The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theo...The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.展开更多
Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry aver...Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry average earning differentials is apparently on the rise along with the subdivision of industry. A theoretical analysis of the labour market indicates that inter-industry wage differentials are mainly due to human capital variation among the employees of different industries and the likelihood of monopoly rent sharing. An empirical study finds that employee characteristics such as sex, age and education can only explain 60 percent of CVs in the period 2003 to 2005 and the rest may be due to the effect of monopoly rent sharing in certain industries. A residual analysis of wage equation proves that the monopoly industries of technology or knowledge share a small proportion of rents with employment, whereas non-competitive monopoly industries generally garner an abnormal share of rents, as much as half of their above-average earnings for their industries. Such abnormal rents and benefits are mainly the result of low cost natural resources, the use of state-owned assets, the misappropriation of consumer welfare and the seeking of fiscal or social subsidy for cost inflation. So, China should deal with the non-competitive monopoly industries by reforming their monopoly power and primary social distribution mechanism to structure a fair income distribution order.展开更多
Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and he...Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and head smut pathogens were evaluated for grain mold resistance under favorable conditions in Isabela, Puerto Rico. Lines BTx643 and IS18760 exhibited the lowest grain mold severity, indicating that these two may possess genes for grain mold resistance. These two lines also recorded the highest germination rates 94.7% and 97.6%, respectively, and their seed weight was among the heaviest. In conclusion, these two lines can be utilized in breeding programs to develop grain mold-resistant hybrid lines.展开更多
Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions a...Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions and condenser operation, revealed increases in the inlet air temperature at the condensers at the upper floors, which in turn increased the power and energy requirements for these units and decreased their cooling capacities. Results indicated that a decrease of up to 16,000 tons in cooling capacity and an increase of up to 67.2 MW in the national peak load demand might be reached for a 4 ℃ temperature differential for Kuwait conditions. It is recommended that the condensers be placed in the wind pathway to minimize the impact of heat rejection and stack effect and to optimize the operation of split-type air-conditioning units, and that other factors regarding installation setup and location are investigated.展开更多
Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and t...Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and the flexibility affect the transient behaviour, reduce the component life and produce noise and vibration for classical joints such as prismatics, cylindrics or universal joints.In this work, a new 3D cylindrical joint model which accounts for the clearance, the misalignment and the friction is presented. This formulation has been used to represent the link between the planet gears and the planet carrier in an automotive differential model. C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301303]展开更多
Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differen...Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differentials of unitary indeterminate forms. The fruit of this work is going to be reported in three parts. The first part presents the standard analysis on this subject which supplements, systematizes and advances L. Hospital抯 principles on differential calculus by applying special ,general, and limit guaranteeing theories together with K(t) and XhK0 theories. The combination of theoretical analysis and geometric signification makes the derivation intuitional, visual and easy to perceive.展开更多
We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattic...We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattice is an antihomomorphism, and that differential calculus has a natural continuum limit.展开更多
Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defin...Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defined. Formulas for star-shaped differential of a pointwise maximum and a pointwise minimum of a finite number of directionally differentiable functions, and a composite of two directionaUy differentiable functions are derived. Furthermore, the mean-value theorem for a directionaUy differentiable function is demonstrated.展开更多
