Objective To investigate the optimal margin in nephron-sparing surgery (NSS) for renal cell carcinoma (RCC) 4 cm or less in diameter. Methods Eighty-two kidneys with RCC 4 cm or less in diameter resected by radical ne...Objective To investigate the optimal margin in nephron-sparing surgery (NSS) for renal cell carcinoma (RCC) 4 cm or less in diameter. Methods Eighty-two kidneys with RCC 4 cm or less in diameter resected by radical nephrectomy were prospectively studied. The kidney samples were sectioned at 3 mm interval and examined for multicentricity. On each layer of tissue sectioned, parenchyma margin of 15 mm beyond pseudocapsule was continuously sectioned and examined for completeness of pseudocapsule and extra-pseudocapsule cancer lesion. The farthest distance between extra-pseudocapsule lesion and primary tumor was measured. PCNA expression was detected in 41 patients by using standard SP immunohistochemistry technique. Results The diameter of 82 primary tumors was 3. 4 ± 0. 8 cm (range 1.5-4.0 cm).Of these,31.7% (26/82) were found without intact pseudocapsules and 17.1% (14/82) with positive cancer lesions beyond pseudocapsule. The average distance between extra-pseudocapsule cancer lesion and primary tumor展开更多
The performance and price of copper-based micro linear products are determined by the diameter uniformity.How to accurately detect the wire diameter of long-length copper based micro linear products without cutting or...The performance and price of copper-based micro linear products are determined by the diameter uniformity.How to accurately detect the wire diameter of long-length copper based micro linear products without cutting or damage has always been a technical concern for production enterprises.Herein,a novel approach was developed for nondestructive detection of the average diameter at any given segment of a long copper wire by assessing the adsorption capacity of arginine on its surface.The amount of adsorbent on the surface of the copper wire exhibits a positive correlation with the area,which can be detected by extractive electrospray ionization mass spectrometry(EESI-MS)after online elution with ammonia.The experimental results demonstrated that the analysis can be completed within 15 min,with a good linear relationship between copper wires with different diameters and the adsorption capacity of arginine.The linear correlation coefficient R2was 0.995,the relative standard deviation was 1.10%-2.81%,and the detection limit reached 2.5μm(length of segment=4 cm),showing potential applications for facile measurement of the average diameter of various metal wires.展开更多
Carbon nanotubes are uniquely featured by the nanoscale tubular structure with a highly-curved surface and defined chirality.The diameter and chirality fundamentally determine their stability and electrical and therma...Carbon nanotubes are uniquely featured by the nanoscale tubular structure with a highly-curved surface and defined chirality.The diameter and chirality fundamentally determine their stability and electrical and thermal properties.Up to now,the relationship between the intrinsic thermal conductivity and the atomic features of CNTs has not been established,due to the challenges in precise measurements and characterizations.In this work,we develop a micro electro-thermal device enabling simultaneous thermal measurements by Raman spectroscopy and atomic structural characterization by transmission electron microscopy for individual CNTs.The influence of diameter and chirality is systematically investigated.In addition,the temperature dependence of the thermal conductivity was extracted from parameter optimization of finite-element modeling.It is found that the thermal transport of CNTs depends mainly on the diameter,while the chiral angle has no significant influence.Along with increasing diameter,the room temperature thermal conductivity increases and eventually approaches the limit of flat graphene.展开更多
Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Convent...Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Conventional diagnostic methods such as computed tomography and lumbar puncture have important limitations,including invasiveness,delayed availability,and limited sensitivity in certain contexts.Point-of-care ultrasound measurement of the optic nerve sheath diameter(ONSD)has emerged as a rapid,non-invasive tool for detecting elevated ICP at the bedside.The technique is based on the anatomical continuity between the intracranial subarachnoid space and the optic nerve sheath,which expands in response to increased ICP.Evidence from multiple studies and meta-analyses indicates that ONSD measurements above 5.0-5.7 mm in adults strongly correlate with elevated ICP,showing pooled sensitivities and specificities approaching 90%.This modality enables immediate triage,guides urgency of neuroimaging,reduces unnecessary radiation exposure,and can be applied in outpatient and low-resource settings.Despite these advantages,ONSD assessment is subject to operator dependency,variability in threshold values,and reduced accuracy in patients with certain ocular or systemic conditions.Advances in artificial intelligence–assisted measurement,coupled with standardized training protocols,have the potential to improve reproducibility and broaden adoption.Overall,point-of-care ultrasound-based ONSD measurement represents a valuable adjunct in the early evaluation of patients with non-traumatic headache,facilitating faster diagnosis,better resource utilization,and improved patient outcomes.展开更多
