Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoti...Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoting high-quality development of new energy in China.This paper constructs an evaluation index system for the development of NEVs and the ecological environment.It uses game theory combining weighting model,particle swarm optimized projection tracking evaluation model,coupling coordination degree model,and machine learning algorithms to calculate and analyze the level of coupling coordination development of NEVs and the ecological environment in China from 2010 to 2021,and identifies the driving factors.The research results show that:(i)From 2010 to 2021,the development index of NEVs in China has steadily increased from 0.085 to 0.634,while the ecological environment level index significantly rose from 0.170 to 0.884,reflecting the continuous development of China in both NEVs and the ecological environment.(ii)From 2010 to 2012,the two systems—new energy vehicle(NEV)development and the ecological environment—were in a period of imbalance and decline.From 2013 to 2016,they underwent a transition period,and from 2017 to 2021,they entered a period of coordinated development showing a trend of benign and continuous improvement.By 2021,they reached a good level of coordination.(iii)Indicators such as the number of patents granted for NEVs,water consumption per unit of GDP,and energy consumption per unit of GDP are the main driving factors affecting the coupling coordination development of NEVs and the ecological environment in China.展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote p...Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote provision of mental health services by digital means can effectively augment conventional services in LMICs to reduce the treatment gap.Digital psychiatry in LMICs has always lagged behind high-income countries,but there have been encouraging developments in the last decade.There is increasing research on the efficacy of digital psychiatric interventions.However,the evidence is not adequate to conclude that digital psychiatric interventions are invariably effective in LMICs.A striking development has been the rise in mobile and smartphone ownership in LMICs,which has driven the increasing use of mobile technologies to deliver mental health services.An innovative use of mobile technologies has been to optimize task-shifting,which involves delivering mental healthcare services in community settings using non-specialist health professionals.Emerging evidence from LMICs shows that it is possible to use digital tools to train non-specialist workers effectively and ensure that the psychosocial interventions they deliver are efficacious.Despite these promising developments,many barriers such as service costs,underdeveloped infrastructure,lack of trained professionals,and significant disparities in access to digital services impede the progress of digital psychiatry in LMICs.To overcome these barriers,digital psychiatric services in LMICs should address contextual factors influencing the delivery of digital services,ensure collaboration between different stakeholders,and focus on reducing the digital divide.展开更多
This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communicatio...This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communications Technology (ICT), digital technologies in PNG, and the development of computing education in PNG since 1975. The research findings reveal that PNG has made solid progress in computing, ICT, national ICT policies, digital technologies, and computing education at universities in the post-independence era. The proposed approach in this article might facilitate the research and development of computing, ICT, digital technologies, and big data analytics in PNG, and beyond.展开更多
During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 202...During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.展开更多
The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established b...The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.展开更多
Hainan Province is situated at the northern edge of the Asian tropics,serving as China’s only tropical province.The province harbors exceptional biodiversity due to its unique geography and climate,particularly in fu...Hainan Province is situated at the northern edge of the Asian tropics,serving as China’s only tropical province.The province harbors exceptional biodiversity due to its unique geography and climate,particularly in fungal diversity.However,previous mycological surveys in Hainan are predominantly focused on central forested regions,while coastal ecosystems are largely overlooked.This study reports the first discovery of the genus Calocybella in China,with one new species and one new record for China collected from coastal Casuarina forests.Calocybella hainanensis sp.nov.is characterized by its ginger-yellow to yellowish-brown pileus,pale yellow lamellae,and small,oblong-ellipsoid basidiospores(4.9–5.5×2.3–3.1μm)with faint ornamentation and inamyloid reaction.The newly recorded species,Calocybella sribuabanensis,exhibits gregarious growth,yellowish-brown pileus,densely arranged lamellae,and ellipsoid,faintly ornamented,inamyloid basidiospores.Phylogenetic analyses based on ITS sequences reveal that C.hainanensis forms a unique evolutionary lineage within Calocybella,but it shows unresolved affinities to other taxa.C.sribuabanensis forms a sister lineage with the Indian species Calocybella dicholamellata.展开更多
