Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We dis...Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.展开更多
BACKGROUND Transduodenal ampullectomy(TDA) is not in wide clinical use due to its low radical effect and a high recurrence rate of tumors. However,TDA is still an effective treatment method; it has great clinical valu...BACKGROUND Transduodenal ampullectomy(TDA) is not in wide clinical use due to its low radical effect and a high recurrence rate of tumors. However,TDA is still an effective treatment method; it has great clinical value in cases of duodenal benign tumors,precancerous lesions,and benign and malignant borderline tumors,and can avoid the risks associated with pancreaticoduodenectomy with larger resection range and greater thoroughness than endoscopic papillectomy.AIM To investigate the surgical method choice and the coincidence rate of pathological diagnoses in TDA for ampullary neoplasms.METHODS Ten patients with ampullary neoplasms underwent TDA based on the fact that their endoscopic biopsy results suggested benign lesions,and the endoscopic ultrasound(EUS)-assessed tumors were resectable. All cases underwent duodenal ampullary lesion endoscopic biopsy,intraoperative frozen-section pathological examination,and postoperative pathological examination.RESULTSThis study included seven patients with benign tumors and three with malignant tumors(1 pTis,2 pT1),according to the postoperative pathology results. The coincidence rate of the postoperative pathology results with the intraoperative frozen-section biopsy results was 100%(10/10),and the coincidence rate with the endoscopic biopsy results was 70%(7/10) based on pathological characteristics.The endoscopic biopsy false-negative rate was 30%(3/10). All patients were followed for 6 to 70 mo without tumor recurrence or metastasis.CONCLUSION The coincidence rate of postoperative pathology results,intraoperative frozensection pathology results,and endoscopic biopsy results is the restraining factor of TDA clinical application. Endoscopic biopsy results and EUS have importance relevance to surgical planning. Intraoperative frozen-section pathology results have a significant influence on the choice of surgical procedure.展开更多
The EFIT program is integrated with the high resolution laser polarimeter interferometer system（POLARIS）, the soft X-ray imaging diagnostic system（SXR） and the electron cyclotron emission radiometer（ECE） in the ...The EFIT program is integrated with the high resolution laser polarimeter interferometer system（POLARIS）, the soft X-ray imaging diagnostic system（SXR） and the electron cyclotron emission radiometer（ECE） in the J-TEXT tokamak. Then some internal information about Faraday angle and the position of safety factor q=1 can be obtained as a constraint to EFIT. The modified EFIT code is used to calculate the internal parameters such as flux function, safety factor q, pressure and current density.展开更多
Leeches and earthworms are the main ingredients of Shuxuetong injection compositions,whichare natural biomedicines.Near infrared(NIR)diffuse reflection spectroscopy has been used forquality assurance of Chinese medici...Leeches and earthworms are the main ingredients of Shuxuetong injection compositions,whichare natural biomedicines.Near infrared(NIR)diffuse reflection spectroscopy has been used forquality assurance of Chinese medicines.In the present work,NIR spectroscopy was proposed as arapid and nondestructive technique to assess the moisture content(MC),soluble solid content(SSC)and hypoxanthine content(HXC)of leeches and earthworms.This study goal was toimprove NIR models for accurate quality control of leech and earthworm using outlier multiplediagnoses(OMD).OMD was composed of four outlier detection methods:spectrum outlier di-agnostic(MD),leverage diagnostic(LD),principal component scores diagnostic(PCSD)andfactor loading diagnostic(FLD),Conventional outlier diagnoses(MD,LD)and OMD werecompared,and the best NIR models were those based on OMD.The correlation coefficients(R)for leech were 0.9779,0.9616 and 0.9406 for MC,SSC and HXC,respectively.The values ofrelative standard error of prediction(RSEP)for leech were 2.3%,5.1%and 9.0%for MC,SSC and HXC,respectively.The values of R for earthworm were 0.9478,0.9991 and 0.9605 for MC,SSC and HXC,respectively.The values of RSEP for earthworm were 8.8%,2.4%and 12%for MC,SSC and HXC,respectively.The performance of the NIR models was certainly improved by OMD.展开更多
BACKGROUND Missed or delayed diagnosis of cervical spine instability after acute trauma can have catastrophic consequences for the patient,resulting in severe neurological impairment.Currently,however,there is no cons...BACKGROUND Missed or delayed diagnosis of cervical spine instability after acute trauma can have catastrophic consequences for the patient,resulting in severe neurological impairment.Currently,however,there is no consensus on the optimal strategy for diagnosing occult cervical spine instability.Thus,we present a case of occult cervical spine instability and provide a clinical algorithm to aid physicians in diagnosing occult instability of the cervical spine.CASE SUMMARY A 57-year-old man presented with cervical spine pain and inability to stand following a serious fall from a height of 2 m.No obvious vertebral fracture or dislocation was found at the time on standard lateral X-ray,computed tomography,and magnetic resonance imaging(MRI).Subsequently,the initial surgical plan was unilateral open-door laminoplasty(C3-7)with alternative levels of centerpiece mini-plate