With the increasing development of deepburied engineering projects,rockburst disasters have become a frequent concern.Studies have indicated that tunnel diameter is a critical factor influencing the occurrence of rock...With the increasing development of deepburied engineering projects,rockburst disasters have become a frequent concern.Studies have indicated that tunnel diameter is a critical factor influencing the occurrence of rockbursts.To investigate the influence of tunnel diameter on the deformation and failure characteristics of surrounding rock,large-sized rocklike gypsum specimens were tested using a selfdeveloped true triaxial rockburst loading system containing circular tunnels with three different diameters(D=0.07 m,0.11 m,and 0.15 m).Acoustic emission monitoring,together with a miniature intelligent camera,was employed to analyze the entire process,focusing on macroscopic failure patterns,fragment characteristics,and underlying failure mechanisms.In addition,theoretical analyses were carried out and combined with numerical simulations to investigate the differences in energy evolution associated with rockburst physical models.The results indicate that:(1)The rockburst process with different tunnel diameters consistently evolved through three distinct stages—initial particle ejection,crack propagation accompanied by flake spalling,and,finally,fragment ejection leading to the formation of a‘V'-shaped notch.(2)Increasing tunnel diameter reduces rockburst failure load while increasing surrounding rock damage extent,total mass and average size of ejected fragments.Additionally,shear failure proportion decreases with tensile failure becoming increasingly dominant.(3)Larger tunnel diameters reduce the attenuation rate of elastic strain energy,thereby expanding the zone of elastic strain energy accumulation and disturbance and creating conditions for larger volume rockburst.(4)Larger tunnel diameters result in a smaller principal stress ratio at equivalent distances in the surrounding rock,indicating a higher likelihood of tensile failure.(5)Numerical analyses further reveal that larger tunnel diameters reduce the maximum elastic strain energy density around the tunnel,lowering the energy released per unit volume of rockburst fragments and their ejection velocities.However,both the total failure volume and overall energy release from rockburst increase.Model experiments with different tunnel diameters are of great significance for optimizing engineering design and parameter selection,as well as guiding tunnel construction under complex geological conditions.展开更多
To elucidate the relationship between pipeline erosion and wear during slurry transportation,this study considers three key influencing parameters,namely,the ratio of inlet to outlet pipe diameter,the length of the va...To elucidate the relationship between pipeline erosion and wear during slurry transportation,this study considers three key influencing parameters,namely,the ratio of inlet to outlet pipe diameter,the length of the variable diameter section,and the roughness of the pipe wall.The impact of these factors on pipeline erosion and wear is analyzed using a single-factor analysis approach.In particular,the Fluent software is employed to conduct the required numerical simulations for variable diameter elbows of varying morphologies.The results indicate that as the inlet to outlet diameter ratio increases,the wear on the pipe inlet and the outer wall of the elbow becomes increasingly pronounced.Notably,when the diameter ratio exceeds 0.8,there is a significant escalation in wear on both the inner and outer elbow walls.Initially,the maximum erosion rate decreases sharply with increasing diameter ratio before a stable condition is attained.Erosion wear in the variable diameter section exhibits a distinct layered distribution pattern.In this region,the wear range for a 40 mm length of the pipe body is relatively small;however,once this length exceeds 40 mm,the wear range expands,ultimately covering the entire pipe section.The length of the variable diameter section significantly influences the maximum erosion rate of the pipeline,with sections shorter than 80 mm experiencing the most severe effects,and showing an exponential decline in erosion rate.As the wall roughness gradually increases,the wear area on both cheeks of the bend section rapidly expands and tends to deepen further.When the roughness reaches 4 mm,the pipeline wear experiences a dramatic shift,resulting in extensive“spot-like”wear patterns emerging at the bottom and sides of the horizontal flow section,which previously exhibited no wear.展开更多
