy Oil Processing(No.2021-03).
文摘Transition metal cobalt exhibits strong activation capabilities for alkanes,however,the instability of Co sites leads to sintering and coke deposition,resulting in rapid deactivation.Hierarchical zeolites,with their diverse pore structures and high surface areas,are used to effectively anchor metals and enhance coke tolerance.Herein,a post-treatment method using an alkaline solution was employed to synthesize meso-microporous zeolite supports,which were subsequently loaded with Co species for propane dehydrogenation catalyst.The results indicate that the application of NaOH,an inorganic base,produces supports with a larger mesopore volume and more abundant hydroxyl nests compared to TPAOH,an organic base.UV-vis,Raman,and XPS analyses reveal that Co in the 0.5Co/SN-1-0.05 catalyst is mainly in the form of tetrahedral Co^(2+),which effectively activates C-H bonds.In contrast,the 0.5Co/S-1 catalyst contains mainly Co_(3)O_(4)species.Co^(2+)supported on hierarchical zeolites shows better propane conversion(58.6%)and propylene selectivity(>96%)compared to pure silica zeolites.Coke characterization indicates that hierarchical zeolites accumulate more coke,but it is mostly in the form of easily removable disordered carbon.The mesopores in the microporous zeolite support help disperse the active Co metal and facilitate coke removal during dehydrogenation,effectively preventing deactivation from sintering and coke coverage.
基金supported by the National Natural Science Foundation of China“Study on the failure mechanism and evaluation method of sand control measures for railway machinery in sandy areas”(12302511)。
文摘Understanding the characteristics of windsand flow field in the curve section of desert highway under different wind directions is helpful for reducing the wind-sand damage in the curve section.Therefore,taking the desert section of Wuma Expressway in Zhongwei city,Ningxia,China as the research background,the wind-sand flow field and sand accumulation phenomenon of concave surface plane curve embankment under different wind directions is calculated and analyzed by computational fluid dynamics(CFD)numerical simulation method.The results show that:(1)Under different wind directions,along the direction of the route,at the starting point of the route,the windward slope of the embankment is a circular arc section,which reduces the resistance of wind-sand flow and promotes the acceleration of sand particles.In the middle of the route,the low-speed area of the windward slope toe and the leeward slope toe is small;at the end of the route,the high-speed area on the shoulder side of the leeward road rises upward.(2)Under different wind directions,the smaller the angle between the wind direction and the route,the stronger the lateral transport effect on the wind-blown sand flow,and the more sand particles transported along the route direction.(3)Under different wind directions,in the concave windward horizontal curve,with the increase of the angle,the sand area on the top of the embankment shows an increasing trend.Whenα=30°,45°,60°,75°,the percentage of the sand area on the top of the embankment to the total embankment area is 0%,33.3%,64.4%,71.0%,respectively.(4)Under different wind directions,along the route direction,the sand transport efficiency of the concave surface upwind plane curve embankment shows a decreasing trend.In the case of a certain radius of the horizontal curve,the angle range between the wind direction and the concave horizontal curve route is recommended to be 30°-45°.
基金supported by the National Natural Science Foundation of China(No.52200120)the R&D Program of Beijing Municipal Education Commission(No.KM202310011003)。
文摘The North China Plain(NCP)frequently experiences ozone pollution events,which are generally related to cross-border transport at multiple scales.However,current methods of calculating ozone transport are insufficient to account for ozone transport at different altitudes.To further understand the characteristics of ozone transport,we applied theWeather Research and Forecasting(WRF)model and the Comprehensive Air Quality Model with Extensions(CAMx)based on flux calculation method.The results showed that the simulated flux calculation method was suitable for revealing the evolutionary trend of ozone fluxes.Monthly inflows,outflows,and total net fluxes ranged from-32985.45 to 37361.46 t/d and indicated strong transport and significant spatial and temporal variations of ozone in the urban boundary segments.Vertical distribution analysis of the net ozone fluxes demonstrated that the net fluxes varied with the altitude,and the altitude at which the corresponding peaks were located had a strong correlation with the neighborhood and season.It was noteworthy that there were three main transport directions throughout the year,namely northwest-southeast(NW-SE),southeast-northwest(SE-NW),and southwestnortheast(SW-NE).Additionally,the ozone flux was mainly affected by temperature,wind speed,and ozone concentration,with the correlation coefficient varying by season and altitude,up to 0.78.Moreover,the correlation analysis of ozone flux and wind direction in each city further verified the accuracy of the transport direction.This paper can provide scientific and technological support for the study of ozone generation mechanisms and the solution of urban/interregional ozone pollution problems.