fixation(C3,5,and 7).However,the intraoperative C-arm fluoroscopic X-rays revealed significantly increased intervertebral space at C5-6,indicating instability at this level that was previously unrecognized on preoperative imaging.We finally performed lateral mass fixation and fusion at the C5-6 level.Looking back at the preoperative images,we found that the preoperative T2 MRI showed non-obvious high signal intensity at the C5-6 intervertebral disc and posterior interspinous ligament.CONCLUSION MRI of cervical spine trauma patients should be carefully reviewed to detect disco-ligamentous injury,which will lead to further cervical spine instability.In patients with highly suspected cervical spine instability indicated on MRI,lateral X-ray under traction or after anesthesia and muscle relaxation needs to be performed to avoid missed diagnoses of occult cervical instability.展开更多
87 patients with pulmonary space-occupied lesions of the peripheral type which were either adhesive of close to pleura were examined using ultuasonography.Of them,64 cases of lung cancers and 23 of bening lesions were...87 patients with pulmonary space-occupied lesions of the peripheral type which were either adhesive of close to pleura were examined using ultuasonography.Of them,64 cases of lung cancers and 23 of bening lesions were then confirmed by展开更多
Cubital tunnel syndrome(CTS)is a chronic condition caused by the compression of the ulnar nerve at the elbow.The ulnar nerve is susceptible to entrapment at multiple sites along its path,with the elbow joint being the...Cubital tunnel syndrome(CTS)is a chronic condition caused by the compression of the ulnar nerve at the elbow.The ulnar nerve is susceptible to entrapment at multiple sites along its path,with the elbow joint being the most critical.Symptoms typically include numbness in the ulnar nerve distribution area,hand muscle atrophy,and weakness.Patients exhibiting mild symptoms can be treated conservatively,whereas those with moderate to severe symptoms often require surgical intervention.Extensive research has been conducted on the clinical treatment of CTS.The complex etiology of this condition,coupled with the unique anatomical structure of the ulnar nerve,has led to less-than-satisfactory clinical outcomes.Physiotherapy plays an important role in aiding nerve recovery and reducing disability rates.Initiating physiotherapy early can address the cause of the disease,mitigate nerve damage,improve functional impairment due to nerve injury,and enhance the quality of patients’daily activities.However,definitive guidelines for the treatment and evaluation of cubital tunnel syndrome are lacking.This review compiles the various modalities and advancements in the diagnosis and rehabilitation of CTS,drawing from recent domestic and international literature.It summarizes and compares the diagnostic tools currently employed in clinical practice and offers suggestions for physicians and therapists in selecting personalized diagnostic tools for patient assessment.Additionally,the review describes various rehabilitation methods,providing fresh insights for patients with cubital tunnel syndrome who have received conservative or surgical treatment.展开更多
Over the past decade,artificial intelligence(AI)has evolved at an unprecedented pace,transforming technology,industry,and society.From diagnosing diseases with remarkable accuracy to powering self-driving cars and rev...Over the past decade,artificial intelligence(AI)has evolved at an unprecedented pace,transforming technology,industry,and society.From diagnosing diseases with remarkable accuracy to powering self-driving cars and revolutionizing personalized learning,AI is reshaping our world in ways once thought impossible.Spanning fields such as machine learning,deep learning,natural language processing,robotics,and ChatGPT,AI continues to push the boundaries of innovation.As AI continues to advance,it is vital to have a platform that not only disseminates cutting-edge research innovations but also fosters broad discussions on its societal impact,ethical considerations,and interdisciplinary applications.With this vision in mind,we proudly introduce Artificial Intelligence Science and Engineering(AISE)-a journal dedicated to nurturing the next wave of AI innovation and engineering applications.Our mission is to provide a premier outlet where researchers can share high-quality,impactful studies and collaborate to advance AI across academia,industry,and beyond.展开更多
We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a c...We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a controlled magneticfield up to 20T.Nitrogen lines(NII)in the visible range were used to diagnose the magneticfield and plasma conditions.This was performed by coupling our data with(563–574 nm)the Stark–Zeeman line-shape code PPPB.The excellent agreement between experiment and simulations paves the way for a non-intrusive experimental platform to get time-resolved measurements of the local magneticfield in laboratory plasmas.展开更多
AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radio...AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies.展开更多
By inspecting and analyzing the debris, which is the most direct and important information units in the lubricating oil, we can monitor the machine condition to predict its failure. The debris monitoring and analyzing...By inspecting and analyzing the debris, which is the most direct and important information units in the lubricating oil, we can monitor the machine condition to predict its failure. The debris monitoring and analyzing system (DMAS) is developed from the traditional iron spectrum technology, and has such characteristics as ease for debris separating, forecasting machine failure automatically and accurately in time and so on. The fundamental theory, components and its application in aeroengine health monitoring of DMAS are presented.展开更多