Closed thoracic drainage can be performed using a steel-needle-guided chest tube to treat pleural effusion or pneumothorax in clinics.However,the puncture procedure during surgery is invisible,increasing the risk of s...Closed thoracic drainage can be performed using a steel-needle-guided chest tube to treat pleural effusion or pneumothorax in clinics.However,the puncture procedure during surgery is invisible,increasing the risk of surgical failure.Therefore,it is necessary to design a visualization system for closed thoracic drainage.Augmented reality(AR)technology can assist in visualizing the internal anatomical structure and determining the insertion point on the body surface.The structure of the currently used steel-needle-guided chest tube was modified by integrating it with an ultrafine diameter camera to provide real-time visualization of the puncture process.After simulation experiments,the overall registration error of the AR method was measured to be within(3.59±0.53)mm,indicating its potential for clinical application.The ultrafine diameter camera module and improved steel-needle-guided chest tube can timely reflect the position of the needle tip in the human body.A comparative experiment showed that video guidance could improve the safety of the puncture process compared to the traditional method.Finally,a qualitative evaluation of the usability of the system was conducted through a questionnaire.This system facilitates the visualization of closed thoracic drainage puncture procedure and pro-vides an implementation scheme to enhance the accuracy and safety of the operative step,which is conducive to reducing the learning curve and improving the proficiency of the doctors.展开更多
BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring trea...BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring treatment response.Previous studies have shown that the baseline ONSD at admission is a prognostic indicator of mortality in adult patients with cerebrovascular events,traumatic brain injury,hepatic encephalopathy,and acute stroke.However,pediatric data on the dynamic changes in ONSD remain limited.AIM To study the association between within-48 hours admission dynamic ONSD changes and mortality in children with clinically relevant elevated ICP.METHODS This single-institution prospective study was performed at a tertiary Children’s Hospital in Vietnam,between November 2023 and August 2024.The primary outcome was in-hospital mortality rate.ONSD data were measured at admission,24 hours,and 48 hours post-admission to pediatric intensive care unit(PICU).Linear mixed-effects models accounting for repeated measures within individuals were used to analyze the association between ONSD changes and in-hospital mortality.RESULTS A total of 69 PICU-admitted children with clinically relevant raised ICP were enrolled and included in the analysis.The median patient age was 6 years(interquartile range:1-12),and males accounted for 54%of all patients.The inhospital mortality rate in children with clinically relevant raised ICP was 23.2%.Traumatic brain injury,sepsisassociated encephalopathy,and septic shock were the main causes of death in this cohort.Linear mixed-effects analysis showed that dynamic variability in ONSD values upon PICU admission and during the first 48 hours later correlated significantly with increased mortality.Nonsurvivors had a 5.3%increase in the mean ONSD at 48 hours compared to baseline levels,while the survivors showed a 5.6%reduction in ONSD.CONCLUSION Serial ultrasound-based ONSD measurements within 48 hours of admission better predicted mortality than baseline data in critically ill children,offering a practical,noninvasive tool for early prognosis in elevated ICP.展开更多
The optimum models of harvesting yield and net profits of large diameter trees for broadleaved forest were developed, of which include matrix growth sub-model, harvesting cost and wood price sub-models, based on the d...The optimum models of harvesting yield and net profits of large diameter trees for broadleaved forest were developed, of which include matrix growth sub-model, harvesting cost and wood price sub-models, based on the data from Hongshi Forestry Bureau, in Changbai Mountain region, Jilin Province, China. The data were measured in 232 permanent sample plots. With the data of permanent sample plots, the parameters of transition probability and ingrowth models were estimated, and some models were compared and partly modified. During the simulation of stand structure, four factors such as largest diameter residual tree （LDT）, the ratio of the number of trees in a given diameter class to those in the next larger diameter class （q）, residual basal area （RBA） and selective cutting cycle （C） were considered. The simulation results showed that the optimum stand structure parameters for large diameter trees are as follows： q is 1.2, LDT is 46cm, RBA is larger than 26 m^2 and selective cutting cycle time （C） is between 10 and 20 years.展开更多
