Experimental mice play a critical role in biomedical research.The phenotype and application of different substrains vary due to genetic differentiation and variation.To ensure validity and reliability of results,it is...Experimental mice play a critical role in biomedical research.The phenotype and application of different substrains vary due to genetic differentiation and variation.To ensure validity and reliability of results,it is imperative to adhere to standardized experiments and controls.This paper objectively reviews the origin,differentiation,and phenotypic and genetic differences between the C57BL/6 and BALB/c mouse substrains.Furthermore,an optimal selection strategy is proposed based on the genetic quality control technology to facilitate the precise application of these two mouse substrains.展开更多
Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden ...Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden of NVL in China by sex and age groups from 1990 to 2021 and to project trends over the next 15 years.Methods:Using data from the Global Burden of Disease(GBD)2021 database,we conducted descriptive analyses of NVL prevalence in China,calculated age-standardized prevalence rates(ASPR)and age-standardized disability-adjusted life years rates(ASDR)to compare burden differences between sexes and age groups,and applied an autoregressive integrated moving average(ARIMA)model to predict NVL trends for the next 15 years.The model selection was based on best-fit criteria to ensure reliable projections.Results:From 1990 to 2021,China’s ASPR of NVL rose from 10096.24/100000 to 15624.54/100000,and ASDR increased from 101.75/100000 to 158.75/100000.In 2021,ASPR(16551.70/100000)and ASDR(167.69/100000)were higher among females than males(14686.21/100000 and 149.76/100000,respectively).China ranked highest globally in both NVL cases and disability-adjusted life years(DALYs),with female burden significantly exceeding male burden.Projections indicated this trend and sex gap will persist until 2036.Compared with 1990,the prevalence cases and DALYs increased by 239.20%and 238.82%,respectively in 2021,with the highest burden among females and the 55−59 age group.The ARIMA model predicted continued increases in prevalence and DALYs by 2036,with females maintaining a higher burden than males.Conclusion:This study reveals a marked increase in the NVL burden in China and predicts continued growth in the coming years.Public health policies should prioritize NVL prevention and control,with special attention to women and middle-aged populations to mitigate long-term societal and health impacts.展开更多
The obesity epidemic continues to challenge global cardiovascular(CV)health,but not all obesity is equal.Emerging evidence underscores that distinct obesity phenotypes—particularly metabolically healthy vs unhealthy ...The obesity epidemic continues to challenge global cardiovascular(CV)health,but not all obesity is equal.Emerging evidence underscores that distinct obesity phenotypes—particularly metabolically healthy vs unhealthy profiles—confer differential CV risks.Recent large-scale studies have revealed that even metabol-ically healthy obesity(MHO)is associated with an increased risk of adverse CV events,particularly in the context of socioeconomic disadvantage.Central is the role of chronic low-grade inflammation,termed“metaflammation”,which can persist even in the absence of overt metabolic syndrome and is shaped by both gender and fat distribution.Epicardial and visceral adiposity contribute to this pro-inflammatory state and are strongly associated with conditions such as heart failure and atrial fibrillation.Notably,aging and hormonal changes,particularly in women,may destabilize MHO status,increasing CV vulnerability over time.This overview calls for a paradigm shift in cardiometabolic care,moving beyond anthropometric parameters toward a more refined assessment that incorporate inflammatory biomarkers,fat distribution and sex-specific factors.Recognizing these underlying biological and phenotypic differences enables more accurate CV risk stratification and supports the development of precision-based therapeutic strategies.Ultimately,understanding not just who is at risk,but why,is essential to improving prevention and outcomes across diverse populations facing the bur-den of obesity.展开更多
Population migration data derived from location-based services has often been used to delineate population flows between cities or construct intercity relationship networks to reveal and explore the complex interactio...Population migration data derived from location-based services has often been used to delineate population flows between cities or construct intercity relationship networks to reveal and explore the complex interaction patterns underlying human activities.Nevertheless,the inherent heterogeneity in multimodal migration big data has been ignored.This study conducts an in-depth comparison and quantitative analysis through a comprehensive lens of spatial association.Initially,the intercity interactive networks in China were constructed,utilizing migration data from Baidu and AutoNavi collected during the same time period.Subsequently,the characteristics and spatial structure similarities of the two types of intercity interactive networks were quantitatively assessed and analyzed from overall(network)and local(node)perspectives.Furthermore,the precision of these networks at the local scale is corroborated by constructing an intercity network from mobile phone(MP)data.Results indicate that the intercity interactive networks in China,as delineated by Baidu and AutoNavi migration flows,exhibit a high degree of structure equivalence.The correlation coefficient between these two networks is 0.874.Both networks exhibit a pronounced spatial polarization trend and hierarchical structure.This is evident in their distinct core and peripheral structures,as well as in the varying importance and influence of different nodes within the networks.Nevertheless,there are notable differences worthy of attention.Baidu intercity interactive network exhibits pronounced cross-regional effects,and its high-level interactions are characterized by a“rich-club”phenomenon.The AutoNavi intercity interactive network presents a more significant distance attenuation effect,and the high-level interactions display a gradient distribution pattern.Notably,there exists a substantial correlation between the AutoNavi and MP networks at the local scale,evidenced by a high correlation coefficient of 0.954.Furthermore,the“spatial dislocations”phenomenon was observed within the spatial structures at different levels,extracted from the Baidu and AutoNavi intercity networks.However,the measured results of network spatial structure similarity from three dimensions,namely,node location,node size,and local structure,indicate a relatively high similarity and consistency between the two networks.展开更多
Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological p...Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological problems and suicidal ideation compared to their non-left-behind peers.The aim of the current study was to examine two potential protective factors,negotiable fate belief and coping self-efficacy,and to test the mediating role of coping self-efficacy in the relationship between negotiable fate belief and suicidal ideation.We also analyzed gender differences in this mediation model.Methods:Across-sectional survey was conducted in rural areas ofChina.A sample of 526 left-behind children(285 males,54.18%;241 females,45.82%;Meanage=13.29 years,SD=0.97 years)was recruited to complete the Negotiable Fate Belief Scale,Coping Self-Efficacy Scale,and the Positive and Negative Suicide Ideation Inventory-Negative Scale.We used structural equation modeling to test the mediation model and multigroup analysis to test the moderation effect of gender.Results:Negotiable fate belief is negatively correlated with suicidal ideation(r=-0.13,p<0.01).Moreover,coping self-efficacy mediates the relationship between negotiable fate belief and suicidal ideation(β=-0.06,95%confidence interval(CI)[-0.12,-0.02]),accounting for 35.29%of the total effect.Finally,the mediating effect of coping self-efficacy was found to be significant only for female left-behind children(male:95%CI[-0.09,0.07];female:95%CI[-0.16,-0.01]).For female left-behind children,the mediating effect was complete,with a coefficient of-0.06,accounting for 85.71%of the total effect.Conclusions:The relationship between negotiable fate belief and suicidal ideation among rural left-behind children is mediated by coping self-efficacy,and this mediation effect was moderated by gender.This study provides a theoretical explanation for how cultivating the belief in negotiable fate and coping self-efficacy is effective for reducing suicidal ideation of rural left-behind children.展开更多
This study explores the impact of intergenerational differences on farmers' terrace abandonment in response to increasing intergenerational differentiation among rural households and the practical issue of terrace...This study explores the impact of intergenerational differences on farmers' terrace abandonment in response to increasing intergenerational differentiation among rural households and the practical issue of terrace abandonment. Logit and Tobit models are employed to conduct empirical analysis and it is found that terrace abandonment increases sequentially among the new, middle, and old generations, confirming that intergenerational differences significantly influence whether farmers abandon terraces and the terrace abandonment scale. Village characteristics and government subsidies significantly influence farmers' terrace abandonment. An increase in the number of migrant workers in the village increases terrace abandonment among new and middle generation farmers, whereas an increase in the distance from the village to the county significantly increases terrace abandonment among old generation farmers. An increase in the village's total population significantly reduces terrace abandonment among new generation farmers. An increase in government subsidies significantly reduces terrace abandonment among middle and old generation farmers. The impact of intergenerational differences on terrace abandonment is more pronounced in low-altitude areas. To reduce terrace abandonment, it is necessary to promote terrace transfer, develop characteristic agriculture, improve terrace farming subsidies, and propose targeted strategies for the different generations of farmers.展开更多
Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of informatio...Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of information sources varies by age and individual habits. With the widespread use of the internet, there are notable differences between younger and older generations in their reliance on the internet versus traditional media sources like newspapers and television. Given the wide age range and diverse backgrounds of nursing students, understanding generational differences in information-gathering methods is important for implementing effective education. Purpose: The purpose of this study is to identify how nursing students in different age groups obtain social information and to examine media usage trends by age group. Additionally, we aim to use the findings to provide insights into effective information dissemination methods in nursing education. Results: The results showed that nursing students in their teens to forties, regardless of gender, primarily relied on the internet as their main information source, with television playing a secondary role. In contrast, students in their fifties tended to obtain information more often from newspapers and television than from the internet. This highlights an age-related difference in preferred information sources, with older students showing a greater reliance on traditional media. Conclusions: This study demonstrates that nursing students use different information-gathering methods based on their age, suggesting a need to custo-mize information dissemination strategies in nursing education. Digital media may be more effective for younger students, while traditional media or printed materials might better serve older students. Educational institutions should consider these generational differences in media usage and adopt strategies that meet the diverse needs of their student populations.展开更多