The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas an...The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas and brought challenges to development policies and revitalization strategies in mountainous rural regions,especially in karst mountainous areas.In light of the difficulty in and as the key to the development of China's mountainous rural areas,the scientific and systematic construction of indicators for evaluating the level of rural revitalization development and clarifying the level of rural revitalization development and influential factors in karst mountainous areas are of great significance to the implementation of the development of the strategy for the revitalization of the rural areas in karst mountainous areas in China.This study constructed an evaluation index system of the rural regional system and rural revitalization development(RTSRD)from the perspective of rural regional system theory,assessed the spatial differentiation patterns and influential factors of RTSRD,and refined a typical territorial model of rural revitalization development in karst mountainous areas by taking Guizhou Province,a typical karst mountainous region,as a case study area.The evaluation and spatial analyses show that the RTSRD indices of karst mountainous areas in the system perspective show a linear growth trend in all single dimensions,with industrial revitalization(IR)showing the most significant increase each year.In time,the RTSRD of karst mountainous regions has developed from low to high,with evident improvement;spatially,the RTSRD shows the characteristics of‘high in the middle and low in the surroundings,and low in the plateau and low in the depression,'with apparent spatial heterogeneity.In addition,this study found that the spatial and temporal differences in RTSRD result from a combination of endogenous push and exogenous pull in the rural system.In particular,this study has refined a typical regional model of rural revitalization development in karst mountainous regions,which provides theoretical support and case practice for rural development in other karst mountainous regions.At the same time,it provides a basis for decision-making for the county level government and rural development planning.展开更多
In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting t...In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.展开更多
As climate crisis intensifies,increasing attention has been drawn to the low-carbon transition of energy and the development of new energy sources.However,recently,new energy development worldwide has faced growing ob...As climate crisis intensifies,increasing attention has been drawn to the low-carbon transition of energy and the development of new energy sources.However,recently,new energy development worldwide has faced growing obstacles,casting a shadow over its prospects.China’s achievements in new energy development are leading globally and have significantly contributed to global climate governance.Despite challenges,the future prospects of new energy development in China will significantly influence the global landscape of energy development and climate governance.展开更多
Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were ...Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.展开更多
Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power o...Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem.展开更多
High-quality industrial development driven by scitech innovation has become a priority area of China-Singapore Cooperation.Chongqing’s Liangjiang New Area is working with Singapore to build a benchmark park for inter...High-quality industrial development driven by scitech innovation has become a priority area of China-Singapore Cooperation.Chongqing’s Liangjiang New Area is working with Singapore to build a benchmark park for international cooperation in scitech innovation with an aim to enhance collaboration with ASEAN member states in industries,infrastructure,and green development,according to an action plan for promoting high-quality development of state-level new areas released by the National Development and Reform Commission in March 2024.展开更多
Based on morphology and phylogenetic analyses,a new species,Efibula candidissima,is described from Bawangling,National Park of Hainan Tropical Rainforest.The basidiomata are resupinate,waxy,snow white when fresh,white...Based on morphology and phylogenetic analyses,a new species,Efibula candidissima,is described from Bawangling,National Park of Hainan Tropical Rainforest.The basidiomata are resupinate,waxy,snow white when fresh,white to cream and soft corky to fragile when dry,with distinct snow white rhizomorph at margin.Hymenophore surface are smooth,and the clamp connections are absent.Ellipsoid to oblong-ellipsoid basidiospores measure 4.8–5.8×3.3–4μm.This species is distributed in tropical forest in southern China.展开更多
In March 2025,the Cellulose Fibers Conference 2025,hosted by nova-Institute,a leading independent research institute in the field of global biotechnology,was held in Cologne,Germany.The conference presented the most s...In March 2025,the Cellulose Fibers Conference 2025,hosted by nova-Institute,a leading independent research institute in the field of global biotechnology,was held in Cologne,Germany.The conference presented the most successful solutions based on cellulose fibers that are currently available on the market,new developments and approaches and also shed light on the policy framework.展开更多