Bridgman-type directional solidification experiments were conducted for Ti-46Al-8Nb （mole fraction, %） alloy. The effects of the growth rate and the diameter on the microstructure, phase transition and hardness of t...Bridgman-type directional solidification experiments were conducted for Ti-46Al-8Nb （mole fraction, %） alloy. The effects of the growth rate and the diameter on the microstructure, phase transition and hardness of the alloy were investigated. The results show that with the increase of the growth rate and the decrease of the diameter, the fullyβphase solidification changes to the peritectic solidification, and the final microstructure is composed of theα2/γlamellar structure and a multiphase microstructure （B2 phase,α2/γlamellar structure） respectively, which can be attributed to the solute enrichment resulting from the decreasing diffusion and convection ability. The occurrence of peritectic reaction at high growth rate promotes the solute segregation heavily and the coarse lamellar spacing in Al-and Nb-rich region, which greatly decreases the hardness values and leads to the discontinuity of the hardness curves with the increase of the growth rate. Comparatively, the Ti-46Al-8Nb alloy has lower hardness values than the other applied TiAl-based alloys in previous studies.展开更多
Diameter is the next authentication,authorization and accounting protocol currently developed in the IETF AAA working group ,which will replace the widely and successfully deployed Radius protocol. In the paper ,the m...Diameter is the next authentication,authorization and accounting protocol currently developed in the IETF AAA working group ,which will replace the widely and successfully deployed Radius protocol. In the paper ,the motivations and backgrounds of Diameter protocols are firstly introduced. The following is a detailed description of the Diameter base protocol and its applications,such as mobile IP,NASREQ. Then the comparisons and analysis between Diameter and Radius are given.展开更多
文摘Objective To investigate the optimal margin in nephron-sparing surgery (NSS) for renal cell carcinoma (RCC) 4 cm or less in diameter. Methods Eighty-two kidneys with RCC 4 cm or less in diameter resected by radical nephrectomy were prospectively studied. The kidney samples were sectioned at 3 mm interval and examined for multicentricity. On each layer of tissue sectioned, parenchyma margin of 15 mm beyond pseudocapsule was continuously sectioned and examined for completeness of pseudocapsule and extra-pseudocapsule cancer lesion. The farthest distance between extra-pseudocapsule lesion and primary tumor was measured. PCNA expression was detected in 41 patients by using standard SP immunohistochemistry technique. Results The diameter of 82 primary tumors was 3. 4 ± 0. 8 cm (range 1.5-4.0 cm).Of these,31.7% (26/82) were found without intact pseudocapsules and 17.1% (14/82) with positive cancer lesions beyond pseudocapsule. The average distance between extra-pseudocapsule cancer lesion and primary tumor
基金supported by the National Natural Science Foundation of China(No.22422402)National Key Research and Development Program of China(No.2022YFF0705300)Key Research and Development Program of Jiangxi Province(No.20232BBG70004)。
文摘The performance and price of copper-based micro linear products are determined by the diameter uniformity.How to accurately detect the wire diameter of long-length copper based micro linear products without cutting or damage has always been a technical concern for production enterprises.Herein,a novel approach was developed for nondestructive detection of the average diameter at any given segment of a long copper wire by assessing the adsorption capacity of arginine on its surface.The amount of adsorbent on the surface of the copper wire exhibits a positive correlation with the area,which can be detected by extractive electrospray ionization mass spectrometry(EESI-MS)after online elution with ammonia.The experimental results demonstrated that the analysis can be completed within 15 min,with a good linear relationship between copper wires with different diameters and the adsorption capacity of arginine.The linear correlation coefficient R2was 0.995,the relative standard deviation was 1.10%-2.81%,and the detection limit reached 2.5μm(length of segment=4 cm),showing potential applications for facile measurement of the average diameter of various metal wires.