Mesoscale research conducted by Chinese meteorologists during the past four years is reviewed. Advances in theoretical studies include (a) mesoscale quasi-balanced and semi-balanced dynamics, derived through scale ana...Mesoscale research conducted by Chinese meteorologists during the past four years is reviewed. Advances in theoretical studies include (a) mesoscale quasi-balanced and semi-balanced dynamics, derived through scale analysis and the perturbation method which are suitable for describing mesoscale vortices; (b) subcritical instability and vortex-sheet instability; (c) frontal adjustment mechanism and the effect of topography on frontgenesis; and (d) slantwise vorticity development theories, the slantwise vortex equation, and moist potential vorticity (MPV) anomalies with precipitation-related heat and mass sinks and MPV impermeability theorem. Prom the MPV conservation viewpoint, the transformation mechanism between different scale weather systems is analyzed. Based on the data analysis, a new dew-point front near the periphery of the West Pacific subtropical high is identified. In the light of MPV theory and Q-vector theory, some events associated with torrential rain systems and severe storms are analyzed and diagnosed. Progress in mesoscale numerical simulation has been made in the development of meso-α, meso-β vortices, meso-γ-scale downbursts and precipitation produced by deep convective systems with MM5 and other mesoscale models.展开更多
BACKGROUND Hepatic perivascular epithelioid cell neoplasms(PEComas)are rare.Diagnostic and treatment experience with hepatic PEComa remains insufficient.CASE SUMMARY Three hepatic PEComa cases are reported in this pap...BACKGROUND Hepatic perivascular epithelioid cell neoplasms(PEComas)are rare.Diagnostic and treatment experience with hepatic PEComa remains insufficient.CASE SUMMARY Three hepatic PEComa cases are reported in this paper:One case of primary malignant hepatic PEComa,one case of benign hepatic PEComa,and one case of hepatic PEComa with an ovarian mature cystic teratoma.During preoperative imaging and pathological assessment of intraoperative frozen samples,patients were diagnosed with hepatocellular carcinoma(HCC),while postoperative pathology and immunohistochemistry subsequently revealed hepatic PEComa.Patients with hepatic PEComa which is misdiagnosed as HCC often require a wider surgical resection.It is easy to mistake them for distant metastases of hepatic PEComa and misdiagnosed as HCC,especially when it’s combined with tumors in other organs.Three patients eventually underwent partial hepatectomy.After 1-4 years of follow-up,none of the patients experienced recurrence or metastases.CONCLUSION A clear preoperative diagnosis of hepatic PEComa can reduce the scope of resection and prevent unnecessary injuries during surgery.展开更多
The oil refining and petrochemical industry in China has made great achievements after decades of development, and its capacity has already ranked second in the world. However, the refining industry is suffering some ...The oil refining and petrochemical industry in China has made great achievements after decades of development, and its capacity has already ranked second in the world. However, the refining industry is suffering some challenges, such as severe overcapacity at present, and has entered a new economic normal, in which the technological progress develops rapidly, the demand for green and low-carbon development is stricter, the market competition is increasingly fiercer and the profit margins are gradually narrowing. In such a situation, informatization and its new technologies are driving the significant reforming of manufacturing patterns, marketing patterns, management and decision-making patterns. Intelligent development is the inevitable choice for the transformation and upgrading of oil refining and petrochemical industry. It is suggested that the intelligent evaluating model and method should be adopted to enterprise’s intelligentializing transformation and upgrading by laying a solid foundation of digital refinery and implemenation of digital upgrading.展开更多
The principles of Gradient operator, Laplacian operator, LOG operator and Sobel operator are discussed. Certain features of breast can be extracted in different degrees and aspects from original images by applying fou...The principles of Gradient operator, Laplacian operator, LOG operator and Sobel operator are discussed. Certain features of breast can be extracted in different degrees and aspects from original images by applying four edge sharpening operators to the breast near-infrared imaging. A great number of cases prove that compared with the other three operators, the improved Sobel operator can effectively extract the structural features of the breast from an original image. It can be concluded that the improved Sobel operator can assist in diagnosing breast diseases.展开更多