Optic neuritis(ON)is a focal inflammatory demyelinating disorder of the optic nerve.Although classically regarded as a sentinel event for multiple sclerosis(MS),ON also occurs in antibody-mediated entities such as aqu...Optic neuritis(ON)is a focal inflammatory demyelinating disorder of the optic nerve.Although classically regarded as a sentinel event for multiple sclerosis(MS),ON also occurs in antibody-mediated entities such as aquaporin-4-IgGpositive neuromyelitis optica spectrum disorder(AQP4-NMOSD)and myelinoligodendrocyte-glycoprotein-antibody disease.In all these settings biological sex is a pivotal determinant of susceptibility,clinical expression,treatment response and long-term outcome.Data synthesized from an extensive literature analysis utilizing PubMed,Scopus,and Web of Science in this review shows that women experience ON far more frequently–with female-to-male ratios ranging from 3:1 in MS to almost 9:1 in AQP4-NMOSD–yet men,when affected,tend to accumulate irreversible neuro-axonal loss more rapidly.Sex-specific patterns arise at every biological stratum:X-linked gene dosage,epigenetic regulation,hormonal cycles from puberty through menopause,metabolic co-modifiers such as obesity and vitamin-D status,and psychosocial forces that influence healthcare utilization.By weaving these elements into an expanded narrative,the present review provides a detailed resource for clinicians and investigators aiming at gender-tailored management of ON.展开更多
This article compares the cognitive differences and influencing factors of traditional Chinese medicine culture among rural residents in Guigang,Guangxi,and Jinhua,Zhejiang,providing a reference for balanced developme...This article compares the cognitive differences and influencing factors of traditional Chinese medicine culture among rural residents in Guigang,Guangxi,and Jinhua,Zhejiang,providing a reference for balanced development.A stratified sampling method was used to conduct a questionnaire survey in three townships in each region,and data were analyzed using SPSS 25.0 and chi-square test.The survey shows that residents in Guigang rely more on personal experience for their understanding,resulting in fragmented cognition,with their needs concentrated on disease treatment.On the other hand,residents in Jinhua rely on rational trust and digital communication,leading to deeper cognition,and their needs tend to focus on preventive healthcare.Occupational factors significantly affect the cognitive level in Jinhua,while in Guigang,it is closely related to trust and cultural atmosphere.The interaction of regional economy,occupational background,and cultural tradition affects cognitive differences.It is suggested that Guigang should build a community traditional Chinese medicine cultural experience matrix,develop digital content for ethnic medical resources,and strengthen the“experience-identification-dissemination”closed loop.Jinhua should deepen the construction of digital IP and promote the integration of industry and education.The two regions should jointly build a cross-regional cultural corridor,cultivate inheritors,and use new media to expand the coverage of dissemination.展开更多
BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structu...BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.展开更多
The inter-model difference in the tropical Pacific SST warming pattern is a big stumbling block for reliable projections of global climate change. Here by conducting an inter-model Empirical Orthogonal Function(EOF) a...The inter-model difference in the tropical Pacific SST warming pattern is a big stumbling block for reliable projections of global climate change. Here by conducting an inter-model Empirical Orthogonal Function(EOF) analysis as well as an ocean mixed-layer heat budget, we find that the first two modes of inter-model difference in the SST warming pattern projected by 30 CMIP6 models, explaining more than three-quarters of the total inter-model variance, are both tied to different cloud–radiation feedbacks. The EOF1 mode that captures the different magnitudes of El Ni?o-like warming as well as the largest inter-model variance in the far eastern equatorial Pacific, is likely driven by highly diverse cloud–radiation feedbacks in the east and, to a lesser extent, by differing changes in the oceanic vertical temperature gradient. The EOF2 mode that mainly represents the different magnitudes of SST warming in the western equatorial Pacific, is associated with differing levels of negative cloud–radiation feedback over the central equatorial Pacific through a dynamic air–sea coupled process involving both the Bjerknes feedback and the wind–evaporation–SST feedback.Considering in isolation the robust common model bias of a weak negative cloud–radiation feedback over the central equatorial Pacific, the projected SST warming in the western equatorial Pacific is likely to be smaller than the multi-model ensemble mean, thereby presenting a more weakeened zonal SST gradient than expected, implying the potential for more severe climate extremes under global warming.展开更多
Clarify the mechanical properties of different laminations and the fracture mechanism of continental shale under in-situ stress can provide theoretical basis for more comprehensive evaluation of the fracability of con...Clarify the mechanical properties of different laminations and the fracture mechanism of continental shale under in-situ stress can provide theoretical basis for more comprehensive evaluation of the fracability of continental shale oil reservoir.The Chang 72continental shale was used to investigate the mechanical properties of laminations and the effect of natural structure on the crack propagation of the shale.The XRD and thin section tests show that the laminations contain two types:bright sandy lamination with void structure and dark muddy lamination with layer structure.The real-time CT uniaxial compression tests were conducted to investigate the differences of mechanical properties between the muddy lamination and sandy lamination.It found that the uniaxial compression strength and elastic modulus of the sandy lamination are higher,forming a simple crack with large opening,and the Poisson's ratio of the muddy lamination is large,forming obvious lateral deformation and more secondary cracks.On this basis,the cuboid-shaped continental shale specimens were tested under true triaxial compression conditions to study the effect of laminations and interface cracks on crack propagation combining AE and CT techniques.It found that nascent cracks connected laminations and interface cracks to form fracture network under appropriate loading condition,tensile cracks developed in sandy lamination and shear cracks occurred in muddy lamination because of deformation dissonance and brittleness index differences,and more secondary cracks formed in muddy lamination with smaller fracture toughness.Moreover,the combination relationships between nascent and natural cracks mainly conclude direct penetration and deflection,which is affected by the filling degree and morphology of interface cracks and the relationship of lamination types.These conclusions show that laminar continental shale is conducive to forming complex fracture network,which can provide a theoretical basis for the proposal of indicators and methods for fracability evaluation.展开更多