Wood-inhabiting fungi can decompose lignin,cellulose and hemicellulose,and play an integral role in the material cycle of forest ecosystems.In this study,a wood-inhabiting polypore collected from Yunnan Province,south...Wood-inhabiting fungi can decompose lignin,cellulose and hemicellulose,and play an integral role in the material cycle of forest ecosystems.In this study,a wood-inhabiting polypore collected from Yunnan Province,southwest China is introduced as a new genus typified by Porphyrostereum punctatum.The new genus Porphyrostereum is characterized by corticioid basidiomata with smooth,cream to slightly buff,cracked and becoming purplish pink or pinkish purple hymenial surface,a monomitic hyphal system and generative hyphae bearing clamp connections,and ellipsoid basidiospores.The phylogenetic analyses were performed with maximum likelihood and Bayesian inference methods based on ITS+nLSU nuclear RNA gene regions.Phylogenetic analyses showed that Porphyrostereum forms a monophyletic lineage within the order Polyporales in which it is closely related to Purpureocorticium.展开更多
Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.T...Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.They all have annual resupinate basidiomata with smooth,white to cream hymenophore and clavate to cylindrical leptocystidia without resinous matter.P.euryhypha is characterized by simple septate subicular hyphae 7.5-9.5μm wide and broadly clavate to sphaeropedunculate cystidia,narrowly ellipsoid basidiospores 9.3-11×3-4.3μm.P.pinicola is characterized by encrusted hyphae and bowl-shaped stephanocysts and thick-walled cystidia,oblong-ellipsoid basidiospores 5.5-8×3.2-5μm.P.stellata is characterized by leptocystidia and sometimes hyphidia encrusted with rosette-like crystals in subhymenium and hymenium,and oblong-ellipsoid basidiospores 8-10×3.5-5μm.In addition,Peniophorella cremea is considered as a synonym of Hyphoderma transiens.A key to Chinese species of Peniophorella is provided.展开更多
Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry....Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.展开更多
基金Supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24_0102)the China Scholarship Council Program(202406190114)。
文摘Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoting high-quality development of new energy in China.This paper constructs an evaluation index system for the development of NEVs and the ecological environment.It uses game theory combining weighting model,particle swarm optimized projection tracking evaluation model,coupling coordination degree model,and machine learning algorithms to calculate and analyze the level of coupling coordination development of NEVs and the ecological environment in China from 2010 to 2021,and identifies the driving factors.The research results show that:(i)From 2010 to 2021,the development index of NEVs in China has steadily increased from 0.085 to 0.634,while the ecological environment level index significantly rose from 0.170 to 0.884,reflecting the continuous development of China in both NEVs and the ecological environment.(ii)From 2010 to 2012,the two systems—new energy vehicle(NEV)development and the ecological environment—were in a period of imbalance and decline.From 2013 to 2016,they underwent a transition period,and from 2017 to 2021,they entered a period of coordinated development showing a trend of benign and continuous improvement.By 2021,they reached a good level of coordination.(iii)Indicators such as the number of patents granted for NEVs,water consumption per unit of GDP,and energy consumption per unit of GDP are the main driving factors affecting the coupling coordination development of NEVs and the ecological environment in China.
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
文摘Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote provision of mental health services by digital means can effectively augment conventional services in LMICs to reduce the treatment gap.Digital psychiatry in LMICs has always lagged behind high-income countries,but there have been encouraging developments in the last decade.There is increasing research on the efficacy of digital psychiatric interventions.However,the evidence is not adequate to conclude that digital psychiatric interventions are invariably effective in LMICs.A striking development has been the rise in mobile and smartphone ownership in LMICs,which has driven the increasing use of mobile technologies to deliver mental health services.An innovative use of mobile technologies has been to optimize task-shifting,which involves delivering mental healthcare services in community settings using non-specialist health professionals.Emerging evidence from LMICs shows that it is possible to use digital tools to train non-specialist workers effectively and ensure that the psychosocial interventions they deliver are efficacious.Despite these promising developments,many barriers such as service costs,underdeveloped infrastructure,lack of trained professionals,and significant disparities in access to digital services impede the progress of digital psychiatry in LMICs.To overcome these barriers,digital psychiatric services in LMICs should address contextual factors influencing the delivery of digital services,ensure collaboration between different stakeholders,and focus on reducing the digital divide.