The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque...The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque amplification factor is the linear combination of the ratio of the differentials of the four elements and the ratio of planetary gear units,and its maximum value is easily more than 10.The E-TVDs with six elements are classified into three types,and there are six different configurations for each type.The torque amplification factor and the speed of interconnection between two planetary gear units are employed to evaluate the different characteristics of each E-TVD with six elements.The feasible configurations of a differential with four elements are also presented by the analysis of velocity level and planarity.This paper helps to further the understanding of the complex interconnection of the planetary gear units in E-TVDs with six elements and the differences of their characteristics.展开更多
By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which...By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which is called a multiplicative intuitionistic fuzzy number(MIFN)and is based on the unbalanced scale(i.e.,Saaty’s 1-9 scale).In order to describe the derivatives and differentials for multiplicative intuitionistic fuzzy information more comprehensively,in this paper,we firstly propose two new basic operational laws for MIFNs,which are the subtraction law and the division law.Secondly,we describe the change values of MIFNs when considering them as variables,classify these change values based on the basic operational laws for MIFNs,and depict the convergences of sequences of MIFNs by the subtraction and division laws.Finally,we focus on the multiplicative intuitionistic fuzzy functions and derive some basic results related to their continuities,derivatives and differentials,and also give their application in selecting the configuration of a computer.展开更多
Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this...Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this question, we derive a simple wage gap equation including educational attainment, market potential and provincial border indicators. The regressions based on city and sector-level data show that, other things being equal, the wage dispersions within Chinese provincial borders are significantly less pronounced than those among provinces. Such border effects on spatial wage differentials, which have been shown to pervasively exist in all sectors considered in the present paper, reflect the distortions generated by migration controls. Finally, we show that despite the recent hukou reforms aimed at relaxing the restrictions on population movement, border effects appear to persisted over the period 2003-2005.展开更多
This paper deals with Mckean-Vlasov backward stochastic differential equations with weak monotonicity coefficients.We first establish the existence and uniqueness of solutions to Mckean-Vlasov backward stochastic diff...This paper deals with Mckean-Vlasov backward stochastic differential equations with weak monotonicity coefficients.We first establish the existence and uniqueness of solutions to Mckean-Vlasov backward stochastic differential equations.Then we obtain a comparison theorem in one-dimensional situation.展开更多
Given a compact Riemann surface S with finitely many punctures, in this paper we obtain a new extremality property of a Jenkins-Strebel differentialψon S. As a consequence, we obtain the solutions of several kinds of...Given a compact Riemann surface S with finitely many punctures, in this paper we obtain a new extremality property of a Jenkins-Strebel differentialψon S. As a consequence, we obtain the solutions of several kinds of moduli problems on 5.展开更多
For the five-point discrete formulae of directional derivatives in the finite point method,overcoming the challenge resulted from scattered point sets and making full use of the explicit expressions and accuracy of th...For the five-point discrete formulae of directional derivatives in the finite point method,overcoming the challenge resulted from scattered point sets and making full use of the explicit expressions and accuracy of the formulae,this paper obtains a number of theoretical results:(1)a concise expression with definite meaning of the complicated directional difference coefficient matrix is presented,which characterizes the correlation between coefficients and the connection between coefficients and scattered geometric characteristics;(2)various expressions of the discriminant function for the solvability of numerical differentials along with the estimation of its lower bound are given,which are the bases for selecting neighboring points and making analysis;(3)the estimations of combinatorial elements and of each element in the directional difference coefficient matrix are put out,which exclude the existence of singularity.Finally,the theoretical analysis results are verified by numerical calculations.The results of this paper have strong regularity,which lay the foundation for further research on the finite point method for solving partial differential equations.展开更多