基金Supported by Key Discipline Construction Project of Neurology of Jiaxing City in Zhejiang Province of China,No.2023-ZC-006.
文摘BACKGROUND Repetitive transcranial magnetic stimulation(rTMS)entered clinical practice in China after 2000,first used in psychiatric surgery,and then in neurology and other disciplines.The First Hospital of Jiaxing introduced TMS in 2015.In practical applications,it has been found that different models of instruments and technical parameters can lead to differences in therapeutic efficacy.Therefore,our hospital selected the Danish TMS instrument,which ranks second in China,to test patients with schizophrenia from March 2021 to July 2021,with a focus on comparing the results at 5 Hz,10 Hz,and 15 Hz.The testing time is concentrated between 8:30 to 10:30 in the morning.A contingency plan was made for the quality after inspection before testing.Two evaluators independently control the quality of the contingency plan.The data is independently saved and proofread by two evaluators.The purpose of this study is to translate the research results into clinical practice and provide reference basis.AIM To investigate the effects of rehabilitation therapy using rTMS on the negative symptoms and event-related potential component of P300 in chronic schizophrenia.METHODS One hundred and five patients with chronic schizophrenia were randomly allocated to three groups based on the frequency of rTMS(5,10,or 15 Hz).The patients underwent five sessions of rTMS per week for 5 weeks.We compared the pre-and post-treatment P300 latency and scores for the Scale for Assessment of Negative Symptoms(SANS).RESULTS A significant decrease in SANS score after rTMS was observed in the 10-Hz group(P<0.05),which was not observed in the 5-Hz and 15-Hz groups.There was a significant increase in P300 amplitude in the 10-Hz group after rTMS treatment(P<0.05),but there was no significant change in P300 latency(P>0.05).The improvement of SANS score in the 10-Hz rTMS group was related to patient age and disease course.CONCLUSION rTMS at 10 Hz improved negative symptoms and cognitive function in chronic schizophrenia;however,further studies on the mechanism of action are required to validate our observations.
文摘Objective:This study aims to explore the benefit analysis of the same disease in different departments of public hospitals under the DIP payment method.Methods:This study is a retrospective analysis that selected clinical data from patients who received treatment in the Department of Orthopedics and the Department of Acupuncture and Moxibustion at our hospital from January 1,2023,to December 31,2023.The study compared the costs of medications,examinations,treatments,laboratory tests,nursing and other expenses,and total treatment costs between the two departments.It analyzed the cost structure of the two departments and proposed further improvement suggestions.Results:The study results indicated that the total costs in the Department of Acupuncture and Moxibustion were significantly higher than those in the Department of Orthopedics.Among medication costs,the total medication costs in the Department of Orthopedics were higher than those in the Department of Acupuncture and Moxibustion,with costs for Western medicine,proprietary Chinese medicine,and herbal medicine all being higher(p<0.05).Regarding examination costs,consultation fees in the Department of Orthopedics were lower than those in the Department of Acupuncture and Moxibustion,while examination costs were higher(p<0.05).In terms of treatment costs,orthopedic treatment and surgical fees were higher than those in the Department of Acupuncture and Moxibustion(p<0.05).For laboratory test costs,orthopedic laboratory fees were significantly higher than those in the Department of Acupuncture and Moxibustion(p<0.05).Among nursing and other expenses,orthopedic blood transfusion,bed fees,and other expenses were higher than those in the Department of Acupuncture and Moxibustion,while nursing fees were lower(p<0.05).Conclusion:Treatment fees in the Department of Acupuncture and Moxibustion are the core and account for a relatively high proportion of the total costs.The benefits generated by the Department of Orthopedics are primarily derived from medication,examination,and laboratory fees,aligning with the characteristics of combining diagnosis,medication,and surgical intervention in orthopedic treatment.Consultation fees,nursing fees,and bed fees in the Department of Acupuncture and Moxibustion are higher than those in the Department of Orthopedics,indicating a longer treatment cycle in acupuncture,which warrants clinical attention.