文摘This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communications Technology (ICT), digital technologies in PNG, and the development of computing education in PNG since 1975. The research findings reveal that PNG has made solid progress in computing, ICT, national ICT policies, digital technologies, and computing education at universities in the post-independence era. The proposed approach in this article might facilitate the research and development of computing, ICT, digital technologies, and big data analytics in PNG, and beyond.
文摘During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.
文摘The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.
基金supported by the National Science Foundation of China(32260005,32470008)the Hainan Province Science and Technology Special Fund(ZDYF2024SHFZ129)+1 种基金the Hainan Provincial Natural Science Foundation(323MS044)the Scientific Research Project of Hainan Higher Education Institutions(Hnky2023ZD-8).
文摘Hainan Province is situated at the northern edge of the Asian tropics,serving as China’s only tropical province.The province harbors exceptional biodiversity due to its unique geography and climate,particularly in fungal diversity.However,previous mycological surveys in Hainan are predominantly focused on central forested regions,while coastal ecosystems are largely overlooked.This study reports the first discovery of the genus Calocybella in China,with one new species and one new record for China collected from coastal Casuarina forests.Calocybella hainanensis sp.nov.is characterized by its ginger-yellow to yellowish-brown pileus,pale yellow lamellae,and small,oblong-ellipsoid basidiospores(4.9–5.5×2.3–3.1μm)with faint ornamentation and inamyloid reaction.The newly recorded species,Calocybella sribuabanensis,exhibits gregarious growth,yellowish-brown pileus,densely arranged lamellae,and ellipsoid,faintly ornamented,inamyloid basidiospores.Phylogenetic analyses based on ITS sequences reveal that C.hainanensis forms a unique evolutionary lineage within Calocybella,but it shows unresolved affinities to other taxa.C.sribuabanensis forms a sister lineage with the Indian species Calocybella dicholamellata.
基金supported by the National Natural Science Foundation of China(Grant No.42061035)the Guizhou Provincial Program on Commercialization of Scientific and Technological Achievements([2022]010)。
文摘The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas and brought challenges to development policies and revitalization strategies in mountainous rural regions,especially in karst mountainous areas.In light of the difficulty in and as the key to the development of China's mountainous rural areas,the scientific and systematic construction of indicators for evaluating the level of rural revitalization development and clarifying the level of rural revitalization development and influential factors in karst mountainous areas are of great significance to the implementation of the development of the strategy for the revitalization of the rural areas in karst mountainous areas in China.This study constructed an evaluation index system of the rural regional system and rural revitalization development(RTSRD)from the perspective of rural regional system theory,assessed the spatial differentiation patterns and influential factors of RTSRD,and refined a typical territorial model of rural revitalization development in karst mountainous areas by taking Guizhou Province,a typical karst mountainous region,as a case study area.The evaluation and spatial analyses show that the RTSRD indices of karst mountainous areas in the system perspective show a linear growth trend in all single dimensions,with industrial revitalization(IR)showing the most significant increase each year.In time,the RTSRD of karst mountainous regions has developed from low to high,with evident improvement;spatially,the RTSRD shows the characteristics of‘high in the middle and low in the surroundings,and low in the plateau and low in the depression,'with apparent spatial heterogeneity.In addition,this study found that the spatial and temporal differences in RTSRD result from a combination of endogenous push and exogenous pull in the rural system.In particular,this study has refined a typical regional model of rural revitalization development in karst mountainous regions,which provides theoretical support and case practice for rural development in other karst mountainous regions.At the same time,it provides a basis for decision-making for the county level government and rural development planning.
基金supported by the Japan Society for the Promotion of Science KAKENHI(grant Nos.23K05678 to IM,19H05711 and 20H00466 to KS)the Joint Research Program of Institute for Molecular and Cellular Regulation,Gunma University(to KS)。
文摘In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.