As a basic principle in classical mechanics,the Galilean invariance states that the force is the same in all inertial frames of reference.But this principle has not been properly addressed by most unsteady aerodynamic...As a basic principle in classical mechanics,the Galilean invariance states that the force is the same in all inertial frames of reference.But this principle has not been properly addressed by most unsteady aerodynamic force theories,if the partial force contributed by a local flow structure is to be evaluated.In this note,we discuss the Galilean-invariance conditions of the partial force for several typical theories and numerically test what would happen if these conditions do not hold.展开更多
This paper reviews the main theoretical progress of mesoscale weather dynamics since 2003, including： （1） The dynamic mechanisms of balanced and unbalanced flow are applied to study the genesis and development prob...This paper reviews the main theoretical progress of mesoscale weather dynamics since 2003, including： （1） The dynamic mechanisms of balanced and unbalanced flow are applied to study the genesis and development problems of mesoscale circulation. The symmetric instability and transverse-wave instability are analyzed in line and vortex atmosphere convection, and further research has been done on nonlinear convective symmetric instability. The interaction between forced convection and unstable convection and the wave characteristics of mesoscale motion are also discussed. （2） Intermediate atmosphere dynamic boundary layer models are developed. The complicated nonlinear interaction is analyzed theoretically between the atmospheric boundary layer and the free atmosphere. The structure of the topography boundary layer, atmospheric frontogenesis, the structure and circulation of the low-level front and other boundary layer dynamic problems are discussed. （3） The formation and development of meso-β-scale rainstorms under the background of the East-Asia atmosphere circulation are diagnosed with the variation of MPV （moist potential vorticity） anomalies. And some physical vectors are modified and applied in the moist atmosphere.展开更多
BACKGROUND The most common site of paragonimiasis is in the lungs.The migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well ...BACKGROUND The most common site of paragonimiasis is in the lungs.The migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well as the liver,intestine,and abdominal cavity may be involved.Here,we present a case of intraperitoneal paragonimiasis without other organ involvement,mimicking tuberculous peritonitis.CASE SUMMARY A 57-year-old man presented with recurrent abdominal pain for 4 wk.Physical examination revealed tenderness in the right lower quadrant.Laboratory findings showed complete blood counts within the normal range without eosinophilia.Multiple reactive lymph nodes and diffuse peritoneal infiltration were noted on abdominal computed tomography(CT).There were no abnormalities on chest CT or colonoscopy.Intraoperative findings of diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis included multiple small whitish nodules and an abscess in the peritoneum.Pathological reports confirmed the presence of numerous eggs of Paragonimus westermani(P.westermani).A postoperative serum enzyme-linked immunosorbent assay revealed P.westermani positivity.Persistent and repetitive history-taking led him to retrospectively recall the consumption of freshwater crab.After 3 d of treatment with praziquantel(1800 mg;25 mg/kg),he recovered from all symptoms.CONCLUSION In patients who require diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis,repetitive history-taking and preoperative serologic antibody tests against Paragonimus may be helpful in diagnosing intraperitoneal paragonimiasis without other organ involvement.展开更多
BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cas...BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cases have been reported.We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment,thereby serving as a guide to correct diagnosis and treatment.CASE SUMMARY A 30-year-old man presented with recurrent itching plaques of 1-year duration in the left tibia that aggravated and involved both legs and the back.Examination revealed multiple symmetrical,purple,and hyperpigmented papules and nodules with surface exfoliation involving the tibia and dorsum of the neck with negative Nissl's sign,no abnormalities in the skin,mucosa,hair,or fingernail,and no local lymph node enlargement.Blisters were never reported prior to presentation.Serum immunoglobulin E level was 636 IU/mL.Clinical manifestations suggested DEB-Pr.Histological examination showed subepidermal fissure,scar tissue,and milia.Direct immunofluorescence showed no obvious abnormalities.However,we were unable to perform electron microscopy or genetic research following his choice.We treated him with topical tacrolimus.After 2 wk,the itching alleviated,and the skin lesions began to subside.No adverse reactions were observed during treatment.CONCLUSION Topical tacrolimus is a safe treatment option for patients with DEB-Pr and can achieve continuous relief of severe itching.展开更多
DNA chip technology employs light- directed in situ oligonucleotide synthesis and/or DNA microarray printing device to produce arrays of large number of probes in the tiny surface of silicon substrates, which makes it...DNA chip technology employs light- directed in situ oligonucleotide synthesis and/or DNA microarray printing device to produce arrays of large number of probes in the tiny surface of silicon substrates, which makes it possible that the gene detection be conducted efficiently with high speed and sensitivity. The DNA chip may take important part in genome research, gene diagnoses and so on.展开更多
文摘Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.