With our country’s social development,the gap between urban and rural education has become increasingly obvious,especially the difference in student achievement.This study aims to explore the impact of the urban-rura...With our country’s social development,the gap between urban and rural education has become increasingly obvious,especially the difference in student achievement.This study aims to explore the impact of the urban-rural education gap on student achievement.The study adopts a quantitative analysis method to collect and analyze the academic performance,learning resources,and social resources of urban and rural students.The results show that the unbalanced distribution of educational resources in urban and rural areas is the key factor leading to the gap in students’achievement.For example,urban education resources are abundant while rural education resources are relatively scarce.At the same time,the difference in social environment and family economic status also have a significant impact on student achievement.The differences between urban and rural areas,particularly in terms of family economic conditions and their ability to invest in education,further widen the gap between urban and rural education.The results of this study can provide a reference for reducing the gap between urban and rural education and improving the academic performance of rural students.A fair education policy is essential to narrow the gap between urban and rural education resources distribution,so as to improve the equality of education in society.展开更多
It is a great honour to participate in this forum and share my research.The title of my presentation is Respecting Differences and Pursuing Transcendence:Léon Vandermeersch's Characters-Oriented Cross-Cultura...It is a great honour to participate in this forum and share my research.The title of my presentation is Respecting Differences and Pursuing Transcendence:Léon Vandermeersch's Characters-Oriented Cross-Cultural China Studies.展开更多
The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data ...The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this assumption.The objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar series.The results show that the time span predicts the time differences.In relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.展开更多
The study of language and gender,especially the study of gender language differences involves many fields such as psychology,sociology,anthropology,language and literature,news media,education,and so on.Starting from ...The study of language and gender,especially the study of gender language differences involves many fields such as psychology,sociology,anthropology,language and literature,news media,education,and so on.Starting from the broad definition of gender language,this paper composes and reviews the research history of domestic gender language and its differences.Around the research history of domestic gender language,the research period is divided according to the timeline into germination,genesis,and growth.Divided by theme and content,the main content is the phenomenon of sexism in language;the second is the study of gender language style differences;the third is the root causes of sexism and verbal gender differences,i.e.,the construction of the corresponding theories;and the fourth is the discussion of the limitations of the study of gender language in foreign countries.展开更多
BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is rising.It is still unclear the extent to which prediabetes contributes to the risk of CVD in ...BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is rising.It is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among adults.To develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on age.AIM To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in China.METHODS The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was conducted.Individuals with prediabetes were categorized into two groups based on age.Chinese atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 years.Random forest was established in both age groups.SHapley Additive exPlanation method prioritized the importance of features from the perspective of assessment contribution.RESULTS In total,6948 people were diagnosed with prediabetes in this study.In prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older group.Overall,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in China equation in ten years.In the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely linked.CONCLUSION The susceptibility to CVD is age-specific in newly diagnosed prediabetes.It is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.展开更多
Due to different geographical backgrounds and development histories,there are certain cultural differences between China and Western countries,which often lead to cultural conflicts and seriously affect the efficiency...Due to different geographical backgrounds and development histories,there are certain cultural differences between China and Western countries,which often lead to cultural conflicts and seriously affect the efficiency and effectiveness of cultural exchanges.In the context of accelerating economic globalization and integration,as well as increasing cooperation among countries,in order to ensure the accuracy of translation,it is necessary to have a proficient and accurate understanding of the cultural differences between China and the West.By relying on these cultural differences,we can improve communication patterns and continuously enhance intercultural translation skills.展开更多
基金National Key R&D Program of China,Grant/Award Number:2021YFF0703200Key Technology Fund of the National Institutes for Food and Drug Control,Grant/Award Number:GJJS-2022-1-5。
文摘Experimental mice play a critical role in biomedical research.The phenotype and application of different substrains vary due to genetic differentiation and variation.To ensure validity and reliability of results,it is imperative to adhere to standardized experiments and controls.This paper objectively reviews the origin,differentiation,and phenotypic and genetic differences between the C57BL/6 and BALB/c mouse substrains.Furthermore,an optimal selection strategy is proposed based on the genetic quality control technology to facilitate the precise application of these two mouse substrains.