基金supported by the National Natural Science Foundation of China(Grant Nos.52379100 and 42462030)。
文摘In the frost-thaw region,prolonged freezethaw weathering can induce fracture and weaken rock masses,threatening engineering stability.While interbedded rock masses are common in such projects,their failure mechanisms remain insufficiently investigated in freezing and thawing environments.Therefore,this research establishes a particle flow code(PFC2D)model of interlayered rock masses with particular emphasis on the role of thickness variation.The analysis focuses on displacement,crack evolution,contact forces,and uniaxial compressive strength.The findings indicate that:(i)Completing 8 freeze-thaw cycles significantly increases displacement and contact forces,with crack growth accelerating markedly after 16 cycles.As the soft rock layer thickness ratio(Hs/H)increases,the peak contact force decreases by 18.3%,while the number of cracks rises by 48%.Once Hs/H exceeded 0.5,the rate of crack development decelerates.This reflects progressive bond degradation and damage accumulation:microscopic bonds weaken and rupture to form microcracks.Increased soft rock thickness promotes micro-damage accumulation,altering contact forces and intensifying degradation.(ii)Compressive cracks predominantly initiate in soft rock(limestone).After 20 cycles,cracking extends into the hard rock regions.As the Hs/H rises,compressive cracks first increase and then decline,with an overall reduction of 10.8%,while the compressive contact force exhibits a consistent downward trend.This trend indicates that freeze-thaw cycles cause severe microscopic degradation in soft rock,weakening its macroscopic strength and influencing compressive crack development.Increased soft rock thickness alters the stress state,thereby modifying crack propagation.(iii)Uniaxial compressive strength experiences a marked deterioration after 15 freeze-thaw cycles.It follows an exponential decay with increasing Hs/H,culminating in a total strength reduction of 76.9%.This demonstrates that freeze-thaw-induced microscopic damage deteriorates interparticle cohesion,reducing rock mass strength.A higher Hs/H ratio accelerates microscopic damage in the soft rock,causing cohesion to decay nonlinearly and macroscopic strength to drop exponentially.These results provide a theoretical basis for assessing the deformation and failure behaviors of rock masses under cyclic freeze-thaw action.
基金supported by the Major Program of National Social Science Foundation of China(No.23&ZD240)。
文摘It has long been noticed that focus is able to influence the truth-conditions of coun-terfactual conditionals.Namely,stressing different parts of a counterfactual leads to distinct interpretations.However,existing theories,such as those by von Finte1 and Rooth,fail to ad-equately account for this phenomenon.In this paper,I exposit the drawbacks of these theories and then propose a novel account,ie.the Good Question-Answer(GQA)view.The GQA account posits that focus triggers question-answer pairs,and pragmatic pressures conceming the adequacy of such question answer pairs in contexts are able to affect the truth-conditions of counterfactuals.I also argue for the GQA account by appeal to its theoretical virtues.
基金supported by the National Natural Science Foundation of China(Grant No.42488101)the Taishan Scholars Program(Grant No.tsqn202306125)+1 种基金the Open Research Fund of the State Key Laboratory of Deep Oil and Gas(Grant No.SKLDOG2024-KFZD-02)the PetroChina Major Research Program on Deep Petroleum Systems in the Tarim Basin(Grant No.ZD2019-183-01-003).
文摘Fluids generated from the source rocks containing various kerogen types at different thermal maturity stages control diagenetic processes and reservoir quality in adjacent sandstone reservoirs.This study focuses on the carbonate cements in the sandstones of the Lower Jurassic Yangxia Formation and the Ahe Formation in the Tarim Basin.Theδ^(18)O,δ^(13)C,and ^(87)Sr/^(86)Sr data indicate that low‑temperature ferroan calcite and manganoan calcite—characterized by strongly negativeδ^(13)C values and enrichment in light rare‑earth elements(LREEs)—record CO_(2) released during the thermal degradation of organic matter predominantly composed of Type III kerogen in coal‑bearing source rocks and of Type Ⅱ kerogen in mudstone source rocks,respectively.High‑temperature ferroan calcite and manganoan calcite,which exhibit similarly strongly negativeδ^(13)C values and enrichment in middle rare‑earth elements(MREEs),record organic acids and CO_(2) produced during the thermal decarboxylation of these same source rocks.The diagenetic fluid evolution sequence comprises early‑stage CO_(2) from thermal degradation of both coal‑bearing and mudstone source rocks;mid‑stage organic acids and CO_(2) from thermal decarboxylation of coal‑bearing source rocks;and late‑stage organic acids and CO_(2) from thermal decarboxylation of mudstone source rocks.Fluids generated during the thermal degradation of mudstone and coal‑bearing source rocks precipitated extensive calcite cements,leading to reservoir densification.Clumped isotope thermometry indicates that the primary generation periods of late‑stage mudstone‑derived fluids coincided with the formation of effective fractures.Feldspar dissolution along these fractures produced an interconnected network of fractures and dissolution pores,significantly enhancing reservoir quality in the Ahe Formation.