基金financially supported by the National Key Research and Development Program of China(Grant No.2022YFA1203302)the National Natural Science Foundation of China(Grant Nos.52130209,52188101)+4 种基金the JSPS Kakenhi(Grant Nos.JP25820336,JP20K05281,and JP23H01796)the JST-FOREST Program(Grant No.JPMJFR223T)the WPI-MANA“Challenging Research Program(CRP)”the National Institute for Materials Science(NIMS)“Support system for curiosity-driven research”the“Advanced Research Infrastructure for Materials and Nanotechnology in Japan(ARIM)”of the Ministry of Education,Culture,Sports,Science and Technology(MEXT)(Grant No.JPMXP1223NM5306).
文摘Carbon nanotubes are uniquely featured by the nanoscale tubular structure with a highly-curved surface and defined chirality.The diameter and chirality fundamentally determine their stability and electrical and thermal properties.Up to now,the relationship between the intrinsic thermal conductivity and the atomic features of CNTs has not been established,due to the challenges in precise measurements and characterizations.In this work,we develop a micro electro-thermal device enabling simultaneous thermal measurements by Raman spectroscopy and atomic structural characterization by transmission electron microscopy for individual CNTs.The influence of diameter and chirality is systematically investigated.In addition,the temperature dependence of the thermal conductivity was extracted from parameter optimization of finite-element modeling.It is found that the thermal transport of CNTs depends mainly on the diameter,while the chiral angle has no significant influence.Along with increasing diameter,the room temperature thermal conductivity increases and eventually approaches the limit of flat graphene.
文摘Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Conventional diagnostic methods such as computed tomography and lumbar puncture have important limitations,including invasiveness,delayed availability,and limited sensitivity in certain contexts.Point-of-care ultrasound measurement of the optic nerve sheath diameter(ONSD)has emerged as a rapid,non-invasive tool for detecting elevated ICP at the bedside.The technique is based on the anatomical continuity between the intracranial subarachnoid space and the optic nerve sheath,which expands in response to increased ICP.Evidence from multiple studies and meta-analyses indicates that ONSD measurements above 5.0-5.7 mm in adults strongly correlate with elevated ICP,showing pooled sensitivities and specificities approaching 90%.This modality enables immediate triage,guides urgency of neuroimaging,reduces unnecessary radiation exposure,and can be applied in outpatient and low-resource settings.Despite these advantages,ONSD assessment is subject to operator dependency,variability in threshold values,and reduced accuracy in patients with certain ocular or systemic conditions.Advances in artificial intelligence–assisted measurement,coupled with standardized training protocols,have the potential to improve reproducibility and broaden adoption.Overall,point-of-care ultrasound-based ONSD measurement represents a valuable adjunct in the early evaluation of patients with non-traumatic headache,facilitating faster diagnosis,better resource utilization,and improved patient outcomes.
基金funded by the National Natural Science Foundation of China(Nos.42077228,52174085)。
文摘With the increasing development of deepburied engineering projects,rockburst disasters have become a frequent concern.Studies have indicated that tunnel diameter is a critical factor influencing the occurrence of rockbursts.To investigate the influence of tunnel diameter on the deformation and failure characteristics of surrounding rock,large-sized rocklike gypsum specimens were tested using a selfdeveloped true triaxial rockburst loading system containing circular tunnels with three different diameters(D=0.07 m,0.11 m,and 0.15 m).Acoustic emission monitoring,together with a miniature intelligent camera,was employed to analyze the entire process,focusing on macroscopic failure patterns,fragment characteristics,and underlying failure mechanisms.In addition,theoretical analyses were carried out and combined with numerical simulations to investigate the differences in energy evolution associated with rockburst physical models.The results indicate that:(1)The rockburst process with different tunnel diameters consistently evolved through three distinct stages—initial particle ejection,crack propagation accompanied by flake spalling,and,finally,fragment ejection leading to the formation of a‘V'-shaped notch.(2)Increasing tunnel diameter reduces rockburst failure load while increasing surrounding rock damage extent,total mass and average size of ejected fragments.Additionally,shear failure proportion decreases with tensile failure becoming increasingly dominant.(3)Larger tunnel diameters reduce the attenuation rate of elastic strain energy,thereby expanding the zone of elastic strain energy accumulation and disturbance and creating conditions for larger volume rockburst.(4)Larger tunnel diameters result in a smaller principal stress ratio at equivalent distances in the surrounding rock,indicating a higher likelihood of tensile failure.(5)Numerical analyses further reveal that larger tunnel diameters reduce the maximum elastic strain energy density around the tunnel,lowering the energy released per unit volume of rockburst fragments and their ejection velocities.However,both the total failure volume and overall energy release from rockburst increase.Model experiments with different tunnel diameters are of great significance for optimizing engineering design and parameter selection,as well as guiding tunnel construction under complex geological conditions.