基金supported by the Natural Science Foundation of Hunan Province(2023JJ30817)Hunan Provincial Natural Science Foundation-Hengyang City Joint Fund Project(2025JJ70129)+1 种基金Changsha Natural Science Foundation(kq2403057)China。
文摘Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden of NVL in China by sex and age groups from 1990 to 2021 and to project trends over the next 15 years.Methods:Using data from the Global Burden of Disease(GBD)2021 database,we conducted descriptive analyses of NVL prevalence in China,calculated age-standardized prevalence rates(ASPR)and age-standardized disability-adjusted life years rates(ASDR)to compare burden differences between sexes and age groups,and applied an autoregressive integrated moving average(ARIMA)model to predict NVL trends for the next 15 years.The model selection was based on best-fit criteria to ensure reliable projections.Results:From 1990 to 2021,China’s ASPR of NVL rose from 10096.24/100000 to 15624.54/100000,and ASDR increased from 101.75/100000 to 158.75/100000.In 2021,ASPR(16551.70/100000)and ASDR(167.69/100000)were higher among females than males(14686.21/100000 and 149.76/100000,respectively).China ranked highest globally in both NVL cases and disability-adjusted life years(DALYs),with female burden significantly exceeding male burden.Projections indicated this trend and sex gap will persist until 2036.Compared with 1990,the prevalence cases and DALYs increased by 239.20%and 238.82%,respectively in 2021,with the highest burden among females and the 55−59 age group.The ARIMA model predicted continued increases in prevalence and DALYs by 2036,with females maintaining a higher burden than males.Conclusion:This study reveals a marked increase in the NVL burden in China and predicts continued growth in the coming years.Public health policies should prioritize NVL prevention and control,with special attention to women and middle-aged populations to mitigate long-term societal and health impacts.
文摘The obesity epidemic continues to challenge global cardiovascular(CV)health,but not all obesity is equal.Emerging evidence underscores that distinct obesity phenotypes—particularly metabolically healthy vs unhealthy profiles—confer differential CV risks.Recent large-scale studies have revealed that even metabol-ically healthy obesity(MHO)is associated with an increased risk of adverse CV events,particularly in the context of socioeconomic disadvantage.Central is the role of chronic low-grade inflammation,termed“metaflammation”,which can persist even in the absence of overt metabolic syndrome and is shaped by both gender and fat distribution.Epicardial and visceral adiposity contribute to this pro-inflammatory state and are strongly associated with conditions such as heart failure and atrial fibrillation.Notably,aging and hormonal changes,particularly in women,may destabilize MHO status,increasing CV vulnerability over time.This overview calls for a paradigm shift in cardiometabolic care,moving beyond anthropometric parameters toward a more refined assessment that incorporate inflammatory biomarkers,fat distribution and sex-specific factors.Recognizing these underlying biological and phenotypic differences enables more accurate CV risk stratification and supports the development of precision-based therapeutic strategies.Ultimately,understanding not just who is at risk,but why,is essential to improving prevention and outcomes across diverse populations facing the bur-den of obesity.
基金National Natural Science Foundation of China,No.42361040。
文摘Population migration data derived from location-based services has often been used to delineate population flows between cities or construct intercity relationship networks to reveal and explore the complex interaction patterns underlying human activities.Nevertheless,the inherent heterogeneity in multimodal migration big data has been ignored.This study conducts an in-depth comparison and quantitative analysis through a comprehensive lens of spatial association.Initially,the intercity interactive networks in China were constructed,utilizing migration data from Baidu and AutoNavi collected during the same time period.Subsequently,the characteristics and spatial structure similarities of the two types of intercity interactive networks were quantitatively assessed and analyzed from overall(network)and local(node)perspectives.Furthermore,the precision of these networks at the local scale is corroborated by constructing an intercity network from mobile phone(MP)data.Results indicate that the intercity interactive networks in China,as delineated by Baidu and AutoNavi migration flows,exhibit a high degree of structure equivalence.The correlation coefficient between these two networks is 0.874.Both networks exhibit a pronounced spatial polarization trend and hierarchical structure.This is evident in their distinct core and peripheral structures,as well as in the varying importance and influence of different nodes within the networks.Nevertheless,there are notable differences worthy of attention.Baidu intercity interactive network exhibits pronounced cross-regional effects,and its high-level interactions are characterized by a“rich-club”phenomenon.The AutoNavi intercity interactive network presents a more significant distance attenuation effect,and the high-level interactions display a gradient distribution pattern.Notably,there exists a substantial correlation between the AutoNavi and MP networks at the local scale,evidenced by a high correlation coefficient of 0.954.Furthermore,the“spatial dislocations”phenomenon was observed within the spatial structures at different levels,extracted from the Baidu and AutoNavi intercity networks.However,the measured results of network spatial structure similarity from three dimensions,namely,node location,node size,and local structure,indicate a relatively high similarity and consistency between the two networks.
