Diabetic Gastroparesis(DGP)is one of the common chronic complications of diabetes mellitus,with main clinical manifestations such as nausea,vomiting,postprandial fullness,and delayed gastric emptying.It seriously affe...Diabetic Gastroparesis(DGP)is one of the common chronic complications of diabetes mellitus,with main clinical manifestations such as nausea,vomiting,postprandial fullness,and delayed gastric emptying.It seriously affects patients’quality of life and nutritional status.This paper systematically sorts out the application evidence of Traditional Chinese Medicine(TCM)nursing in DGP,verifies its effectiveness from three aspects:evidence from ancient literature,modern clinical studies,and results of Meta-analyses.It also elaborates on specific nursing methods including Syndrome Differentiation-Based Nursing,characteristic technical nursing,and health guidance,analyzes the existing problems in current research,and puts forward future development directions,so as to provide a reference for the clinical promotion and standardization of TCM nursing for DGP.展开更多
The safety issue on herbal and traditional medicines(H&TM) is one of the most challenging problems and serious concern worldwide. With scientific endeavor and further exploration, we came to realize that there are...The safety issue on herbal and traditional medicines(H&TM) is one of the most challenging problems and serious concern worldwide. With scientific endeavor and further exploration, we came to realize that there are great differences between H&TM and synthetic drugs in many aspects, such as medical theory, medication experience, compatibility, processing, toxicological characteristics, and safety evaluating requirements. In the current preclinical models for synthetic drugs, the safety assessment results of some conventional deemed 'nontoxic' H&TM were not well consistent with clinical situations, which resulted in major difficulties to understand the mechanisms and guide the safe and rational uses of these H&TM. Thus, based on the traditional Chinese medicine toxicity theory called You Gu Wu Yun, this paper introduces a novel safety assessment strategy for H&TM, named as disease-based toxicology. It aims to cognize the relativity and susceptibility of the toxicity of H&TM, and then to enhance controllability in new drug development and clinical applications. It also provides a theoretical practice for the traditional Chinese medicine toxicity theory and a methodological promotion for the future development of the precision toxicology for H&TM.展开更多
文摘Diabetic Gastroparesis(DGP)is one of the common chronic complications of diabetes mellitus,with main clinical manifestations such as nausea,vomiting,postprandial fullness,and delayed gastric emptying.It seriously affects patients’quality of life and nutritional status.This paper systematically sorts out the application evidence of Traditional Chinese Medicine(TCM)nursing in DGP,verifies its effectiveness from three aspects:evidence from ancient literature,modern clinical studies,and results of Meta-analyses.It also elaborates on specific nursing methods including Syndrome Differentiation-Based Nursing,characteristic technical nursing,and health guidance,analyzes the existing problems in current research,and puts forward future development directions,so as to provide a reference for the clinical promotion and standardization of TCM nursing for DGP.
基金financially supported by the National Key Technologies R and D Program of China(No.2015ZX09501-004-001-008)by the Industry Research Program of Traditional Chinese Medicine(No.201507004-04)
文摘The safety issue on herbal and traditional medicines(H&TM) is one of the most challenging problems and serious concern worldwide. With scientific endeavor and further exploration, we came to realize that there are great differences between H&TM and synthetic drugs in many aspects, such as medical theory, medication experience, compatibility, processing, toxicological characteristics, and safety evaluating requirements. In the current preclinical models for synthetic drugs, the safety assessment results of some conventional deemed 'nontoxic' H&TM were not well consistent with clinical situations, which resulted in major difficulties to understand the mechanisms and guide the safe and rational uses of these H&TM. Thus, based on the traditional Chinese medicine toxicity theory called You Gu Wu Yun, this paper introduces a novel safety assessment strategy for H&TM, named as disease-based toxicology. It aims to cognize the relativity and susceptibility of the toxicity of H&TM, and then to enhance controllability in new drug development and clinical applications. It also provides a theoretical practice for the traditional Chinese medicine toxicity theory and a methodological promotion for the future development of the precision toxicology for H&TM.