基金Supported by the Key Research and Development Plan of Shandong Province,No.2016GSF201108
文摘BACKGROUND Transduodenal ampullectomy(TDA) is not in wide clinical use due to its low radical effect and a high recurrence rate of tumors. However,TDA is still an effective treatment method; it has great clinical value in cases of duodenal benign tumors,precancerous lesions,and benign and malignant borderline tumors,and can avoid the risks associated with pancreaticoduodenectomy with larger resection range and greater thoroughness than endoscopic papillectomy.AIM To investigate the surgical method choice and the coincidence rate of pathological diagnoses in TDA for ampullary neoplasms.METHODS Ten patients with ampullary neoplasms underwent TDA based on the fact that their endoscopic biopsy results suggested benign lesions,and the endoscopic ultrasound(EUS)-assessed tumors were resectable. All cases underwent duodenal ampullary lesion endoscopic biopsy,intraoperative frozen-section pathological examination,and postoperative pathological examination.RESULTSThis study included seven patients with benign tumors and three with malignant tumors(1 pTis,2 pT1),according to the postoperative pathology results. The coincidence rate of the postoperative pathology results with the intraoperative frozen-section biopsy results was 100%(10/10),and the coincidence rate with the endoscopic biopsy results was 70%(7/10) based on pathological characteristics.The endoscopic biopsy false-negative rate was 30%(3/10). All patients were followed for 6 to 70 mo without tumor recurrence or metastasis.CONCLUSION The coincidence rate of postoperative pathology results,intraoperative frozensection pathology results,and endoscopic biopsy results is the restraining factor of TDA clinical application. Endoscopic biopsy results and EUS have importance relevance to surgical planning. Intraoperative frozen-section pathology results have a significant influence on the choice of surgical procedure.
文摘The EFIT program is integrated with the high resolution laser polarimeter interferometer system（POLARIS）, the soft X-ray imaging diagnostic system（SXR） and the electron cyclotron emission radiometer（ECE） in the J-TEXT tokamak. Then some internal information about Faraday angle and the position of safety factor q=1 can be obtained as a constraint to EFIT. The modified EFIT code is used to calculate the internal parameters such as flux function, safety factor q, pressure and current density.
文摘Leeches and earthworms are the main ingredients of Shuxuetong injection compositions,whichare natural biomedicines.Near infrared(NIR)diffuse reflection spectroscopy has been used forquality assurance of Chinese medicines.In the present work,NIR spectroscopy was proposed as arapid and nondestructive technique to assess the moisture content(MC),soluble solid content(SSC)and hypoxanthine content(HXC)of leeches and earthworms.This study goal was toimprove NIR models for accurate quality control of leech and earthworm using outlier multiplediagnoses(OMD).OMD was composed of four outlier detection methods:spectrum outlier di-agnostic(MD),leverage diagnostic(LD),principal component scores diagnostic(PCSD)andfactor loading diagnostic(FLD),Conventional outlier diagnoses(MD,LD)and OMD werecompared,and the best NIR models were those based on OMD.The correlation coefficients(R)for leech were 0.9779,0.9616 and 0.9406 for MC,SSC and HXC,respectively.The values ofrelative standard error of prediction(RSEP)for leech were 2.3%,5.1%and 9.0%for MC,SSC and HXC,respectively.The values of R for earthworm were 0.9478,0.9991 and 0.9605 for MC,SSC and HXC,respectively.The values of RSEP for earthworm were 8.8%,2.4%and 12%for MC,SSC and HXC,respectively.The performance of the NIR models was certainly improved by OMD.
基金Supported by grants from China Postdoctoral Science Foundation General Program No.2019M653417Sichuan Science and Technology Program,No.2020YJ0025,No.2017SZ0046,and No.2017SZDZX0021+1 种基金Post-Doctor Research Project,Sichuan University,No.2019SCU12043and International Postdoctoral Exchange Fellowship Program,No.PC2019060.