The generation of synthetic trajectories has become essential in various fields for analyzing complex movement patterns.However,the use of real-world trajectory data poses significant privacy risks,such as location re...The generation of synthetic trajectories has become essential in various fields for analyzing complex movement patterns.However,the use of real-world trajectory data poses significant privacy risks,such as location reidentification and correlation attacks.To address these challenges,privacy-preserving trajectory generation methods are critical for applications relying on sensitive location data.This paper introduces DPIL-Traj,an advanced framework designed to generate synthetic trajectories while achieving a superior balance between data utility and privacy preservation.Firstly,the framework incorporates Differential Privacy Clustering,which anonymizes trajectory data by applying differential privacy techniques that add noise,ensuring the protection of sensitive user information.Secondly,Imitation Learning is used to replicate decision-making behaviors observed in real-world trajectories.By learning from expert trajectories,this component generates synthetic data that closely mimics real-world decision-making processes while optimizing the quality of the generated trajectories.Finally,Markov-based Trajectory Generation is employed to capture and maintain the inherent temporal dynamics of movement patterns.Extensive experiments conducted on the GeoLife trajectory dataset show that DPIL-Traj improves utility performance by an average of 19.85%,and in terms of privacy performance by an average of 12.51%,compared to state-of-the-art approaches.Ablation studies further reveal that DP clustering effectively safeguards privacy,imitation learning enhances utility under noise,and the Markov module strengthens temporal coherence.展开更多
BACKGROUND The treatment technology of liver cancer is progressing.In addition to traditional surgical resection,combined therapies of immunotherapy based on immune checkpoint inhibitors,chemotherapy,and transcatheter...BACKGROUND The treatment technology of liver cancer is progressing.In addition to traditional surgical resection,combined therapies of immunotherapy based on immune checkpoint inhibitors,chemotherapy,and transcatheter arterial chemoembolization for hepatocellular carcinoma are more and more widely used.Accurate preoperative diagnosis of liver cancer will provide important information for comprehensive treatment and prognosis evaluation of liver cancer.Sonazoidcontrast-enhanced ultrasound is not only helpful for the qualitative diagnosis of liver lesions,but also has great potential in the diagnosis of histological differentiation of liver cancer.AIM To assess the differentiation of hepatocellular carcinoma(HCC)by utilizing the parameters and imaging features of Sonazoid-contrast-enhanced ultrasound(CEUS).METHODS A retrospective analysis was conducted on the CEUS data of 239 lesions through case-control study.These patients received Sonazoid-CEUS within one week before surgery and were confirmed as HCC by postoperative pathology.Within the cases,patients were further categorized into well-differentiated and poorlydifferentiated group.Time-intensity curves of the region of interest in both arterial and Kupffer phases were generated,allowing for the acquisition of quantitative parameters to assess the diagnostic efficacy in distinguishing lesions between these two groups and determining an appropriate cut-off value.RESULTS Univariate analysis showed that the absolute value of enhancement intensity(EIAV),intensity ratio(IR)and intensity difference(ID)in Kupffer phase were statistically different between the groups with different degree(P=0.015,P=0.000,P=0.000).The sensitivity and specificity were 40.2%,82.4%,80.4% and 78.1%,86.9% and 74.5%,respectively,for differentiating HCC lesions with EIAV≥56.384 dB,IR≥1.215 and ID≥9.184 dB.The area under the receiver operating characteristic curve were 0.590,0.877,0.815.There was no significant difference in the parameters of arterial phase,including peak time,initial growth time,rise time and the absolute value of peak intensity of lesions between the two groups(P>0.05).Multivariate analysis showed that the level of alphafetoprotein(AFP)and IR were risk factors for poor differentiation(P=0.001).CONCLUSION Among the parameters of Sonazoid-CEUS,IR in Kupffer phase exhibits superior diagnostic efficacy with high sensitivity and specificity in the diagnose of pathological differentiation of HCC.Combined with preoperative AFP level,a more accurate diagnosis will be obtained.Compared with portal vein phase,Kupffer phase showed the ability to identify HCC lesions more sensitive.These findings hold significant guiding implications and reference value for clinical practice.展开更多
Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrins...Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.展开更多
BACKGROUND Mesenchymal stem cells(MSCs)are considered a promising therapy for various diseases due to their strong potential in regenerative medicine and immunomodulation.The tissue source of MSCs has gained attention...BACKGROUND Mesenchymal stem cells(MSCs)are considered a promising therapy for various diseases due to their strong potential in regenerative medicine and immunomodulation.The tissue source of MSCs has gained attention for its role in influencing their function,accessibility,and readiness for clinical use.AIM To identify the most suitable adipose source for MSC isolation and expansion for further applications.METHODS We isolated MSCs from solid adipose tissue and liposuction aspirates using the enzyme method.The MSCs were examined for their expansion using population doubling time,differentiation capacity using multilineage differentiation induction,surface markers using flow cytometry,and stability of chromosomes using the karyotyping method.Growth factors and cytokines in MSC-conditioned media were analyzed using the Luminex assay.RESULTS MSCs were isolated from solid adipose tissue and lipoaspirates and expanded from passage 0 to passage 2.All adipose-derived MSCs(AD-MSCs)exhibited the typical elongated,spindle-shaped morphology and comparable proliferation rate.They expressed positive surface markers(cluster of differentiation 73[CD73]:>97%,CD90:>98%,and CD105:>95%),and negative markers(<1%).All MSCs expressed similar levels of stemness genes(octamer-binding transcription factor 4,SRY-box 2,Krüppel-like factor,and MYC),colonyforming,and trilineage differentiation potential.Karyotyping analysis revealed normal chromosomal patterns in all samples,except one sample exhibiting a polymorphism(1qh+).Furthermore,the growth factors and cytokines of hepatocyte growth factor,vascular endothelial growth factor A,interleukin 6(IL-6),and IL-8 were detected in all AD-MSC conditioned media;but fibroblast growth factor-2 and keratinocyte growth factor were selectively expressed in conditioned media from solid or lipoaspirate AD-MSCs,respectively.CONCLUSION These findings indicate that AD-MSCs from both adipose sources possess all of the characteristic features of MSCs with source-specific secretome differences,which are suitable for further expansion and various clinical applications.展开更多
BACKGROUND Ulcerative colitis(UC)is a chronic and treatment-resistant disorder requiring potent therapeutics that are effective and safe.Cedrol(CE)is a bioactive natural product present in many traditional Chinese med...BACKGROUND Ulcerative colitis(UC)is a chronic and treatment-resistant disorder requiring potent therapeutics that are effective and safe.Cedrol(CE)is a bioactive natural product present in many traditional Chinese medicines.It is known for its suppression of inflammation and mitigation of oxidative stress.Its therapeutic efficacy and mechanistic underpinnings in UC remain uncharacterized.AIM To investigate the therapeutic potential and mechanisms of CE in UC.METHODS The anti-inflammatory activity and intestinal barrier-repairing effects of CE were assessed in a dextran sulfate sodium-induced murine colitis model.Network pharmacology was employed to predict potential targets and pathways.Then molecular docking and dynamics simulations were utilized to confirm a stable interaction between CE and the toll-like receptor 4(TLR4)/myeloid differentiation factor 2(MD2)complex.The anti-inflammatory mechanisms were further verified using in vitro assays.Additionally,the gut microbiota composition was analyzed via 16S rRNA gene sequencing.RESULTS CE significantly alleviated colitis symptoms,mitigated histopathological damage,and suppressed inflammation.Moreover,CE restored intestinal barrier integrity by enhancing mucus secretion and upregulating tight junction proteins(zonula occludens 1,occludin,claudin-1).Mechanistically,CE stably bound to MD2,inhibiting lipopolysaccharide-induced TLR4 signaling in RAW264.7 cells.This led to suppression of the downstream mitogen-activated protein kinase and nuclear factor kappa B signaling pathways,downregulating the expression of tumor necrosis factor-alpha,interleukin-1β,and interleukin-6.Gut microbiota analysis revealed that CE reversed dextran sulfate sodium-induced dysbiosis with significant enrichment of butyrogenic Christensenella minuta.CONCLUSION CE acted on MD2 to suppress proinflammatory cascades,promoting mucosal barrier reconstitution and microbiota remodeling and supporting its therapeutic use in UC.展开更多
基金support from the National Natural Science Foundation of China(Grant Nos.52374180 and 52327804).
文摘The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.
