In Wuhu,urban renewal has not only transformed the development process,but improved people’s lives.DURING the 14th Five-Year Plan period(2021-2025),urban renewal has served as a crucial measure to promote high-qualit...In Wuhu,urban renewal has not only transformed the development process,but improved people’s lives.DURING the 14th Five-Year Plan period(2021-2025),urban renewal has served as a crucial measure to promote high-quality urban development and continuously meet people’s growing aspirations for a better life.Wuhu,in central China’s Anhui Province,has consistently enhanced its urban functions and services to build a modern,people-oriented city that is innovative,livable,beautiful,resilient,and smart.展开更多
Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This...Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry.展开更多
Colorectal cancer(CRC)is one of the most lethal and common malignancies in the world.Chemotherapy has been the conventional treatment for metastatic CRC(mCRC)patients.However,the effects of chemotherapy have been unsa...Colorectal cancer(CRC)is one of the most lethal and common malignancies in the world.Chemotherapy has been the conventional treatment for metastatic CRC(mCRC)patients.However,the effects of chemotherapy have been unsatisfactory.With the advent of targeted therapy,the survival of patients with CRC have been prolonged.Over the past 20 years,targeted therapy for CRC has achieved substantial progress.However,targeted therapy has the same challenge of drug resistance as chemotherapy.Consequently,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research topic.In this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.展开更多
Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman an...Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed展开更多
This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensiona...This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.展开更多
1. Introduction Thermodynamics forms the fundamental underpinning of reactivity, transformation, and stability, and controls processes such as synthesis, corrosion and degradation, environmental transport, catalysis, ...1. Introduction Thermodynamics forms the fundamental underpinning of reactivity, transformation, and stability, and controls processes such as synthesis, corrosion and degradation, environmental transport, catalysis, and biological reactivity. In the materials field, the wealth of new compounds, polymorphs, hybrid organic–inorganic hybrid materials and metal organic frameworks, high-entropy alloys, and multiphase and nanophase materials attained by a variety of non-equilibrium synthesis and processing methodologies has outrun the available thermodynamic data, hampering current understanding of synthetic pathways, materials compatibility, and longevity during use, degradation, corrosion, and dissolution, and limiting our understanding of environmental contamination and transport for new materials.展开更多
I.IntroductionIt is well known that China is rich in natural resources of tungsten.Before 1949 there was al-most no tungsten industry in our country except mining and ore dressing.Tremendous changeshave taken place af...I.IntroductionIt is well known that China is rich in natural resources of tungsten.Before 1949 there was al-most no tungsten industry in our country except mining and ore dressing.Tremendous changeshave taken place after 1949.We have built our metallurgical industry of tungsten.Especially start-ing from the last decade much progress has been made not only in production technologies and展开更多
For Westerners,2016 was a year of frequent 'black swan' events.Following a referendum held on June 23,Britain decided to leave the European Union.On November 8,Donald Trump won the U.S.presidential election un...For Westerners,2016 was a year of frequent 'black swan' events.Following a referendum held on June 23,Britain decided to leave the European Union.On November 8,Donald Trump won the U.S.presidential election unsurprisingly.Another referendum was held in Italy on December展开更多
Since the 21^(st) century,great attention has been paid to ultra fast cooling(UFC) technology in the whole world.The industries and the research institutions began to carry out investigations on basic theories and ind...Since the 21^(st) century,great attention has been paid to ultra fast cooling(UFC) technology in the whole world.The industries and the research institutions began to carry out investigations on basic theories and industrial applications.Since 2003,the RAL of Northeastern University has made some progresses on microstructure control theories,understanding of strengthening mechanisms and their industrial applications.In this paper,these achievements since the last Baosteel BAC in 2008 will be reported on the industrialization of UFC, strengthening mechanism,development of new steel grades,and so on.展开更多
Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoti...Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoting high-quality development of new energy in China.This paper constructs an evaluation index system for the development of NEVs and the ecological environment.It uses game theory combining weighting model,particle swarm optimized projection tracking evaluation model,coupling coordination degree model,and machine learning algorithms to calculate and analyze the level of coupling coordination development of NEVs and the ecological environment in China from 2010 to 2021,and identifies the driving factors.The research results show that:(i)From 2010 to 2021,the development index of NEVs in China has steadily increased from 0.085 to 0.634,while the ecological environment level index significantly rose from 0.170 to 0.884,reflecting the continuous development of China in both NEVs and the ecological environment.(ii)From 2010 to 2012,the two systems—new energy vehicle(NEV)development and the ecological environment—were in a period of imbalance and decline.From 2013 to 2016,they underwent a transition period,and from 2017 to 2021,they entered a period of coordinated development showing a trend of benign and continuous improvement.By 2021,they reached a good level of coordination.(iii)Indicators such as the number of patents granted for NEVs,water consumption per unit of GDP,and energy consumption per unit of GDP are the main driving factors affecting the coupling coordination development of NEVs and the ecological environment in China.展开更多
Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.T...Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.They all have annual resupinate basidiomata with smooth,white to cream hymenophore and clavate to cylindrical leptocystidia without resinous matter.P.euryhypha is characterized by simple septate subicular hyphae 7.5-9.5μm wide and broadly clavate to sphaeropedunculate cystidia,narrowly ellipsoid basidiospores 9.3-11×3-4.3μm.P.pinicola is characterized by encrusted hyphae and bowl-shaped stephanocysts and thick-walled cystidia,oblong-ellipsoid basidiospores 5.5-8×3.2-5μm.P.stellata is characterized by leptocystidia and sometimes hyphidia encrusted with rosette-like crystals in subhymenium and hymenium,and oblong-ellipsoid basidiospores 8-10×3.5-5μm.In addition,Peniophorella cremea is considered as a synonym of Hyphoderma transiens.A key to Chinese species of Peniophorella is provided.展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new ag...In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.展开更多
Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote p...Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote provision of mental health services by digital means can effectively augment conventional services in LMICs to reduce the treatment gap.Digital psychiatry in LMICs has always lagged behind high-income countries,but there have been encouraging developments in the last decade.There is increasing research on the efficacy of digital psychiatric interventions.However,the evidence is not adequate to conclude that digital psychiatric interventions are invariably effective in LMICs.A striking development has been the rise in mobile and smartphone ownership in LMICs,which has driven the increasing use of mobile technologies to deliver mental health services.An innovative use of mobile technologies has been to optimize task-shifting,which involves delivering mental healthcare services in community settings using non-specialist health professionals.Emerging evidence from LMICs shows that it is possible to use digital tools to train non-specialist workers effectively and ensure that the psychosocial interventions they deliver are efficacious.Despite these promising developments,many barriers such as service costs,underdeveloped infrastructure,lack of trained professionals,and significant disparities in access to digital services impede the progress of digital psychiatry in LMICs.To overcome these barriers,digital psychiatric services in LMICs should address contextual factors influencing the delivery of digital services,ensure collaboration between different stakeholders,and focus on reducing the digital divide.展开更多
In June 2012,with the approval of the State Council,the State Council Information Office issued the National Human Rights Action Plan(2012-15)(the"Action Plan"),the second national plan under the same theme....In June 2012,with the approval of the State Council,the State Council Information Office issued the National Human Rights Action Plan(2012-15)(the"Action Plan"),the second national plan under the same theme.In the past two years,under the leadership of the CPC Central Committee and General Secretary Xi Jinping,the Action Plan展开更多
This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communicatio...This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communications Technology (ICT), digital technologies in PNG, and the development of computing education in PNG since 1975. The research findings reveal that PNG has made solid progress in computing, ICT, national ICT policies, digital technologies, and computing education at universities in the post-independence era. The proposed approach in this article might facilitate the research and development of computing, ICT, digital technologies, and big data analytics in PNG, and beyond.展开更多
During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 202...During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.展开更多
The numbers of farmers in-terested in learning about human reproduction,living healthy,well-balanced lives,improving standards of living and education,and finding out more about technological pro-duction,are growing d...The numbers of farmers in-terested in learning about human reproduction,living healthy,well-balanced lives,improving standards of living and education,and finding out more about technological pro-duction,are growing daily.They thoroughly approve of,hence sup-port,the new methods,and these methods have also gone a long way toward improving relations between officials and the people.Song Jiyin,who used to be the family planning official for his village,infuriated his neighbors so much by his uncouth manner,they destroyed his fruit trees and vegetable garden on sev-eral occasions.He finally set things right with the community last year by applying the I new,method of combining family planning with economic benefits:he set up a car-pet factory that employed 33 wom-en from single-child families.展开更多
文摘In Wuhu,urban renewal has not only transformed the development process,but improved people’s lives.DURING the 14th Five-Year Plan period(2021-2025),urban renewal has served as a crucial measure to promote high-quality urban development and continuously meet people’s growing aspirations for a better life.Wuhu,in central China’s Anhui Province,has consistently enhanced its urban functions and services to build a modern,people-oriented city that is innovative,livable,beautiful,resilient,and smart.