文摘BACKGROUND Missed or delayed diagnosis of cervical spine instability after acute trauma can have catastrophic consequences for the patient,resulting in severe neurological impairment.Currently,however,there is no consensus on the optimal strategy for diagnosing occult cervical spine instability.Thus,we present a case of occult cervical spine instability and provide a clinical algorithm to aid physicians in diagnosing occult instability of the cervical spine.CASE SUMMARY A 57-year-old man presented with cervical spine pain and inability to stand following a serious fall from a height of 2 m.No obvious vertebral fracture or dislocation was found at the time on standard lateral X-ray,computed tomography,and magnetic resonance imaging(MRI).Subsequently,the initial surgical plan was unilateral open-door laminoplasty(C3-7)with alternative levels of centerpiece mini-plate fixation(C3,5,and 7).However,the intraoperative C-arm fluoroscopic X-rays revealed significantly increased intervertebral space at C5-6,indicating instability at this level that was previously unrecognized on preoperative imaging.We finally performed lateral mass fixation and fusion at the C5-6 level.Looking back at the preoperative images,we found that the preoperative T2 MRI showed non-obvious high signal intensity at the C5-6 intervertebral disc and posterior interspinous ligament.CONCLUSION MRI of cervical spine trauma patients should be carefully reviewed to detect disco-ligamentous injury,which will lead to further cervical spine instability.In patients with highly suspected cervical spine instability indicated on MRI,lateral X-ray under traction or after anesthesia and muscle relaxation needs to be performed to avoid missed diagnoses of occult cervical instability.
文摘87 patients with pulmonary space-occupied lesions of the peripheral type which were either adhesive of close to pleura were examined using ultuasonography.Of them,64 cases of lung cancers and 23 of bening lesions were then confirmed by
基金This research was funded by the Zhejiang Key Research and Development Programof China(No.2021C03050)the Zhejiang Key Research and Development Program of China(No.2022C03038).
文摘Cubital tunnel syndrome(CTS)is a chronic condition caused by the compression of the ulnar nerve at the elbow.The ulnar nerve is susceptible to entrapment at multiple sites along its path,with the elbow joint being the most critical.Symptoms typically include numbness in the ulnar nerve distribution area,hand muscle atrophy,and weakness.Patients exhibiting mild symptoms can be treated conservatively,whereas those with moderate to severe symptoms often require surgical intervention.Extensive research has been conducted on the clinical treatment of CTS.The complex etiology of this condition,coupled with the unique anatomical structure of the ulnar nerve,has led to less-than-satisfactory clinical outcomes.Physiotherapy plays an important role in aiding nerve recovery and reducing disability rates.Initiating physiotherapy early can address the cause of the disease,mitigate nerve damage,improve functional impairment due to nerve injury,and enhance the quality of patients’daily activities.However,definitive guidelines for the treatment and evaluation of cubital tunnel syndrome are lacking.This review compiles the various modalities and advancements in the diagnosis and rehabilitation of CTS,drawing from recent domestic and international literature.It summarizes and compares the diagnostic tools currently employed in clinical practice and offers suggestions for physicians and therapists in selecting personalized diagnostic tools for patient assessment.Additionally,the review describes various rehabilitation methods,providing fresh insights for patients with cubital tunnel syndrome who have received conservative or surgical treatment.
文摘Over the past decade,artificial intelligence(AI)has evolved at an unprecedented pace,transforming technology,industry,and society.From diagnosing diseases with remarkable accuracy to powering self-driving cars and revolutionizing personalized learning,AI is reshaping our world in ways once thought impossible.Spanning fields such as machine learning,deep learning,natural language processing,robotics,and ChatGPT,AI continues to push the boundaries of innovation.As AI continues to advance,it is vital to have a platform that not only disseminates cutting-edge research innovations but also fosters broad discussions on its societal impact,ethical considerations,and interdisciplinary applications.With this vision in mind,we proudly introduce Artificial Intelligence Science and Engineering(AISE)-a journal dedicated to nurturing the next wave of AI innovation and engineering applications.Our mission is to provide a premier outlet where researchers can share high-quality,impactful studies and collaborate to advance AI across academia,industry,and beyond.