基金funded by the National Philosophy and Social Science Innovation Centre of Economic ransition and Development of Nanjing University sponsored by the Ministry of Education of China
文摘Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry average earning differentials is apparently on the rise along with the subdivision of industry. A theoretical analysis of the labour market indicates that inter-industry wage differentials are mainly due to human capital variation among the employees of different industries and the likelihood of monopoly rent sharing. An empirical study finds that employee characteristics such as sex, age and education can only explain 60 percent of CVs in the period 2003 to 2005 and the rest may be due to the effect of monopoly rent sharing in certain industries. A residual analysis of wage equation proves that the monopoly industries of technology or knowledge share a small proportion of rents with employment, whereas non-competitive monopoly industries generally garner an abnormal share of rents, as much as half of their above-average earnings for their industries. Such abnormal rents and benefits are mainly the result of low cost natural resources, the use of state-owned assets, the misappropriation of consumer welfare and the seeking of fiscal or social subsidy for cost inflation. So, China should deal with the non-competitive monopoly industries by reforming their monopoly power and primary social distribution mechanism to structure a fair income distribution order.
文摘Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and head smut pathogens were evaluated for grain mold resistance under favorable conditions in Isabela, Puerto Rico. Lines BTx643 and IS18760 exhibited the lowest grain mold severity, indicating that these two may possess genes for grain mold resistance. These two lines also recorded the highest germination rates 94.7% and 97.6%, respectively, and their seed weight was among the heaviest. In conclusion, these two lines can be utilized in breeding programs to develop grain mold-resistant hybrid lines.
文摘Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions and condenser operation, revealed increases in the inlet air temperature at the condensers at the upper floors, which in turn increased the power and energy requirements for these units and decreased their cooling capacities. Results indicated that a decrease of up to 16,000 tons in cooling capacity and an increase of up to 67.2 MW in the national peak load demand might be reached for a 4 ℃ temperature differential for Kuwait conditions. It is recommended that the condensers be placed in the wind pathway to minimize the impact of heat rejection and stack effect and to optimize the operation of split-type air-conditioning units, and that other factors regarding installation setup and location are investigated.
基金the Belgian National Fund for Scientific research (FRIA) for its financial support
文摘Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and the flexibility affect the transient behaviour, reduce the component life and produce noise and vibration for classical joints such as prismatics, cylindrics or universal joints.In this work, a new 3D cylindrical joint model which accounts for the clearance, the misalignment and the friction is presented. This formulation has been used to represent the link between the planet gears and the planet carrier in an automotive differential model. C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301303]
文摘Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differentials of unitary indeterminate forms. The fruit of this work is going to be reported in three parts. The first part presents the standard analysis on this subject which supplements, systematizes and advances L. Hospital抯 principles on differential calculus by applying special ,general, and limit guaranteeing theories together with K(t) and XhK0 theories. The combination of theoretical analysis and geometric signification makes the derivation intuitional, visual and easy to perceive.
文摘We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattice is an antihomomorphism, and that differential calculus has a natural continuum limit.
文摘Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defined. Formulas for star-shaped differential of a pointwise maximum and a pointwise minimum of a finite number of directionally differentiable functions, and a composite of two directionaUy differentiable functions are derived. Furthermore, the mean-value theorem for a directionaUy differentiable function is demonstrated.
基金Natural Science Foundation of Jiangsu Province(BK20160223)。
文摘The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque amplification factor is the linear combination of the ratio of the differentials of the four elements and the ratio of planetary gear units,and its maximum value is easily more than 10.The E-TVDs with six elements are classified into three types,and there are six different configurations for each type.The torque amplification factor and the speed of interconnection between two planetary gear units are employed to evaluate the different characteristics of each E-TVD with six elements.The feasible configurations of a differential with four elements are also presented by the analysis of velocity level and planarity.This paper helps to further the understanding of the complex interconnection of the planetary gear units in E-TVDs with six elements and the differences of their characteristics.