基金supported by the project of the Educational Department of Liaoning Province(No.LJKMZ20220825)the National Natural Science Foundation of China(51774199).
文摘To elucidate the relationship between pipeline erosion and wear during slurry transportation,this study considers three key influencing parameters,namely,the ratio of inlet to outlet pipe diameter,the length of the variable diameter section,and the roughness of the pipe wall.The impact of these factors on pipeline erosion and wear is analyzed using a single-factor analysis approach.In particular,the Fluent software is employed to conduct the required numerical simulations for variable diameter elbows of varying morphologies.The results indicate that as the inlet to outlet diameter ratio increases,the wear on the pipe inlet and the outer wall of the elbow becomes increasingly pronounced.Notably,when the diameter ratio exceeds 0.8,there is a significant escalation in wear on both the inner and outer elbow walls.Initially,the maximum erosion rate decreases sharply with increasing diameter ratio before a stable condition is attained.Erosion wear in the variable diameter section exhibits a distinct layered distribution pattern.In this region,the wear range for a 40 mm length of the pipe body is relatively small;however,once this length exceeds 40 mm,the wear range expands,ultimately covering the entire pipe section.The length of the variable diameter section significantly influences the maximum erosion rate of the pipeline,with sections shorter than 80 mm experiencing the most severe effects,and showing an exponential decline in erosion rate.As the wall roughness gradually increases,the wear area on both cheeks of the bend section rapidly expands and tends to deepen further.When the roughness reaches 4 mm,the pipeline wear experiences a dramatic shift,resulting in extensive“spot-like”wear patterns emerging at the bottom and sides of the horizontal flow section,which previously exhibited no wear.
基金the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(No.20172005)。
文摘Closed thoracic drainage can be performed using a steel-needle-guided chest tube to treat pleural effusion or pneumothorax in clinics.However,the puncture procedure during surgery is invisible,increasing the risk of surgical failure.Therefore,it is necessary to design a visualization system for closed thoracic drainage.Augmented reality(AR)technology can assist in visualizing the internal anatomical structure and determining the insertion point on the body surface.The structure of the currently used steel-needle-guided chest tube was modified by integrating it with an ultrafine diameter camera to provide real-time visualization of the puncture process.After simulation experiments,the overall registration error of the AR method was measured to be within(3.59±0.53)mm,indicating its potential for clinical application.The ultrafine diameter camera module and improved steel-needle-guided chest tube can timely reflect the position of the needle tip in the human body.A comparative experiment showed that video guidance could improve the safety of the puncture process compared to the traditional method.Finally,a qualitative evaluation of the usability of the system was conducted through a questionnaire.This system facilitates the visualization of closed thoracic drainage puncture procedure and pro-vides an implementation scheme to enhance the accuracy and safety of the operative step,which is conducive to reducing the learning curve and improving the proficiency of the doctors.