基金supported by grants managed by l’Agence Nationale de la Recherche under the Investissements d’Avenir programs Grant Nos. ANR-18-EURE-0014, ANR-10-LABX-0039-PALM, and ANR-22-CE30-0044supported by grants from Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant No. 23K20038)+2 种基金JSPS Core-to-Core program (Grant No. JPJSCCA20230003)carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (Grant Agreement No. 101052200-EUROfusion)operated within the framework of the Enabling Research Project No. AWP24-ENR-IFE.02.CEA-01 “Magnetized ICF”
文摘We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a controlled magneticfield up to 20T.Nitrogen lines(NII)in the visible range were used to diagnose the magneticfield and plasma conditions.This was performed by coupling our data with(563–574 nm)the Stark–Zeeman line-shape code PPPB.The excellent agreement between experiment and simulations paves the way for a non-intrusive experimental platform to get time-resolved measurements of the local magneticfield in laboratory plasmas.
基金Supported by The National Natural Science Foundation of China,No 30971148
文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies.
文摘By inspecting and analyzing the debris, which is the most direct and important information units in the lubricating oil, we can monitor the machine condition to predict its failure. The debris monitoring and analyzing system (DMAS) is developed from the traditional iron spectrum technology, and has such characteristics as ease for debris separating, forecasting machine failure automatically and accurately in time and so on. The fundamental theory, components and its application in aeroengine health monitoring of DMAS are presented.
文摘Mesoscale research conducted by Chinese meteorologists during the past four years is reviewed. Advances in theoretical studies include (a) mesoscale quasi-balanced and semi-balanced dynamics, derived through scale analysis and the perturbation method which are suitable for describing mesoscale vortices; (b) subcritical instability and vortex-sheet instability; (c) frontal adjustment mechanism and the effect of topography on frontgenesis; and (d) slantwise vorticity development theories, the slantwise vortex equation, and moist potential vorticity (MPV) anomalies with precipitation-related heat and mass sinks and MPV impermeability theorem. Prom the MPV conservation viewpoint, the transformation mechanism between different scale weather systems is analyzed. Based on the data analysis, a new dew-point front near the periphery of the West Pacific subtropical high is identified. In the light of MPV theory and Q-vector theory, some events associated with torrential rain systems and severe storms are analyzed and diagnosed. Progress in mesoscale numerical simulation has been made in the development of meso-α, meso-β vortices, meso-γ-scale downbursts and precipitation produced by deep convective systems with MM5 and other mesoscale models.
文摘BACKGROUND Hepatic perivascular epithelioid cell neoplasms(PEComas)are rare.Diagnostic and treatment experience with hepatic PEComa remains insufficient.CASE SUMMARY Three hepatic PEComa cases are reported in this paper:One case of primary malignant hepatic PEComa,one case of benign hepatic PEComa,and one case of hepatic PEComa with an ovarian mature cystic teratoma.During preoperative imaging and pathological assessment of intraoperative frozen samples,patients were diagnosed with hepatocellular carcinoma(HCC),while postoperative pathology and immunohistochemistry subsequently revealed hepatic PEComa.Patients with hepatic PEComa which is misdiagnosed as HCC often require a wider surgical resection.It is easy to mistake them for distant metastases of hepatic PEComa and misdiagnosed as HCC,especially when it’s combined with tumors in other organs.Three patients eventually underwent partial hepatectomy.After 1-4 years of follow-up,none of the patients experienced recurrence or metastases.CONCLUSION A clear preoperative diagnosis of hepatic PEComa can reduce the scope of resection and prevent unnecessary injuries during surgery.
文摘The oil refining and petrochemical industry in China has made great achievements after decades of development, and its capacity has already ranked second in the world. However, the refining industry is suffering some challenges, such as severe overcapacity at present, and has entered a new economic normal, in which the technological progress develops rapidly, the demand for green and low-carbon development is stricter, the market competition is increasingly fiercer and the profit margins are gradually narrowing. In such a situation, informatization and its new technologies are driving the significant reforming of manufacturing patterns, marketing patterns, management and decision-making patterns. Intelligent development is the inevitable choice for the transformation and upgrading of oil refining and petrochemical industry. It is suggested that the intelligent evaluating model and method should be adopted to enterprise’s intelligentializing transformation and upgrading by laying a solid foundation of digital refinery and implemenation of digital upgrading.
文摘The principles of Gradient operator, Laplacian operator, LOG operator and Sobel operator are discussed. Certain features of breast can be extracted in different degrees and aspects from original images by applying four edge sharpening operators to the breast near-infrared imaging. A great number of cases prove that compared with the other three operators, the improved Sobel operator can effectively extract the structural features of the breast from an original image. It can be concluded that the improved Sobel operator can assist in diagnosing breast diseases.