基金supported in part by the National Natural Science Foundation of China(71571123,71771155)
文摘By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which is called a multiplicative intuitionistic fuzzy number(MIFN)and is based on the unbalanced scale(i.e.,Saaty’s 1-9 scale).In order to describe the derivatives and differentials for multiplicative intuitionistic fuzzy information more comprehensively,in this paper,we firstly propose two new basic operational laws for MIFNs,which are the subtraction law and the division law.Secondly,we describe the change values of MIFNs when considering them as variables,classify these change values based on the basic operational laws for MIFNs,and depict the convergences of sequences of MIFNs by the subtraction and division laws.Finally,we focus on the multiplicative intuitionistic fuzzy functions and derive some basic results related to their continuities,derivatives and differentials,and also give their application in selecting the configuration of a computer.
文摘Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this question, we derive a simple wage gap equation including educational attainment, market potential and provincial border indicators. The regressions based on city and sector-level data show that, other things being equal, the wage dispersions within Chinese provincial borders are significantly less pronounced than those among provinces. Such border effects on spatial wage differentials, which have been shown to pervasively exist in all sectors considered in the present paper, reflect the distortions generated by migration controls. Finally, we show that despite the recent hukou reforms aimed at relaxing the restrictions on population movement, border effects appear to persisted over the period 2003-2005.
基金Supported by the National Natural Science Foundation of China(12001074)the Research Innovation Program of Graduate Students in Hunan Province(CX20220258)+1 种基金the Research Innovation Program of Graduate Students of Central South University(1053320214147)the Key Scientific Research Project of Higher Education Institutions in Henan Province(25B110025)。
文摘This paper deals with Mckean-Vlasov backward stochastic differential equations with weak monotonicity coefficients.We first establish the existence and uniqueness of solutions to Mckean-Vlasov backward stochastic differential equations.Then we obtain a comparison theorem in one-dimensional situation.
基金This work was partially supported by the National Natural Science Foundation of China (Grant No. 10501046).
文摘Given a compact Riemann surface S with finitely many punctures, in this paper we obtain a new extremality property of a Jenkins-Strebel differentialψon S. As a consequence, we obtain the solutions of several kinds of moduli problems on 5.
基金supported by the National Natural Science Foundation of China(11671049)the Foundation of LCP,and the CAEP Foundation(CX2019026).
文摘For the five-point discrete formulae of directional derivatives in the finite point method,overcoming the challenge resulted from scattered point sets and making full use of the explicit expressions and accuracy of the formulae,this paper obtains a number of theoretical results:(1)a concise expression with definite meaning of the complicated directional difference coefficient matrix is presented,which characterizes the correlation between coefficients and the connection between coefficients and scattered geometric characteristics;(2)various expressions of the discriminant function for the solvability of numerical differentials along with the estimation of its lower bound are given,which are the bases for selecting neighboring points and making analysis;(3)the estimations of combinatorial elements and of each element in the directional difference coefficient matrix are put out,which exclude the existence of singularity.Finally,the theoretical analysis results are verified by numerical calculations.The results of this paper have strong regularity,which lay the foundation for further research on the finite point method for solving partial differential equations.
基金supported by the Natural Science Foundation of Fujian Province of China(2025J01380)National Natural Science Foundation of China(No.62471139)+3 种基金the Major Health Research Project of Fujian Province(2021ZD01001)Fujian Provincial Units Special Funds for Education and Research(2022639)Fujian University of Technology Research Start-up Fund(GY-S24002)Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare(GY-H-24179).