文摘As climate crisis intensifies,increasing attention has been drawn to the low-carbon transition of energy and the development of new energy sources.However,recently,new energy development worldwide has faced growing obstacles,casting a shadow over its prospects.China’s achievements in new energy development are leading globally and have significantly contributed to global climate governance.Despite challenges,the future prospects of new energy development in China will significantly influence the global landscape of energy development and climate governance.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008).
文摘Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.
基金funded by the“Research and Application Project of Collaborative Optimization Control Technology for Distribution Station Area for High Proportion Distributed PV Consumption(4000-202318079A-1-1-ZN)”of the Headquarters of the State Grid Corporation.
文摘Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem.
文摘High-quality industrial development driven by scitech innovation has become a priority area of China-Singapore Cooperation.Chongqing’s Liangjiang New Area is working with Singapore to build a benchmark park for international cooperation in scitech innovation with an aim to enhance collaboration with ASEAN member states in industries,infrastructure,and green development,according to an action plan for promoting high-quality development of state-level new areas released by the National Development and Reform Commission in March 2024.
基金supported by the Hainan Institute of National Park(KY-24ZK02)the Key Research and Development Program Project of Hainan Province,China(ZDYF2023RDYL01)+1 种基金the Postdoctoral Fellowship Program(Grade C)of China Postdoctoral Science Foundation(GZC20230254)the National Natural Science Foundation of China(32270011).
文摘Based on morphology and phylogenetic analyses,a new species,Efibula candidissima,is described from Bawangling,National Park of Hainan Tropical Rainforest.The basidiomata are resupinate,waxy,snow white when fresh,white to cream and soft corky to fragile when dry,with distinct snow white rhizomorph at margin.Hymenophore surface are smooth,and the clamp connections are absent.Ellipsoid to oblong-ellipsoid basidiospores measure 4.8–5.8×3.3–4μm.This species is distributed in tropical forest in southern China.
文摘In March 2025,the Cellulose Fibers Conference 2025,hosted by nova-Institute,a leading independent research institute in the field of global biotechnology,was held in Cologne,Germany.The conference presented the most successful solutions based on cellulose fibers that are currently available on the market,new developments and approaches and also shed light on the policy framework.
文摘Wood-inhabiting fungi can decompose lignin,cellulose and hemicellulose,and play an integral role in the material cycle of forest ecosystems.In this study,a wood-inhabiting polypore collected from Yunnan Province,southwest China is introduced as a new genus typified by Porphyrostereum punctatum.The new genus Porphyrostereum is characterized by corticioid basidiomata with smooth,cream to slightly buff,cracked and becoming purplish pink or pinkish purple hymenial surface,a monomitic hyphal system and generative hyphae bearing clamp connections,and ellipsoid basidiospores.The phylogenetic analyses were performed with maximum likelihood and Bayesian inference methods based on ITS+nLSU nuclear RNA gene regions.Phylogenetic analyses showed that Porphyrostereum forms a monophyletic lineage within the order Polyporales in which it is closely related to Purpureocorticium.
文摘Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.They all have annual resupinate basidiomata with smooth,white to cream hymenophore and clavate to cylindrical leptocystidia without resinous matter.P.euryhypha is characterized by simple septate subicular hyphae 7.5-9.5μm wide and broadly clavate to sphaeropedunculate cystidia,narrowly ellipsoid basidiospores 9.3-11×3-4.3μm.P.pinicola is characterized by encrusted hyphae and bowl-shaped stephanocysts and thick-walled cystidia,oblong-ellipsoid basidiospores 5.5-8×3.2-5μm.P.stellata is characterized by leptocystidia and sometimes hyphidia encrusted with rosette-like crystals in subhymenium and hymenium,and oblong-ellipsoid basidiospores 8-10×3.5-5μm.In addition,Peniophorella cremea is considered as a synonym of Hyphoderma transiens.A key to Chinese species of Peniophorella is provided.
基金funded by Research on Policy Design and Implementation Path for High-Quality Development of Digital Cultural Industry(23&ZD087),a major project of the National Social Science Foundation of China.
文摘Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.
