Metamaterials hold great potential to enhance the imaging performance of magnetic resonance imaging(MRI)as auxiliary devices,due to their unique ability to confine and enhance electromagnetic fields.Despite their prom...Metamaterials hold great potential to enhance the imaging performance of magnetic resonance imaging(MRI)as auxiliary devices,due to their unique ability to confine and enhance electromagnetic fields.Despite their promise,the current implementation of metamaterials faces obstacles for practical clinical adoption due to several notable limitations,including their bulky and rigid structures,deviations from optimal resonance frequency,and inevitable interference with the radiofrequency(RF)transmission field in MRI.Herein,we address these restrictions by introducing a flexible and smart metamaterial that enhances sensitivity by conforming to patient anatomies while ensuring comfort during MRI procedures.The proposed metamaterial selectively amplifies the magnetic field during the RF reception phase by passively sensing the excitation signal strength,remaining“off”during the RF transmission phase.Additionally,the metamaterial can be readily tuned to achieve a precise frequency match with the MRI system through a controlling circuit.The metamaterial presented here paves the way for the widespread utilization of metamaterials in clinical MRI,thereby translating this promising technology to the MRI bedside.展开更多
In the realm of precise medicine,the advancement of manufacturing technologies is vital for enhancing the capabilities of medical devices such as nano/microrobots,wearable/implantable biosensors,and organon-chip syste...In the realm of precise medicine,the advancement of manufacturing technologies is vital for enhancing the capabilities of medical devices such as nano/microrobots,wearable/implantable biosensors,and organon-chip systems,which serve to accurately acquire and analyze patients’physiopathological information and to perform patient-specific therapy.Electrospinning holds great promise in engineering materials and components for advanced medical devices,due to the demonstrated ability to advance the development of nanomaterial science.Nevertheless,challenges such as limited composition variety,uncontrollable fiber orientation,difficulties in incorporating fragile molecules and cells,and low production effectiveness hindered its further application.To overcome these challenges,advanced electrospinning techniques have been explored to manufacture functional composites,orchestrated structures,living constructs,and scale-up fabrication.This review delves into the recent advances of electrospinning techniques and underscores their potential in revolutionizing the field of precise medicine,upon introducing the fundamental information of conventional electrospinning techniques,as well as discussing the current challenges and future perspectives.展开更多
基金supported by the National Institutes of Health(NIH)of Biomedical Imaging and Bioengineering grant no.5R21EB024673-03the Rajen Kilachand Fund for Integrated Life Science and Engineering.
文摘Metamaterials hold great potential to enhance the imaging performance of magnetic resonance imaging(MRI)as auxiliary devices,due to their unique ability to confine and enhance electromagnetic fields.Despite their promise,the current implementation of metamaterials faces obstacles for practical clinical adoption due to several notable limitations,including their bulky and rigid structures,deviations from optimal resonance frequency,and inevitable interference with the radiofrequency(RF)transmission field in MRI.Herein,we address these restrictions by introducing a flexible and smart metamaterial that enhances sensitivity by conforming to patient anatomies while ensuring comfort during MRI procedures.The proposed metamaterial selectively amplifies the magnetic field during the RF reception phase by passively sensing the excitation signal strength,remaining“off”during the RF transmission phase.Additionally,the metamaterial can be readily tuned to achieve a precise frequency match with the MRI system through a controlling circuit.The metamaterial presented here paves the way for the widespread utilization of metamaterials in clinical MRI,thereby translating this promising technology to the MRI bedside.
基金supported by the National Natural Science Foundation of China(32201126)the Beijing Natural Science Foundation(7232344)+2 种基金the Henan Provincial Key R&D and Promotion Project(232103810036)the Beijing Institute of Technology Research Funding Program for Young Scholars(XSQD-202123003,XSQD-202213001,and XSQD-6120220130)the Beijing Institute of Technology Teli Young Fellow Program(RCPT-20220029).
文摘In the realm of precise medicine,the advancement of manufacturing technologies is vital for enhancing the capabilities of medical devices such as nano/microrobots,wearable/implantable biosensors,and organon-chip systems,which serve to accurately acquire and analyze patients’physiopathological information and to perform patient-specific therapy.Electrospinning holds great promise in engineering materials and components for advanced medical devices,due to the demonstrated ability to advance the development of nanomaterial science.Nevertheless,challenges such as limited composition variety,uncontrollable fiber orientation,difficulties in incorporating fragile molecules and cells,and low production effectiveness hindered its further application.To overcome these challenges,advanced electrospinning techniques have been explored to manufacture functional composites,orchestrated structures,living constructs,and scale-up fabrication.This review delves into the recent advances of electrospinning techniques and underscores their potential in revolutionizing the field of precise medicine,upon introducing the fundamental information of conventional electrospinning techniques,as well as discussing the current challenges and future perspectives.