文摘The generation of synthetic trajectories has become essential in various fields for analyzing complex movement patterns.However,the use of real-world trajectory data poses significant privacy risks,such as location reidentification and correlation attacks.To address these challenges,privacy-preserving trajectory generation methods are critical for applications relying on sensitive location data.This paper introduces DPIL-Traj,an advanced framework designed to generate synthetic trajectories while achieving a superior balance between data utility and privacy preservation.Firstly,the framework incorporates Differential Privacy Clustering,which anonymizes trajectory data by applying differential privacy techniques that add noise,ensuring the protection of sensitive user information.Secondly,Imitation Learning is used to replicate decision-making behaviors observed in real-world trajectories.By learning from expert trajectories,this component generates synthetic data that closely mimics real-world decision-making processes while optimizing the quality of the generated trajectories.Finally,Markov-based Trajectory Generation is employed to capture and maintain the inherent temporal dynamics of movement patterns.Extensive experiments conducted on the GeoLife trajectory dataset show that DPIL-Traj improves utility performance by an average of 19.85%,and in terms of privacy performance by an average of 12.51%,compared to state-of-the-art approaches.Ablation studies further reveal that DP clustering effectively safeguards privacy,imitation learning enhances utility under noise,and the Markov module strengthens temporal coherence.
文摘BACKGROUND The treatment technology of liver cancer is progressing.In addition to traditional surgical resection,combined therapies of immunotherapy based on immune checkpoint inhibitors,chemotherapy,and transcatheter arterial chemoembolization for hepatocellular carcinoma are more and more widely used.Accurate preoperative diagnosis of liver cancer will provide important information for comprehensive treatment and prognosis evaluation of liver cancer.Sonazoidcontrast-enhanced ultrasound is not only helpful for the qualitative diagnosis of liver lesions,but also has great potential in the diagnosis of histological differentiation of liver cancer.AIM To assess the differentiation of hepatocellular carcinoma(HCC)by utilizing the parameters and imaging features of Sonazoid-contrast-enhanced ultrasound(CEUS).METHODS A retrospective analysis was conducted on the CEUS data of 239 lesions through case-control study.These patients received Sonazoid-CEUS within one week before surgery and were confirmed as HCC by postoperative pathology.Within the cases,patients were further categorized into well-differentiated and poorlydifferentiated group.Time-intensity curves of the region of interest in both arterial and Kupffer phases were generated,allowing for the acquisition of quantitative parameters to assess the diagnostic efficacy in distinguishing lesions between these two groups and determining an appropriate cut-off value.RESULTS Univariate analysis showed that the absolute value of enhancement intensity(EIAV),intensity ratio(IR)and intensity difference(ID)in Kupffer phase were statistically different between the groups with different degree(P=0.015,P=0.000,P=0.000).The sensitivity and specificity were 40.2%,82.4%,80.4% and 78.1%,86.9% and 74.5%,respectively,for differentiating HCC lesions with EIAV≥56.384 dB,IR≥1.215 and ID≥9.184 dB.The area under the receiver operating characteristic curve were 0.590,0.877,0.815.There was no significant difference in the parameters of arterial phase,including peak time,initial growth time,rise time and the absolute value of peak intensity of lesions between the two groups(P>0.05).Multivariate analysis showed that the level of alphafetoprotein(AFP)and IR were risk factors for poor differentiation(P=0.001).CONCLUSION Among the parameters of Sonazoid-CEUS,IR in Kupffer phase exhibits superior diagnostic efficacy with high sensitivity and specificity in the diagnose of pathological differentiation of HCC.Combined with preoperative AFP level,a more accurate diagnosis will be obtained.Compared with portal vein phase,Kupffer phase showed the ability to identify HCC lesions more sensitive.These findings hold significant guiding implications and reference value for clinical practice.
基金supported by the Argentine Agency for the Promotion of Science and Technology ANPCyT(PICT2019-1472 to GP,PICT2019-4597 to FL,PICT2020-1524 to GP,and PICT2021-00627 to FL)supported by an Independent Career Position from CONICETsupported by a postdoctoral fellowship from ANPCyT。
文摘Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.