基金Supported by Special Soft Science Research Project for Hubei Province Science and Technology Innovation Talents and Services (2022EDA060)。
文摘Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry.
基金the National Natural Science Foundation of China,No.82073338Sichuan Science and Technology Support Project,No.2021YFSY0039 and No.22ZDYF0499+1 种基金1·3·5 Project for Disciplines of Excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University,No.2020HXFH0021.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYJC21059.
文摘Colorectal cancer(CRC)is one of the most lethal and common malignancies in the world.Chemotherapy has been the conventional treatment for metastatic CRC(mCRC)patients.However,the effects of chemotherapy have been unsatisfactory.With the advent of targeted therapy,the survival of patients with CRC have been prolonged.Over the past 20 years,targeted therapy for CRC has achieved substantial progress.However,targeted therapy has the same challenge of drug resistance as chemotherapy.Consequently,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research topic.In this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.
文摘Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed
文摘This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.
基金the US Department of Energy, Office of Science,Basic Energy Sciences (DE-SC0001089)while that on ultra-ightemperature calorimetry was supported by the National Science Foundation DMR (1506229 and 1835848).
文摘1. Introduction Thermodynamics forms the fundamental underpinning of reactivity, transformation, and stability, and controls processes such as synthesis, corrosion and degradation, environmental transport, catalysis, and biological reactivity. In the materials field, the wealth of new compounds, polymorphs, hybrid organic–inorganic hybrid materials and metal organic frameworks, high-entropy alloys, and multiphase and nanophase materials attained by a variety of non-equilibrium synthesis and processing methodologies has outrun the available thermodynamic data, hampering current understanding of synthetic pathways, materials compatibility, and longevity during use, degradation, corrosion, and dissolution, and limiting our understanding of environmental contamination and transport for new materials.
文摘I.IntroductionIt is well known that China is rich in natural resources of tungsten.Before 1949 there was al-most no tungsten industry in our country except mining and ore dressing.Tremendous changeshave taken place after 1949.We have built our metallurgical industry of tungsten.Especially start-ing from the last decade much progress has been made not only in production technologies and
文摘For Westerners,2016 was a year of frequent 'black swan' events.Following a referendum held on June 23,Britain decided to leave the European Union.On November 8,Donald Trump won the U.S.presidential election unsurprisingly.Another referendum was held in Italy on December
文摘Since the 21^(st) century,great attention has been paid to ultra fast cooling(UFC) technology in the whole world.The industries and the research institutions began to carry out investigations on basic theories and industrial applications.Since 2003,the RAL of Northeastern University has made some progresses on microstructure control theories,understanding of strengthening mechanisms and their industrial applications.In this paper,these achievements since the last Baosteel BAC in 2008 will be reported on the industrialization of UFC, strengthening mechanism,development of new steel grades,and so on.
基金Supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24_0102)the China Scholarship Council Program(202406190114)。
文摘Studying the coupling coordination development of new energy vehicles(NEVs)and the ecological environment in China is helpful in promoting the development of NEVs in the country and is of great significance in promoting high-quality development of new energy in China.This paper constructs an evaluation index system for the development of NEVs and the ecological environment.It uses game theory combining weighting model,particle swarm optimized projection tracking evaluation model,coupling coordination degree model,and machine learning algorithms to calculate and analyze the level of coupling coordination development of NEVs and the ecological environment in China from 2010 to 2021,and identifies the driving factors.The research results show that:(i)From 2010 to 2021,the development index of NEVs in China has steadily increased from 0.085 to 0.634,while the ecological environment level index significantly rose from 0.170 to 0.884,reflecting the continuous development of China in both NEVs and the ecological environment.(ii)From 2010 to 2012,the two systems—new energy vehicle(NEV)development and the ecological environment—were in a period of imbalance and decline.From 2013 to 2016,they underwent a transition period,and from 2017 to 2021,they entered a period of coordinated development showing a trend of benign and continuous improvement.By 2021,they reached a good level of coordination.(iii)Indicators such as the number of patents granted for NEVs,water consumption per unit of GDP,and energy consumption per unit of GDP are the main driving factors affecting the coupling coordination development of NEVs and the ecological environment in China.
