The concept of micro-total analysis systems(µTAS)introduced in the early 1990s revolutionized the development of lab-on-a-chip(LoC)technologies by miniaturizing and automating complex laboratory processes.Despite...The concept of micro-total analysis systems(µTAS)introduced in the early 1990s revolutionized the development of lab-on-a-chip(LoC)technologies by miniaturizing and automating complex laboratory processes.Despite their potential in diagnostics,drug development,and environmental monitoring,the widespread adoption of LoC systems has been hindered by challenges in scalability,integration,and cost-effective mass production.Traditional substrates like silicon,glass,and polymers struggle to meet the multifunctional requirements of practical applications.Lab-on-Printed Circuit Board(Lab-on-PCB)technology has emerged as a transformative solution,leveraging the cost-efficiency,scalability,and precision of PCB fabrication techniques.This platform facilitates the seamless integration of microfluidics,sensors,and actuators within a single device,enabling complex,multifunctional systems suitable for real-world deployment.Recent advancements have demonstrated Lab-on-PCB’s versatility across biomedical applications,such as point-of-care diagnostics,electrochemical biosensing,and molecular detection,as well as drug development and environmental monitoring.This review examines the evolution of Lab-on-PCB technology over the past eight years,focusing on its applications and impact within the research community.By analyzing recent progress in PCB-based microfluidics and biosensing,this work highlights how Lab-on-PCB systems address key technical barriers,paving the way for scalable and practical lab-on-chip solutions.The growing academic and industrial interest in Lab-on-PCB is underscored by a notable increase in publications and patents,signaling its potential for commercialization and broader adoption.展开更多
文摘The concept of micro-total analysis systems(µTAS)introduced in the early 1990s revolutionized the development of lab-on-a-chip(LoC)technologies by miniaturizing and automating complex laboratory processes.Despite their potential in diagnostics,drug development,and environmental monitoring,the widespread adoption of LoC systems has been hindered by challenges in scalability,integration,and cost-effective mass production.Traditional substrates like silicon,glass,and polymers struggle to meet the multifunctional requirements of practical applications.Lab-on-Printed Circuit Board(Lab-on-PCB)technology has emerged as a transformative solution,leveraging the cost-efficiency,scalability,and precision of PCB fabrication techniques.This platform facilitates the seamless integration of microfluidics,sensors,and actuators within a single device,enabling complex,multifunctional systems suitable for real-world deployment.Recent advancements have demonstrated Lab-on-PCB’s versatility across biomedical applications,such as point-of-care diagnostics,electrochemical biosensing,and molecular detection,as well as drug development and environmental monitoring.This review examines the evolution of Lab-on-PCB technology over the past eight years,focusing on its applications and impact within the research community.By analyzing recent progress in PCB-based microfluidics and biosensing,this work highlights how Lab-on-PCB systems address key technical barriers,paving the way for scalable and practical lab-on-chip solutions.The growing academic and industrial interest in Lab-on-PCB is underscored by a notable increase in publications and patents,signaling its potential for commercialization and broader adoption.