文摘BACKGROUND Mesenchymal stem cells(MSCs)are considered a promising therapy for various diseases due to their strong potential in regenerative medicine and immunomodulation.The tissue source of MSCs has gained attention for its role in influencing their function,accessibility,and readiness for clinical use.AIM To identify the most suitable adipose source for MSC isolation and expansion for further applications.METHODS We isolated MSCs from solid adipose tissue and liposuction aspirates using the enzyme method.The MSCs were examined for their expansion using population doubling time,differentiation capacity using multilineage differentiation induction,surface markers using flow cytometry,and stability of chromosomes using the karyotyping method.Growth factors and cytokines in MSC-conditioned media were analyzed using the Luminex assay.RESULTS MSCs were isolated from solid adipose tissue and lipoaspirates and expanded from passage 0 to passage 2.All adipose-derived MSCs(AD-MSCs)exhibited the typical elongated,spindle-shaped morphology and comparable proliferation rate.They expressed positive surface markers(cluster of differentiation 73[CD73]:>97%,CD90:>98%,and CD105:>95%),and negative markers(<1%).All MSCs expressed similar levels of stemness genes(octamer-binding transcription factor 4,SRY-box 2,Krüppel-like factor,and MYC),colonyforming,and trilineage differentiation potential.Karyotyping analysis revealed normal chromosomal patterns in all samples,except one sample exhibiting a polymorphism(1qh+).Furthermore,the growth factors and cytokines of hepatocyte growth factor,vascular endothelial growth factor A,interleukin 6(IL-6),and IL-8 were detected in all AD-MSC conditioned media;but fibroblast growth factor-2 and keratinocyte growth factor were selectively expressed in conditioned media from solid or lipoaspirate AD-MSCs,respectively.CONCLUSION These findings indicate that AD-MSCs from both adipose sources possess all of the characteristic features of MSCs with source-specific secretome differences,which are suitable for further expansion and various clinical applications.
基金Supported by the Provincial Key Cultivation Laboratory for Digestive Disease Research,No.2021SYS13Shanxi Province’s“Si Ge Yi Pi”Science and Technology Driven Medical Innovation Project,No.2021MX03Shanxi Provincial Basic Research Program,No.202403021222423.
文摘BACKGROUND Ulcerative colitis(UC)is a chronic and treatment-resistant disorder requiring potent therapeutics that are effective and safe.Cedrol(CE)is a bioactive natural product present in many traditional Chinese medicines.It is known for its suppression of inflammation and mitigation of oxidative stress.Its therapeutic efficacy and mechanistic underpinnings in UC remain uncharacterized.AIM To investigate the therapeutic potential and mechanisms of CE in UC.METHODS The anti-inflammatory activity and intestinal barrier-repairing effects of CE were assessed in a dextran sulfate sodium-induced murine colitis model.Network pharmacology was employed to predict potential targets and pathways.Then molecular docking and dynamics simulations were utilized to confirm a stable interaction between CE and the toll-like receptor 4(TLR4)/myeloid differentiation factor 2(MD2)complex.The anti-inflammatory mechanisms were further verified using in vitro assays.Additionally,the gut microbiota composition was analyzed via 16S rRNA gene sequencing.RESULTS CE significantly alleviated colitis symptoms,mitigated histopathological damage,and suppressed inflammation.Moreover,CE restored intestinal barrier integrity by enhancing mucus secretion and upregulating tight junction proteins(zonula occludens 1,occludin,claudin-1).Mechanistically,CE stably bound to MD2,inhibiting lipopolysaccharide-induced TLR4 signaling in RAW264.7 cells.This led to suppression of the downstream mitogen-activated protein kinase and nuclear factor kappa B signaling pathways,downregulating the expression of tumor necrosis factor-alpha,interleukin-1β,and interleukin-6.Gut microbiota analysis revealed that CE reversed dextran sulfate sodium-induced dysbiosis with significant enrichment of butyrogenic Christensenella minuta.CONCLUSION CE acted on MD2 to suppress proinflammatory cascades,promoting mucosal barrier reconstitution and microbiota remodeling and supporting its therapeutic use in UC.