基金funded by the 2023Laibin City Philosophy and Social Science Research Project(No.2023LBZS035)2024Guangxi Student Innovation and Entrepreneurship Training Program Project(No.S202411546046X)2025 Research Project of Guangxi Science&Technology Normal University(No.GXKS2025YB020).
文摘Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological problems and suicidal ideation compared to their non-left-behind peers.The aim of the current study was to examine two potential protective factors,negotiable fate belief and coping self-efficacy,and to test the mediating role of coping self-efficacy in the relationship between negotiable fate belief and suicidal ideation.We also analyzed gender differences in this mediation model.Methods:Across-sectional survey was conducted in rural areas ofChina.A sample of 526 left-behind children(285 males,54.18%;241 females,45.82%;Meanage=13.29 years,SD=0.97 years)was recruited to complete the Negotiable Fate Belief Scale,Coping Self-Efficacy Scale,and the Positive and Negative Suicide Ideation Inventory-Negative Scale.We used structural equation modeling to test the mediation model and multigroup analysis to test the moderation effect of gender.Results:Negotiable fate belief is negatively correlated with suicidal ideation(r=-0.13,p<0.01).Moreover,coping self-efficacy mediates the relationship between negotiable fate belief and suicidal ideation(β=-0.06,95%confidence interval(CI)[-0.12,-0.02]),accounting for 35.29%of the total effect.Finally,the mediating effect of coping self-efficacy was found to be significant only for female left-behind children(male:95%CI[-0.09,0.07];female:95%CI[-0.16,-0.01]).For female left-behind children,the mediating effect was complete,with a coefficient of-0.06,accounting for 85.71%of the total effect.Conclusions:The relationship between negotiable fate belief and suicidal ideation among rural left-behind children is mediated by coping self-efficacy,and this mediation effect was moderated by gender.This study provides a theoretical explanation for how cultivating the belief in negotiable fate and coping self-efficacy is effective for reducing suicidal ideation of rural left-behind children.
基金Key Program of National Natural Science Foundation of China,No.41930757National Natural Science Foundation of China,No.42371285。
文摘This study explores the impact of intergenerational differences on farmers' terrace abandonment in response to increasing intergenerational differentiation among rural households and the practical issue of terrace abandonment. Logit and Tobit models are employed to conduct empirical analysis and it is found that terrace abandonment increases sequentially among the new, middle, and old generations, confirming that intergenerational differences significantly influence whether farmers abandon terraces and the terrace abandonment scale. Village characteristics and government subsidies significantly influence farmers' terrace abandonment. An increase in the number of migrant workers in the village increases terrace abandonment among new and middle generation farmers, whereas an increase in the distance from the village to the county significantly increases terrace abandonment among old generation farmers. An increase in the village's total population significantly reduces terrace abandonment among new generation farmers. An increase in government subsidies significantly reduces terrace abandonment among middle and old generation farmers. The impact of intergenerational differences on terrace abandonment is more pronounced in low-altitude areas. To reduce terrace abandonment, it is necessary to promote terrace transfer, develop characteristic agriculture, improve terrace farming subsidies, and propose targeted strategies for the different generations of farmers.
文摘Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of information sources varies by age and individual habits. With the widespread use of the internet, there are notable differences between younger and older generations in their reliance on the internet versus traditional media sources like newspapers and television. Given the wide age range and diverse backgrounds of nursing students, understanding generational differences in information-gathering methods is important for implementing effective education. Purpose: The purpose of this study is to identify how nursing students in different age groups obtain social information and to examine media usage trends by age group. Additionally, we aim to use the findings to provide insights into effective information dissemination methods in nursing education. Results: The results showed that nursing students in their teens to forties, regardless of gender, primarily relied on the internet as their main information source, with television playing a secondary role. In contrast, students in their fifties tended to obtain information more often from newspapers and television than from the internet. This highlights an age-related difference in preferred information sources, with older students showing a greater reliance on traditional media. Conclusions: This study demonstrates that nursing students use different information-gathering methods based on their age, suggesting a need to custo-mize information dissemination strategies in nursing education. Digital media may be more effective for younger students, while traditional media or printed materials might better serve older students. Educational institutions should consider these generational differences in media usage and adopt strategies that meet the diverse needs of their student populations.