文摘Three new wood-rotting fungi Peniophorella growing on Pinus yunnanensis in southwestern China,Peniophorella euryhypha,Peniophorella pinicola and Peniophorella stellata,are described based on morphology and phylogeny.They all have annual resupinate basidiomata with smooth,white to cream hymenophore and clavate to cylindrical leptocystidia without resinous matter.P.euryhypha is characterized by simple septate subicular hyphae 7.5-9.5μm wide and broadly clavate to sphaeropedunculate cystidia,narrowly ellipsoid basidiospores 9.3-11×3-4.3μm.P.pinicola is characterized by encrusted hyphae and bowl-shaped stephanocysts and thick-walled cystidia,oblong-ellipsoid basidiospores 5.5-8×3.2-5μm.P.stellata is characterized by leptocystidia and sometimes hyphidia encrusted with rosette-like crystals in subhymenium and hymenium,and oblong-ellipsoid basidiospores 8-10×3.5-5μm.In addition,Peniophorella cremea is considered as a synonym of Hyphoderma transiens.A key to Chinese species of Peniophorella is provided.
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
文摘In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.
文摘Low-and middle-income countries(LMICs)bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap.The remote provision of mental health services by digital means can effectively augment conventional services in LMICs to reduce the treatment gap.Digital psychiatry in LMICs has always lagged behind high-income countries,but there have been encouraging developments in the last decade.There is increasing research on the efficacy of digital psychiatric interventions.However,the evidence is not adequate to conclude that digital psychiatric interventions are invariably effective in LMICs.A striking development has been the rise in mobile and smartphone ownership in LMICs,which has driven the increasing use of mobile technologies to deliver mental health services.An innovative use of mobile technologies has been to optimize task-shifting,which involves delivering mental healthcare services in community settings using non-specialist health professionals.Emerging evidence from LMICs shows that it is possible to use digital tools to train non-specialist workers effectively and ensure that the psychosocial interventions they deliver are efficacious.Despite these promising developments,many barriers such as service costs,underdeveloped infrastructure,lack of trained professionals,and significant disparities in access to digital services impede the progress of digital psychiatry in LMICs.To overcome these barriers,digital psychiatric services in LMICs should address contextual factors influencing the delivery of digital services,ensure collaboration between different stakeholders,and focus on reducing the digital divide.
文摘In June 2012,with the approval of the State Council,the State Council Information Office issued the National Human Rights Action Plan(2012-15)(the"Action Plan"),the second national plan under the same theme.In the past two years,under the leadership of the CPC Central Committee and General Secretary Xi Jinping,the Action Plan
文摘This article looks at the developments of computing in Papua New Guinea (PNG) in the post-independence era. More specifically, this article examines the development of national policies on Information and Communications Technology (ICT), digital technologies in PNG, and the development of computing education in PNG since 1975. The research findings reveal that PNG has made solid progress in computing, ICT, national ICT policies, digital technologies, and computing education at universities in the post-independence era. The proposed approach in this article might facilitate the research and development of computing, ICT, digital technologies, and big data analytics in PNG, and beyond.
文摘During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.
文摘The numbers of farmers in-terested in learning about human reproduction,living healthy,well-balanced lives,improving standards of living and education,and finding out more about technological pro-duction,are growing daily.They thoroughly approve of,hence sup-port,the new methods,and these methods have also gone a long way toward improving relations between officials and the people.Song Jiyin,who used to be the family planning official for his village,infuriated his neighbors so much by his uncouth manner,they destroyed his fruit trees and vegetable garden on sev-eral occasions.He finally set things right with the community last year by applying the I new,method of combining family planning with economic benefits:he set up a car-pet factory that employed 33 wom-en from single-child families.