文摘BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring treatment response.Previous studies have shown that the baseline ONSD at admission is a prognostic indicator of mortality in adult patients with cerebrovascular events,traumatic brain injury,hepatic encephalopathy,and acute stroke.However,pediatric data on the dynamic changes in ONSD remain limited.AIM To study the association between within-48 hours admission dynamic ONSD changes and mortality in children with clinically relevant elevated ICP.METHODS This single-institution prospective study was performed at a tertiary Children’s Hospital in Vietnam,between November 2023 and August 2024.The primary outcome was in-hospital mortality rate.ONSD data were measured at admission,24 hours,and 48 hours post-admission to pediatric intensive care unit(PICU).Linear mixed-effects models accounting for repeated measures within individuals were used to analyze the association between ONSD changes and in-hospital mortality.RESULTS A total of 69 PICU-admitted children with clinically relevant raised ICP were enrolled and included in the analysis.The median patient age was 6 years(interquartile range:1-12),and males accounted for 54%of all patients.The inhospital mortality rate in children with clinically relevant raised ICP was 23.2%.Traumatic brain injury,sepsisassociated encephalopathy,and septic shock were the main causes of death in this cohort.Linear mixed-effects analysis showed that dynamic variability in ONSD values upon PICU admission and during the first 48 hours later correlated significantly with increased mortality.Nonsurvivors had a 5.3%increase in the mean ONSD at 48 hours compared to baseline levels,while the survivors showed a 5.6%reduction in ONSD.CONCLUSION Serial ultrasound-based ONSD measurements within 48 hours of admission better predicted mortality than baseline data in critically ill children,offering a practical,noninvasive tool for early prognosis in elevated ICP.
基金This paper was supported by National Strategy Key Project, Research and Paradigm on Ecological Harvesting and Regeneration Tech-nique for Northeast Natural Forest (2001BA510B07-02)
文摘The optimum models of harvesting yield and net profits of large diameter trees for broadleaved forest were developed, of which include matrix growth sub-model, harvesting cost and wood price sub-models, based on the data from Hongshi Forestry Bureau, in Changbai Mountain region, Jilin Province, China. The data were measured in 232 permanent sample plots. With the data of permanent sample plots, the parameters of transition probability and ingrowth models were estimated, and some models were compared and partly modified. During the simulation of stand structure, four factors such as largest diameter residual tree （LDT）, the ratio of the number of trees in a given diameter class to those in the next larger diameter class （q）, residual basal area （RBA） and selective cutting cycle （C） were considered. The simulation results showed that the optimum stand structure parameters for large diameter trees are as follows： q is 1.2, LDT is 46cm, RBA is larger than 26 m^2 and selective cutting cycle time （C） is between 10 and 20 years.
基金Projects(51071062,51274077,51271068)supported by the National Natural Science Foundation of ChinaProject(2011-P03)supported by Open Fund of State Key Laboratory of Mold and Die Technology of Huazhong University of Science and Technology+1 种基金Project(HIT.NSRIF.2013002)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(2011CB605504)supported by the National Basic Research Program of China
文摘Bridgman-type directional solidification experiments were conducted for Ti-46Al-8Nb （mole fraction, %） alloy. The effects of the growth rate and the diameter on the microstructure, phase transition and hardness of the alloy were investigated. The results show that with the increase of the growth rate and the decrease of the diameter, the fullyβphase solidification changes to the peritectic solidification, and the final microstructure is composed of theα2/γlamellar structure and a multiphase microstructure （B2 phase,α2/γlamellar structure） respectively, which can be attributed to the solute enrichment resulting from the decreasing diffusion and convection ability. The occurrence of peritectic reaction at high growth rate promotes the solute segregation heavily and the coarse lamellar spacing in Al-and Nb-rich region, which greatly decreases the hardness values and leads to the discontinuity of the hardness curves with the increase of the growth rate. Comparatively, the Ti-46Al-8Nb alloy has lower hardness values than the other applied TiAl-based alloys in previous studies.
文摘Diameter is the next authentication,authorization and accounting protocol currently developed in the IETF AAA working group ,which will replace the widely and successfully deployed Radius protocol. In the paper ,the motivations and backgrounds of Diameter protocols are firstly introduced. The following is a detailed description of the Diameter base protocol and its applications,such as mobile IP,NASREQ. Then the comparisons and analysis between Diameter and Radius are given.