文摘Optic neuritis(ON)is a focal inflammatory demyelinating disorder of the optic nerve.Although classically regarded as a sentinel event for multiple sclerosis(MS),ON also occurs in antibody-mediated entities such as aquaporin-4-IgGpositive neuromyelitis optica spectrum disorder(AQP4-NMOSD)and myelinoligodendrocyte-glycoprotein-antibody disease.In all these settings biological sex is a pivotal determinant of susceptibility,clinical expression,treatment response and long-term outcome.Data synthesized from an extensive literature analysis utilizing PubMed,Scopus,and Web of Science in this review shows that women experience ON far more frequently–with female-to-male ratios ranging from 3:1 in MS to almost 9:1 in AQP4-NMOSD–yet men,when affected,tend to accumulate irreversible neuro-axonal loss more rapidly.Sex-specific patterns arise at every biological stratum:X-linked gene dosage,epigenetic regulation,hormonal cycles from puberty through menopause,metabolic co-modifiers such as obesity and vitamin-D status,and psychosocial forces that influence healthcare utilization.By weaving these elements into an expanded narrative,the present review provides a detailed resource for clinicians and investigators aiming at gender-tailored management of ON.
文摘This article compares the cognitive differences and influencing factors of traditional Chinese medicine culture among rural residents in Guigang,Guangxi,and Jinhua,Zhejiang,providing a reference for balanced development.A stratified sampling method was used to conduct a questionnaire survey in three townships in each region,and data were analyzed using SPSS 25.0 and chi-square test.The survey shows that residents in Guigang rely more on personal experience for their understanding,resulting in fragmented cognition,with their needs concentrated on disease treatment.On the other hand,residents in Jinhua rely on rational trust and digital communication,leading to deeper cognition,and their needs tend to focus on preventive healthcare.Occupational factors significantly affect the cognitive level in Jinhua,while in Guigang,it is closely related to trust and cultural atmosphere.The interaction of regional economy,occupational background,and cultural tradition affects cognitive differences.It is suggested that Guigang should build a community traditional Chinese medicine cultural experience matrix,develop digital content for ethnic medical resources,and strengthen the“experience-identification-dissemination”closed loop.Jinhua should deepen the construction of digital IP and promote the integration of industry and education.The two regions should jointly build a cross-regional cultural corridor,cultivate inheritors,and use new media to expand the coverage of dissemination.
基金Supported by The Sanming Project of Medicine in Shenzhen,No.SZSM202211003Shenzhen-Hong Kong Jointly Funded Project,Shenzhen Science and Technology Program,No.SGDX20230116093645007+1 种基金Shenzhen Second People's Hospital Clinical Project,No.20243357003Shenzhen Medical Research Fund,No.B2303005.
文摘BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.
基金supported by the National Natural Science Foundation of China (Grant Nos.42227901, 42476020)the Scientific Research Fund of the Second Institute of Oceanography, Ministry of Natural Resources (Grant No.QNYC2001)+4 种基金the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University (Project No.SL2023MS020)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (No.311024001)supported by the Natural Environment Research Council grant NE/W005239/1supported by the open fund of the State Key Laboratory of Satellite Ocean Environment Dynamics, Second Institute of Oceanography, MNR (No.QNHX2328)supported by the National Natural Science Foundation of China (Grant No.42222502)。
文摘The inter-model difference in the tropical Pacific SST warming pattern is a big stumbling block for reliable projections of global climate change. Here by conducting an inter-model Empirical Orthogonal Function(EOF) analysis as well as an ocean mixed-layer heat budget, we find that the first two modes of inter-model difference in the SST warming pattern projected by 30 CMIP6 models, explaining more than three-quarters of the total inter-model variance, are both tied to different cloud–radiation feedbacks. The EOF1 mode that captures the different magnitudes of El Ni?o-like warming as well as the largest inter-model variance in the far eastern equatorial Pacific, is likely driven by highly diverse cloud–radiation feedbacks in the east and, to a lesser extent, by differing changes in the oceanic vertical temperature gradient. The EOF2 mode that mainly represents the different magnitudes of SST warming in the western equatorial Pacific, is associated with differing levels of negative cloud–radiation feedback over the central equatorial Pacific through a dynamic air–sea coupled process involving both the Bjerknes feedback and the wind–evaporation–SST feedback.Considering in isolation the robust common model bias of a weak negative cloud–radiation feedback over the central equatorial Pacific, the projected SST warming in the western equatorial Pacific is likely to be smaller than the multi-model ensemble mean, thereby presenting a more weakeened zonal SST gradient than expected, implying the potential for more severe climate extremes under global warming.