基金This work was supported by the National Natural Science Foundation of China(Grant 11472016).
文摘As a basic principle in classical mechanics,the Galilean invariance states that the force is the same in all inertial frames of reference.But this principle has not been properly addressed by most unsteady aerodynamic force theories,if the partial force contributed by a local flow structure is to be evaluated.In this note,we discuss the Galilean-invariance conditions of the partial force for several typical theories and numerically test what would happen if these conditions do not hold.
基金This work was supported by the National Nature Science Foundation of China （Grant Nos. 40575022, 40575025, 40333025, 40325014, and 40333031）the National Key Basic Research and Development Project of China （Grant No. 2004CB418301）.
文摘This paper reviews the main theoretical progress of mesoscale weather dynamics since 2003, including： （1） The dynamic mechanisms of balanced and unbalanced flow are applied to study the genesis and development problems of mesoscale circulation. The symmetric instability and transverse-wave instability are analyzed in line and vortex atmosphere convection, and further research has been done on nonlinear convective symmetric instability. The interaction between forced convection and unstable convection and the wave characteristics of mesoscale motion are also discussed. （2） Intermediate atmosphere dynamic boundary layer models are developed. The complicated nonlinear interaction is analyzed theoretically between the atmospheric boundary layer and the free atmosphere. The structure of the topography boundary layer, atmospheric frontogenesis, the structure and circulation of the low-level front and other boundary layer dynamic problems are discussed. （3） The formation and development of meso-β-scale rainstorms under the background of the East-Asia atmosphere circulation are diagnosed with the variation of MPV （moist potential vorticity） anomalies. And some physical vectors are modified and applied in the moist atmosphere.
文摘BACKGROUND The most common site of paragonimiasis is in the lungs.The migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well as the liver,intestine,and abdominal cavity may be involved.Here,we present a case of intraperitoneal paragonimiasis without other organ involvement,mimicking tuberculous peritonitis.CASE SUMMARY A 57-year-old man presented with recurrent abdominal pain for 4 wk.Physical examination revealed tenderness in the right lower quadrant.Laboratory findings showed complete blood counts within the normal range without eosinophilia.Multiple reactive lymph nodes and diffuse peritoneal infiltration were noted on abdominal computed tomography(CT).There were no abnormalities on chest CT or colonoscopy.Intraoperative findings of diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis included multiple small whitish nodules and an abscess in the peritoneum.Pathological reports confirmed the presence of numerous eggs of Paragonimus westermani(P.westermani).A postoperative serum enzyme-linked immunosorbent assay revealed P.westermani positivity.Persistent and repetitive history-taking led him to retrospectively recall the consumption of freshwater crab.After 3 d of treatment with praziquantel(1800 mg;25 mg/kg),he recovered from all symptoms.CONCLUSION In patients who require diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis,repetitive history-taking and preoperative serologic antibody tests against Paragonimus may be helpful in diagnosing intraperitoneal paragonimiasis without other organ involvement.
基金National Natural Science Foundation of China,No.81874393.
文摘BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cases have been reported.We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment,thereby serving as a guide to correct diagnosis and treatment.CASE SUMMARY A 30-year-old man presented with recurrent itching plaques of 1-year duration in the left tibia that aggravated and involved both legs and the back.Examination revealed multiple symmetrical,purple,and hyperpigmented papules and nodules with surface exfoliation involving the tibia and dorsum of the neck with negative Nissl's sign,no abnormalities in the skin,mucosa,hair,or fingernail,and no local lymph node enlargement.Blisters were never reported prior to presentation.Serum immunoglobulin E level was 636 IU/mL.Clinical manifestations suggested DEB-Pr.Histological examination showed subepidermal fissure,scar tissue,and milia.Direct immunofluorescence showed no obvious abnormalities.However,we were unable to perform electron microscopy or genetic research following his choice.We treated him with topical tacrolimus.After 2 wk,the itching alleviated,and the skin lesions began to subside.No adverse reactions were observed during treatment.CONCLUSION Topical tacrolimus is a safe treatment option for patients with DEB-Pr and can achieve continuous relief of severe itching.
基金This work was supported by the China National Science Foundation (No.39880032)
文摘DNA chip technology employs light- directed in situ oligonucleotide synthesis and/or DNA microarray printing device to produce arrays of large number of probes in the tiny surface of silicon substrates, which makes it possible that the gene detection be conducted efficiently with high speed and sensitivity. The DNA chip may take important part in genome research, gene diagnoses and so on.