基金funded by the National Natural Science Foundation of China(42102309 and 42007243)the Natural Science Foundation of Liaoning Province(2023-MSBA-120)the National Key Research and Development Program(2022YFB3304705)。
文摘Clarify the mechanical properties of different laminations and the fracture mechanism of continental shale under in-situ stress can provide theoretical basis for more comprehensive evaluation of the fracability of continental shale oil reservoir.The Chang 72continental shale was used to investigate the mechanical properties of laminations and the effect of natural structure on the crack propagation of the shale.The XRD and thin section tests show that the laminations contain two types:bright sandy lamination with void structure and dark muddy lamination with layer structure.The real-time CT uniaxial compression tests were conducted to investigate the differences of mechanical properties between the muddy lamination and sandy lamination.It found that the uniaxial compression strength and elastic modulus of the sandy lamination are higher,forming a simple crack with large opening,and the Poisson's ratio of the muddy lamination is large,forming obvious lateral deformation and more secondary cracks.On this basis,the cuboid-shaped continental shale specimens were tested under true triaxial compression conditions to study the effect of laminations and interface cracks on crack propagation combining AE and CT techniques.It found that nascent cracks connected laminations and interface cracks to form fracture network under appropriate loading condition,tensile cracks developed in sandy lamination and shear cracks occurred in muddy lamination because of deformation dissonance and brittleness index differences,and more secondary cracks formed in muddy lamination with smaller fracture toughness.Moreover,the combination relationships between nascent and natural cracks mainly conclude direct penetration and deflection,which is affected by the filling degree and morphology of interface cracks and the relationship of lamination types.These conclusions show that laminar continental shale is conducive to forming complex fracture network,which can provide a theoretical basis for the proposal of indicators and methods for fracability evaluation.
文摘With our country’s social development,the gap between urban and rural education has become increasingly obvious,especially the difference in student achievement.This study aims to explore the impact of the urban-rural education gap on student achievement.The study adopts a quantitative analysis method to collect and analyze the academic performance,learning resources,and social resources of urban and rural students.The results show that the unbalanced distribution of educational resources in urban and rural areas is the key factor leading to the gap in students’achievement.For example,urban education resources are abundant while rural education resources are relatively scarce.At the same time,the difference in social environment and family economic status also have a significant impact on student achievement.The differences between urban and rural areas,particularly in terms of family economic conditions and their ability to invest in education,further widen the gap between urban and rural education.The results of this study can provide a reference for reducing the gap between urban and rural education and improving the academic performance of rural students.A fair education policy is essential to narrow the gap between urban and rural education resources distribution,so as to improve the equality of education in society.
文摘It is a great honour to participate in this forum and share my research.The title of my presentation is Respecting Differences and Pursuing Transcendence:Léon Vandermeersch's Characters-Oriented Cross-Cultural China Studies.
文摘The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this assumption.The objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar series.The results show that the time span predicts the time differences.In relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.
文摘The study of language and gender,especially the study of gender language differences involves many fields such as psychology,sociology,anthropology,language and literature,news media,education,and so on.Starting from the broad definition of gender language,this paper composes and reviews the research history of domestic gender language and its differences.Around the research history of domestic gender language,the research period is divided according to the timeline into germination,genesis,and growth.Divided by theme and content,the main content is the phenomenon of sexism in language;the second is the study of gender language style differences;the third is the root causes of sexism and verbal gender differences,i.e.,the construction of the corresponding theories;and the fourth is the discussion of the limitations of the study of gender language in foreign countries.
文摘BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is rising.It is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among adults.To develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on age.AIM To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in China.METHODS The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was conducted.Individuals with prediabetes were categorized into two groups based on age.Chinese atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 years.Random forest was established in both age groups.SHapley Additive exPlanation method prioritized the importance of features from the perspective of assessment contribution.RESULTS In total,6948 people were diagnosed with prediabetes in this study.In prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older group.Overall,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in China equation in ten years.In the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely linked.CONCLUSION The susceptibility to CVD is age-specific in newly diagnosed prediabetes.It is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.
文摘Due to different geographical backgrounds and development histories,there are certain cultural differences between China and Western countries,which often lead to cultural conflicts and seriously affect the efficiency and effectiveness of cultural exchanges.In the context of accelerating economic globalization and integration,as well as increasing cooperation among countries,in order to ensure the accuracy of translation,it is necessary to have a proficient and accurate understanding of the cultural differences between China and the West.By relying on these cultural differences,we can improve communication patterns and continuously enhance intercultural translation skills.
